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| 1 | Focus on emerging drugs for the treatment of patients with non-alcoholic fatty liver disease显示文摘Non-alcoholic fatty liver disease(NAFLD)has become the most common liver disorder in Western countries and is increasingly being recognized in developing nations.Fatty liver disease encompasses a spectrum of hepatic pathology,ranging from simple steatosis to non-alcoholic steatohepatitis,cirrhosis,hepatocellular carcinoma and end-stage liver disease.Moreover,NAFLD is often associated with other metabolic conditions,such as diabetes mellitus type 2,dyslipidemia and visceral obesity.The most recent guidelines suggest the management and treatment of patients with NAFLD considering both the liver disease and the associated metabolic co-morbidities.Diet and physical exercise are considered the first line of treatment for patients with NAFLD,but their results on therapeutic efficacy are often contrasting.Behavior therapy is necessary most of the time to achieve a sufficient result.Pharmacological therapy includes a wide variety of classes of molecules with different therapeutic targets and,often,little evidence supporting the real efficacy.Despite the abundance of clinical trials,NAFLD therapy remains a challenge for the scientific community,and there are no licensed therapies for NAFLD.Urgently,new pharmacological approaches are needed.Here,we will focus on the challenges facing actual therapeutic strategies and the most recent investigated molecules. | Alessandro Federico Claudio Zulli Ilario de Sio Anna Del Prete Marcello Dallio Mario Masarone Carmela Loguercio | 2014 | World Journal of Gastroenterology2014，20，45： | 10 |
| 2 | Efficacy and safety of endoscopic papillary balloon dilation for the removal of bile duct stones: Data from a “real-life” multicenter study on Dilation-Assisted Stone Extraction显示文摘AIM To report data on Dilation-Assisted Stone Extraction(DASE) use in clinical practice and its efficacy and safety trough three Italian referral centers for biliopancreatic diseases treatment. METHODS From January 2011 to December 2015 we collected data on 120 patients treated with DASE. Technical success was obtained when the endoscopist was able to place the balloon trough the papilla inflating the balloon until the final diameter for an adequate time(at least 30 s). Clinical success was obtained after complete stone removal(no remaining stones were visible at the cholangiogram).RESULTS Forty-nine male(40.8%) and 71 female(59%) were enrolled. The mean age was 67.8 years ± 15.7. The mean common bile duct(CBD) dilation was 19.2 mm± 3.9 and the mean size of stones 15.8 ± 2.9. DASE was applied as first approach in 38%(62% after initial failure of stones extraction). Technical and clinical success was of 91% and 87% respectively. In those in which DASE failed alternative treatment were adopted. After DASE 18% of patients experienced a complication(bleeding 9%, pancreatitis 8%, perforation 0.8%). At univariable analysis, elective endoscopic retrograde cholangiopancreatography(P = 0.031), DASE as first approach(P = 0.032), and cannulation of major papilla followed by guidewire insertion(P = 0.004) were related to low risk of complications. Pre-cut was related to an increased risk of complications(P = 0.01). CONCLUSION DASE allowed a higher first-session success rate and can be consider a valid alternative to endoscopic sphincterotomy not only for bigger CBD stones. | Roberto Di Mitri Filippo Mocciaro Socrate Pallio Giulia Maria Pecoraro Andrea Tortora Claudio Zulli Simona Attardo Attilio Maurano | 2016 | World Journal of Gastrointestinal Endoscopy2016，8，18： | 3 |
| 3 | Analytical and numerical approaches to nonlinear galloping of internally resonant suspended cables显示文摘 | Angelo Luongo Daniele Zulli Giuseppe Piccardo | 2008 | Journal of Sound and Vibration2008，，3： | 2 |
| 4 | Reduction of cardiovascular structuralchanges by nifedipine GITS in essential hypertensive patients显示文摘 | Agabiti-Rosei E Zulli R Muiesan ML | 1998 | BloodPress1998，7，3： | 1 |
| 5 | Three- dimension modeling of the wall heat transfer in the lower stack region of a blast furnace显示文摘 | Wang G X Yu A B Zulli P | 1997 | ISIJ Int1997，37，5： | 1 |
| 6 | Cardiovascular characteristics in normotensive subjects with or without family history of hypertension显示文摘 | Rizzoni D Zulli R | 1996 | Clin Exp Hypertens1996，18，7： | 1 |
| 7 | Studies of charging stream trajectories and burden distribution in the blast furnace显示文摘 | P L Mayfield P Zulli | 1993 | Ironmaking Conference Proceedings1993，，： | 1 |
| 8 | ACE2 and AT4R are pres- ent in diseased human blood vessels显示文摘 | Zulli A Burrell LM Buxton BF | 2008 | EurJ Histochem2008，52，1： | 1 |
| 9 | Modeling the discontinuous liquid flow in a blast furnace显示文摘 | G. X. Wang S. J. Chew A. B. Yu P. Zulli | 1997 | Metallurgical and Materials Transactions B1997，，2： | 1 |
| 10 | Augmented effects of methionine and cholesterol in decreasing the elastic lamina while thickening the aortic wall in the rat aorta显示文摘 | Zulli A Buxton B F Doolan L | 1998 | Clin Sci (Lond)1998，95，5： | 1 |
| 11 | Three-Dimensional Simulation of Flow and Combustion for Pulverized Coal Injection 显示文摘 | Guo B Y Zulli P Roger H | 2005 | ISIJ International2005，45，9： | 1 |
| 12 | Modelling of energy consumption and CO2 emissions in Port Kembla Steelworks显示文摘 | Zughbi H Mathieson J Zulli P | 2008 | Scanmet Ⅲ2008，，： | 1 |
| 13 | Particle scale study of heat transfer in packed and bubbling fluidized beds显示文摘 | Zhou Z Y Yu A B Zulli P | 2009 | AIChE Journal2009，55，4： | 1 |
| 14 | Analytical and numerical approaches to nonlinear galloping of internally resonant suspended cables显示文摘 | Angelo Luongo Daniele Zulli Giuseppe Piccardo | 2008 | Journal of Sound and Vibrition2008，315，3： | 1 |
| 15 | A matrix for computing the Jones polynomial of a knot显示文摘 | ZULLI L | 1995 | Topology1995，34，3： | 1 |
| 16 | Numerical simulation of solids flow in a blast furnace 显示文摘 | ZI-IANG S J YU A B ZULLI P | 2002 | Applied Mathematical Modeling2002，26，2： | 1 |
| 17 | Polymorphism of the estrogen receptor beta gene is related to infertility and infertility- associated endometriosis 显示文摘 | Zulli K Bianco B Mafra FA | 2010 | Arq Bras Endoerinol Netabol2010，54，10： | 1 |
| 18 | On the effect of twist angle on nonlinear galloping of suspended cables显示文摘 | Angelo Luongo Daniele Zulli Giuseppe Piccardo | 2008 | Computers and Structures2008，，15： | 1 |
| 19 | Dispersion of titanium dioxide pigments by alkyl polyglycoside surfactants in aqueous solution显示文摘 | Smith G A Zulli A L Grieser M D | 1994 | Colliods and surfaces A:physicocbemical and engineering aspects1994，88，1： | 1 |
| 20 | High eradication rates of Helico- bacter pylori with a new sequential treatment 显示文摘 | Zulli A Vaira D Vakil N | 2003 | Aliment Pharma- col Ther2003，17，： | 1 |
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