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| 1 | Hymecromone:a clinical prescription hyaluronan inhibitor for efficiently blocking COVID-19 progression显示文摘Currently,there is no effective drugs for treating clinically COVID-19 except dexamethasone.We previously revealed that human identical sequences of SARS-CoV-2 promote the COVID-19 progression by upregulating hyaluronic acid(HA).As the inhibitor of HA synthesis,hymecromone is an approved prescription drug used for treating biliary spasm.Here,we aimed to investigate the relation between HA and COVID-19,and evaluate the therapeutic effects of hymecromone on COVID-19.Firstly,HA was closely relevant to clinical parameters,including lymphocytes(n=158;r=−0.50;P<0.0001),C-reactive protein(n=156;r=0.55;P<0.0001),D-dimer(n=154;r=0.38;P<0.0001),and fibrinogen(n=152;r=0.37;P<0.0001),as well as the mass(n=78;r=0.43;P<0.0001)and volume(n=78;r=0.41;P=0.0002)of ground-glass opacity,the mass(n=78;r=0.48;P<0.0001)and volume(n=78;r=0.47;P<0.0001)of consolidation in patient with low level of hyaluronan(HA<48.43 ng/mL).Furthermore,hyaluronan could directly cause mouse pulmonary lesions.Besides,hymecromone remarkably reduced HA via downregulating HAS2/HAS3 expression.Moreover,89%patients with hymecromone treatment had pulmonary lesion absorption while only 42%patients in control group had pulmonary lesion absorption(P<0.0001).In addition,lymphocytes recovered more quickly in hymecromone-treated patients(n=8)than control group(n=5)(P<0.05).These findings suggest that hymecromone is a promising drug for COVID-19 and deserves our further efforts to determine its effect in a larger cohort. | Shuai Yang Yun Ling Fang Zhao Wei Li Zhigang Song Lu Wang Qiuting Li Mengxing Liu Ying Tong Lu Chen Daoping Ru Tongsheng Zhang Kaicheng Zhou Baolong Zhang Peng Xu Zhicong Yang Wenxuan Li Yuanlin Song Jianqing Xu Tongyu Zhu Fei Shan Wenqiang Yu Hongzhou Lu | 2022 | Signal Transduction and Targeted Therapy2022，7，4： | 2 |
| 2 | Bi_(2)S_(3) spheres coated with MOF-derived Co_(9)S_(8) and N-doped carbon composite layer for half/full sodium-ion batteries with superior performance显示文摘Bismuth sulfide(Bi_(2)S_(3))has attracted particular interest as a potential anode material for sodium-ion batteries(SIBs).However,the low electrical conductivity and dramatic volumetric change greatly restrict its practical applications.In view of the apparent structural and compositional advantages of metal-organic frameworks(MOFs)derived carbon-based composite,herein,as a proof of concept,Bi_(2)S_(3) spheres coated with the MOF-derived Co_(9)S_(8) and N-doped carbon composite layer(Bi_(2)S_(3)@Co_(9)S_(8)/NC composite spheres)have been rational designed and synthesized.As expected,the core-shell Bi_(2)S_(3)@Co_(9)S_(8)/NC composite spheres exhibit remarkable electrochemical performance in terms of high reversible capacity(597 m Ah g^(-1) after 100 cycles at 0.1 A g^(-1)),good rate capability(341 m Ah g^(-1) at 8 A g^(-1))and long-term cycling stability(458 m Ah g^(-1) after 1000 cycles at 1 A g^(-1))when investigated as anode materials for SIBs.Electrochemical analyses further reveal the favorable reaction kinetics in the Bi_(2)S_(3)@Co_(9)S_(8)/NC composite spheres.In addition,the possible sodium storage mechanism has been studied by ex-situ X-ray diffraction technique.More importantly,a sodium-ion full cell based on Na_(3) V_(2)(PO_(4))_(3)/r GO as cathode and Bi_(2)S_(3)@Co_(9)S_(8)/NC as anode is also fabricated,suggesting their potential for practical applications.It is anticipated that the present work could be extended to construct other advanced electrode materials using MOFs-derived carbon-based composites as surface coating materials for various energy storagerelated applications. | Youzhang Huang Xueshuang Zhu Daoping Cai Zhixiang Cui Qianting Wang Hongbing Zhan | 2021 | Journal of Energy Chemistry2021，30，8： | 2 |
| 3 | Joint target delay determination and rate control for real-time videos in heterogeneous wireless networks显示文摘In heterogeneous wireless networks with time-varying channels,the video rate is usually adjusted based on the network bandwidth to guarantee ultra-low latency video transmission under an end-to-end target delay constraint.However,the target delay with a fixed value according to historical experience cannot guarantee the quality of video continuously since wireless network bandwidth changes rapidly,especially when the network deteriorates.An alternative scheme is to dynamically set the target delay according to the network status within an acceptable delay range.However,this scheme cannot be ensured in heterogeneous wireless networks with time-varying channels.Thus,to address this issue,a multi-objective optimization algorithm for joint optimization of rate control and target delay is proposed,where the target delay and video rate are jointly adjusted dynamically.Second,to reduce the optimization complexity due to the multi-objective and multi-parameter characteristics,multi-objective optimization algorithm be decomposed and solved by optimizing each independent sub-problem.Finally,the proposed algorithm is verified on a semi-physical simulation platform.Experiments show that the frame loss rate is reduced from 6.65%to 2.06%,and a peak signal-to-noise ratio(PSNR)gain of 18.32%is obtained when the network performance is low. | Chen Feng Zhu Daoping Jiang Chen Zheng Mingkui Lin Nan | 2021 | The Journal of China Universities of Posts and Telecommunications2021，28，3： | 0 |
| 4 | Design of A Hot Redundant Communication Network for Drive Control Systems of Mobile Launch Platforms显示文摘In order to ensure that a mobile launch platform is able to transport a launch vehicle which is assembled vertically on a complex orbit,a communication network for the drive control system was designed.Based on the char-acteristics of equipment of the drive control system and its position,Industrial Ethernet and Profibus were selected.To meet the requirements for reliability and maintainability of aerospace products,the communication network featured a hot redundant to avoid single point failure risk,so that if any point in the system fails,the control strategy of standby switches using heartbeat detection and parity check would ensure the normal communication and failure diagnostics,which could enable the transport mission of the launch vehicle to be completed smoothly. | LI Daoping ZHU Maioxin LI Chunlin CHEN Yaozu ZHENG Guokun | 2023 | Aerospace China2023，24，3： | 0 |
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