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| 1 | α-MSH inhibits TNF-α-induced maturation of human dendritic cells in vitro through the up-regulation of ANXA1显示文摘-Melanocyte-stimulating 荷尔蒙(-MSH), 一反煽动性并且 immunomodulatory neuropeptide,被显示了在自体免疫的疾病和 allograft 拒绝的试验性的治疗有效。然而,它的规章的机制仍然是不清楚的。成熟树枝状的房间(DC ) 是有免疫力的反应和发炎的枢轴的开始者。我们假设了在 DC 成熟的 -MSH 的规章的角色将在 immune-response-mediated 疾病贡献 -MSH 的效果,这当模特儿。-MSH 禁止了导致的肿瘤坏死 factor-alpha (TNF-) ,这被发现人的 peripheral-monocyte-derived DC (MoDCs ) 的成熟, phenotypically 并且机能上地。这通过 co-stimulatory 分子 CD83 的表示的下面规定发生了,建议由 -MSH 的 DC 成熟的抑制能贡献这 neuropeptide 的反煽动性的效果并且 CD86, IL-12 的生产, IL-10 分泌物的提升,和 MoDC 吞噬细胞的活动。而且,增加了 A1 (ANXA1 ) 被发现为在 TNF 上禁止效果的 -MSH 负责的 annexin 的表示 -- 导致的 MoDC 成熟,能被 MoDCs 的处理与指向 ANXA1 (ANXA1-siRNA ) 的特定的、小介入的 RNA 废除,建议那 -MSH-induced ANXA1 调停抑制。因此, -MSH 禁止 TNF -- 通过 -MSH-up-regulated ANXA1 的人的 DC 的导致的成熟,由 -MSH 建议 DC 的成熟的那抑制能调停 neuropeptide 的反煽动性的效果。而且, ANXA1 能在调停免疫者的煽动性的疾病基于 DC 的角色作为一个新治疗学的药目标被识别。 | Yan Min Deping Han Zhanjiang Fu Honghai Wang Lirong Liu Yeping Tian | 2011 | Acta Biochimica et Biophysica Sinica2011，43，1： | 3 |
| 2 | Components in Antineoplastic Actinomycete Strain (N2010-37) of Bottom Mud in Mangrove显示文摘Objective To study the antitumor components from an actinomycete strain(N2010-37) of bottom mud in Zhanjiang Mangrove,South China Sea.Methods The components were isolated and purified by chromatographic techniques and recrystallization,and the structures were identified by spectral methods together with physicochemical analyses.The antitumor effects of these components were tested in vitro by MTT method.Results Three compounds were identified including two anthrones and one novel lactone.They are(3S,4R,7R,8R,9S)-3,8-dihydroxy-4,7,9-trimethyl-2,6-cyclononanediolacetone(1) ,2-hydroxy-1-methoxy-3-methylanthraquinone(2) ,and 1,6,8-thihydroxy-3-methylanthraquinone(3) .Conclusion Compound 1 is a new compound,and compounds 1 and 3 show the favorable cytotoxic activities against human chronic granulocytic leukemia cell line K562 strain by MTT method in vitro. | ZHOU Zhong-liu1,2,JIN Bei1,YIN Wen-qing2,FU Chun-yan2,FENG Hua-fen2 1.Chemistry Science and Technology School,Zhanjiang Normal University,Zhanjiang 524048,China 2.Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources,Ministry of Education,School of Chemistry and Chemical Engineering,Guangxi Normal University,Guilin 541004,China | 2011 | Chinese Herbal Medicines2011，3，3： | 2 |
| 3 | 抗瘤中药制剂对结直肠癌T及NK细胞免疫抑制的体外逆转作用(英文)显示文摘Objective: Reversing effects of traditional Chinese medicines on colorectal tumor immunosuppressions of natural killer (NK) cell and T lymphocyte were analyzed to provide evidence on selecting medicines for patients according to the different types of tumor immunosuppression. Methods: Six traditional Chinese medicines, including Arsenious acid (AS), Ligustra-zine hydrochloride (LHC), Astragalus mongholicus bge (AMB), Matrine N-oxide (MOX), Polyporus umbellatus polysaccharide (PUPS) and Artesunate (ART), were enrolled. The reversing effects on suppression of murine splenocyte transformation and NK killing activity were measured by 3-{4,5-dimethyl-2-thiazolyl}-2,5-diphenyl tetrazolium (MTT), and the effects on the suppressed expression of interleukin 2 receptor α (IL-2Rα), CD3ε + ζ + and CD3ε - ζ + were detected by flow cytometry (FCM). The effects on immunosuppressive molecules were measured by enzyme linked immunosorbent assay (ELISA), including transforming growth factor β1 (TGF-β 1), vascular endothelial growth factor (VEGF), interleukin 4 (IL-4), IL-6, IL-10 and pros-taglandin (PG) E 2 . Results: (1) The reversing effects of AMB on the inhibition of NK killing and CD3ε + ζ + expression were the most significant; the effect of LHC on inhibition of CD3ε - ζ + expression was the strongest; the effects of AMB, PUPS and ART on inhibition of transformation were the greatest; and the effect of ART on inhibition of IL-2Rα expression was the strongest. (2) The correlated molecules of these medicines that exerted reversing effects on colorectal tumor immunosuppression were TGF-β 1 and IL-10. AMB had the highest down-regulating effect on the secretion of TGF-β 1 . AS and ART had the highest effects on IL-10. Conclusion: Reversing tumor immunosuppression through the down-regulation of immunosuppressive molecules is one of the novel antitumor mechanisms of traditional Chinese medicines. The clinical use of compounded prescriptions of ART combined with AMB and LHC should be considered to avoid the reduced treatment efficiency caused by tumor immunosuppression. | Cheng Cui Aixia Zhang Jianjun Hu Wenguang Zheng Zhanjiang Fu Lirong Oi Meixiang LiWei Lv | 2012 | The Chinese-German Journal of Clinical Oncology2012，11，12： | 1 |
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