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| 1 | Tumor cells educate mesenchymal stromal cells to release chemoprotective and immunomodulatory factors显示文摘Factors released by surrounding cells such as cancer-associated mesenchymal stromal cells(CA-MSCs)are involved in tumor progression and chemoresistance.In this study,we characterize the mechanisms by which naYve mesenchymal stromal cells(MSCs)can acquire a CA-MSCs phenotype.Ovarian tumor cells trigger the transformation of MSCs to CA-MSCs by expressing pro-tumoral genes implicated in the chemoresistance of cancer cells,resulting in the secretion of high levels of CXC chemokine receptors 1 and 2(CXCR1/2)ligands such as chemokine(C-X-C motif)ligand 1(CXCL1),CXCL2,and interleukin 8(IL-8).CXCR1/2 ligands can also inhibit the immune response against ovarian tumor cells.Indeed,through their released factors,CA-MSCs promote the differentiation of monocytes towards M2 macrophages,which favors tumor progression.When CXCR1/2 receptors are inhibited,these CA-MSC-activated macrophages lose their M2 properties and acquire an anti-tumoral phenotype.Both ex vivo and in vivo,we used a CXCR1/2 inhibitor to sensitize ovarian tumor cells to carboplatin and circumvent the pro-tumoral effects of CA-MSCs.Since high concentrations of CXCR1/2 ligands in patients*blood are associated with chemoresistance,CXCR1/2 inhibition could be a potential therapeutic strategy to revert carboplatin resistance. | Augustin Le Naour Melissa Prat Benolt Thibault Renaud Mével Léa Lemaitre Helene Leray Marie-Veronique Joubert Kimberley Coulson Muriel Golzio Lise Lefevre Eliane Mery Alejandra Martinez Gwénael Ferron Jean-Pierre Delord Agnès Coste Bettina Couderc | 2020 | Journal of Molecular Cell Biology2020，12，3： | 3 |
| 2 | Automatic regulation of activated sludge aeration-single-tank nitrification-denitrification 显示文摘 | Lefevre F Audic J M Bujon B | 1993 | Water Science & Technology1993，28，10： | 2 |
| 3 | 迷走神经刺激和意识水平显示文摘研究表明,植物人状态的患者皮质皮质间和丘脑-皮质间远程通路中断.自我恢复的神经特征与丘脑-皮质活动的增加和前额叶功能连接改善有关.本研究通过刺激-位植物状态患者的植物神经评估来评估丘脑-皮质刺激的作用.该案例研究报道了-名35岁的有创伤性脑损伤史的男性,他15年来-直处于植物人状态.基线评估包括行为、脑电图和18F-FDGPET记录.然后患者接受了手术植入迷走神经刺激器,刺激增加至最大强度为1.5mA. | 李建华 Corazzol M Lio G Lefevre A | 2017 | 中国康复2017，32，6： | 2 |
| 4 | Perspectives damelioration genetique des peupliers en France显示文摘 | Villar M Lefevre F Augustin S | 1995 | Comptes Rendus de I′Academie d′Agriculture de France1995，81，3： | 2 |
| 5 | Some new classes of stochastic order relations among arithmetic random variables with applica-tions in actuarial sciences 显示文摘 | DENUIT M LEFEVRE C L | 1997 | Insurance:Mathematics and Economics1997，20，3： | 1 |
| 6 | On s-convex stochastic extrema for arithmetic risks显示文摘 | DENUIT M LEFEVRE C L MESFIOUI M | 1999 | Insurance:Mathematics and Economics1999，25，2： | 1 |
| 7 | Synthesis of bayerite (h-Al(OH)3)microrods by neutralization of aluminate ions at constant pH显示文摘 | Lefevre G Fe'doroff M | | 0，，： | 1 |
| 8 | Fe-based catalysts for the reduction of oxygen in polymer electrolyte membrane fuel cell conditions, Determination of the amount of peroxide released during electroreduction and its influence on the stability of the catalysts显示文摘 | Lefevre M Dodelet J P | 2003 | Electrochimica Acta2003，48，： | 1 |
| 9 | Common apolipoprotein A-Ⅳ variants are associated with differences in body mass index levels and percentage body fat显示文摘 | Lovejoy JC DeFelice SM | 2000 | Int J Obes Rslat Metab Disord2000，24，8： | 1 |
| 10 | Secretome of pri mary cultures of human adipose-derived stem cells:modulation of serpins by adipogenesis显示文摘 | Zvonic S Lefevre M Kilroy G | 2007 | Mol Cell Proteomics2007，6，1： | 1 |
| 11 | Pharmacokinetics of a novel transdermal rivastigmine patch for the treatment of Alzheimer's disease: a review 显示文摘 | KURZ A FARLOW M LEFEVRE G | 2009 | 3(5): 799-8052009，3，5： | 1 |
| 12 | Dietary fatty acids, hemostasis,and cardiovascular disease risk显示文摘 | Lefevre M Kris-Etherton PM ZhaoG | 2004 | J Am Diet A ssoc2004，104，： | 1 |
| 13 | Morbidity risk factors after low anterior resection with total mesorectal excision and coloanal anastomosis:a retrospective series of 483 patients显示文摘 | Bennis M Parc Y Lefevre JH | 2012 | Ann Surg2012，255，3： | 1 |
| 14 | Bioactive compounds in nuturtion and health-research methodol- gies for establishing biological fuetion: the antioxidant and anti- inflammatory effects of flavonoids on atherosclerosis显示文摘 | KIRS-ETHERON P M LEFEVRE M BEECHER G R | 2004 | Annu Rev Nutr2004，，： | 1 |
| 15 | Adult papillaryrenal tumor with oncocytic cells : clinicopathologic,immunohistochemical, and cytogenetic features of 10 cases 显示文摘 | LEFEVRE M COUTURIER J SIBONY M | 2005 | Am J Surg Pathol2005，29，12： | 1 |
| 16 | Stochastic orderings of convex/concave type on an arbitrary grid显示文摘 | DENU1T M LEFEVRE C L UTEV S | 1999 | Mathematics of Operations Research1999，24，4： | 1 |
| 17 | Novel interferon delta genes in mammals: Cloning of one gene from the sheep, two genes expressed by the horse conceptus and discovery of related sequences in several taxa by genomic database screening显示文摘 | Cochet M Vaiman D Lefevre F | 2009 | Gene2009，433，12： | 1 |
| 18 | Molecular oxygen reduction in PEM fuel cells: Evidence for the simultaneous presence of two active sites in Fe-based catalysts 显示文摘 | LEFEVRE M DODELET J P BERTRAND P | 2002 | J Phys Chem B2002，106，34： | 1 |
| 19 | Altering a histone H3K4 methylation pathway in glomerular podocytes promotes a chronic disease phenotype显示文摘 | Lefevre G M Patel S R Kim D | 2010 | PLoS Genet2010，6，10： | 1 |
| 20 | Lipid control in the management of type 2 diabetes mellitus: a clinical practice guideline from the American College of Physicians显示文摘 | Snow V Weiss KB LeFevre M | 2004 | Ann Intern Med2004，140，8： | 1 |
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