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| 1 | Electrical activities of neural systems exposed to sinusoidal induced electric field with random phase显示文摘The brain neural system is often disturbed by electromagnetic and noise environments, and research on dynamic response of its interaction has received extensive attention. This paper investigates electrical activity of Morris-Lecar neural systems exposed to sinusoidal induced electric field(IEF) with random phase generated by electromagnetic effect. By introducing a membrane depolarization model under the effect of random IEF, transition state of firing patterns, including mixed-mode oscillations(MMOs) with layered inter-spike intervals(ISI) and intermittency with a power law distribution in probability density function of ISI, is obtained in a single neuron. Considering the synergistic effects of frequency and noise, coherence resonance is performed by phase noise of IEF under certain parameter conditions. For the neural network without any internal coupling, we demonstrate that synchronous oscillations can be induced by IEF coupling, and suppression of synchronous spiking is achieved effectively by phase noise of IEF. Results of the study enrich the dynamical response to electromagnetic induction and provide insights into mechanisms of noise affecting information coding and transmission in neural systems. | DU Lin CAO ZiLu LEI YouMing DENG ZiChen | 2019 | Science China(Technological Sciences)2019，62，7： | 5 |
| 2 | First-generation EGFR tyrosine kinase inhibitor therapy in 106 patients with compound EGFR-mutated lung cancer: a single institution’s clinical practice experience显示文摘Background:The antitumour efficacy of tyrosine kinase inhibitors(TKIs)in lung cancer patients with compound epidermal growth factor receptor(EGFR)mutations has not been resolved.Our study summarizes a single institutional experience of first-generation TKI therapy for lung cancers with compound EGFR mutations.Methods:A total of 106 consecutive patients with tumours bearing compound EGFR mutations were identified between January 2012 and May 2016;all patients received first-generation TKI therapy.Deletions in exon 19 and the L858R point mutation in exon 21 were considered common mutations;T790M was considered separately because of its association with TKIs resistances.Any other mutation was defined as a rare mutation.Patients were divided as follows:double common mutations(group A);common plus T790M mutations(group B);common plus rare muta-tions(group C);double rare mutations(group D);and rare plus T790M mutations(group E).A separate group of 115 consecutive patients with a single common mutation was created for comparative analysis(group F).Results:The frequency of patients with compound EGFR was 2.9%(114/3925)and their response rate to first-genera-tion TKIs was 50.9%,which was not significantly different from group F(67.0%,P=0.088).The progression-free survival(PFS)of the 106 patients receiving TKI therapy was worse than that of group F(median,9.1 vs.13.0 months,respec-tively;P<0.001).The PFS of the compound mutation group was shorter than that of the single common mutation group(median,10.1 months in group A,P=0.240;9.1 months in group B,P<0.001;9.6 months in group C,P=0.010;6.5 months in group D,P=0.048;5.4 months in group E,P=0.017).Patients with a co-occurring mutation in exon 20(excluding T790M)exhibited significantly worse PFS than the patients with other compound mutations or with a single common mutation(median,6.5 vs.9.1 vs.13.0 months,respectively,P=0.002).Conclusions:There was significant heterogeneity among the compound EGFR mutations and their response to first-generation TKIs.Individualized treatment in clinical practice should be considered for each case. | Xiangyang Yu Xuewen Zhang Zichen Zhang Yongbin Lin Yingsheng Wen Yongqiang Chen Weidong Wang Lanjun Zhang | 2018 | Cancer Communications2018，38，1： | 5 |
| 3 | Particle swarm optimization-based algorithm of a symplectic method for robotic dynamics and control显示文摘Multibody system dynamics provides a strong tool for the estimation of dynamic performances and the optimization of multisystem robot design. It can be described with differential algebraic equations(DAEs). In this paper, a particle swarm optimization(PSO) method is introduced to solve and control a symplectic multibody system for the first time. It is first combined with the symplectic method to solve problems in uncontrolled and controlled robotic arm systems. It is shown that the results conserve the energy and keep the constraints of the chaotic motion, which demonstrates the efficiency, accuracy, and time-saving ability of the method. To make the system move along the pre-planned path, which is a functional extremum problem, a double-PSO-based instantaneous optimal control is introduced. Examples are performed to test the effectiveness of the double-PSO-based instantaneous optimal control. The results show that the method has high accuracy, a fast convergence speed, and a wide range of applications.All the above verify the immense potential applications of the PSO method in multibody system dynamics. | Zhaoyue XU Lin DU Haopeng WANG Zichen DENG | 2019 | Applied Mathematics and Mechanics(English Edition)2019，40，1： | 3 |
| 4 | Theoretical and Applied Mechanics Letters显示文摘The placement of pressure taps on the surface of the wind tunnel test model is an important means toobtain the surface pressure distribution.However,limited by space location and experimental cost,it isdifficult to arrange enough pressure measuring taps on the surface of complex models to obtain completepressure distribution information,thus it is impossible to obtain accurate lift and moment characteristicsthrough integration.The paper proposes a refined reconstruction method of airfoil surface pressure basedon compressed sensing,which can reconstruct the pressure distribution with high precision with lesspressure measurement data.Tests on typical airfoil subsonic flow around flow show that the accuracyof lift and moment after the pressure integration reconstructed by 4-8 measuring points can meet therequirements of the national military standard.The algorithm is robust to noise,and provides a new ideafor obtaining accurate force data from sparse surface pressure tests in engineering. | Xuan Zhao Lin Du Xuhao Peng Zichen Deng Weiwei Zhang | 2021 | Theoretical & Applied Mechanics Letters2021，11，2： | 2 |
| 5 | Targeted minicircle DNA delivery using folate–poly(ethylene glycol)–polyethylenimine as non-viral carrier显示文摘 | Chao Zhang Shijuan Gao Wei Jiang Song Lin Fusheng Du Zichen Li Wenlin Huang | 2010 | Biomaterials2010，，23： | 1 |
| 6 | Discharge rate consistency of each channel for UAV-based pneumatic granular fertilizer spreader显示文摘Unmanned aerial vehicles(UAVs)are widely being used to spread granular fertilizer in China.Granular fertilizer spreaders equipped with UAVs are mainly centrifugal disc-type and pneumatic.The multichannel pneumatic granular fertilizer spreaders(MPGFSs)have a banded fertilizer deposition distribution pattern,which are more suitable for variable rate fertilization with high precision requirement than the circular deposition distribution pattern of disc-type granular fertilizer spreaders(DGFSs).However,the existing MPGFS has the disadvantage of inconsistent discharge rate of each channel,which affects the uniformity of fertilization.In order to explore the causes of inconsistent discharge rate of each channel,the discrete element method(DEM)and bench test were performed to analysis the discharge process of the fluted roller fertilizing apparatus and distribution of fertilizer in axial direction of fluted roller.The computational fluid dynamics(CFD)was used to simulate the airflow field of pneumatic system to analyze the influence of airflow on the movement of fertilizer particles.The simulation results of the discharge process of the fluted roller fertilizing apparatus showed that the filling velocity at the axial ends of the fluted roller fertilizing apparatus was lower than that of the middle.The reason was that the filling capacity was weak near the wall.The simulated results of the airflow field without partitions showed that the airflow provided by the axial flow fan was rotational,and this caused the particles to move irregularly in the throat,resulting in inconsistency discharge rate of each channel.Based on the analysis of reasons of inconsistent discharge rate of each channel,a MPGFS with partitions in the throat was developed.The discharge rate bench tests were carried out to optimize the partition spacing parameters,and fertilization test was performed to test the performance of the improved MPGFS.The discharge rate test results showed better consistency with partition.The coefficient of variation(CV)of the discharge rate of each channel was 20.16%without the partition and 7.70%with the optimal partition.The fertilizer spreading uniformity bench test results shown that the CV of spreading uniformity of MPGFS without partitions was 15.32%,and that MPGFS with partitions was 8.69%.The partitions design was beneficial to improve the consistency of each channel discharge rate and the uniformity of fertilization.The finding can provide a strong reference to design the MPGFS. | Xunwei Wang Rui Jiang Zhiyan Zhou Cancan Song Xiwen Luo Ruifeng Bao Zichen Lyu Junhao Huang Jianqin Lin | 2023 | International Journal of Agricultural and Biological Engineering2023，16，4： | 1 |
| 7 | Pressureless two-step sintering of ultrafine-grained refractory metals:Tungsten-rhenium and molybdenum显示文摘The challenge of sintering ultrafine-grained refractory metals and alloys to full density is hereby addressed by pressureless two-step sintering in tungsten-rhenium alloy and pure molybdenum. Using properly processed nano powders(~50 nm average particle size), we are able to sinter W-10Re alloy to 98.4% density below 1200 ℃ while maintaining a fine grain size of 260 nm, and sinter molybdenum to 98.3% density below 1120 ℃ while maintaining a fine grain size of 290 nm. Compared to normal sintering,two-step sintering offers record-fine grain sizes and better microstructural uniformity, which translates to better mechanical properties with higher hardness(6.3 GPa for tungsten-rhenium and 4.0 GPa for molybdenum, both being the highest in all pressurelessly sintered samples of the respective material system)and larger Weibull modulus. Together with our previous demonstration in tungsten, we believe that twostep sintering is a general effective method to produce high-quality fine-grained refractory metals and alloys, and the lessons learned here are transferable to other materials for powder metallurgy. | Zhongyou Que Zichen Wei Xingyu Li Lin Zhang Yanhao Dong Mingli Qin Junjun Yang Xuanhui Qu Ju Li | 2022 | Journal of Materials Science & Technology2022，，31： | 1 |
| 8 | APPLICATION OF FEA TO THE COLLOCATION OF ACTUATOR/SENSOR IN THE INTELLIGENT STRUCTURES显示文摘The piezothermoelectric actuator/sensor collocation for advanced intelligent structure is studied. The quasi-static equations of piezothermoelasticity are used to analyze the coupling effects between the displacement, temperature and electric fields of piezothermoelasticity continua and the governing equations for piezothermoelasticity continua are derived to discuss the effects of coupling factors on the control/sensing performance in intelligent structure. Based on those analyses, a finite element analysis model of distributed piezothertnoelectric continua is developed later. The thermal stress and deformation of a beam are calculated by FEA method so as to determine the optimal actuator/sensor placement. Based on the results of the optimal analysis procedure of actuator/sensor placement, some conclusions of actuator/sensor placement are obtained. Thus, the optimal actuator/sensor placement for piezothermoelectric intelligent structure can be found from the actuator/sensor placements available so that intelligent system will have the best controllability and observability. | Du Sheliang, Lin Zhongqin (Institute of Mechanical Engineering ,Shanghai Jiaotong University) Yang Keji,Fu Jianzhong,Chen Zichen (Zhejiang University) | 2001 | Chinese Journal of Mechanical Engineering2001，14，3： | 1 |
| 9 | 第一代EGFR酪氨酸激酶抑制剂治疗106例复合EGFR突变肺癌患者:一项单中心临床研究显示文摘背景与目的酪氨酸激酶抑制剂(tyrosine kinase inhibitors,TKIs)对具有复合表皮生长因子受体(epidermal growth factor receptor,EGFR)突变的肺癌患者的疗效尚不确切。我们对第一代TKI治疗存在复合EGFR突变肺癌患者的疗效进行了单中心研究。方法2012年1月至2016年5月共确诊106例存在复合EGFR突变的连续肿瘤患者,所有患者均接受第一代TKI治疗。外显子19缺失和外显子21的L858R点突变为常见突变;由于T790M与TKIs耐药性相关,因此单独考虑T790M;其他突变均被定义为罕见突变。患者分组如下:双重常见突变(A组),常见加T790M突变(B组),常见加罕见突变(C组),双重罕见突变(D组)和罕见加T790M突变(E组)。我们建立了一个单独的组(F组),由115例存在单一常见突变的连续患者组成,以进行比较分析。结果EGFR复合突变患者的发生率为2.9%(114/3925),对第一代TKI的反应率为50.9%,与F组相比无显著性差异(67.0%,P=0.088)。接受TKI治疗的106例患者的无进展生存期(progression-free survival,PFS)比F组短(中位数,9.1个月vs.13.0个月,P<0.001)。复合突变组的PFS短于单一常见突变组(中位数,A组10.1个月,P=0.240;B组9.1个月,P<0.001;C组9.6个月,P=0.010;D组6.5个月,P=0.048;E组5.4个月,P=0.017)。外显子20中(不包括T790M)发生共同突变的患者显示出比其他复合突变或单一常见突变患者更短的PFS,差异具有统计学意义(中位数,6.5个月vs.9.1个月vs.13.0个月,P=0.002)。结论复合EGFR突变及其对第一代TKIs的反应存在显著的异质性。在临床中对每位患者都应考虑进行个体化治疗。 | Xiangyang Yu Xuewen Zhang Zichen Zhang Yongbin Lin Yingsheng Wen Yongqiang Chen Weidong Wang Lanjun Zhang | 2019 | 癌症2019，38，10： | 1 |
| 10 | Assessment of Atmospheric Reanalysis Data Based on Buoy Observations over the Tropical Western Indian Ocean in 2019显示文摘Atmospheric reanalysis data are an important data source for studying weather and climate systems.The sea surface wind and sea level pressure observations measured from a real-time buoy system deployed in Kenya’s offshore area in 2019 conducted jointly by Chinese and Kenyan scientists were used to evaluate the performance of the major high-frequency atmospheric reanalysis products in the western Indian Ocean region.Compared with observations,the sea level pressure field could be accurately simulated using the atmospheric reanalysis data.However,significant discrepancies existed between the surface wind reanalysis data,especially between meridional wind and the observational data.Most of the data provide a complete understanding of sea level pressure,except for the Japanese 55-year Reanalysis data,which hold a significant system bias.The Modern-Era Reanalysis for Research and Applications,Version-2,provides an improved description of all datasets.All the reanalysis datasets for zonal wind underestimate the strength during the study period.Among reanalysis data,NCEP-DOE Atmospheric Model Intercomparison Project reanalysis data presents an inaccurate description due to the worst correlation with the observations.For meridional wind,most reanalysis datasets underestimate the variance,while the European Centre for Medium-Range Weather Forecasts Atmospheric Composition Reanalysis 4 has a larger variance than the observations.In addition to the original data comparison,the diurnal variability of sea level pressure and surface wind are also assessed,and the result indicates that the diurnal variations have a significant gap between observation and reanalysis data.This study indicates that the current high-frequency reanalysis data still have disadvantages when describing the atmospheric parameters in the Western Indian Ocean region. | LUO Yulan LIU Lin PAUL Oloo PHILIP Sagero LI Kuiping YANG Yang SU Qinglei LI Qiuchi MIAO Zichen | 2023 | Journal of Ocean University of China2023，22，4： | 0 |
| 11 | Global path guided vehicle obstacle avoidance path planning with artificial potential field method显示文摘An artificial potential field method based on global path guidance(G-APF)is proposed for target unreachability and local minima problems of the conventional artificial potential field(APF)method in complex environments with dynamic obstacles.First,for the target unreachability problem,the global path attraction is added to the APF;second,an obstacle detection optimisation method is proposed and the optimal virtual target point is selected by setting the evaluation function to improve the local minima problem;finally,based on the obstacle detection optimisation method,the gravitational and repulsive processes are improved so that the path can pass through the narrow channel smoothly and remain collision-free.Experiments show that the method optimises 40.8%of the total path corners,reduces 81.8%of the number of path oscillations,and shortens 4.3%of the path length in Map 1.It can be applied to the vehicle obstacle avoidance path planning problem in complex environments with dynamic obstacles. | Yangde Chen Peiliang Wang Zichen Lin Chenhao Sun | 2023 | IET Cyber-Systems and Robotics2023，5，1： | 0 |
| 12 | Targeting LncRNA LLNLR-299G3.1 with antisense oligonucleotide inhibits malignancy of esophageal squamous cell carcinoma cells in vitro and in vivo显示文摘Accumulating evidence has indicated that long non-coding RNAs(lncRNAs)play critical roles in the development and progression of cancers,including esophageal squamous cell carcinoma(ESCC).However,the mechanisms of lncRNAs in ESCC are still incompletely understood and therapeutic attempts for in vivo targeting cancer-associated lncRNA remain a challenge.By RNA-sequencing analysis,we identified that LLNLR-299G3.1 was a novel ESCC-associated lncRNA.LLNLR-299G3.1 was up-regulated in ESCC tissues and cells and promoted ESCC cell proliferation and invasion.Silencing of LLNLR-299G3.1 with ASO(antisense oligonucleotide)resulted in opposite effects.Mechanistically,LLNLR-299G3.1 bound to cancerassociated RNA binding proteins and regulated the expression of cancer-related genes,including OSM,TNFRSF4,HRH3,and SSTR3.ChIRP-seq(chromatin isolation by RNA purification and sequencing)revealed that these genes contained enriched chromatin binding sites for LLNLR-299G3.1.Rescue experiments confirmed that the effects of LLNLR-299G3.1 on ESCC cell proliferation were dependent on interaction with HRH3 and TNFRSF4.Therapeutically,intravenous delivery of placental chondroitin sulfate A binding peptide-coated nanoparticles containing antisense oligonucleotide(pICSA-BP-ANPs)strongly inhibited ESCC tumor growth and significantly improved animal survival in vivo.Overall,our results suggest that LLNLR-299G3.1 promotes ESCC malignancy through regulating gene-chromatin interactions and targeting ESCC by pICSA-BP-ANPs may be an effective strategy for the treatment of lncRNA-associated ESCC. | LI TIAN YONGYI HUANG BAOZHEN ZHANG YI SONG LIN YANG QIANQIAN CHEN ZHENG WANG YILING WANG QIHAN HE WENHAN YANG SHUYONG YU TIANYU LU ZICHEN LIU KAIPING GAO XIUJUN FAN JIAN SONG RIHONG ZHAI | 2023 | Oncology Research2023，31，4： | 0 |
| 13 | Identification of S-RNase genotype and analysis of its origin and evolutionary patterns in Malus plants显示文摘Identification of the S genotype of Malus plants will greatly promote the discovery of new genes,the cultivation and production of apple,the breeding of new varieties,and the origin and evolution of self-incompatibility in Malus plants.In this experiment,88 Malus germplasm resources,such as Aihuahong,Xishuhaitang,and Reguanzi,were used as materials.Seven gene-specific primer combinations were used in the genotype identification.PCR amplification using leaf DNA produced a single S-RNase gene fragment in all materials.The results revealed that 70 of the identified materials obtained a complete S-RNase genotype,while only one S-RNase gene was found in 18 of them.Through homology comparison and analysis,13 S-RNase genotypes were obtained:S_(1)S_(2)(Aihuahong,etc.),S_(1)S_(28)(Xixian Haitang,etc.),S_(1)S_(51)(Hebei Pingdinghaitang),S_(1)S_(3)(Xiangyangcun Daguo,etc.),S_(2)S_(3)(Zhaiyehaitang,etc.),S_(3)S_(51)(Xishan 1),S_(3)S_(28)(Huangselihaerde,etc.),S_(2)S_(28)(Honghaitang,etc.),S_(4)S_(28)(Bo 11),S_(7)S_(28)(Jiuquan Shaguo),S_(10)S_e(Dongchengguan 13),S_(10)S_(21)(Dongxiangjiao)and S_(3)S_(51)(Xiongyue Haitang).Simultaneously,the frequency of the S gene in the tested materials was analyzed.The findings revealed that different S genes had varying frequencies in Malus resources,as well as varying frequencies between intraspecific and interspecific.S_(3)had the highest frequency of 68.18%,followed by S_(1)(42.04%).In addition,the phylogenetic tree and origin evolution analysis revealed that the S gene differentiation was completed prior to the formation of various apple species,that cultivated species also evolved new S genes,and that the S_(50)gene is the oldest S allele in Malus plants.The S_(1),S_(29),and S_(33)genes in apple-cultivated species,on the other hand,may have originated in M.sieversii,M.hupehensis,and M.kansuensis,respectively.In addition to M.sieversii,M.kansuensis and M.sikkimensis may have also played a role in the origin and evolution of some Chinese apples. | Zhao Liu Yuan Gao Kun Wang Jianrong Feng Simiao Sun Xiang Lu Lin Wang Wen Tian Guangyi Wang Zichen Li Qingshan Li Lianwen Li Dajiang Wang | 2024 | Journal of Integrative Agriculture2024，23，4： | 0 |
| 14 | Research on data assimilation strategy of turbulent separated flow over airfoil显示文摘In order to increase the accuracy of turbulence field reconstruction,this paper combines experimental observation and numerical simulation to develop and establish a data assimilation framework,and apply it to the study of S809 low-speed and high-angle airfoil flow.The method is based on the ensemble transform Kalman filter(ETKF)algorithm,which improves the disturbance strategy of the ensemble members and enhances the richness of the initial members by screening high flow field sensitivity constants,increasing the constant disturbance dimensions and designing a fine disturbance interval.The results show that the pressure distribution on the airfoil surface after assimilation is closer to the experimental value than that of the standard Spalart-Allmaras(S-A)model.The separated vortex estimated by filtering is fuller,and the eddy viscosity field information is more abundant,which is physically consistent with the observation information.Therefore,the data assimilation method based on the improved ensemble strategy can more accurately and effectively describe complex turbulence phenomena. | Ying ZHANG Lin DU Weiwei ZHANG Zichen DENG | 2022 | Applied Mathematics and Mechanics(English Edition)2022，43，4： | 0 |
| 15 | Development of UAV-based shot seeding device for rice planting显示文摘In order to realize the high-quality row seeding operation with unmanned aerial vehicle(UAV)in paddy field,a shot seeding device that can sow five rows of pelleted rice seeds at the same time was designed.The shot seeding device mainly consists of an external grooved wheel seed metering device and five shot seeding modules.The designed external grooved wheel seed metering device can take the seeds out of the seed box and divide the seeds into five parts.The shot seeding module can accelerate the pelleted rice seeds to reduce the impact of the UAV wind on the direction of seed movement.Furthermore,an angle adjustment mechanism for the shot seeding module was used to change the row spacing.The seed metering device test verified that when the speed of the seed metering wheel was 15 r/min,the coefficient of variation of the discharge rate of each row(C.V1)and total seed discharge rate stability(C.V2)were 1.70%and 1.04%,respectively.Image processing technique was used to test the UAV seeding performance.The distribution characteristics of seeds on the ground showed that the number of seeds in each row gradually increased from both sides to the middle in the width direction.According to the statistics,there were 60%-70%of the seeds in each row in the 100 mm width range.The field test showed that when the working height was 1.5 m and the seeding quantity was 38.56 kg/hm^(2),the performance of sowing in rows was obvious,the deviation rate of seeding quantity was 1.89%.After 16 d of sowing,the seeds’emergence rate was stable,and the average emergence rate was 82.63%and the yield was 6775.50 kg/hm^(2). | Wei Liu Shuaishuai Zou Xuelang Xu Qingyu Gu Weizhuo He Jun Huang Junhao Huang Zichen Lyu Jianqin Lin Zhiyan Zhou Rui Jiang Xiwen Luo | 2022 | International Journal of Agricultural and Biological Engineering2022，15，6： | 0 |
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