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| 1 | Blockade of cholecystokinin-2 receptor and cyclooxygenase-2 synergistically induces cell apoptosis, and inhibits the proliferation of human gastric cancer cells in vitro显示文摘Gastrin and cyclooxygenase-2(COX-2) playimportant roles in the carcinogenesis and progression ofgastric cancer.However,it remains unknown whether the combination of cholecystokinin-2(CCK-2) receptor antagonist plus COX-2 inhibitor exerts synergistic anti-tumor effects on human gastric cancer.Here,we demonstrated that the combination of AG-041R(a CCK-2 receptor antagonist) plus NS-398(a selective COX-2 inhibitor) treatment had synergistic effects on proliferation inhibition,apoptosis induction,down-regulation of Bcl-2 and up-regulation of Bax expression in MKN-45 cells.These results indicate that simultaneous targeting of CCK-2 receptor and COX-2 may inhibit gastric cancer development more effectively than targeting either molecule alone.(C)2008 Elsevier Ireland Ltd.All rights reserved. | Sun, W. H. | 2008 | 南京医科大学学报(自然科学版)2008，28，9： | 30 |
| 2 | Safety aod efficacy of holmium laser resection for primary nonmuscle - invasive bladder cancer versus traosurethral electroresection: single - center experience 显示文摘 | Zhu Y Jiaog X Zhaog J | 2008 | Urology2008，72，3： | 1 |
| 3 | Dietary fatty acids, hemostasis,and cardiovascular disease risk显示文摘 | Lefevre M Kris-Etherton PM ZhaoG | 2004 | J Am Diet A ssoc2004，104，： | 1 |
| 4 | Mechanicalstiffnessoflivertissuesinrelationtointegrinβ1expressionmayinfluencethedevelopmentofhepaticcirrhosisandhepatocellularcarcinoma显示文摘 | ZhaoG CuiJ QinQ etal | 2010 | JSurgOn-col2010，102，5： | 1 |
| 5 | Roles of GRP78 in physiology and can- cer显示文摘 | Zhaog LH Zhang X | 2010 | Cell Bioehem2010，10，6： | 1 |
| 6 | HighsurfaceenGergyenhancescellresponsetotitaniumsubstratemicroGstructure显示文摘 | ZhaoG SchwartzZ WielandM etal | 2005 | JournalofBiomedicalMaterialsResearch2005，74，1： | 1 |
| 7 | The synthesis of polyaerylonitrile/carbon nanotubes mierospheres by aqueous deposition polymerization under ultrasonication 显示文摘 | Zhaog H L Xu L H Yang F Y | 2010 | Carbon2010，48，： | 1 |
| 8 | Galectin-9 promotes TGF-betal- dependent induction of regulatory T ceils via the TGF-beta/Smad signaling pathway 显示文摘 | Lv K Zhaog Y Zhang M | 2013 | MolMed Rep2013，7，1： | 1 |
| 9 | StudyofMicrobialPredictiveModelanditsApplicationontheMeatIndustry显示文摘 | LiM ZhuYJ ZhaoG | | 0，，02： | 1 |
| 10 | Harmonic QPOs and thick accretion disk oscillations in The BL Laceretae object AO 0235 + 164显示文摘 | LIUFK ZHAOG WUXB | 2006 | Ap J2006，650，： | 1 |
| 11 | Central neuropeptlde Ysignaling ameliorates N (omega)-nitro-L-arginine methyl ester hypertension in the rat through a Y1 receptor mechanism 显示文摘 | Michalkiewicz M ZhaoG Jia Z | 2005 | Hypertension2005，45，4： | 1 |
| 12 | Fabrication of porous nanoscale polmide structures显示文摘 | Hitoshi K Hideham M Zhaog et a1 | 2008 | Chemistry Letters2008，37，10： | 1 |
| 13 | Determination of the refractive index dispersion using multi-wavelength second harmonic generation in an aperiodic LiTaO3 superlattice显示文摘 | ZHAOG YAN Z ZHANG C | 2009 | J Phys D :Appl Phys2009，42，5： | 1 |
| 14 | Calibrating camera radial distortion with cross-ratio invariability 显示文摘 | Zhaog Guangjun He Junji Yang Xianming | 2003 | Optics and Laser Technology2003，35，6： | 1 |
| 15 | Molecular cloningof a cottonphosphatase gene and its functional characterization显示文摘 | Lu S Y ZhaoG R Wu A M | 2010 | Bio-chemistry(Mosc)2010，75，1： | 1 |
| 16 | A conformation-dependent neutralizing monoclonal antibody specifically targeting receptor-binding domain in Middle East respiratory syndrome coronavirus spike protein显示文摘 | DuL ZhaoG YangY | 2014 | J Virol2014，88，70： | 1 |
| 17 | PBBs,PBDEs,and PCBs lev-els in hair of residents around e-waste disassembly sitesin Zhe-jiang Province,China,and their potential sources显示文摘 | ZhaoG Wang Z Deng M | 2008 | Sei TotalEnviron2008，397，： | 1 |
| 18 | Toughening of polyamide 6 with beta-nucleated thermoplastic vulcanizates based on polypropylene/ ethylene-propylene-diene rubber grafted with maleic anhydride blends显示文摘 | Ma Lifeng Wei Xinfeng Zhaog Qi | 2012 | Materials & Design2012，33，： | 1 |
| 19 | Choledochoscopic high-frequency needle-knife electrotomy as an effective treatment for intrahepatic biliary strictures显示文摘 | YangYL ZhangC ZhaoG | 2015 | J Gastroenterol Hepatol2015，30，9： | 1 |
| 20 | ISSR, an effective molecular ap-proach for studying genetic variability among Schistosomajaponicum isolates from different provinces in mainlandChina显示文摘 | ZhaoG H Li J | 2009 | Infect Genet Evol2009，，5： | 1 |
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