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| 1 | Hymecromone:a clinical prescription hyaluronan inhibitor for efficiently blocking COVID-19 progression显示文摘Currently,there is no effective drugs for treating clinically COVID-19 except dexamethasone.We previously revealed that human identical sequences of SARS-CoV-2 promote the COVID-19 progression by upregulating hyaluronic acid(HA).As the inhibitor of HA synthesis,hymecromone is an approved prescription drug used for treating biliary spasm.Here,we aimed to investigate the relation between HA and COVID-19,and evaluate the therapeutic effects of hymecromone on COVID-19.Firstly,HA was closely relevant to clinical parameters,including lymphocytes(n=158;r=−0.50;P<0.0001),C-reactive protein(n=156;r=0.55;P<0.0001),D-dimer(n=154;r=0.38;P<0.0001),and fibrinogen(n=152;r=0.37;P<0.0001),as well as the mass(n=78;r=0.43;P<0.0001)and volume(n=78;r=0.41;P=0.0002)of ground-glass opacity,the mass(n=78;r=0.48;P<0.0001)and volume(n=78;r=0.47;P<0.0001)of consolidation in patient with low level of hyaluronan(HA<48.43 ng/mL).Furthermore,hyaluronan could directly cause mouse pulmonary lesions.Besides,hymecromone remarkably reduced HA via downregulating HAS2/HAS3 expression.Moreover,89%patients with hymecromone treatment had pulmonary lesion absorption while only 42%patients in control group had pulmonary lesion absorption(P<0.0001).In addition,lymphocytes recovered more quickly in hymecromone-treated patients(n=8)than control group(n=5)(P<0.05).These findings suggest that hymecromone is a promising drug for COVID-19 and deserves our further efforts to determine its effect in a larger cohort. | Shuai Yang Yun Ling Fang Zhao Wei Li Zhigang Song Lu Wang Qiuting Li Mengxing Liu Ying Tong Lu Chen Daoping Ru Tongsheng Zhang Kaicheng Zhou Baolong Zhang Peng Xu Zhicong Yang Wenxuan Li Yuanlin Song Jianqing Xu Tongyu Zhu Fei Shan Wenqiang Yu Hongzhou Lu | 2022 | Signal Transduction and Targeted Therapy2022，7，4： | 2 |
| 2 | Effects of Y2O3 on the microstructure and mechanical properties ofspark plasma sintered fine-grained W-Ni-Mn alloy显示文摘Fine-grained W-Ni-Mn-Y_2 O_3 alloys were fabricated by mechanical alloying-assisted spark plasma sintering(SPS), and the effects of Y_2 O_3 content on the microstructure and mechanical properties of the alloys were studied. Fine-grained 90 W-6 Ni-4 Mn-Y_2 O_3 alloys with uniform microstructure and excellent properties were prepared by SPS at 1150 ℃. The addition of trace Y_2 O_3 inhibited the sintering densification process and refined the W grain size. The average W grain size decreased from 5.5 μm to 2.1 μm.The fracture mode changed from W grain transgranular fracture and W-W interface fracture to W-W and W-Matrix phase interface fracture. The Rockwell hardness and bending strength of alloys initially increased and then decreased with increasing Y_2 O_3 content. The optimum comprehensive mechanical properties(Rockwell hardness and bending strength) of the alloys were obtained at the same time when the mass fraction of Y_2 O_3 was 0.4%. | Yanlin Pan Lei Ding Hui Li Daoping Xiang | 2017 | Journal of Rare Earths2017，35，11： | 1 |
| 3 | Multi- wavelength erbium-doped fiber ring lasers with overlap- written fiber Bragg gratings显示文摘 | Wei Daoping Li Tangjun Zhao Yucheng | 2000 | Optics Letters2000，25，16： | 1 |
| 4 | Design of A Hot Redundant Communication Network for Drive Control Systems of Mobile Launch Platforms显示文摘In order to ensure that a mobile launch platform is able to transport a launch vehicle which is assembled vertically on a complex orbit,a communication network for the drive control system was designed.Based on the char-acteristics of equipment of the drive control system and its position,Industrial Ethernet and Profibus were selected.To meet the requirements for reliability and maintainability of aerospace products,the communication network featured a hot redundant to avoid single point failure risk,so that if any point in the system fails,the control strategy of standby switches using heartbeat detection and parity check would ensure the normal communication and failure diagnostics,which could enable the transport mission of the launch vehicle to be completed smoothly. | LI Daoping ZHU Maioxin LI Chunlin CHEN Yaozu ZHENG Guokun | 2023 | Aerospace China2023，24，3： | 0 |
| 5 | 硼替佐米治疗多发性骨髓瘤的临床初步研究(英文)显示文摘Objective:To explore the outcome and side-effects in patients with multiple myeloma treated with velcade and combined chemotherapy. Methods: 6 patients with multiple myeloma were treated with the combination of velcade and dexamethasone or DVD (V-DVD regimen) chemotherapy. Results: 6 patients responded to treatment. 4 patients achieved complete remission (CR), 1 achieved partial remission (PR) and 1 achieved micro responded (MR). Major toxicities consisted of peripheral neuropathy, thrombocytopenia and hepatic impairment. Conclusion: Velcade combined chemotherapy is an effective and safety treatment for patients with multiple myeloma. | Caixia Li Depei Wu Aining Sun Miao Miao Yuejun Liu Ye Zhao Xiaohui Hu Daoping Sun | 2007 | The Chinese-German Journal of Clinical Oncology2007，6，6： | 0 |
| 6 | The Application of Experimental Analysis Technology in the Tight Reservoirs Research of Jimusaer Sag显示文摘Junggar Basin bears abundant tight oil resources[1-3].During recent years,some geological scholars[3]have made important discoveries in the exploration of Lucaogou Formation in Jimusar Sag.The research shows there are following characteristics in tight oil reservoir of Lucaogou Formation in Jimusar Sag:1)the source rock and reservoir live together and are frequently interbedded; | JIN Jun LI Lulu YANG Zhao XIANG Baoli LV Daoping ZHANG Yi | 2015 | Acta Geologica Sinica(English Edition)2015，89，A01： | 0 |
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