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| 1 | Prevention and treatment technologies of railway tunnel water inrush and mud gushing in China显示文摘Water inrush and mud gushing are one of the biggest hazards in tunnel construction. Unfavorable geological sections can be observed in almost all railway tunnels under construction or to be constructed, and vary in extent. Furthermore, due to the different heights of mountains and the lengths of tunnels, the locations of the unfavorable geological sections cannot be fully determined before construction, which increases the risk of water inrush and mud gushing. Based on numerous cases of water inrush and mud gushing in railway tunnels, the paper tries to classify water inrush and mud gushing in railway tunnels in view of the conditions of the surrounding rocks and meteorological factors associated with tunnel excavation. In addition, the causes of water inrush and mud gushing in combination of macroand micromechanisms are summarized, and site-specifc treatment method is put forward. The treatment methods include choosing a method of advance geological forecast according to risk degrees of different sections in the tunnel, determining the items of predictions, and choosing the appropriate methods, i.e. draining-oriented method, blocking-oriented method or draining-and-blocking method. The treatment technologies of railway water inrush and mud gushing are also summarized, including energy relief and pressure relief technology, advance grouting technology, and advance jet grouting technology associated with their key technical features and applicable conditions. The results in terms of treatment methods can provide reference to the prevention and treatment of tunnel water inrush and mud gushing. | Yong Zhao Pengfei Li Siming Tian | 2013 | Journal of Rock Mechanics and Geotechnical Engineering2013，5，6： | 16 |
| 2 | Metaverse:Perspectives from graphics,interactions and visualization显示文摘The metaverse is a visual world that blends the physical world and digital world.At present,the development of the metaverse is still in the early stage,and there lacks a framework for the visual construction and exploration of the metaverse.In this paper,we propose a framework that summarizes how graphics,interaction,and visualization techniques support the visual construction of the metaverse and user-centric exploration.We introduce three kinds of visual elements that compose the metaverse and the two graphical construction methods in a pipeline.We propose a taxonomy of interaction technologies based on interaction tasks,user actions,feedback and various sensory channels,and a taxonomy of visualization techniques that assist user awareness.Current potential applications and future opportunities are discussed in the context of visual construction and exploration of the metaverse.We hope this paper can provide a stepping stone for further research in the area of graphics,interaction and visualization in the metaverse. | Yuheng Zhao Jinjing Jiang Yi Chen Richen Liu Yalong Yang Xiangyang Xue Siming Chen | 2022 | Visual Informatics2022，6，1： | 10 |
| 3 | Cellulose fibers-reinforced self-expanding porous composite with multiple hemostatic efficacy and shape adaptability for uncontrollable massive hemorrhage treatment显示文摘Uncontrollable hemorrhage leads to high mortality and thus effective bleeding control becomes increasingly important in the military field and civilian trauma arena.However,current hemostats not only present limitation when treating major bleeding,but also have various side effects.Here we report a self-expanding porous composites(CMCP)based on novel carboxymethyl cellulose(CMC)fibers and acetalized polyvinyl alcohol(PVA)for lethal hemorrhage control.The CMC fibers with uniform fibrous structure,high liquid absorption and procoagulant ability,are evenly interspersed inside the composite matrix.The obtained composites possess unique fiber-porous network,excellent absorption capacity,fast liquid-triggered self-expanding ability and robust fatigue resistance,and their physicochemical performance can be fine-tuned through varying the CMC content.In vitro tests show that the porous composite exhibits strong blood clotting ability,high adhesion to blood cells and protein,and the ability to activate platelet and the coagulation system.In vivo hemostatic evaluation further confirms that the CMCP presents high hemostatic efficacy and multiple hemostatic effects in swine femoral artery major hemorrhage model.Additionally,the CMCP will not fall off from the injury site,and is also easy to surgically remove from the wound cavity after the hemostasis.Importantly,results of CT tomography and 3D reconstruction indicate that CMCP can achieve shape adaptation to the surrounding tissues and the wound cavities with different depths and shapes,to accelerate hemostasis while protecting wound tissue and preventing infection. | Yansen Wang Yifan Zhao Longxue Qiao Faxing Zou Yajie Xie Yudong Zheng Yong Chao Ying Yang Wei He Siming Yang | 2021 | Bioactive Materials2021，6，7： | 6 |
| 4 | PP2 and piceatannol inhibit PrP106-126-induced iNOS activation mediated by CD36 in BV2 microglia显示文摘Prion 疾病是人和动物的一组能递送的致命的 neurodegenerative 混乱,包括牛的海绵状的 encephalopathy, scrapie,和 CreutzfeldtJakob 疾病。Microglia,中央神经系统的居民巨噬细胞,对病理学的织物改变精致地敏感,改变他们的形态学和显型采用一个所谓的激活的状态并且执行免疫学的响应 pathophysiological 大脑侮辱工作。尽管最近的调查结果提供了珍贵卓见进角色 microglia,在在 prion 观察的 proinflammatory 事件玩,为这些回答的开始负责的细胞内部的发信号分子尚待被阐明。看起来 microglial 激活包含 PrP106126 绑定和象 CD36 和 integrins 那样的房间表面免疫者和粘附分子的激活与象 Fyn 那样的 Src 家庭酷氨酸 kinases 的随后的招募, Lyn,和 Syk kinases。在现在的学习,我们证明 CD36 涉及导致 PrP106126 的 microglial 激活并且 PP2 和 piceatannol (照片) 能废除毒害神经的 prion 在 microglia 的导致肽的可诱导的氮的氧化物 synthase 激活。这些调查结果作为 Src 家庭 kinase Fyn 和涉及毒害神经的 prion peptidesmicroglia 相互作用的酷氨酸 kinase Syk 禁止者揭开 PP2 和照片的一个以前未被认出的角色,因此提供新卓见进由毒害神经的 prion 肽位于 microglia 的激活下面的机制。 | Siming Zhang Lifeng Yang Mohammed Kouadir Rongrong Tan Yun Lu Jiaxin Chang Binrui Xu Xiaomin Yin Xiangmei Zhou Deming Zhao | 2013 | Acta Biochimica et Biophysica Sinica2013，45，9： | 2 |
| 5 | Stiffness-mediated mesenchymal stem cell fate decision in 3D-bioprinted hydrogels显示文摘Background:Hydrogels with tuneable mechanical properties are an attractive material platform for 3D bioprinting.Thus far,numerous studies have confirmed that the biophysical cues of hydrogels,such as stiffness,are known to have a profound impact on mesenchymal stem cell(MSC)differentiation;however,their differentiation potential within 3D-bioprinted hydrogels is not completely understood.Here,we propose a protocol for the exploration of how the stiffness of alginate–gelatin(Alg-Gel)composite hydrogels(the widely used bioink)affects the differentiation of MSCs in the presence or absence of differentiation inducing factors.Methods:Two types of Alg-Gel composite hydrogels(Young’s modulus:50 kPa vs.225 kPa)were bioprinted independently of porosity.Then,stiffness-induced biases towards adipogenic and osteogenic differentiation of the embedded MSCs were analysed by co-staining with alkaline phosphatase(ALP)and oil red O.The expression of specific markers at the gene level was detected after a 3-day culture.Results:Confocal microscopy indicated that all tested hydrogels supported MSC growth and viability during the culture period.Higher expression of adipogenic and osteogenic markers(ALP and lipoprotein lipase(LPL))in stiffer 3D-bioprinted matrices demonstrated a more significant response of MSCs to stiffer hydrogels with respect to differentiation,which was more robust in differentiation-inducing medium.However,the LPL expression in stiffer 3D-bioprinted constructs was reduced at day 3 regardless of the presence of differentiation-inducing factors.Although MSCs embedded in softer hydrogels to some extent proceeded toward adipogenic and osteogenic lineages within a few days,their differentiation seemed to be slower and more limited.Interestingly,the hydrogel itself(without differentiation-inducing factors)exhibited a slight effect on whether MSCs differentiated towards an adipogenic or an osteogenic fate.Considering that the mechanoregulated protein Yes-associated protein(YAP)is involved in MSC fate decisions,we further found that inhibition of YAP significantly downregulated the expression of ALP and LPL in MSCs in stiffer constructs regardless of the induced growth factors present.Conclusions:These results demonstrate that the differentiation of MSCs in 3D-bioprinted matrices is dependent on hydrogel stiffness,which emphasizes the importance of biophysical cues as a determinant of cellular behaviour. | Yufan Liu Zhao Li Jianjun Li Siming Yang Yijie Zhang Bin Yao Wei Song Xiaobing Fu Sha Huang | 2020 | Burns & Trauma2020，8，1： | 2 |
| 6 | Contribution of protein conformation and intermolecular bonds to fish and pork gelation properties显示文摘 | LIU Ru ZHAO Siming XIE Bijun | | 0，，： | 1 |
| 7 | Studies on fish and pork paste gelation by dynamic rheology and circular dichroism显示文摘 | LIU Ru ZHAO Siming LIU Haimei | | 0，，07： | 1 |
| 8 | Role of secondary structures in the gelation of porcine myosin at different pH values 显示文摘 | Ru Liu Siming Zhao Shanbai Xiong | 2008 | Meat Science2008，80，3： | 1 |
| 9 | Adenovirus-mediated decorin gene transfer prevents TGF-beta induced inhibition of lung morphogenesis显示文摘 | Sime PJ Bringas P | 1999 | Am J Physiol1999，277，2： | 1 |
| 10 | Role of secondary structure in the gelation of porcinemyosin at different pH values显示文摘 | Liu Ru Zhao Siming Xiong Shanbai | 2008 | Meat Science2008，80，3： | 1 |
| 11 | Synthesis of oetenyl succinic derivative of mechanically activated indica rice starch显示文摘 | Zhang Zhengmao Zhao Siming Xiong Shanbai | 2010 | Starch2010，62，2： | 1 |
| 12 | Effect of microwaves on rice quality显示文摘 | Zhao Siming Xiong Shanbo Qiu Chengguang | 2007 | Journal of Stored Products Research2007，43，： | 1 |
| 13 | Role of secondary structure in the gelation of porcine myosin at different pH values显示文摘 | LIU Ru ZHAO Siming XIONG Shanbai | 2008 | Meat Science2008，80，3： | 1 |
| 14 | Contribution of protein conformation and intermolecular bonds to fish and pork gelation properties显示文摘 | LIU Ru ZHAO Siming XIE Bijun | | 0，，05： | 1 |
| 15 | A thermal lethal model of rice weevils subjected to microwave irradiation显示文摘 | Siming Zhao Chengguang Qiu Shanbai Xiong | 2007 | Journal of Stored Products Rescarch2007，，43： | 1 |
| 16 | Synthesis of octenyl succinic derivative of mechanically activated Indica rice starch显示文摘 | ZHANG Zhengmao ZHAO Siming XIONG Shanbai | | 0，，02： | 1 |
| 17 | Rheological properties of fish actomyosin and pork actomyosin solutions显示文摘 | LIU Ru ZHAO Siming XIONG Shanbai | 2008 | Journal of Food Engineering2008，85，2： | 1 |
| 18 | A thermal lethal model of rice weevils subjected to microwave irradiation显示文摘 | Siming Zhao Chengguang Qiu Shanbai Xiong | 2007 | Journal of Stored Products Research2007，43，： | 1 |
| 19 | Role of secondary structure in the gelation of porcine myosin at different pH values显示文摘 | LIU Ru ZHAO Siming XIONG Shanbai | 2008 | Meat Science2008，80，3： | 1 |
| 20 | Effect of pH on the gel properties and secondary structure of fish myosin显示文摘 | LIU Ru ZHAO Siming LIU Youming | 2010 | Food Chemistry2010，121，1： | 1 |
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