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| 1 | Dysregulation of mTOR activity through LKB1 inactivation显示文摘Mammalian target of rapamycin (mTOR) is aberrantly activated in many cancer types, and two rapamycin derivatives are currently approved by the Food and Drug Administration (FDA) of the United States for treating renal cell carcinoma. Mechanistically, mTOR is hyperactivated in human cancers either due to the genetic activation of its upstream activating signaling pathways or the genetic inactivation of its negative regulators. The tumor suppressor liver kinase B1 (LKB1), also known as serine/threonine kinase 11 (STK11), is involved in cell polarity, cell detachment and adhesion, tumor metastasis, and energetic stress response. A key role of LKB1 is to negatively regulate the activity of mTOR complex 1 (mTORC1). This review summarizes the molecular basis of this negative interaction and recent research progress in this area. | Wei Zhou Adam I. M arcus Paula M. Vertino | 2013 | Chinese Journal of Cancer2013，32，8： | 4 |
| 2 | Superantigens - powerful modifiers of the immune system显示文摘 | Fraser J Arcus V Kong P | 2000 | Mol Med Today2000，6，3： | 1 |
| 3 | X-ray diffraction Analysis of the structure of poly(dichlorophosphazene)显示文摘 | H Allcock R Arcus E Stroh | 1980 | Macromolecules1980，13，4： | 1 |
| 4 | The multifunctional histone-like protein Lsr2 protects mycobacteria against reactive oxygen intermediates显示文摘 | Colangeli R Haq A Arcus VL | 2009 | Proc Natl Acad Sci USA2009，106，11： | 1 |
| 5 | Conformation, bonding, and flexibility in short-chain linear phosphazenes, 显示文摘 | ALLCOCK H R TOLLEFSON N M ARCUS R A | 1985 | J Am Chem Soc1985，107，18： | 1 |
| 6 | COMSOAL-A Computer Method of Sequencing Operations for Assembly Line显示文摘 | Arcus A L | 1966 | International Journal for Production Research1966，，4： | 1 |
| 7 | The relationship between coercivity and the structure and composition of electroless Co- P films 显示文摘 | Miksic M G Travieso R Arcus A | 1966 | Journal of the Eloctrochemical Society1966，113，4： | 1 |
| 8 | The potential impact of structral genomics on tuberculosis drug discovery 显示文摘 | ARCUS V L LOTT J S JOHNSTON J M | 2006 | Drug Discov Today2006，11，12： | 1 |
| 9 | Superantigens-powerful modifiers of the immune system显示文摘 | Fraser J Arcus V Kong P | | 0，，3： | 1 |
| 10 | A palcebocontrolled double-blind study of the efficacy and safety of aripiprazole in patients with acute bipolar mania显示文摘 | Keck PE M arcus R Tourkodimitris S | | 0，，： | 1 |
| 11 | Superantigens powerful modifiers of the immune system显示文摘 | Fraser J Arcus V Kong P | 2000 | Mol Med Today2000，6，3： | 1 |
| 12 | Superantigens-powerful modifiers of the immune system显示文摘 | Fraser J Arcus V Kong P | 2000 | Mol Med Today2000，6，3： | 1 |
| 13 | Distant structural ho- mology leads to the functional characterization of an ar- chaeal PIN domain as an exonuclease显示文摘 | Arcus VL Backbro K Roos A | 2004 | J Biol Chem2004，279，16： | 1 |
| 14 | The lipid research clinics pro- gram prevalence study 显示文摘 | Segal P Insull W Jr Chambless LE Stinnett S LaRosa JC Weissfeld L The association of dyslipoproteinemia with corneal arcus and xanthelasma | 1986 | Circulation1986，73，12： | 1 |
| 15 | Using the stages of change model to increase the adoption of physical activity among community participants显示文摘 | M arcus B H Banspach S W Lefebvre R C | | 0，，06： | 1 |
| 16 | A comparison of the pH,urea,and temperaturedenatured states of barnase by heteronuclear NMR:implications for the initiation of protein folding显示文摘 | ARCUS V L VUILLEUMIER S FREUND S M | 1995 | J Mol Biol1995，254，： | 1 |
| 17 | The Three-dimensional structure of a superantigen-like protein, SET3, from a pathogenicity island of the Staphylococcus aureus genome 显示文摘 | Arcus V L Langley R Proft T | 2002 | J Biol Chem2002，277，32： | 1 |
| 18 | Superantigens-powerful modifiers of the immune system 显示文摘 | FRASER J ARCUS V KONG P | 2000 | Mol Med Today2000，6，3： | 1 |
| 19 | COMSOAL: a computer method for sequencing operations for assembly lines 显示文摘 | Arcus A L | 1966 | International Journal of Production Research1966，4，4： | 1 |
| 20 | A new vaccine againsttuber-culosis affords greater survival after challenge than the current vaccine in the Guinea Pig model of pulmonary tuberc-ulosis显示文摘 | Gunter Harth | 2003 | Infection and Immunity2003，71，： | 1 |
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