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| 1 | 2018加拿大心境障碍与焦虑障碍治疗协作组/国际双相障碍学会指南:双相障碍的管理显示文摘加拿大心境障碍与焦虑障碍治疗协作组(Canadian Network for Mood and Anxiety Treatments,CANMAT)曾于2005年发布了第1版双相障碍管理指南,并分别于2007、2009和2013年对该指南进行了更新,其中最近的2次更新是与国际双相障碍学会(International Society for Bipolar Disorders,ISBD)合作完成。2018版CANMAT/ISBD双相障碍治疗指南(以下简称指南)反映了自2005年首版指南发表以来本领域取得的重大进展,包括疾病诊断与疾病管理的更新以及药物治疗与心理治疗的近期研究进展。这些前沿进展中综合考虑了循证证据的级别,并基于治疗疗效、临床实践经验、安全性、耐受性和药物导致的转相风险等,对一线、二线及三线治疗方案进行了简明而清晰的推荐。本指南中新增内容涵盖了双相Ⅰ型障碍(BD-Ⅰ)的躁狂发作急性期、抑郁发作急性期和双相障碍维持期的一线及二线治疗推荐等级划分。这种对治疗推荐等级的划分综合考虑了治疗方法对双相障碍不同时相的影响,将进一步帮助临床医生做出基于循证证据的治疗决策。锂盐、喹硫平、双丙戊酸盐、阿塞那平、阿立哌唑、帕利哌酮、利培酮和卡利拉嗪单药或联合使用被推荐为躁狂发作急性期的一线治疗选择。BD-Ⅰ抑郁期的一线治疗选择包括喹硫平、鲁拉西酮、锂盐、拉莫三嗪单药,鲁拉西酮联合锂盐或双丙戊酸盐或拉莫三嗪辅助治疗。尽管急性期治疗有效的药物通常应继续用于BD-Ⅰ的维持期治疗,但也存在一些特殊情况(例如抗抑郁药)。现有数据表明,锂盐、喹硫平、双丙戊酸盐、拉莫三嗪、阿塞那平和阿立哌唑单药或联合治疗应被视为维持治疗的初始或更换治疗方案时的一线选择。除了探讨BD-Ⅰ的相关问题外,本指南中还对双相Ⅱ型障碍(BD-Ⅱ)的临床管理进行了系统回顾并给予治疗推荐,同时针对特殊人群也有相关推荐,如处于各个生殖周期的女性、儿童、青少年和老年人。此外,本指南中还讨论了特定精神疾病及共病(如物质滥用、焦虑障碍和代谢性疾病)的影响。最后,本指南中概述了安全性和药物监测的相关问题。CANMAT/ISBD工作组希望本指南能够成为全球临床医生的实用工具。 | Lakshmi N Yatham Sidney H Kennedy Sagar V Parikh Ayal Sehaffer David J Bond Benicio N Frey Verinder Sharma Benjamin I Goldstein Soham Rej Serge Beaulieu Martin Alda Glenda MaeQueen Roumen V Milev Arun Ravindran Claire O'Donovan Diane Mclntosh Raymond W Lam Gustavo Vazquez Flavio Kapczinski Roger S Melntyre Jan Kozicky Shigenobu Kanba Beny Lafer Trisha Suppes Joseph R Calabrese Eduard Vieta Gin Malhi Robert M Post Michael Berk 胡晨(译) 王刚(译) | 2019 | 中华精神科杂志2019，52，1： | 25 |
| 2 | 关于面向新建议书的进展情况报告——来自国际放射防护委员会的通讯显示文摘致电离辐射在医学和工业中使用的百年历史 ,从一开始就有了需要保护人类使之防御与照射有关的危害的忠告。在这整个时期 ,防护标准发生的演变 ,既反映了对照射的生物效应的科学认识 ,也反映了适用的社会标准与伦理标准。目前 ,ICRP主委员会正在考虑一个经过修改的简单方法 ,该方法基于一种面向个人的哲理 ,意味着委员会可能从过去强调的面向社会准则上做出转变。最初的建议通过 IRPA散发 ,并公开发表在 1999年 6月的《放射防护杂志 (Journal of RadiologicalProtection)上。委员会在收到意见和 IRPA 10大会评论的基础上 ,开始拟定下一建议书。本文阐述了在准备下一建议书时所涉及的问题 ,指出了委员会拟遵循的过程。委员会希望在未来的几年内将会有持续不断的争论 。 | Roger H Clarke 胡遵素 | 2001 | 辐射防护2001，21，4： | 15 |
| 3 | DNA damage induced by chronic inflammation contributes to colon carcinogenesis in mice显示文摘 | Meira Lisiane B Bugni James M Green Stephanie L Lee Chung-Wei Pang Bo Borenshtein Diana Rickman Barry H Rogers Arlin B Moroski-Erkul Catherine A McFaline Jose L Schauer David B Dedon Peter C Fox James G Samson Leona D | 2008 | Journal of Clinical Investigation2008，，7： | 2 |
| 4 | Solid-phase sequence scanning for drug resistance detection in tuberculosis 显示文摘 | Head S R Parikh K Rogers Y H | 1999 | Mol Cellular Probes1999，13，2： | 2 |
| 5 | Solid phase microextraction(SPME)technique for measurement of generation of fresh cucumber flavor compounds显示文摘 | CHERYL P H ROGER F | 2001 | J Agric Food Chem2001，49，： | 2 |
| 6 | Highlights of marine invertebrate-derived biosynthetic products: Their biomedical potential and possible production by microbial associants显示文摘 | Ocky K. Radjasa Yvette M. Vaske Gabriel Navarro Hélène C. Vervoort Karen Tenney Roger G. Linington Phillip Crews | 2011 | Bioorganic & Medicinal Chemistry2011，，22： | 2 |
| 7 | Modeling cardiac arrest and resuscitation in the domestic pig显示文摘Cardiac arrest remains a leading cause of death and permanent disability worldwide. Although many victims are initially resuscitated, they often succumb to the extensive ischemia-reperfusion injury inflicted on the internal organs, especially the brain. Cardiac arrest initiates a complex cellular injury cascade encompassing reactive oxygen and nitrogen species, Ca2+ overload, ATP depletion, pro- and anti-apoptotic proteins, mitochondrial dysfunction, and neuronal glutamate excitotoxity, which injures and kills cells, compromises function of internal organs and ignites a destructive systemic inflammatory response. The sheer complexity and scope of this cascade challenges the development of experimental models of and effective treatments for cardiac arrest. Many experimental animal preparations have been developed to decipher the mechanisms of damage to vital internal organs following cardiac arrest and cardiopulmonary resuscitation(CPR), and to develop treatments to interrupt the lethal injury cascades. Porcine models of cardiac arrest and resuscitation offer several important advantages over other species, and outcomes in this large animal are readily translated to the clinical setting. This review summarizes porcine cardiac arrest-CPR models reported in the literature, describes clinically relevant phenomena observed during cardiac arrest and resuscitation in pigs, and discusses numerous methodological considerations in modeling cardiac arrest/CPR. Collectively, published reports show the domestic pig to be a suitable large animal model of cardiac arrest which is responsive to CPR, defibrillatory countershocks and medications, and yields extensive information to foster advances in clinical treatment of cardiac arrest. | Brandon H Cherry Anh Q Nguyen Roger A Hollrah Albert H Olivencia-Yurvati Robert T Mallet | 2015 | World Journal of Critical Care Medicine2015，4，1： | 2 |
| 8 | ISSUES THAT ARE OF IMPORTANCE FOR THE INTERNATIONAL COMMISSION ON RADIOLOGICAL PROTECTION AS THE MILLENNIUM APPROACHES显示文摘1Introduction1.TheprimarybodyinradiologicalprotectionisICRP.Itwasformedin1928astheInternationalXrayandRadiumProtectionCommit... | Roger H Clarke(Chairman, International Commission on Radiological Protection) | 1998 | 辐射防护1998，18，Z1： | 2 |
| 9 | Binding pathway determines norepinephrine selectivity for the human β_(1)AR over β_(2)AR显示文摘Beta adrenergic receptors(βARs)mediate physiologic responses to the catecholamines epinephrine and norepinephrine released by the sympathetic nervous system.While the hormone epinephrine binds β_(1)AR and β_(2)AR with similar affinity,the smaller neurotransmitter norepinephrine is approximately tenfold selective for the β_(1)AR.To understand the structural basis for this physiologically important selectivity,we solved the crystal structures of the human β_(1)AR bound to an antagonist carazolol and different agonists including norepinephrine,epinephrine and BI-167107.Structural comparison revealed that the catecholamine-binding pockets are identical between β_(1)AR and β_(2)AR,but the extracellular vestibules have different shapes and electrostatic properties.Metadynamics simulations and mutagenesis studies revealed that these differences influence the path norepinephrine takes to the orthosteric pocket and contribute to the different association rates and thus different affinities. | Xinyu Xu Jonas Kaindl Mary J.Clark Harald Hübner Kunio Hirata Roger K.Sunahara Peter Gmeiner Brian K.Kobilka Xiangyu Liu | 2021 | Cell Research2021，31，5： | 2 |
| 10 | Intravitreal triamcinolone for refractory diabetic macular edema显示文摘 | Adam Martidis Jay S Duker Paul B Greenberg Adam H Rogers Carmen A Puliafito Elias Reichel Caroline Baumal | 2002 | Ophthalmology2002，，5： | 2 |
| 11 | Muscle morphogenetic protein induces myogenic geneexpression in Swiss-3T3 cells显示文摘 | YOUNG H E ROGERS J J ADKISON L R | 1998 | Wound Rep Reg1998，6，： | 1 |
| 12 | Effects of in-situ chemical vapour deposition using tetraethoxysilane on the catalytic and sorption properties of ZSM-5显示文摘 | Roger H P Kramer M Moiler K P | 1998 | Mieroporous Mesoporous Mater1998，21，46： | 1 |
| 13 | Shoulder plates and shafts in tesion and torsion显示文摘 | Rogers C C Stanley P | 1969 | J of Strain Analysis1969，4，1： | 1 |
| 14 | Immobilization of oligonucleotides onto a glass support via disulfide bonds: A method for preparation of DNA microarrays 显示文摘 | Rogers Y H Jiang - Baucom P Huang Z J | 1999 | Anal Biochem1999，266，： | 1 |
| 15 | Re commendations for the use of botulinum toxin type A in the man agement of cerebral palsy显示文摘 | H KERR GRAHAN K ROGER AOKI LLONA AUTTI RAMO | 2000 | Gait Posture2000，11，： | 1 |
| 16 | Root to shoot ratio of crops as influenced by CO2显示文摘 | Rogers H H Prior S A Runion G B | 1996 | Plant Soil1996，187，： | 1 |
| 17 | Episodic Tremor and Slip on the Cascadia Subduction Zone: The Chatter of Silent Slip显示文摘 | Rogers G Dragert H | 2003 | Science2003，300，： | 1 |
| 18 | Pricing practices in tourist attractions : An inves- tigation into how pricing decisions are made in the UK显示文摘 | Rogers H A | 1995 | Tourism Management1995，16，3： | 1 |
| 19 | The relationshipbetween check list scores on a communication OSCE and analoguepatients, perceptions of communication显示文摘 | MAZOR K M OCKENE J K ROGERS H J ct al | 2005 | Adv Health Sci EducTheory Pract2005，10，1： | 1 |
| 20 | Subunit expression of the cardiac L-type calcium channel is differentially regulated in diastolic heart failure of the cardiac allograft显示文摘 | ROGER H FRIEDRICH A ANDREAS L | 1999 | Circulation1999，100，： | 1 |
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