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| 1 | Synergistic effects of elevated homocysteine level and abnormal blood lipids on the onset of stroke显示文摘Hyperhomocysteinemia and abnormal blood lipids are independent risk factors for stroke.However,whether both factors exert a synergistic effect in the onset of stroke remains unclear.The present study is a retrospective analysis of 2 089 cases of stroke and 2 089 control cases of simple intervertebral disk protrusion using a paired multivariate logistic regression method.Adjusting for known confounding variables including the patients’age,gender,smoking status,alcohol consumption status,patient and family medical history,and clinical biochemical indices,elevated homocysteine level was related to the onset of stroke.Patients with elevated homocysteine levels and abnormal blood lipids showed a 40.9%increase in the risk for stroke compared to patients with normal homocysteine levels and blood lipids(odds ratio 1.409;95%confidence interval1.127–1.761).These results indicate that elevated homocysteine and abnormal blood lipids exert synergistic effects in the onset of stroke.Patients with elevated homocysteine levels and abnormal blood lipids are predisposed to stroke. | Lu Hao Liming Chen Xiaoyong Sai Zhefeng Liu Guang Yang Rongzeng Yan Lili Wang Caiyun Fu Xuan Xu Zhenzhen Cheng Qiang Wu Shuzhang Li | 2013 | Neural Regeneration Research2013，8，31： | 9 |
| 2 | Cancer:A proteomic disease显示文摘The development of cancer is a pathological process involving multiple environmental carcinogenic factors and genetic alterations.For decades,cancer researchers have focused on genomic and transcriptomic analyses.The completion of the Human Genome Project has opened the door to the post-genome era and oncoproteomics.Proteins play a critical role in tumorigenesis and influence the differences between normal cells and malignant cells.This report proposes the concept that cancer is a proteomic disease.This concept is based on examining protein expression profiles,post-translational modifications,and protein-protein interactions in carcinogenesis using recent advances in comparative,functional and structural proteomics.This approach provides a new way of viewing carcinogenesis,presents new clues in biomarker discovery for cancer diagnosis and therapy,and reveals important scientific findings and their significance to clinical applications. | LI GuoQing XIAO ZheFeng LIU JianPing LI Cui LI Feng CHEN ZhuChu | 2011 | Science China(Life Sciences)2011，54，5： | 8 |
| 3 | Recent Advances in the Genetic Dissection of Neural Circuits in Drosophila显示文摘Nervous systems endow animals with cognition and behavior. To understand how nervous systems control behavior, neural circuits mediating distinct functions need to be identified and characterized. With superior genetic manipulability, Drosophila is a model organism at the leading edge of neural circuit analysis. We briefly introduce the state-of-the-art genetic tools that permit precise labeling of neurons and their interconnectivity and investigating what is happening in the brain of a behaving animal and manipulating neurons to determine how behaviors are affected. Brain-wide wiring diagrams, created by light and electron microscopy, bring neural circuit analysis to a new level and scale. Studies enabled by these tools advances our understanding of the nervous system in relation to cognition and behavior. | Chao Guo Yufeng Pan Zhefeng Gong | 2019 | Neuroscience Bulletin2019，35，6： | 5 |
| 4 | Ice-templated porous tungsten and tungsten carbide inspired by natural wood显示文摘The structures of tungsten and tungsten carbide scaffolds play a key role in determining the properties of their infiltrated composites for multifunctional applications.However,it is challenging to construct and control the architectures by means of self-assembly in W/WC systems because of their large densities.Here we present the development of unidirectionally porous architectures,with high porosities exceeding 65 vol.%,for W and WC scaffolds which in many respects reproduce the design motif of natural wood using a direct ice-templating technique.This was achieved by adjusting the viscosities of suspensions to retard sedimentation during freezing.The processing,structural characteristics and mechanical properties of the resulting scaffolds were investigated with the correlations between them explored.Quantitative relationships were established to describe their strengths based on the mechanics of cellular solids by taking into account both inter-and intra-lamellar pores.The fracture mechanisms were also identified,especially in light of the porosity.This study extends the effectiveness of the ice-templating technique for systems with large densities or particle sizes.It further provides preforms for developing new natureinspired multifunctional materials,as represented by W/WC-Cu composites. | Yuan Zhang Guoqi Tan Da Jiao Jian Zhang Shaogang Wang Feng Liu Zengqian Liu Longchao Zhuo Zhefeng Zhang Sylvain Deville Robert O.Ritchie | 2020 | Journal of Materials Science & Technology2020，42，10： | 4 |
| 5 | A Neuronal Pathway that Commands Deceleration in Drosophila Larval Light-Avoidance显示文摘When facing a sudden danger or aversive condition while engaged in on-going forward motion,animals transiently slow down and make a turn to escape.The neural mechanisms underlying stimulation-induced deceleration in avoidance behavior are largely unknown.Here, we report that in Drosophila larvae, light-induced deceleration was commanded by a continuous neural pathway that included prothoracicotropic hormone neurons, eclosion hormone neurons, and tyrosine decarboxylase 2 motor neurons(the PET pathway). Inhibiting neurons in the PET pathway led to defects in lightavoidance due to insufficient deceleration and head casting.On the other hand, activation of PET pathway neurons specifically caused immediate deceleration in larval locomotion. Our findings reveal a neural substrate for the emergent deceleration response and provide a new understanding of the relationship between behavioral modules in animal avoidance responses. | Caixia Gong Zhenhuan Ouyang Weiqiao Zhao Jie Wang Kun Li Peipei Zhou Ting Zhao Nenggan Zheng Zhefeng Gong | 2019 | Neuroscience Bulletin2019，35，6： | 3 |
| 6 | Mechanical Properties,Damage and Fracture Mechanisms of Bulk Metallic Glass Materials显示文摘The deformation,damage,fracture,plasticity and melting phenomenon induced by shear fracture were investi- gated and summarized for Zr-,Cu-,Ti-and Mg-based bulk metallic glasses(BMGs)and their composites.The shear fracture angles of these BMG materials often display obvious differences under compression and tension, and follow either the Mohr-Coulomb criterion or the unified tensile fracture criterion.The compressive plas- ticity of the composites is always higher than the tensile plasticity,leading to a significant inconsistency.The enhanced plasticity of BMG composites containing ductile dendrites compared to monolithic glasses strongly depends on the details of the microstructure of the composites.A deformation and damage mechanism of pseudo-plasticity,related to local cracking,is proposed to explain the inconsistency of plastic deformation under tension and compression.Besides,significant melting on the shear fracture surfaces was observed.It is suggested that melting is a common phenomenon in these materials with high strength and high elastic energy,as it is typical for BMGs and their composites failing under shear fracture.The melting mechanism can be explained by a combined effect of a significant temperature rise in the shear bands and the instantaneous release of the large amount of elastic energy stored in the material. | Zhefeng ZHANG Fufa WU Guo HE Eckert | 2007 | Journal of Materials Science & Technology2007，23，6： | 3 |
| 7 | Notch Effect of Materials: Strengthening or Weakening?显示文摘Notch is a very important geometry with widespread applications in engineering structural components. Finding a universal equation to predict the effect of notch on strength of materials is of much significance for structural design and materials selection. In the present work, we tried to find this universal equation from experimental results of metallic glasses(MGs) and other materials as well as theoretical derivations based on a universal fracture criterion(Qu and Zhang, Sci. Rep. 3(2013) 1117). Experimental results showed that the notch effect of the studied MG was affected by the notch geometry characterized by the stress concentration factor Kt.As Ktbecomes smaller, the notch strength ratio(NSR, which is the ratio of nominal ultimate tensile strength(UTS) of the notched sample to UTS of the unnotched sample) increases. By comparing MGs with other materials like brittle ceramics and ductile crystalline metals, we find that when Ktis same, the NSR is larger for ductile metals but smaller for brittle ceramics. Theoretically, we derived a universal equation for notch effect on strength of materials: NSR ? M/Kt, where M is a constant related to materials. This universal equation was found to be consistent with the experimental results. | Ruitao Qu Peng Zhang Zhefeng Zhang | 2014 | Journal of Materials Science & Technology2014，30，6： | 3 |
| 8 | ROS-responsive 18β-glycyrrhetic acid-conjugated polymeric nanoparticles mediate neuroprotection in ischemic stroke through HMGB1 inhibition and microglia polarization regulation显示文摘Ischemic stroke is an acute and serious cerebral vascular disease,which greatly affects people’s health and brings huge economic burden to society.Microglia,as important innate immune components in central nervous system(CNS),are double-edged swords in the battle of nerve injury,considering their polarization between pro-inflammatory M1 or anti-inflammatory M2 phenotypes.High mobility group box 1(HMGB1)is one of the potent pro-inflammatory mediators that promotes the M1 polarization of microglia.18β-glycyrrhetinic acid(GA)is an effective intracellular inhibitor of HMGB1,but of poor water solubility and dose-dependent toxicity.To overcome the shortcomings of GA delivery and to improve the efficacy of cerebral ischemia therapy,herein,we designed reactive oxygen species(ROS)responsive polymer-drug conjugate nanoparticles(DGA)to manipulate microglia polarization by suppressing the translocation of nuclear HMGB1.DGA presented excellent therapeutic efficacy in stroke mice,as evidenced by the reduction of infarct volume,recovery of motor function,suppressed of M1 microglia activation and enhanced M2 activation,and induction of neurogenesis.Altogether,our work demonstrates a close association between HMGB1 and microglia polarization,suggesting potential strategies for coping with inflammatory microglia-related diseases. | Lulu Jin Zhixin Zhu Liangjie Hong Zhefeng Qian Fang Wang Zhengwei Mao | 2023 | Bioactive Materials2023，，1： | 3 |
| 9 | Identify crystal structures by a new paradigm based on graph theory for building materials big data显示文摘Material identification technique is crucial to the development of structure chemistry and materials genome project. Current methods are promising candidates to identify structures effectively, but have limited ability to deal with all structures accurately and automatically in the big materials database because different material resources and various measurement errors lead to variation of bond length and bond angle. To address this issue, we propose a new paradigm based on graph theory(GTscheme) to improve the efficiency and accuracy of material identification, which focuses on processing the 'topological relationship' rather than the value of bond length and bond angle among different structures. By using this method, automatic deduplication for big materials database is achieved for the first time, which identifies 626,772 unique structures from 865,458 original structures.Moreover, the graph theory scheme has been modified to solve some advanced problems such as identifying highly distorted structures, distinguishing structures with strong similarity and classifying complex crystal structures in materials big data. | Mouyi Weng Zhi Wang Guoyu Qian Yaokun Ye Zhefeng Chen Xin Chen Shisheng Zheng Feng Pan | 2019 | Science China Chemistry2019，62，8： | 3 |
| 10 | Bioinspired tungsten-copper composites with Bouligand-type architectures mimicking fish scales显示文摘The microscopic Bouligand-type architectures of fish scales demonstrate a notable efficiency in enhancing the damage tolerance of materials;nevertheless,it is challenging to reproduce in metals.Here bioinspired tungsten-copper composites with different Bouligand-type architectures mimicking fish scales were fabricated by infiltrating a copper melt into woven contextures of tungsten fibers.These composites exhibit a synergetic enhancement in both strength and ductility at room temperature along with an improved resistance to high-temperature oxidization.The strengths were interpreted by adapting the classical laminate theory to incorporate the characteristics of Bouligand-type architectures.In particular,under load the tungsten fibers can reorient adaptively within the copper matrix by their straightening,stretching,interfacial sliding with the matrix,and the cooperative kinking deformation of fiber grids,representing a successful implementation of the optimizing mechanisms of the Bouligand-type architectures to enhance strength and toughness.This study may serve to promote the development of new high-performance tungsten-copper composites for applications,e.g.,as electrical contacts or heat sinks,and offer a viable approach for constructing bioinspired architectures in metallic materials. | Yuan Zhang Guoqi Tan Mingyang Zhang Qin Yu Zengqian Liu Yanyan Liu Jian Zhang Da Jiao Faheng Wang Longchao Zhuo Zhefeng Zhang Robert O.Ritchie | 2022 | Journal of Materials Science & Technology2022，，1： | 3 |
| 11 | Innate preference in Drosophila melanogaster显示文摘Innate preference behaviors are fundamental for animal survival. They actually form the basis for many animal complex behaviors. Recent years have seen significant progresses in disclosing the molecular and neural mechanism underlying animal innate preferences, especially in Drosophila. In this review, I will review these studies according to the sensory modalities adopted for preference assaying, such as vision, olfaction, thermal sensation. The behavioral strategies and the theoretic models for the formation of innate preferences are also reviewed and discussed. | GONG ZheFeng | 2012 | Science China(Life Sciences)2012，55，1： | 2 |
| 12 | Twin boundary: Controllable interface to fatigue cracking显示文摘Twin boundaries(TBs) are key factors influencing the mechanical properties of crystalline materials. We have investigated the intrinsic fatigue cracking mechanisms of TBs during the past decade. The effects of TB orientations on the fatigue cracking mechanisms were revealed via cyclic deformation of a series of grown Cu bicrystals with a sole TB. Furthermore, the combined effects of crystallographic orientation and stacking fault energy(SFE) on the fatigue cracking mechanisms were clarified through cyclic deformation of polycrystalline Cu and Cu alloys. Both developments were reviewed in this report which will provide implications to optimize the interfacial design for the improvement of fatigue performance of metallic materials. | Zhefeng Zhang Linlin Li Zhenjun Zhang Peng Zhang | 2017 | Journal of Materials Science & Technology2017，33，7： | 2 |
| 13 | Understanding the mechanism of social tie in the propagation process of social network with communication channel显示文摘The propagation of information in online social networks plays a critical role in modern life,and thus has been studied broadly.Researchers have proposed a series of propagation models,generally,which use a single transition probability or consider factors such as content and time to describe the way how a user activates her/his neighbors.However,the research on the mechanism how social ties between users play roles in propagation process is still limited.Specifically,comprehensive summary of factors which affect user’s decision whether to share neighbor’s content was lacked in existing works,so that the existing models failed to clearly describe the process a user be activated by a neighbor.To this end,in this paper,we analyze the close correspondence between social tie in propagation process and communication channel,thus we propose to exploit the communication channel to describe the information propagation process between users,and design a social tie channel(STC)model.The model can naturally incorporate many factors affecting the information propagation through edges such as content topic and user preference,and thus can effectively capture the user behavior and relationship characteristics which indicate the property of a social tie.Extensive experiments conducted on two real-world datasets demonstrate the effectiveness of our model on content sharing prediction between users. | Kai LI Guangyi LV Zhefeng WANG Qi LIU Enhong CHEN Lisheng QIAO | 2019 | Frontiers of Computer Science2019，13，6： | 2 |
| 14 | Feeling Hot and Cold:Thermal Sensation in Drosophila显示文摘Sensing environmental temperature is crucial for animal life.The model animal,Drosophila melanogaster,can be investigated with a large number of genetic tools,which have greatly facilitated studies of the cellular and molecular mechanisms of thermal sensing.At the molecular level,a group of proteins,including Transient Receptor Potential channels and ionotropic receptors,have been characterized as potential thermal sensors in both larval and adult Drosophila.At the cellular and circuit levels,peripheral and central thermosensory neurons have been identified.More interestingly,thermal information has been found to be specifically encoded by specific central neurons.In this short review,we mainly survey the progress in understanding the molecular mechanisms of thermosensation and the neuronal mechanisms of thermal information processing in the brain of Drosophila.Other recent temperature-related findings such as its impact on neurosecretion and thermotactic behavior in Drosophila are also introduced. | Kun Li Zhefeng Gong | 2017 | Neuroscience Bulletin2017，33，3： | 2 |
| 15 | Microstructure and fatigue behavior of laser-powder bed fusion austenitic stainless steel显示文摘The microstructures and stress-controlled fatigue behavior of austenitic stainless steel(AISI 316 L stainless steel)fabricated via laser-powder bed fusion(L-PBF)technique were investigated.For L-PBF process,zigzag laser scanning strategy(scan rotation between successive layer was 0°,ZZ sample)and crosshatching layer scanning strategy(scan rotation between successive layer was 67°,CH sample)were employed.By inducing different thermal history,it is found that the scan strategies of laser beam have a significant impact on grain size and morphology.Fatigue cracks generally initiated from persistent slip bands(PSBs)or grain boundaries(GBs).It is observed that PSBs could transfer the melt pool boundaries(MPBs)continuously.The MPBs have better strain compatibility compared with grain boundaries(GBs),thus MPBs would not be the initiation site of fatigue cracks.A higher fatigue limit strength could be achieved by employing a crosshatching scanning strategy.For the CH sample,fatigue cracks also initiated from GBs and PSBs.However,fatigue crack initiated from process-induced defects were observed in ZZ sample in high-cycle regions.Solidification microstructures and defects characteristics are important factors affecting the fatigue performance of L-PBF 316 L stainless.Process-induced defects originated from fluid instability can be effectively reduced by adjusting the laser scan strategy. | Chenfan Yu Peng Zhang Zhefeng Zhang Wei Liu | 2020 | Journal of Materials Science & Technology2020，42，11： | 2 |
| 16 | Repeated Failure in Reward Pursuit Alters Innate Drosophila Larval Behaviors显示文摘Animals always seek rewards and the related neural basis has been well studied. However, what happens when animals fail to get a reward is largely unknown,although this is commonly seen in behaviors such as predation. Here, we set up a behavioral model of repeated failure in reward pursuit(RFRP) in Drosophila larvae. In this model, the larvae were repeatedly prevented from reaching attractants such as yeast and butyl acetate, before finally abandoning further attempts. After giving up, they usually showed a decreased locomotor speed and impaired performance in light avoidance and sugar preference,which were named as phenotypes of RFRP states. In larvae that had developed RFRP phenotypes, the octopamine concentration was greatly elevated, while tbh mutants devoid of octopamine were less likely to develop RFRP phenotypes, and octopamine feeding efficiently restored such defects. By down-regulating tbh in different groups of neurons and imaging neuronal activity, neurons that regulated the development of RFRP states and the behavioral exhibition of RFRP phenotypes were mapped to a small subgroup of non-glutamatergic and glutamatergic octopaminergic neurons in the central larval brain. Our results establish a model for investigating the effect of depriving an expected reward in Drosophila and provide a simplified framework for the associated neural basis. | Yue Fei Dikai Zhu Yixuan Sun Caixia Gong Shenyang Huang Zhefeng Gong | 2018 | Neuroscience Bulletin2018，34，6： | 2 |
| 17 | Relation Between Strength and Hardness of High-Entropy Alloys显示文摘High-entropy alloys(HEAs)are composed of multiple principal elements and exhibit not only remarkable mechanical properties,but also promising potentials for developing numerous new compositions.To fully realize such potentials,highthroughput preparation and characterization technologies are especially useful;thereby,the fast evaluations of mechanical properties will be urgently required.Revealing the relation between strength and hardness is of significance for quickly predicting the strength of materials through simple hardness testing.However,up to now the strength-hardness relation for HEAs is still a puzzle.In this work,the relations between tensile or compressive strength and Vickers hardness of various HEAs with hundreds of compositions at room temperature are investigated,and finally,the solution for estimating the strengths of HEAs from their hardness values is achieved.Data for hundreds of different HEAs were extracted from studies reported in the period from 2010 to 2020.The results suggested that the well-known three-time relation(i.e.,hardness equals to three times the magnitude of strength)works for nearly all HEAs,except for a few brittle HEAs which show quite high hardness but low strength due to early fracture.However,for HEAs with different phase structures,different strengths should be applied in using the 3-time relation,i.e.,yield strength for low ductility body-centered cubic(BCC)HEAs and ultimate strength for highly plastic and work-hardenable face-centered cubic(FCC)HEAs.As for dual-phase or multi-phase HEAs,similar 3-time relations can be also found.The present approach sheds light on the mechanisms of hardness and also provides useful guidelines for quick estimation of strength from hardness for various HEAs. | Xiaojuan Fan Ruitao Qu Zhefeng Zhang | 2021 | Acta Metallurgica Sinica(English Letters)2021，34，11： | 2 |
| 18 | On the order of the high - dimensional Cochrane sum and its mean value显示文摘 | Xu Zhefeng Zhang Wenpeng | 2006 | Journal of Number Theory2006，117，1： | 1 |
| 19 | Antisense inhibition of the NR Gene restores norml ripening to the tomato Never- ripe mutant consistent with the ethylene receptor- inhibition model 显示文摘 | Rachel M H Chin - Wen Ho Zhefeng L | 2000 | Plant Physiol2000，，10： | 1 |
| 20 | On the Mean Value of the Smarandache Power Function显示文摘 | Xu Zhefeng | 2006 | ACTA MATHE-MATICA SINICA(Chinese series)2006，49，1： | 1 |
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