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| 1 | Whole-exome mutational landscape of metastasis in patient-derived hepatocellular carcinoma cells显示文摘In order to explore the genomic basis for liver cancer metastasis,whole-exome sequencing(WES)was performed on patient-derived hepatocellular carcinoma(HCC)cell lines with differential metastatic potentials and analyzed their clonal evolution relationships.An evolutionary tree based on genomic single nucleotide polymorphism(SNP)was constructed in MegaX software.The WES data showed that the average percentage of heterogeneous mutations in each HCC cell lines was 16.55%(range,15.38%e18.17%).C:G>T:A and T:A>C:G somatic transitions were the two most frequent substitutions.In these metastatic HCC cell lines,non-silent gene mutations were found in 21.88%of known driver genes and 10 classical signaling pathways.The protein interaction network was constructed by STRING,and hub genes were found in the shared trunk mutation genes and the heterogeneous branch mutations respectively.In cBioPortal database,some of the selected hub genes were found to be associated with poor overall survival(OS)of HCC patients.Among the mutated HCC driver genes,a novel KEAP1 mutation with a homozygous frameshift truncation at the c-terminal Nrf2 binding region was detected and verified in MHCC97-H and HCC97LM3 cells.In conclusion,WES data demonstrate that HCC cell lines from tumor biopsy specimens of the same patient have obtained different metastatic potentials through repeated selection in rodents in vivo,and they do indeed have a genetic relationship at the genomic level. | Qian Zhou Zuli Li Linlan Song Di Mu Jin Wang Li Tian Yong Liao | 2020 | Genes & Diseases2020，7，3： | 1 |
| 2 | Bone marrow metastasis from advanced gastric cancer complicated with disseminated intravascular coagulation:a highly aggressive but manageable disease subtype显示文摘Dear Editor,Gastric cancer(GC)is the fifth most commonly diagnosed cancer and the fourth cause of cancer-related death worldwide[1,2].It has a greater prevalence in Eastern Asia,compared to other parts of the world,whereby more than two-thirds of the cases are diagnosed as advanced gastric cancer(AGC)[3].Disseminated intravascular coagulation(DIC)is a clinicopathologic syndrome characterized by laboratory evidence of platelets and clotting factors consumption,and proteolytic degradation. | Xiaohui Zhai Caiqin Wang Shanshan Li Taiyuan Cao Ge Du Yan Zhang Dianke Chen Xinjuan Fan Yan Huang Ping Hu Jian Zheng Zuli Yang Lei Lian Junsheng Peng Ping Lan Jian Xiao | 2022 | Cancer Communications2022，42，4： | 0 |
| 3 | Effect of Yttrium on Microstructure and Creep Resistance of Mg-9Al-1Si Alloy显示文摘 | Huang Xiaofeng Mao Zuli Yan Fengyun Li Yuandong Ma Ying Hao Yuan | 2006 | Journal of Rare Earths2006，24，4： | 0 |
| 4 | IL4I1-driven AHR signature: a new avenue for cancer therapy显示文摘Aryl hydrocarbon receptor(AHR)was considered to be an important pan-tumor therapeutic target,but small molecule inhibitors targeting AHR target gene ID01 have failed in clinical trials.The recent paper published in Cell by Opitz et al.explained the failure of previous clinical trials and identified new therapeutic targets(Fig.1). | Zuli Wang Tiansheng Li Chao Mao Wenliang Liu Yongguang Tao | 2021 | Signal Transduction and Targeted Therapy2021，6，4： | 0 |
| 5 | Reactive DC Magnetron Sputtering Deposition of Copper Nitride Thin Film显示文摘一氮化三铜薄电影被 reactiveDC (直接水流)在玻璃底层上扔磁控管在 0.5 Pa N2 部分压力和不同 substratetemperatures.The 劈啪作响同样准备的电影,与X光检查衍射描绘了,原子力量显微镜学,andX光线光电子光谱学大小,显示出 CU3N 雏晶 withanti-Re03 结构的镇静的结构和结果的电影的细微氧化。CU3N 电影的晶体结构和生长率被底层温度强烈影响。CU3N 电影的比较喜欢的水晶的取向是(111 ) 并且(200 ) 在 RT, 100 座 deg C.These 山峰在 200 deg C 和 300deg C 腐烂了仅仅 Cu (111 ) 山峰被注意。在 100 deg C 的 Cu3N 电影的生长是为生产的最佳底层温度高质量(111 ) CU3N 电影。当玻璃底层的温度增加了时,估计在当抵抗力和 CU3N 的微坚硬拍摄时,增加的 18-30 nm/min 的范围的 CU3N 电影的免职率减少了。 | Xing'ao LI Zuli LIU Kailun YAO | 2007 | Journal of Materials Science & Technology2007，23，4： | 0 |
| 6 | 广州市天河区结直肠癌筛查:基于粪便免疫化学检测和危险因素初步筛选出需要行结肠镜检查者显示文摘目的:探讨联合粪便免疫化学检测(FIT)和高危因素问卷调查(HRFQ)初筛出需行结肠镜检查者的结直肠癌(CRC)筛查方案应用于中国的可行性。方法:2015-2016年间,我们对中国广州市天河区45岁以上居民进行了一项CRC筛查项目。所有筛查对象均接受FIT检测和HRFQ调查,作为初筛。对于FIT阳性和/或HRFQ调查结果考虑存在高危风险的受检者,我们推荐其行进一步结肠镜检查。结果:共计10074名居民纳入CRC筛查项目,其中17.5%的受检者FIT阳性,19.4%经HRFQ调查被认为具有高危风险。经推荐,有773名受检者接受了进一步的结肠镜检查。该筛查方案对非腺瘤性息肉、低危腺瘤、高危腺瘤和CRC的总体阳性预测值分别为4.9%、11.4%、15.9%和1.6%。其中,FIT阳性结果对上述四种病变的阳性预测值分别为5.2%、15.9%、22.5%和2.5%,HRFQ阳性结果分别为4.1%、10.2%、14.3%和1.4%,FIT和HRFQ均为阳性结果的阳性预测值分别为4.5%、16.4%、23.7%和2.8%。结论:我们的两步法CRC筛查策略(FIT和HRFQ阳性者行进一步结肠镜检查)可有效发现早期CRC。鉴于对CRC和腺瘤较的高检出率和阳性预测值,该筛查方案可继续用于我们这项大规模CRC筛查项目的后续研究。 | Yi Liao Senmao Li Chunyu Chen Xuan He Feng Lin Jianping Wang Zuli Yang Ping Lan | 2018 | Gastroenterology Report2018，6，2： | 0 |
| 7 | La-doped Copper Nitride Films Prepared by Reactive Magnetron Sputtering显示文摘Copper nitride film (Cu3N) and La-doped copper nitride films (LaxCu3N) were prepared on glass substrates by reactive magnetron sputtering of a pure Cu and a pure La targets under N2 atmosphere. The results show that La-free film was composed of Cu3N crystallites with anti-ReO3 structure with (111) texture. The formation of the LaxCu3N films is affected strongly by La, and the peak intensity of the preferred crystalline [111]-orientation decreases with increasing the concentration of La. High concentration of La may prevent the formation of the Cu3N from crystallization. Compared with the Cu3N films, the resistivity of the LaxCu3N films have been decreased. | Xinn'ao Li Jianping Yang Anyou Zuo Zuobin Yuan Zuli Liu Kailun Yao | 2009 | Journal of Materials Science & Technology2009，25，2： | 0 |
| 8 | Control Effect of Triptolide on Farmland Rats in Sanya City显示文摘[Objective] The paper was to explore the deratization and anti fertility effect of triptolide on farmland rats in Sanya City. [Method] Autumn and spring control tests were carried out in Potianyang and Miaolinyang,respectively. [Result] The rat density in autumn control area decreased from 28. 57%( outbreak) to 2. 86%,3. 81% and 6. 80% at 11,41 and 70 d after triptolide treatment,respectively. The rat density in spring control area was lower at 19 and 47 d post treatment,and the correction deratization effect was 99. 48%-99. 88%. The testicular descent rate and pregnancy rate decreased significantly after treatment of triptolide. [Conclusion] Triptolide was safe in application,and is hence recommended for large scale extension in the farmland in Sanya City. | Wang Shuo Yuan Weifang Chen Chuanfeng Li Zuli Deng Dezhi Luo Hongwei | 2017 | Plant Diseases and Pests2017，8，1： | 0 |
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