|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Phase 1 clinical trial demonstrated that MUC1 positive metastatic seminal vesicle cancer can be effectively eradicated by modified Anti-MUC1 chimeric antigen receptor transduced T cells显示文摘Recent progress in chimeric antigen receptor-modified T-cell(CAR-T cell) technology in cancer therapy is extremely promising, especially in the treatment of patients with B-cell acute lymphoblastic leukemia. In contrast, due to the hostile immunosuppressive microenvironment of a solid tumor, CAR T-cell accessibility and survival continue to pose a considerable challenge, which leads to their limited therapeutic efficacy. In this study, we constructed two anti-MUC1 CAR-T cell lines. One set of CAR-T cells contained SM3 single chain variable fragment(sc Fv) sequence specifically targeting the MUC1 antigen and co-expressing interleukin(IL) 12(named SM3-CAR). The other CAR-T cell line carried the SM3 sc Fv sequence modified to improve its binding to MUC1 antigen(named p SM3-CAR) but did not co-express IL-12. When those two types of CAR-T cells were injected intratumorally into two independent metastatic lesions of the same MUC1+ seminal vesicle cancer patient as part of an interventional treatment strategy, the initial results indicated no side-effects of the MUC1 targeting CAR-T cell approach, and patient serum cytokines responses were positive. Further evaluation showed that p SM3-CAR effectively caused tumor necrosis, providing new options for improved CAR-T therapy in solid tumors. | Fengtao You Licui Jiang Bozhen Zhang Qiang Lu Qiao Zhou Xiaoyang Liao Hong Wu Kaiqi Du Youcai Zhu Huimin Meng Zhishu Gong Yunhui Zong Lei Huang Man Lu Jirong Tang Yafen Li Xiaochen Zhai Xiangling Wang Sisi Ye Dan Chen Lei Yuan Lin Qi Lin Yang | 2016 | Science China(Life Sciences)2016，59，4： | 16 |
| 2 | A Highly Efficient and Selective Water-Soluble Bimetallic Catalyst for Hydrogenation of Chloronitrobenzene to Chloroaniline显示文摘Selective hydrogenation of chloronitrobenzene(CNB) to chloroaniline(CAN) catalyzed by water-soluble Ru/Pt bimetallic catalyst in an aqueous-organic biphasic system was studied. It was found that the catalytic activity increased obviously due to the addition of platinum. Ru/Pt bimetallic catalysts exhibited a strong synergistic effect when the molar ratio of Pt was in the range of 5%—80%. Under the mild conditions including a temperature of 25 ℃, a hydrogen pressure of 1.0 MPa and a Pt molar ratio of 20%, the conversion of p-chloronitrobenzene(p-CNB) reached 99.9%, with the selectivity to p-chloroaniline(p-CAN) equating to 99.4%. The Ru/Pt catalyst also showed high activity and selectivity for the hydrogenation of other chloro- and dichloro-nitrobenzenes with different substituted positions. In addition, the catalyst can be recycled five times without significant loss of activity. | Zhou Yafen Yang Wenjuan Zhou Limei Wang Manman Ma Xiaoyan | 2015 | China Petroleum Processing & Petrochemical Technology2015，17，2： | 1 |
| 3 | N^(6)-methyladenosine and Its Implications in Viruses显示文摘N6-methyladenine(m^(6)A)is the most abundant RNA modification in mammalian messenger RNAs(mRNAs),which participates in and regulates many important biological activities,such as tissue development and stem cell differentiation.Due to an improved understanding of m^(6)A,researchers have discovered that the biological function of m^(6)A can be linked to many stages of mRNA metabolism and that m^(6)A can regulate a variety of complex biological processes.In addition to its location on mammalian mRNAs,m^(6)A has been identified on viral transcripts.m^(6)A also plays important roles in the life cycle of many viruses and in viral replication in host cells.In this review,we briefly introduce the detection methods of m^(6)A,the m^(6)A-related proteins,and the functions of m^(6)A.We also summarize the effects of m^(6)A-related proteins on viral replication and infection.We hope that this review provides researchers with some insights for elucidating the complex mechanisms of the epitranscriptome related to viruses,and provides information for further study of the mechanisms of other modified nucleobases acting on processes such as viral replication.We also anticipate that this review can stimulate collaborative research from different fields,such as chemistry,biology,and medicine,and promote the development of antiviral drugs and vaccines. | Yafen Wang Xiang Zhou | 2023 | Genomics, Proteomics & Bioinformatics2023，21，4： | 1 |
| 4 | A multi-band atomic candle with microwave-dressed Rydberg atoms显示文摘Stabilizing important physical quantities to atom-based standards lies at the heart of modern atomic,molecular and optical physics,and is widely applied to the field of precision metrology.Of particular importance is the atom-based microwave field amplitude stabilizer,the so-called atomic candle.Previous atomic candles are realized with atoms in their ground state,and hence suffer from the lack of frequency band tunability and small stabilization bandwidth,severely limiting their development and potential applications.To tackle these limitations,we employ microwave-dressed Rydberg atoms to realize a novel atomic candle that features multi-band frequency tunability and large stabilization bandwidth.We demonstrate amplitude stabilization of microwave field from C-band to Ka-band,which could be extended to quasi-DC and terahertz fields by exploring abundant Rydberg levels.Our atomic candle achieves stabilization bandwidth of 100 Hz,outperforming previous ones by more than two orders of magnitude.Our simulation indicates the stabilization bandwidth can be further increased up to 100 kHz.Our work paves a route to develop novel electric field control and applications with a noise-resilient,miniaturized,sensitive and broadband atomic candle. | Yafen Cai Shuai Shi Yijia Zhou Jianhao Yu Yali Tian Yitong Li Kuan Zhang Chenhao Du Weibin Li Lin Li | 2023 | Frontiers of physics2023，18，1： | 1 |
| 5 | A highly efficient fluorescence-based switch-on detection method of 5-formyluracil in DNA显示文摘在 genomic DNA 的 hydroxylmethyl- 和 formylpyrimidines 的鉴定是在 epigenetics 的一个里程碑事件。相关的地里的众多的实验室正在调查这些和另外的 nucleic 酸修正的生物学。然而,处于检测并且综合的能力的限制拨出修正是妨碍。此处,我们在 5-formyluracil 的选择察觉探索了显著开发在搁浅单人赛并且在温和条件下面的双 stranded DNA。向 5-formyluracil 的打开特性在检测包含 5-formyluracil 的材料的品质上和份量上启用了高 signal-to-noise 比率,它没被 abasic 地点和 5-formylcytosine 的存在影响, 5-formyluracil 的修改 cytosine 对应物。在 5-formyluracil phosphoramidite 的摘要,无毒,便利,和费用效率,合成常规将支持这自然 thymidine 修正的 epigenetic 角色的理解。 | Chaoxing Liu Yuqi Chen Yafen Wang Fan Wu Xiong Zhang Wei Yang Jiaqi Wang Yi Chen Zhiyong He Guangrong Zou Shaoru Wang Xiang Zhou | 2017 | Nano Research2017，10，7： | 0 |
| 6 | Chemical labelling for m^(6)A detection:opportunities and challenges显示文摘N^(6)-methyladenosine(m^(6)A)is one of the most abundant and important epigenetic modifications in eukaryotic mRNA.The finding that m^(6)A is a dynamic modification based on methyltransferase and demethylase has sparked a wave of‘epitranscriptomics’,although the term‘epitran-scriptomics’is still controversial.With increasingly intensive research,an increasing number of functions of m^(6)A have been explored,and the results have elucidated that m^(6)A is involved in the splicing,nuclear export,translation,and degradation of mRNA.m^(6)A also has some implications in human disease.For example,promoter-bound m^(6)A methy-lase METTL3 maintains acute myeloid leukemia(AML)through m^(6)A-dependent translation control[1].Recent studies have also found that overexpression of METTL3 promotes the development of AML and those small molecules inhibitors of METTL3 effectively inhibit the development of AML.These results represent an encouraging step towards the development of new drugs to treat AML[2]. | Yafen Wang Wei Yang Xiang Zhou | 2022 | Fundamental Research2022，2，1： | 0 |
| 7 | A Metal-free Polyimide Photocatalyst for the Oxidation of Amines to Imines显示文摘Polyimide(PI) is an organic polymer material with good stability and diverse sources that has attracted widespread attention in the field of photocatalysis. In this study, a series of PI photocatalysts were synthesized by a thermal polymerization approach using pyromellitic dianhydride(PMDA) and various diamine monomers(melamine(MA), 4,4′-oxydianiline, and melem) as the precursors as well as different heating rates. The effects of the diamine precursor and heating rate on the structure, composition, morphology, and optical properties of the as-prepared PI materials were systematically investigated by various characterization techniques. The selective photo-oxidation of benzylamine was used as a model reaction to evaluate the photocatalytic activities of the resulting PI samples for the oxidation of amines to imines. The results revealed that the PI sample prepared using MA and PMDA as the precursors and a heating rate of 7 ℃/min(MA-PI-7) exhibited the best catalytic performance, with 98% benzylamine conversion and 98% selectivity for N-benzylidene benzylamine after 4 h of irradiation. Several benzylamine derivatives and heterocyclic amines also underwent the photo-oxidation reaction over the MA-PI-7 catalyst to afford the corresponding imines with good activity. In addition, MA-PI-7 exhibited good stability over four successive photocatalytic cycles. | Zhou Yafen Cheng Hong Song Yu Wang Qing Zhao Wenjie Chen Qilin Zhou Limei Xu Bin | 2023 | China Petroleum Processing & Petrochemical Technology2023，25，3： | 0 |
| 8 | The application of CRISPR-Cas in disease diagnosis and treatment显示文摘Clustered regularly interspaced short palindromic repeat(CRISPR)has been gaining much attention in the modern medical field and has been widely used for the diagnosis and treatment of diseases in recent years.In this review,we will introduce the application of CRISPR in disease diagnosis and treatment,including its use in detecting pathogens,gene mutations,and genetic diseases,as well as its application in gene therapy for single-gene diseases,cancer,viral infectious diseases,and cardiovascular diseases.Additionally,we will discuss the potential future directions and challenges of CRISPR in the diagnosis and treatment of diseases,and provide a thorough overview of the ways in which CRISPR is used for diagnosing and treating diseases. | Zhiying Wang Yin Liu Fuling Zhou Yafen Wang Xiang Zhou | 2023 | Science China Chemistry2023，66，10： | 0 |
| 9 | Highly Efficient Hydrogenation of Methyl Propionate to Propanol over Hydrous Zirconia Supported Ruthenium显示文摘含水的氧化锆支持了钌催化剂 Ru/ZrO2 吗?? | Fan Guangyin Zhou Yafen Fu Haiyan Ye Xiaoli Li Ruixiang Chen Hua Li Xianjun | 2011 | Chinese Journal of Chemistry2011，29，2： | 0 |
| 10 | Promotional Effect of CoO(OH) on Selective Hydrogenation of Maleic Anhydride to γ-Butyrolactone over Supported Ruthenium Catalyst显示文摘A decorated ruthenium catalyst was prepared by the coprecipitation method and used for the selective hydrogenation of maleic anhydride(MA) to γ-butyrolactone(GBL). The as-prepared catalyst was characterized by XRD, TGDTG and N2 adsorption techniques. The characterization tests revealed that the catalyst carrier was composed of monoclinic zirconia(m-ZrO2) and hydroxyl cobalt oxide(CoO(OH)). The hydrogenation results showed that the content of CoO(OH), the reaction temperature, the hydrogen pressure and the reaction time significantly affected the catalytic selectivity to GBL. The promotional effect of CoO(OH) was remarkable, which led to an obvious increase in GBL selectivity. An 100% MA conversion and 92.0% selectivity to GBL were achieved over the Ru/ZrO2-CoO(OH)(35%) catalyst in water solvent under the conditions involving a reaction temperature of 180 ℃, a hydrogen pressure of 3.0 MPa, and a reaction time of 6 h. | Zhou Yafen Wang Qing Wang Manman Yang Wenjuan Zhou Limei Ma Xiaoyan | 2015 | China Petroleum Processing & Petrochemical Technology2015，17，4： | 0 |
| 11 | Selective Hydrogenation of Maleic Anhydride to Succinic Anhydride over Nickel Catalyst Supported on Carbon Microspheres显示文摘The colloidal carbon microspheres(CMS)were prepared by the hydrothermal method.The nickel catalysts supported on carbon microspheres(Ni/CMS)were further prepared and were characterized by the Fourier transform infrared spectroscopy(FTIR),the X-ray diffraction(XRD),the scanning electron microscopy(SEM),the transmission electron microscopy(TEM),and the N_(2)adsorption technique.The selective hydrogenation of maleic anhydride(MA)to succinic anhydride(SA)over the Ni/CMS catalysts was investigated.The results indicated that the Ni/CMS catalyst,which was prepared with glucose as carbon source and calcined at 500℃,exhibited the best performance.The hydrogen pressure,reaction temperature,and reaction time could significantly affect the conversion of maleic anhydride during the hydrogenation reaction.A 98.4%conversion of MA and an 100%selectivity to SA were achieved over the Ni/CMS catalyst in acetic anhydride solvent under mild conditions covering a temperature of 90℃,a H2 pressure of 1.0 MPa,and a reaction time of 3 h. | Zhou Yafen Chen Qilin Wang Qing Song Yu Zhou Limei | 2021 | China Petroleum Processing & Petrochemical Technology2021，23，4： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员