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| 1 | Contemporary meta-analysis of short-term probiotic consumption on gastrointestinal transit显示文摘AIM: To determine the efficacy of probiotic supplementation on intestinal transit time(ITT) in adults and to identify factors that influence these outcomes. METHODS: We conducted a systematic review of randomized controlled trials of probiotic supplementation that measured ITT in adults. Study quality was assessed using the Jadad scale. A random effects meta-analysis was performed with standardized mean difference(SMD) of ITT between probiotic and control groups as the primary outcome. Meta-regression and subgroup analyses examined the impact of moderator variables on SMD of ITT.RESULTS: A total of 15 clinical trials with 17 treatment effects representing 675 subjects were included in this analysis. Probiotic supplementation was moderately efficacious in decreasing ITT compared to control, with an SMD of 0.38(95%CI: 0.23-0.53, P < 0.001). Subgroup analyses demonstrated statistically greater reductions in ITT with probiotics in subjects with vs without constipation(SMD: 0.57 vs 0.22, P < 0.01) and in studies with high vs low study quality(SMD: 0.45 vs 0.00, P = 0.01). Constipation(R^2 = 38%, P < 0.01), higher study quality(R^2 = 31%, P = 0.01), older age(R^2 = 27%, P = 0.02), higher percentage of female subjects(R^2 = 26%, P = 0.02), and fewer probiotic strains(R^2 = 20%, P < 0.05) were predictive of decreased ITT with probiotics in meta-regression. Medium to large treatment effects were identified with B. lactis HN019(SMD: 0.67, P < 0.001) and B. lactis DN-173 010(SMD: 0.54, P < 0.01) while other probiotic strains yielded negligible reductions in ITT relative to control.CONCLUSION: Probiotic supplementation is moderately efficacious for reducing ITT in adults. Probiotics were most efficacious in constipated subjects, when evaluated in high-quality studies, and with certain probiotic strains. | Larry E Miller Angela K Zimmermann Arthur C Ouwehand | 2016 | World Journal of Gastroenterology2016，22，21： | 2 |
| 2 | Noninvasive m echanical ventilation improves walking distance but not quadriceps strength in c hronic respiratory failure显示文摘 | Schonhofer B Zimmermann C Abramek P | 2003 | Respir Med2003，97，： | 2 |
| 3 | The effects of vitamin A deficiency and vitamin A supplementation on thyroid function in goitrous children 显示文摘 | ZIMMERMANN M B WEGMULLER R ZEDER C | 2004 | J Clin Endoerinol Metab2004，89，： | 1 |
| 4 | The Aging Males ' Symptoms scale (AMS) as outcome measure for treatment of androgen deficiency 显示文摘 | Moore C Huebler D Zimmermann T | 2004 | Eur Urol2004，46，1： | 1 |
| 5 | Xylem water transport: is the available evidence consistent with the cohesion theory显示文摘 | ZIMMERMANN U MEINZER F C BENKERT R ZHU J J SCHNEIDER H GOLDSTEIN G KUCHENBROD E HAASE A | 1994 | Plant Cell Environ1994，17，： | 1 |
| 6 | Size separation of circulatory DNA in maternal plasma permits ready detection of fetal DNA polymorphisms显示文摘 | Li Y Zimmermann B Rusterholz C Kang A Holzgreve W Hahn S | 2004 | Clin Chem2004，50，： | 1 |
| 7 | Hepatic encephalopathy in thioacetamide-induced acute liver failure in rats:characterization of an improved model and study of amino acidergic neurotransmission 显示文摘 | ZIMMERMANN C FERENCI P PIFL C | 1989 | Hepatology1989，9，4： | 1 |
| 8 | Accuracy of stroke vol- ume variation compared:with pleth variability index to predict fluid responsiveness in mechanically ventilated patients undergoing ma- jor surgery显示文摘 | Zimmermann M Feibicke T Keyl C | 2010 | Eur J Anaesthesiol2010，27，6： | 1 |
| 9 | Lipopolysaccharide- induced ischemic tolerance is associated with increased levels of ceramide in brain and in plasma 显示文摘 | Zimmermann C Ginis I Furuya K | 2001 | Brain Res2001，895，12： | 1 |
| 10 | Myrtol Standardized in the Treatment of Acute and Chronic Respiratory Infections in Children/A multicenter postmarketing surveillance study显示文摘 | Sengespeik HC Zimmermann T Peiske C | 1998 | Arzneimittelforsc-hung1998，48，： | 1 |
| 11 | Cellular origin and diag- nostic significance of high-fluorescent cells in cerebrospinal fluid detected by the XE-5000 hematology analyzer显示文摘 | Zimmermann M Otto C Gonzalez J B et 01 | 2013 | Int J Lab Hematol2013，35，6： | 1 |
| 12 | Assessment of primary cancers in growth hormone-treated adult hypopituitary patients:an analysis from the hypopituitary control and complications study (hypoccs)显示文摘 | Child C Zimmermann A Woodmansee W | | 0，，02： | 1 |
| 13 | Fatty Acid Binding Protein as a Serum Marker for the Early Diagnosis of Stroke:A Pilot Study显示文摘 | Zimmermann Ivol C G Burkhard P K Allard L | 2004 | Mol Cell Proteomics2004，3，1： | 1 |
| 14 | Surfactant protein A influences reepithelialization in an alveolocapillary model system显示文摘 | Willems C H Zimmermann L J Langen R M | 2012 | Lung2012，190，6： | 1 |
| 15 | Accuracy of stroke volume variation compared with pleth variability index to predict fluid responsiveness in mechanically ventilated patients undergoing major surgery显示文摘 | Zimmermann M Feibicke T Keyl C | 2010 | Eur J Anaesthesiol2010，27，6： | 1 |
| 16 | Are angiotensin receptor blockersneuroprotective?显示文摘 | Thone-Reineke C Zimmermann M Neumann C | 2004 | Curr Hypertens Rep2004，6，： | 1 |
| 17 | Hepatic encephalopathy in thioacetamide - induced acute liver failure in rat : characterization of improve model and study of aminoacidergic neurotransmission显示文摘 | Zimmermann C Peter F Christian P | 1989 | Hepatology1989，9，4： | 1 |
| 18 | Symptom clus ters in patients with advanced cancers显示文摘 | Cheung W Y Le L W Zimmermann C | 2009 | Support Care Cancer2009，17，9： | 1 |
| 19 | Integration of matrix- assisted laser desorption/ionization time-of-flight mass spectrometry in blood culture diagnostics: a fast and effective approach 显示文摘 | Klein S Zimmermann S Khler C | 2012 | J Med Microbiol2012，61，3： | 1 |
| 20 | Hepatitis C virus core protein impairs in vitro priming of specific T cell responses by dendritic cells and hepatocytes显示文摘 | Zimmermann M Flechsig C La Monica N | 2008 | J Hepatol2008，48，1： | 1 |
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