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| 1 | Development of highly glyphosate-tolerant tobacco by coexpression of glyphosate acetyltransferase gat and EPSPS G2-aroA genes显示文摘The widely used herbicide glyphosate targets 5-enolpyruvylshikimate-3-phosphate synthase(EPSPS).Glyphosate acetyltransferase(GAT)effectively detoxifies glyphosate by N-acetylation.With the aim of identifying a new strategy for development of glyphosate-tolerant crops,the plant expression vector pG2-GAT harboring gat and G2-aroA(encoding EPSPS)has been transformed into tobacco(Nicotiana tabacum)to develop novel plants with higher tolerance to glyphosate.Results from Southern and Western blotting analyses indicated that the target genes were integrated into tobacco chromosomes and expressed effectively at the protein level.Glyphosate tolerance was compared among transgenic tobacco plants containing gat,G2-aroA,or both genes.Plants containing both gat and G2-aroA genes were the most glyphosate-tolerant.This study has shown that a combination of different strategies may result in higher tolerance in transgenic crops,providing a new approach for development of glyphosate-tolerant crops. | Baoqing Dun Xujing Wang Wei Lu Ming Chen Wei Zhang Shuzhen Ping Zhixing Wang Baoming Zhang Min Lin | 2014 | The Crop Journal2014，2，Z1： | 4 |
| 2 | Transarterial infusion chemotherapy with FOLFOX for advanced hepatocellular carcinoma:a multi-center propensity score matched analysis of real-world practice显示文摘Background:To compare the treatment effectiveness and safety among transarterial infusion chemotherapy(TAI)with FOLFOX regimen,transarterial chemoembolization(TACE),and sorafenib in patients with BCLC stage C hepatocellular carcinoma(HCC).Methods:The data of consecutive patients with BCLC stage C HCC treated with TAI,TACE,or sorafenib from January 2015 to December 2018 at three centers were retrospectively analyzed.Propensity-score matched(PSM)analysis was pairwise performed to reduce selection bias.Treatment effectiveness and safety were evaluated and compared using the Kaplan-Meier method,log-rank test,Cox regression models,andχ2 test.Results:The median overall survival(OS)in the matched TAI cohort was significantly longer than the sorafenib cohort(19.6 vs.7.5 months,P=0.009),and the TACE cohort(estimated 27.8 vs.6.6 months,P<0.001).The difference in median progression-free survival(PFS)between the matched TAI and sorafenib cohorts was not significant(5.8 vs.2.3 months,P=0.219).The median PFS in the matched TAI cohort was significantly longer than the TACE cohort(6.5 vs.2.8 months,P<0.001).The objective response rate(ORR)in the matched TAI cohort was significantly higher than the sorafenib cohort(36.4%vs.0.0%,P<0.001)and the TACE cohort(48.7%vs.4.7%,P<0.001).The incidences of adverse events(AEs)were similar among these three cohorts.Conclusions:TAI with FOLFOX regimen was an effective and safe therapy that improved survival of patients with BCLC stage C HCC. | Shaohua Li Jie Mei Qiaoxuan Wang Feng Shi Hongyan Liu Ming Zhao Lianghe Lu Yihong Ling Zhixing Guo Yabing Guo Xiaoming Chen Ming Shi Wan Yee Lau Wei Wei Rongping Guo | 2021 | Hepatobiliary Surgery and Nutrition2021，10，5： | 2 |
| 3 | Highly crystalline ReSe2 atomic layers synthesized by chemical vapor transport显示文摘Two-dimensional (2D) anisotropic rhenium diselenide (ReSe2) has attracted lots ofattention due to its promising applications in electronics and optoelectronics. However,controlled synthesis of high quality ultrathin ReSe2 remains as a challenge.Here we developed an approach for synthesizing high quality 2D ReSe2 flakes witha thickness down to monolayer by chemical vapor transport (CVT) through carefullytuning the growth kinetics. The atomic structures and anisotropy of theobtained ReSe2 flakes were intensively characterized with scanning transmissionelectron microscope and angle-resolved polarized Raman spectroscopy. Fieldeffecttransistors fabricated on the CVT-grown ReSe2 flakes showed n-typesemiconducting behavior with an on/off current ratio of 105 and a mobility up to5 cm2 V−1 s−1, which is comparable to mechanically exfoliated flakes and isobvious higher than the samples synthesized with other approaches. This study notonly make high quality 2D ReSe2 easily accessible for both fundamental and applicationexplorations but also sheds new lights on the chemical synthesis of otheranisotropic 2D materials. | Lei Xing Xingxu Yan Jingying Zheng Guanchen Xu Zhixing Lu Lina Liu Jinghui Wang Peng Wang Xiaoqing Pan Liying Jiao | 2019 | InfoMat2019，1，4： | 2 |
| 4 | The Homogeneity of Distributional Patterns of the Global Terrestrial Animal,Plant and Microorganism under the Influence of Ecological Conditions显示文摘The world animal geographical regionalization scheme and the plant geographical regionalization scheme have been formulated by zoologists and botanists respectively since the biogeography has been established.This research team initially confirmed the homogeneity of Chinese animal and plant geography.To explore the relationship between the distribution pattern of global animals,plants,and microorganisms,global 141,814 genera of terrestrial animals,17,526 genera of plants,21,321 genera of microorganisms,and their major taxa were analyzed using their proposed SGF(Similarity General Formula)and a new multivariate similarity clustering analysis method.Almost identical analytical results were obtained,meeting the requirements of statistics,geography,ecology and biology respectively.The expected consistency of their distribution pattern was achieved for the first time.We prove that the earth’s ecological conditions affect the homogeneity and accumulation of the distribution of animals,plants and microorganisms.Homogeneity determines the distribution pattern of global kinds of biological consistency,accumulation determines the impact of the evolutionary period on the breadth of distribution,microorganisms appear earliest,plants second,animals later,and their average distribution domain decreases in turn,reflecting these differences.Therefore,this study not only provides a theoretical basis and quantitative basis for the establishment of geographical regionalization scheme but also advances the development of biogeography to a new stage and raises the theory of biogeographic analysis to a new height. | Shen Qi Lu Jiqi You Zhixing Ren Yingdang Shen Xiaocheng | 2022 | Journal of Environmental Science and Engineering(A)2022，11，4： | 1 |
| 5 | Constructing a Type of New Wavelet Function and its Application in GPS Data Pre-processing显示文摘 | ZHENG Zuoya LU Xiushan DU Zhixing | | AVN0，，： | 1 |
| 6 | Mechanochemical devuleanization of ground tire and its application in acoustic absorbent polyurethane foamed composites 显示文摘 | Xinxin Zhang Zhixing Lu Dong Tian | 2013 | Journal of Applied Polymer Science2013，127，5： | 1 |
| 7 | Biodegradation of di - n - butyl phthalate by a stable bacterial consorti- um, HD - 1, enriched from activated sludge 显示文摘 | He Zhixing Xiao Hailong Tang Lu | 2013 | Bioresource Technology2013，128，： | 1 |
| 8 | Mechanochemical devulcanization of ground tire rubber and its application in acoustic absorbent polyurethane foamed composites显示文摘 | Zhang Xinxing Lu Zhixing Tian Dong | 2013 | J Appl Polym Sci2013，127，5： | 1 |
| 9 | Selective recognition and large enrichment of dimethoate from tea leaves by molecularly imprinted polymers 显示文摘 | LU Yongqin LIN Zhixing FENG Wei | 2007 | Biochem Eng J2007，36，3： | 1 |
| 10 | Translational potential of allosteric modulators targeting the cannabinoid CB1 receptor显示文摘The cannabinoid type-1(CB1)receptor,a G-protein-coupled receptor,is an attractive target for drug discovery due to its involvement in many physiological processes.Historically,drug discovery efforts targeting the CB1 receptor have focused on thedevelopment of orthosteric ligands that interact with the active site to which endogenous cannabinoids bind.Research performed over the last several decades has revealed substantial difficulties in translating CB1orthosteric ligands into druggable candidates.The dificulty is mainly due to the adverse effects associated with orthosteric CB1 ligands.Recent discoveries of allosteric CB1 modulators provide tremendous opportunities to develop CB1 ligands with novel mechanisms of action;these ligands may potentially improve the pharmacological effects and enhance drug safety in treating the disorders by regulating the functionsof the CB1receptor.In this paper,we review and summarize the complex pharmacological profiles of each class of CB1 allosteric modulators,the development of new classes of CB1 allosteric modulators and the results from in vivo assessments of their therapeutic value. | Dai Lu Sri Sujana Immadi Zhixing Wu Debra A.Kendall | 2019 | Acta Pharmacologica Sinica2019，40，3： | 1 |
| 11 | EFFECT OF SURFACE ENERGY ON DISLOCATION-INDUCED FIELD IN HALF-SPACE WITH APPLICATION TO THIN FILM-SUBSTRATE SYSTEMS显示文摘In this work the elastic field of an edge dislocation in a half-space with the effect of surface energy has been obtained.The elastic field is then used to study the image force on the dislocation,the critical thickness for dislocation generation in epitaxial thin films with strain mismatch and the yielding strength of thin films on substrates.The results show that the image forces on the dislocation deviate from the conventional solutions when the distance of the dislocation from the free surface is smaller than several times of the characteristic length.Also due to the effect of surface energy,the critical thickness for dislocation generation is smaller than that predicted by the conventional elastic solutions and the extent of the deviation depends on the magnitude of mismatch strain.In contrast,the effect of surface energy on the yielding strength for many practical thin films can be neglected except for some soft ones where the characteristic length is comparable to the thickness. | Ganyun Huang Bob Svendsen Zhixing Lu | 2009 | Acta Mechanica Solida Sinica2009，22，5： | 1 |
| 12 | Preliminary Study on Bystander Effects and Associated Mechanism Mediated through Irradiated Conditioned Medium显示文摘The bystander effects and associated mechanism have been studied by irradiated conditioned medium (ICM) method. ICR strain mice were used to detect the activation of natural killer (NK) cells to tumor cell Yac-I which cultured with ICM. And the effects of ICM on splenic lymphocyte proliferation were observed. Yac-I | Li Wenjian Wang Jufang Tu Xumin Lei Suweni Lu Huimini Zhang Zhixing Zhang Cuilang Hao Shuxia Liu Hongwu | 2004 | 近代物理研究所和兰州重离子加速器实验室年报:英文版2004，，1： | 0 |
| 13 | Neddylation is a novel therapeutic target for lupus by regulating double negative T cell homeostasis显示文摘Systemic lupus erythematosus(SLE),a severe autoimmune disorder,is characterized by systemic inflammatory response,autoantibody accumulation and damage to organs.The dysregulation of double-negative(DN)T cells is considered as a crucial commander during SLE.Neddylation,a significant type of protein post-translational modification(PTM),has been well-proved to regulate T cell-mediated immune response.However,the function of neddylation in SLE is still unknown.Here,we reported that neddylation inactivation with MLN4924,a specific inhibitor of NEDD8-activating enzyme E1(NAE1),or genetic abrogation of Ube2m in T cells decreased DN T cell accumulation and attenuated murine lupus development.Further investigations revealed that inactivation of neddylation blocked Bim ubiquitination degradation and maintained Bim level in DN T cells,contributing to the apoptosis of the accumulated DN T cells in lupus mice.Then double knockout(KO)lupus-prone mice(Ube2m-/-Bim-/-lpr)were generated and results showed that loss of Bim reduced Ube2m deficiency-induced apoptosis in DN T cells and reversed the alleviated lupus progression.Our findings identified that neddylation inactivation promoted Bim-mediated DN T cell apoptosis and attenuated lupus progression.Clinically,we also found that in SLE patients,the proportion of DN T cells was raised and their apoptosis was reduced.Moreover,compared to healthy groups,SLE patients exhibited decreased Bim levels and elevated Cullin1 neddylation levels.Meantime,the inhibition of neddylation induced Bim-dependent apoptosis of DN T cells isolated from SLE patients.Altogether,our findings provide the direct evidence about the function of neddylation during lupus,suggesting a promising therapeutic approach for this disease. | Yun Zhang Lijun Du Chenxi Wang Zhangsheng Jiang Qingchi Duan Yiping Li Zhijun Xie Zhixing He Yi Sun Lin Huang Liwei Lu Chengping Wen | 2024 | Signal Transduction and Targeted Therapy2024，9，2： | 0 |
| 14 | Distribution Pattern and Geographical Division of Terrestrial Living Things in the World显示文摘After summary of the distribution data of 180,661 genera of terrestrial animals,plants,fungi,bacteria and viruses in the world,according to the ecological conditions such as topography and climate,the world land is divided into 67 BGUs(Basic Geographic Units),which are analyzed by four quantitative methods:Single linkage method,Average group linkage method,Sum of squares method and MSCA(Multivariate Similarity Clustering Analysis)method.The MSCA has stronger data mining ability than the first three traditional clustering methods,and can obtain more,more detailed,more accurate and more stable clustering results.According to the clustering results,the first world biogeographical regionalization system was established.This system not only affirms and supports the reasonable scientific core of the mammalian and flowering plant geographical division plan formulated by the predecessors of scholars in the 19th century,but also revises some imbalances in the division criteria and boundary determination caused by their qualitative methods,unifying various global geographical division plans emerging since the 21st century. | Shen Xiaocheng Lu Jiqi Ren Yingdang Shen Qi You Zhixing Liu Xintao Zhang Shujie Wang Guanghua Yang Linlin | 2022 | Journal of Environmental Science and Engineering(B)2022，11，5： | 0 |
| 15 | STRENGTH-DUCTILITY AND γ'PRECIPITATES IN Ni-BASE ALLOYS显示文摘STRENGTH-DUCTILITYANDγ'PRECIPITATESINNi-BASEALLOYS￥WANGZhixing;XIEShishu;LUJunying;WANGLei;YANGHongcai(NortheasternUniversity... | WANG Zhixing XIE Shishu LU Junying WANG Lei YANG Hongcai (Northeastern University,Shenyang,China ) | 1995 | Acta Metallurgica Sinica(English Letters)1995，8，2： | 0 |
| 16 | Atmospheric Degradation and Performance Recovery of Two-Dimensional MoS2 Field Effect Transistor显示文摘Two-dimensional(2D)transition metal dichalcogenides(TMDCs)showed great potentials in 2D nanoelectronic devices due to their abundant and unique properties.The performance stability of the 2D TMDCs devices turns into one of the keys for their practical applications but has been rarely explored.Here,we investigated stability of MoS_(2)devices in ambient condition and contributed the device performance degradation to the surface oxidation of the contact metals with low work function,which increased the contact barrier and hindered the electron injection.We developed a new approach to recover the performance of the aged devices through the selective doping of contacts with organolithium,which prolonged the lifetime of MoS_(2)devices.Our work not only provides important insights into the stability of 2D TMDCs devices,but also opens up a new avenue for optimizing the performance of 2D MoS_(2)devices. | Lifei Sun Zhixing Lu Rui Xu Zhewei Li Guanchen Xu Fengen Chen Zhihai Cheng Liying Jiao | 2023 | Chinese Journal of Chemistry2023，41，21： | 0 |
| 17 | EFFECTS OF DISLOCATION CONFIGURATION,CRACK BLUNTING AND FREE SURFACES ON THE TRIGGERING LOAD OF DISLOCATION SOURCES显示文摘脱臼配置,快克在一个裂缝或一个楔尖端的附近在脱臼来源的被触发的负担上弄钝和免费表面的效果在远地里使遭到了到张力的负担被调查。为脱臼来源的一个适当被触发标准被考虑对每脱臼起作用的 configurational 力量建议。脱臼来源的被触发的行为接近一个裂缝的尖端,楔被比较。这也被发现在裂缝或楔附近弄钝裂缝尖端和免费表面的存在在脱臼来源的被触发的负担上有可观的影响。这研究可能具有到获得材料的 brittle-to-ductile 转变的更深的理解的意义。 | Lu Zhixing Wang Xuyue Yu Shouwen Feng Xiqiao | 2007 | Acta Mechanica Solida Sinica2007，20，2： | 0 |
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