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| 1 | Surface modification of sulfonated poly(ether ether ketone) membranes using Nafion solution for direct methanol fuel cells显示文摘 | Suzhen Ren Chennan Li Xinsheng Zhao Zhimo Wu Suli Wang Gongquan Sun Qin Xin Xuefeng Yang | 2004 | Journal of Membrane Science2004，，1： | 1 |
| 2 | Curing Technology for Improving the Quality of Upper Tobacco Leaves显示文摘In order to improve the curing quality and industrial availability of upper tobacco leaves,the effects of different temperature differences between dry and wet bulbs in yellowing stage on the chemical composition,aroma substances and economic characters of upper tobacco leaves were investigated using field test and indoor test. The results showed that when the dry bulb temperature was 38℃ and the temperature difference between dry and wet bulbs was 1. 5℃,the coordination of chemical constituents and the content of aroma substances in the upper tobacco leaves were increased,the appearance quality and sensory evaluation quality were significantly improved,and the economic characters after curing were improved,thereby improving the yield and quality of the upper tobacco leaves. | Weijun ZHANG Xiangli DONG Musen LIN Zhimo LI Yi WANG Zhixiao YANG Haiqian XIA Shengdong XIE | 2018 | Asian Agricultural Research2018，10，11： | 1 |
| 3 | 40 Hz light flickering promotes sleep through cortical adenosine signaling显示文摘Flickering light stimulation has emerged as a promising non-invasive neuromodulation strategy to alleviate neuropsychiatric disorders.However,the lack of a neurochemical underpinning has hampered its therapeutic development.Here,we demonstrate that light flickering triggered an immediate and sustained increase(up to 3 h after flickering)in extracellular adenosine levels in the primary visual cortex(V1)and other brain regions,as a function of light frequency and intensity,with maximal effects observed at 40 Hz frequency and 4000 lux.We uncovered cortical(glutamatergic and GABAergic)neurons,rather than astrocytes,as the cellular source,the intracellular adenosine generation from AMPK-associated energy metabolism pathways(but not SAM-transmethylation or salvage purine pathways),and adenosine efflux mediated by equilibrative nucleoside transporter-2(ENT2)as the molecular pathway responsible for extracellular adenosine generation.Importantly,40 Hz(but not 20 and 80 Hz)light flickering for 30 min enhanced non-rapid eye movement(non-REM)and REM sleep for 2–3 h in mice.This somnogenic effect was abolished by ablation of V1(but not superior colliculus)neurons and by genetic deletion of the gene encoding ENT2(but not ENT1),but recaptured by chemogenetic inhibition of V1 neurons and by focal infusion of adenosine into V1 in a dose-dependent manner.Lastly,40 Hz light flickering for 30 min also promoted sleep in children with insomnia by decreasing sleep onset latency,increasing total sleep time,and reducing waking after sleep onset.Collectively,our findings establish the ENT2-mediated adenosine signaling in V1 as the neurochemical basis for 40 Hz flickering-induced sleep and unravel a novel and non-invasive treatment for insomnia,a condition that affects 20%of the world population. | Xuzhao Zhou Yan He Tao Xu Zhaofa Wu Wei Guo Xi Xu Yuntao Liu Yi Zhang Huiping Shang Libin Huang Zhimo Yao Zewen Li Lingya Su Zhihui Li Tao Feng Shaomin Zhang Olivia Monteiro Rodrigo A.Cunha Zhi-Li Huang Kang Zhang Yulong Li Xiahong Cai Jia Qu Jiang-Fan Chen | 2024 | Cell Research2024，34，3： | 0 |
| 4 | Entrainment of Astrocytic and Neuronal Ca^(2+) Population Dynamics During Information Processing of Working Memory in Mice显示文摘Astrocytes are increasingly recognized to play an active role in learning and memory,but whether neural inputs can trigger event-specific astrocytic Ca^(2+)dynamics in real time to participate in working memory remains unclear due to the difficulties in directly monitoring astrocytic Ca^(2+)dynamics in animals performing tasks.Here,using fiber photometry,we showed that population astrocytic Ca^(2+)dynamics in the hippocampus were gated by sensory inputs(centered at the turning point of the T-maze)and modified by the reward delivery during the encoding and retrieval phases.Notably,there was a strong inter-locked and antagonistic relationship between the astrocytic and neuronal Ca^(2+)dynamics with a 3-s phase difference.Furthermore,there was a robust synchronization of astrocytic Ca^(2+)at the population level among the hippocampus,medial prefrontal cortex,and striatum.The inter-locked,bidirectional communication between astrocytes and neurons at the population level may contribute to the modulation of information processing in working memory. | Zhu Lin Feng You Ting Li Yijia Feng Xinyue Zhao Jingjing Yang Zhimo Yao Ying Gao Jiang-Fan Chen | 2022 | Neuroscience Bulletin2022，38，5： | 0 |
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