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| 1 | Alterations of DNA damage response pathway:Biomarker and therapeutic strategy for cancer immunotherapy显示文摘Genomic instability remains an enabling feature of cancer and promotes malignant transformation.Alterations of DNA damage response(DDR)pathways allow genomic instability,generate neoantigens,upregulate the expression of programmed death ligand 1(PD-L1)and interact with signaling such as cyclic GMPe AMP synthase-stimulator of interferon genes(cGASe STING)signaling.Here,we review the basic knowledge of DDR pathways,mechanisms of genomic instability induced by DDR alterations,impacts of DDR alterations on immune system,and the potential applications of DDR alterations as biomarkers and therapeutic targets in cancer immunotherapy. | Minlin Jiang Keyi Jia Lei Wang Wei Li Bin Chen Yu Liu Hao Wang Sha Zhao Yayi He Caicun Zhou | 2021 | Acta Pharmaceutica Sinica B2021，11，10： | 12 |
| 2 | Electrochemically driven conversion reaction in fluoride electrodes for energy storage devices显示文摘Exploring electrochemically driven conversion reactions for the development of novel energy storage materials is an important topic as they can deliver higher energy densities than current Li-ion battery electrodes.Conversion-type fluorides promise particularly high energy densities by involving the light and small fluoride anion,and bond breaking can occur at relatively low Li activity(i.e.,high cell voltage).Cells based on such electrodes may become competitors to other envisaged alternatives such as Lisulfur or Li-air systems with their many unsolved thermodynamic and kinetic problems.Relevant conversion reactions are typically multiphase redox reactions characterized by nucleation and growth processes along with pronounced interfacial and mass transport phenomena.Hence significant overpotentials and nonequilibrium reaction pathways are involved.In this review,we summarize recent findings in terms of phase evolution phenomena and mechanistic features of(oxy)fluorides at different redox stages during the conversion process,enabled by advanced characterization technologies and simulation methods.It can be concluded that well-designed nanostructured architectures are helpful in mitigating kinetic problems such as the usually pronounced voltage hysteresis.In this context,doping and open-framework strategies are useful.By these tools,simple materials that are unable to allow for substantial Li nonstoichiometry(e.g.,by Li-insertable channels)may be turned into electroactive materials. | Chilin Li Keyi Chen Xuejun Zhou Joachim Maier | 2018 | npj Computational Materials2018，，1： | 8 |
| 3 | Mathematical Modeling for On -line Performanee Analysis of Heat Exehange System显示文摘 | Zhou Keyi Zhang Chenyue | 1993 | Science In China1993，36，7： | 1 |
| 4 | Mass Spectrometry Analysis of SARS-CoV-2 Nucleocapsid Protein Reveals Camouflaging Glycans and Unique Post-Translational Modifications显示文摘The devastating coronavirus disease 2019(COVID-19)pandemic has prompted worldwide efforts to study structural biological traits of severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)and its viral components.Compared to the Spike protein,which is the primary target for currently available vaccines or antibodies,knowledge about other virion structural components is incomplete.Using high-resolution mass spectrometry,we report a comprehensive post-translational modification(PTM)analysis of nucleocapsid phosphoprotein(NCP),the most abundant structural component of the SARS-CoV-2 virion.In addition to phosphoryl groups,we show that the SARS-CoV-2 NCP is decorated with a variety of PTMs,including N-glycans and ubiquitin.Based on newly identified PTMs,refined protein structural models of SARS-CoV-2 NCP were proposed and potential immune recognition epitopes of NCP were aligned with PTMs.These data can facilitate the design of novel vaccines or therapeutics targeting NCP,as valuable alternatives to the current vaccination and treatment paradigm that is under threat of the ever-mutating SARS-CoV-2 Spike protein. | Zeyu Sun Xiaoqin Zheng Feiyang Ji Menghao Zhou Xiaoling Su Keyi Ren Lanjuan Li | 2021 | Infectious Microbes & Diseases2021，3，3： | 1 |
| 5 | Complex Motion Modeling and State Estimation in Road Coordinates显示文摘Constrained modeling and state estimation have attracted much attention in recent years. This paper focuses on target motion modeling and tracking in road coordinates. An improved initialization method,which uses the optimal fusion of the position measurements in different directions,is presented for the constraint coordinate Kalman filter(CCKF). The CCKF is evaluated with a comprehensive comparison to the state-of-art linear equality constraint estimation methods. Numerical simulation results demonstrate the better performance of the CCKF. Then the interacting multiple model CCKF(IMM-CCKF) is proposed to manifest the advantages of the CCKF in complex motion modeling and state estimations. The effectiveness of the IMM-CCKF in maneuvering target tracking with spatial equality constraints is demonstrated by numerical experiments. | Keyi Li Xi Chen Gongjian Zhou | 2017 | Journal of Harbin Institute of Technology(New Series)2017，24，1： | 1 |
| 6 | Resource Transition Circuits and Siphons for Deadlock Control of Automated Manufacturing Systems显示文摘 | Xing Keyi Zhou Mengchu Wang Feng | 2011 | IEEE Transactions on Systems Man and Cybernetics Part A:Systems and Humans2011，41，1： | 1 |
| 7 | Optimal Petri-net-based polynomial-complexity deadlock-avoidance policies for automated manufacturing systems显示文摘 | XING Keyi ZHOU Mengchu LIU Huixia | 2009 | IEEE Transactions on Systems Man and Cybernetics Part A:Systems and Humans2009，39，1： | 1 |
| 8 | Optimal petri- net - based polynomial - complexity deadlock - avoidance policies for automated mantffaeturing systems 显示文摘 | Keyi Xing Meng Chu Zhou Huixia Liu | 2009 | Systems Man and Cybernetics Part A IEEE Transactions on2009，39，1： | 1 |
| 9 | Identification of novel Z/W chromosome-specific markers from the giant freshwater prawn Macrobrachium rosenbergii显示文摘The giant freshwater prawn(Macrobrachium rosenbergii)is a commercially cultured species in China.A sex chromosome-specific marker is crucial for sex identification and distinguishing sex chromosomes.Here,based on the results of reduced-representation genome sequencing and genome survey of M.rosenbergii,we identified steady sex-linked markers.Further nucleotide alignment analysis revealed 83.42%nucleotide similarity between the amplified W-and Z-chromosome fragments.qPCR confirmed that Z chromosome-specific fragments were present in males approximately twice as often compared to females.Similarly,the W chromosome-specific fragments were present in super females approximately twice as often compared to females.Our findings elucidate the ZW/ZZ sex determination type and contribute to exploring sex-related or sex-determining genes present on the sex chromosomes of M.rosenbergii. | Xue Liu Lingxia Zhou Biyun Luo Hongli Qian Baoqing Ye Keyi Ma Gaofeng Qiu | 2023 | Aquaculture and Fisheries2023，8，5： | 0 |
| 10 | Study on the Fouling Propensity of Effluent from the MBR System for the Electronics Wastewater with High Salinity显示文摘To the electronics wastewater with high salinity,the fouling propensity of effluent from the membrane bioreactor( MBR) system played an important role for the design and long-term operational sustainability of the MBR + Reverse Osmosis( RO) system. In this text,the effluent quality,settling performance and membrane fouling were researched with three dimension excitation-emission fluorescence spectra( EEM) and scanning electron microscope( SEM)-Energy Dispersive Spectrometer( EDS). The results showed that there were few organics with a strong adhesion in the effluent. The metal ions in the effluent not only had a complexation reaction with the macromolecules fulvic acid and protein but also with silicon colloid. It caused a compact fouling layer on the RO membrane surface. But the organics and most of inorganic matters could form settling of flocs and be removed from the effluent by improving p H of the effluent,which would relieve the membrane fouling. In addition,the removal of metal ions in the fouling layer was critical for enhancing the cleaning efficiency of RO membrane. | Han Yongping Li Keyi Li Haiyan Zhou Wenping Li Hongmei | 2018 | Meteorological and Environmental Research2018，9，2： | 0 |
| 11 | State estimation in range coordinate using range-only measurements显示文摘In some tracking applications,due to the sensor characteristic,only range measurements are available.If this is the case,due to the lack of full position measurements,the observability of Cartesian states(e.g.,position and velocity)are limited to particular cases.For general cases,the range measurements can be utilized by developing a state estimation algorithm in range-Doppler(R-D)plane to obtain accurate range and Doppler estimates.In this paper,a state estimation method based on the proper dynamic model in the R-D plane is proposed.The unscented Kalman filter is employed to handle the strong nonlinearity in the dynamic model.Two filtering initialization methods are derived to extract the initial state estimate and the initial covariance in the R-D plane from the first several range measurements.One is derived based on the well-known two-point differencing method.The other incorporates the correct dynamic model information and uses the unscented transformation method to obtain the initial state estimates and covariance,resulting in a model-based method,which capitalizes the model information to yield better performance.Monte Carlo simulation results are provided to illustrate the effectiveness and superior performance of the proposed state estimation and filter initialization methods. | LI Keyi GUO Zhengkun ZHOU Gongjian | 2022 | Journal of Systems Engineering and Electronics2022，33，3： | 0 |
| 12 | Research on the Impact of VR Technology Application on Red Tourism in Jiangxi Province显示文摘Jiangxi Province is rich in red tourism resources.However,its current situation in the development of red culture and the combination of tourism and VR technology is not optimistic.This paper takes the subsequent development of Jiangxi red tourism as the research object and looks through the historical background of Jiangxi red resources to analyze the current situation of the Jiangxi red tourism.In the meantime,it explores and investigates the current situation of the development of VR technology in Jiangxi,the degree of the combination between theory with practice and the possibility of VR technology application.On this basis,it studies how to reasonably apply VR technology to promote the sustainable development of red tourism in Jiangxi,how to pull the economic growth of Jiangxi,and how to achieve a win-win scenario for the modern economy and traditional culture of Jiangxi. | WANG Keyi LU Yang CAI Yiwen CHEN Wenjie ZHOU Guang ZHOU Siyi | 2022 | Journal of Tourism and Hospitality Management2022，10，2： | 0 |
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