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| 1 | VX-765 reduces neuroinflammation after spinal cord injury in mice显示文摘Inflammation is a major cause of neuronal injury after spinal cord injury. We hypothesized that inhibiting caspase-1 activation may reduce neuroinflammation after spinal cord injury, thus producing a protective effect in the injured spinal cord. A mouse model of T9 contusive spinal cord injury was established using an Infinite Horizon Impactor, and VX-765, a selective inhibitor of caspase-1, was administered for 7 successive days after spinal cord injury. The results showed that:(1) VX-765 inhibited spinal cord injury-induced caspase-1 activation and interleukin-1β and interleukin-18 secretion.(2) After spinal cord injury, an increase in M1 cells mainly came from local microglia rather than infiltrating macrophages.(3) Pro-inflammatory Th1 Th17 cells were predominant in the Th subsets. VX-765 suppressed total macrophage infiltration, M1 macrophages/microglia, Th1 and Th1 Th17 subset differentiation, and cytotoxic T cells activation;increased M2 microglia;and promoted Th2 and Treg differentiation.(4) VX-765 reduced the fibrotic area, promoted white matter myelination, alleviated motor neuron injury, and improved functional recovery. These findings suggest that VX-765 can reduce neuroinflammation and improve nerve function recovery after spinal cord injury by inhibiting caspase-1/interleukin-1β/interleukin-18. This may be a potential strategy for treating spinal cord injury. This study was approved by the Animal Care Ethics Committee of Bengbu Medical College(approval No. 2017-037) on February 23, 2017. | Jing Chen Yu-Qing Chen Yu-Jiao Shi Shu-Qin Ding Lin Shen Rui Wang Qi-Yi Wang Cheng Zha Hai Ding Jian-Guo Hu He-Zuo Lü | 2021 | Neural Regeneration Research2021，16，9： | 8 |
| 2 | Rayleigh wave phase velocities of South China block and its adjacent areas显示文摘Using records of continuous seismic waveforms from 609 broadband seismic stations in the South China Block and its adjacent areas in 2010–2012, empirical Green's functions of surface waves were obtained from cross-correlation functions of ambient noise data between these stations. High quality phase velocity dispersion curves of Rayleigh waves were obtained using time-frequency analysis. These interstation dispersion curves were then inverted to build Rayleigh wave phase velocity maps at periods of 6–50 s. The results of phase velocity maps indicate that phase velocities at 6–10 s periods are correlated with the geological features in the upper crust. Major basins and small-scale grabens and basins display slow velocity anomalies; while most of the orogenic belts and the fold belts display high velocity anomalies. With the gravity gradient zone along Taihang Mountain to Wuling Mountain as the boundary for the phase velocity maps at period of 20–30 s, the western area mainly displays low velocity anomalies, while the eastern side shows high velocity anomalies. Phase velocities in the eastern South China Block south to the Qinling-Dabie orogenic belt is higher than that in the eastern North China Block to the north, which is possibly due to the differences of tectonic mechanisms between the North China Craton and the South China Block. The phase velocities at periods of40–50 s are possibly related to the lateral variations of the velocity structure in the lower crust and upper mantle: The low-velocity anomalies in the eastern part of the Tibetan Plateau are caused by the thick crust; while the Sichuan Basin and the southern part of the Ordos Basin display distinct high-velocity anomalies, reflecting the stable features of the lithosphere in these blocks. The lateral variation pattern of phase velocities in the southern part of the South China Block is not consistent with the surface trace of the block boundary in the eastern Yunnan Province and its vicinities. The phase velocities in the Sichuan Basin are overall slow at short periods and gradually increase with period from the central part to the edge of the basin, indicating the features of shallower basement in the center and overall stable lithospheric mantle of the basin. The middle and upper crust of the southern Ordos Basin in the North China Block is heterogeneous, while in lower crust and the uppermost mantle the phase velocities mainly exhibit high anomalies. High-velocity anomalies are widespread at the middle of the Qinling-Dabie orogenic belt, as well as the areas in southeastern Guangxi with Caledonian granite explosion, but its detailed mechanism is still unclear. | L Jian XIE ZuJun ZHENG Yong ZHA XiaoHui HU Rui ZENG XinFu | 2016 | Science China Earth Sciences2016，59，11： | 5 |
| 3 | Grassland Degradation and Its Control in Region AroundQinghai Lake显示文摘A quite severe degradation was found in all seven types of grasslands in the study area involving 12counties of the northwestern Qinghai Province. The slightly, moderately and severely degraded grasslandsoccupied 49.7%, 32.0% and 18.3% of the area respectively. The major factors resulting in the degradationwere overgrazing, the damages from mice and grasshopper and blown sands, and improper use of grasslands.The measures to deal with these problems should be: 1) to make livestock development in accordancewith grassland carrying capacity for animals; 2) to build more artificial grasslands with a stable and highergraas yield; 3) to put more widely the rotation grazing system into practice; 4) to clear up the poisonousgrass species; and 5) to adopt more effective measures to deal with the damages to grasslands by mice andgrasshoppers. | JIANG JIANJUN NI SHAOXIANG GONG AIQI WANG WEIJUN ZHA YONG WANG JIECHENG F. VOSS(l College of Geographic Science, Nanjing Normal University, Nanjing 210097 (China))(2 General Grassland Station of Qinghai Province, Xining 810001 (China))(3 Institute of Ceog | 1999 | Pedosphere1999，9，4： | 4 |
| 4 | Impact of monsoonal climatic change on Holocene overbank flooding along Sushui River, middle reach of the Yellow River, China 显示文摘 | Huang C C Pang J L Zha X C | 2007 | Quaternary Science Reviews2007，26，： | 1 |
| 5 | Simulation and Optimization of a Piezo- electric Micropttmpfor Medical Applications 显示文摘 | Cui Q F Liu C L Zha X F | 2008 | International Journal of Advarlced Manufacturing Technology2008，36，5： | 1 |
| 6 | Coaxial electrospinning with acetic acid for preparing ferulic acid/zein composite fibers with improveddrug release profiles显示文摘 | Yang J M Zha L Yu D G | 2013 | Colloids and Surfaces B: Biointerfaces2013，102，： | 1 |
| 7 | Nonlinear pre-fire and postfire analysis of steel frames 显示文摘 | Iu C K Chan S L Zha X X | 2005 | Engineering Structures2005，27，11： | 1 |
| 8 | Adsorption of aniline and phenol on West Lake' sediments 显示文摘 | Zha L Z Xu X Hu S | 2002 | Chin J Environ Sci2002，21，2： | 1 |
| 9 | Mi R-718 represses VEGF and inhibits ovarian cancer cell progression显示文摘 | Leng R Zha L Tang L | 2014 | FEBS Lett2014，588，12： | 1 |
| 10 | Preparation and characterization of poly ( N-isopropylacrylamide-co-dimethylaminoethyl methacrylate) microgel latexes 显示文摘 | Zha L Hu J Wang C | 2002 | Colloid Polymer Science2002，280，： | 1 |
| 11 | A modified super-efficiency DEA model for infeasibility 显示文摘 | Cook W D Liang L Zha Y | 2009 | J Oper Res Soc2009，60，2： | 1 |
| 12 | Impact of mon- soonal climatic change on Holocene overbank flooding along Sushui River, middle reach of the Yellow River, China显示文摘 | HUANG C C PANG J L ZHA X C | 2007 | Quaternary Science Reviews2007，26，： | 1 |
| 13 | Effect of aldrin on life history characteristics of rotifer Brachionus calyciflorus Pallas显示文摘 | Huang L Xi Y L Zha C W | 2007 | Bulletin of Environmental Contamination and Toxicology2007，79，1： | 1 |
| 14 | Efficacy of trivalent chromium on growth performance, carcass characteristics and tissue chromium in heat-stressed broiler chicks显示文摘 | Zha L Y ? Zeng J W ? Ch X W | 2009 | Journal of the Science of Food and Agriculture2009，89，10： | 1 |
| 15 | 显示文摘 | Zha L Hu J | 2002 | Colloid Polym Sci2002，280，： | 1 |
| 16 | Preparation of a pitchbased activated carbon with a high specific surface area 显示文摘 | Qiao w M Ling L C Zha Q F | 1997 | J Mater Sci1997，32，： | 1 |
| 17 | Effect of sublethal exposure to chlordecone on life history characteristics of freshwater rotifer Brachionus calyciflorus pallas显示文摘 | ZHA C W XI Y L HUANG L | 2007 | Bulletin of envimzunental contamination & toxicolo- gy2007，78，1： | 1 |
| 18 | lrlomeostatic proliferation plus regulatory T cell depletion promotes potent rejection of B16 melanoma显示文摘 | Kline J Brown IE Zha YY Blank C Strickler J Wouters H Zhang L Gajewski TF | 2008 | Clin Cancer Res2008，14，： | 1 |
| 19 | Relationship among gastric- mucosa CIM, CD8 cells infiltration, Hp infection and symptoms in patients with chronic gastritis 显示文摘 | Lu A P Zhang S S Zha Q L | 2005 | World J Gastroenterol2005，11，16： | 1 |
| 20 | Two-stage cooperation model with in- put freely distributed among the stages显示文摘 | Zha Y Liang L | 2010 | European Journal of Operational Research2010，205，2： | 1 |
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