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| 1 | Experimental cancer gene therapy by multiple anti-survivin hammerhead ribozymes显示文摘为癌症改进基因治疗的功效,我们设计了指向 survivin mRNA 的暴露的区域的四撞木鲛 ribozyme 侵入人体气管粘膜的病菌(到 R4 的 R1 ) 。除了在里面 vitro 描述,由教材扩展包括了劈开的顺序特性的一颗决心,为细胞增长并且为的试金在 vivo 肿瘤,生长被用来为 ribozyme 效率得分。survivin 表示的产生抑制经由 caspase-3-dependent 小径导致了有丝分裂的大祸和房间死亡。重要地, ribozyme 侵入人体气管粘膜的病菌的管理在一个 hepato 细胞的癌异种皮移植老鼠模型禁止了肿瘤生长。R1, R3 和 R4 ribozymes 的合作表示 synergistically 压制了 survivin 并且当这联合指向 survivin 抄本的所有主要形式,生产了大多数有势力反癌症效果。带在这份报告描述的多重撞木鲛 ribozymes 的侵入人体气管粘膜的病菌对癌症提供了柔韧的基因治疗策略。 | Qi Fei Hongyu Zhang Lili Fu Xinlan Dai Baomei Gao Min Ni Chao Ge Jinjun Li Xia Ding Yuwen Ke Xuebiao Yao Jingde Zhu | 2008 | Acta Biochimica et Biophysica Sinica2008，40，6： | 10 |
| 2 | Caspase-1 inhibition attenuates activation of BV2 microglia induced by LPS-treated RAW264.7 macrophages显示文摘Neuroinflammation has been recognized as a factor in the pathogenesis of neurodegenerative diseases.Emerging evidence suggests that peripheral inflammation,besides neuroinflammation,functions as a modulator of disease progression and neuropathology in several neurodegenerative diseases.However,detailed correlations among peripheral inflammation,neuroinflammation and neurodegeneration remain unknown.In the present study,we prepared a peripheral inflammation model with lipopolysaccharides(LPS)-stimulated RAW264.7 macrophages to explore its activation on BV2 microglia.We found that LPS induced the production of IL-1 β,IL-6 and TNF-α in the culture medium of RAW264.7 macrophages.We further showed that LPS plus ATP activated inflammasome,evidenced by the upregulation of caspase-1 and IL-1β,which was suppressed by ZYVAD,a caspase-1 inhibitor.Furthermore,the conditioned medium obtained from LPS-treated RAW264.7 macrophages activated BV2 microglia,stimulating the release of IL-1β,IL-6 and TNF-a from BV2 cells.ZYVAD pretreatment markedly suppressed BV2 microglia activation induced by RAW264.7 cells conditioned medium.Taken together,our study indicates that macrophage-mediated peripheral inflammation subsequently evokes neuroinflammation and may aggravate neural damage.Inflammasome and caspase-1 may be potential targets for modulating systemic inflammatory responses in neurodegenerative diseases. | Yang Pan Bo Shen Qin Gao Jun Zhu Jingde Dong Li Zhang Yingdong Zhang | 2016 | The Journal of Biomedical Research2016，30，3： | 5 |
| 3 | A stringent dual control system overseeing transcription and activity of the Cre recombinase for the liver-specific conditional gene knock-out mouse model显示文摘Liver cancer is one of the most threatening diseases in Chinese population. Just like in other tissues, tumor initiation and development in liver involve multiple steps of genetic and epigenetic alterations with several unknown details. However, unlike in other tissues, a tis-sue specific inducible Cre recombinase system that allows temporal and spatial deletion of a target DNA fragment is still not available for in vivo functional gene annotation in hepatocytes. In our pursuit to establish such a mouse model, we designed a dual inducible Cre transgene system and tested it in cultured cells. By combining a CCAAT/enhancer binding protein β (C/EBP β) promoter derived Tet-off expression system and the estrogen receptor (ER) mediated functional control, we show a desirable profile of both hepatocyte-specificity and regulability of the Cre expression in a series of critical assessments in the cell culture system, which provides confidence in continua-tion of our ongoing pursuit in mouse. | Yu Wu Yinghua He Hongyu Zhang Xinlan Dai Xiaoyu Zhou Jun Gu Guan Wang Jingde Zhu | 2008 | Journal of Genetics and Genomics2008，35，7： | 3 |
| 4 | Speciation evolutions of target metals (Cd, Pb) influenced by chlorine and sulfur during sewage sludge incineration显示文摘在污泥焚化,重金属的热行为是一颗成长担心。在这个工作,在有约束力的精力划分在蒸汽阶段和压缩阶段,在压缩阶段的种形成再分配和金属种类的差别之间的行为的金属的联合分析被执行在高温度的污泥焚化调查重金属的可能的挥发冷凝作用机制。在金属挥发有二步,这被发现。重金属的起始的挥发发源从他们的可交换(EXC ) ,碳酸盐界限(汽车) 和部分,它是首先简单物质,氯化物,氧化物和硫化物填写了的铁锰界限(FM ) 。随在污泥的氯和硫的增加,重金属的内部种形成再分配在压缩阶段发生了,它是影响重金属的潜在的轻快的一个重要因素。有 complexed (COM ) 和部分逐渐地分解了成简单物质或离子,氧化物和碳酸盐的剩余(物件) 的金属种类部分的 A,它显著地加强了第二轻快。在氯的存在,当 Cd 的轻快率增加了 44.89% 时,有 RES 部分的大约 46% Cd 消失了。而且,当处于挥发率有将近 10% 的增加时,有 COM 部分的大约 9% Pb 消失了。因此,第二挥发被金属种类的分解主要与 COM 和物件部分控制。由 XRD 分析和有约束力的精力计算的优点,它被发现那金属复杂,硅酸盐被使倾向作为与硫酸盐相比由于差的 thermo 稳定性在高温度下面分解。 | Jingde LUAN Rundong LI Zhihui ZHANG Yanlong LI Yun ZHAO | 2014 | Frontiers of Environmental Science & Engineering2014，8，6： | 3 |
| 5 | Subjective poor sleep quality in Chinese patients with Parkinson's disease without dementia显示文摘Parkinson's disease (PD) is a common progressive neurological disorder and is composed of motor and nonmotor symptoms. Sleep disturbances are frequent problems for patients with PD. The relationship between sleep disturbances with Hoehn and Yahr (H&Y) staging have been demonstrated. However, the relationship between sleep disorders and H&Y is still unclear in patients with PD without dementia in Chinese PD patients. In this study, we interviewed 487 non-demented PD patients of Chinese Han descents by H&Y classification. We found that night sleep quality was significantly associated with the severity of PD (P=0.008). Panic disorder severity scale (PDSS) total scores were correlated with PD non-motor symptoms scale (PDNMS) scores (r=-0.528, P<0.001), the Hamilton depression scale (HAMD) scores (r=-0.545, P<0.001) and the Hamilton anxiety scale (HAMA) scores (r=-0.498, P<0.001). Our results indicated that sleep quality deteriorated with the advancing of PD in Chinese non-demented patients with PD. Depression and anxiety may partly explain sleep disturbances in nondemented patients with PD. | Li Zhang Jingde Dong Weiguo Liu Yingdong Zhang | 2013 | The Journal of Biomedical Research2013，27，4： | 2 |
| 6 | Effects of chronic peripheral pretreatment with an angiotensin II type-1 receptor blocker on apoptosis-related molecules in rats with cerebral ischemia/reperfusion injury显示文摘Chronic systemic treatment with blockers of angiotensin II type-1(AT1) receptors inhibits ischemia-induced apoptosis and reduces ischemic neuronal damage.However,the molecular mechanisms of AT1 receptor blockers in modulating neuronal apoptosis remain poorly understood.Pretreatment with irbesartan significantly suppressed cell apoptosis at 1-7 days following cerebral ischemia/reperfusion,increased levels of brain-derived neurotrophic factor,and elevated the ratios of Bcl-2/Bax and phosphorylated cyclic adenosine monophosphate response element-binding protein(pCREB)/CREB in the ischemic cortex at 1 day after reperfusion,as well as suppressing caspase-3 activation.Cerebral ischemia increased the mRNA expression of AT1 and AT2 receptors in the ischemic cortex,whereas irbesartan blocked this increase in AT1 expression but potentiated the expression of AT2.Therefore,this AT1 receptor blocker was neuroprotective by increasing the ratios of Bcl-2/Bax and pCREB/CREB,increasing brain-derived neurotrophic factor levels,inhibiting caspase-3 activation,and modulating AT receptor expression. | Jingping Shi Jingde Dong Jie Lu Yingdong Zhang | 2010 | Neural Regeneration Research2010，5，15： | 2 |
| 7 | ZIF-7@carbon composites as multifunctional interlayer for rapid and durable Li-S performance显示文摘The notorious'shuttle effect'of polysulfide during charge-discharge process induces grievous capacity fading,while the sluggish polysulfide conversion kinetics significantly hinders the development of practically viable lithium-sulfur(Li-S)batteries.In this study,a novel ZIF-7@carbon composite with ZIF-7 sheets vertically rooted on carbon cloth was developed as multifunctional interlayer to address these issues.The composite shows directional layered structure with outstanding compactness,and thus can provide massive active sites for accelerated redox reactions.The pore channels are perpendicular to the square surface,resulting in extremely high utilization of one-dimensional channels.Therefore,this structure can not only maintain the structural stability during the charge-discharge process by providing enough space for volume expansion,but also contribute to efficient exposure and utilization of active sites for the physical/chemical adsorption and catalytic conversion of polysulfide.As a result,Li-S batteries with the as-developed interlayer deliver a considerable areal capacity of 4.75 mAh cm^(-2) at an elevated sulfur loading of 5.5 mg cm^(-2),and an impressive cyclability with an extremely low capacity-fading rate of merely 0.04%per cycle over 500 cycles at 1 C. | Xingbo Wang Yan Zhao Feichao Wu Shuming Liu Zisheng Zhang Zhaoyang Tan Xiaohang Du Jingde Li | 2021 | Journal of Energy Chemistry2021，30，6： | 2 |
| 8 | Fabrication and properties of Fe3Al-Al2O3graded coatings显示文摘 | Jingde Zhang Yansheng Yin Jing Li | 2003 | Journal of Materials Processing Technology2003，134，2： | 1 |
| 9 | Preparation, microstructure and properties of yttrium aluminum garnet fibers prepared by sol–gel method显示文摘 | Chengshun Li Yujun Zhang Hongyu Gong Jingde Zhang Lifang Nie | 2008 | Materials Chemistry and Physics2008，，1： | 1 |
| 10 | Fabrication and properties of Fe3 Al-Al2O3 graded coatings 显示文摘 | ZHANG Jingde YIN Yansheng LI Jing etal | 2003 | J Mater Process Technol2003，134，2： | 1 |
| 11 | 显示文摘 | Fan Runhua Chen Yun Zhang Jingde | 2004 | Journal of Functional Materials2004，35，4： | 1 |
| 12 | Mechanical properties of Fe3Al/Al2O3 composite graded coatings显示文摘 | Yin Yansheng Zhang Jingde Li Jia | 2004 | Applied Surface Science2004，221，： | 1 |
| 13 | Experimental Study on Performance of a Closed Wet Cooling Tower for Air Wet-Bulb Temperature near 0°C显示文摘Closed wet cooling towers(CWCTs) are used widely because of their better water quality and smaller water consumption. However, the operating parameters shown in the technical documents are only for rated conditions in summer, not for any other conditions, especially in low air wet-bulb temperature areas such as those near 0℃. In addition, CWCTs often fail to achieve the designed cooling effect at low air wet-bulb temperatures. A experiment set of CWCT was built, and the performance of the CWCT at low air wet-bulb temperature near 0℃ was investigated. The impact of the operating parameters(air flow rate, cooling water flow rate, and spray water flow rate) on the heat and mass transfer performance of the CWCT was measured and analyzed. The results show the cooling performance of the CWCT at an air wet-bulb temperature 0℃, 2℃, and 4℃ is about 47%–63% of the rated operating condition;the optimal operating parameters of these conditions for the CWCT are just the same as those of the rated operating condition in summer. According to the experimental results, some operating advices are given. | ZHOU Yasu ZHANG Pan ZHAO Jingde YANG Honghai BAI Yufeng | 2019 | Journal of Thermal Science2019，28，5： | 1 |
| 14 | Fabrication and properties of Fe3Al-Al2O3 graded coatings显示文摘 | Zhang Jingde Yin Yansheng Li Jing | 2003 | Journal of Materials Processing Technology2003，134，2： | 1 |
| 15 | Granulocyte-macrophage colony-stimulating factor-transfected bone marrow stromal cells for the treatment of ischemic stroke显示文摘Adult,male,Sprague-Dawley rats were injected with granulocyte-macrophage colony-stimulating factor-transfected bone marrow stromal cells(GM-CSF-BMSCs) into the ischemic boundary zone at 24 hours after onset of middle cerebral artery occlusion.Results showed reduced infarct volume,decreased number of apoptotic cells,improved neurological functions,increased angiogenic factor expression,and increased vascular density in the ischemic boundary zone in rats that underwent GM-CSF-BMSCs transplantation compared with the BMSCs group.Experimental findings suggested that GM-CSF-BMSCs could serve as a potential therapeutic strategy for ischemic stroke and are superior to BMSCs alone. | Xingjian Lin Yingdong Zhang Weiguo Liu Jingde Dong Jie Lu Qing Di Jingping Shi | 2012 | Neural Regeneration Research2012，7，16： | 1 |
| 16 | PPreparation, microstrncture and properties of yttrium aluminum garnet fibers prepared by sol - gel method 显示文摘 | Chengshun Li Yujun Zhang Hongyu Gong Jingde Zhang Lifang Nie | 2009 | Materials Chemistry and Physics2009，，113： | 1 |
| 17 | An orderly arranged dual-role MIL-53(Al)nanorods array rooted on carbon nanotube film for long-life and stable lithium-sulfur batteries显示文摘It is of great value to synchronously resolve the critical issues of the polysulfide shuttle and dendrite growth in lithium-sulfur(Li-S)batteries.Herein,a bifunctional Al-based Material of Institute Lavoisier-53(MIL-53(Al))/carbon nanotube(MIL-53/CNT)composite is reported for this matter,which was constructed by growing an ordered MIL-53(Al)nanorods array on the CNT film.For the sulfur cathode,the proposed structure serves as a multifunctional interlayer to block polysulfides and accelerate their catalytic conversion,thus efficaciously inhibiting the shuttle effect.Meanwhile,when applied as the anode host material(Li@MIL-53/CNT),the flexible CNT film serves as a self-standing framework to accommodate Li metal and alleviate the volume expansion,while the uniform ion channels built by the MIL-53(Al)nanorods array along with the abundant oxygen groups can homogenize Li ion diffusion,enabling a steady Li plating/stripping behavior and limiting the dendrite growth.Not surprisingly,Li-S full battery with MIL-53/CNT interlayer and Li@MIL-53/CNT anode delivers an appreciable specific capacity of 735 mAh·g^(–1)and excellent cycle durability at 5 C,presenting a limited capacity decay of 0.03%per cycle in 500 cycles.Besides,an impressive cycle stability and rate capability are also achieved at high-sulfur loading and lean electrolyte conditions. | Feichao Wu Quanqing Li Gaofeng Jin Yuhong Luo Xiaohang Du Jingde Li Zisheng Zhang | 2023 | Nano Research2023，16，2： | 1 |
| 18 | Surgical treatment of hermaphroditism experience with 25 cases显示文摘 | Zhang Jingde Xing Xin | 2009 | Ann Plast Surg2009，63，： | 1 |
| 19 | 显示文摘 | Fan Runhua Chen Yun Zhang Jingde | 2004 | Journal of Functional Materials2004，35，4： | 1 |
| 20 | Fabrication and properties of FeEAL-AI2O3graded coatings 显示文摘 | Zhang Jingde Yin Yansheng Li Jing | 2003 | Journal of Materials Processing Technology2003，134，2： | 1 |
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