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| 1 | Chemical comparison of dried rehmannia root and prepared rehmannia root by UPLC-TOF MS and HPLC-ELSD with multivariate statistical analysis显示文摘To identify the chemical differences which lead to the different therapeutic effects of dried rehmannia root(DRR)and prepared rehmannia root(PRR),we compared the chemical composition of decoctions of randomly purchased DRR and PRR using ultra performance liquid chromatography(UPLC)coupled with time-of-fight mass spectrometry and high performance liquid chromatography(HPLC)coupled with evaporative light scattering detection(ELSD)with the aid of multivariate statistical analysis.Both approaches clearly revealed compositional and quantitative differences between DRR and PRR.UPLC-MS data indicated stachyose,rehmaiono-side A(or rehmaionoside B),acteoside(or forsythiaside,or isoacteoside),6-O-coumaroylajugol(or 6-O-E-feruloylajugol,or 6-O-Z-feruloylajugol)as important discriminators between DRR and PRR decoctions.HPLC-ELSD analysis showed that the content of fructose in the decoctions of PRR was about four times greater than that of DRR(P<10^(-5)),while sucrose content in the decoctions of PRR was only about one seventh of that in DRR(P<0.01).Our results suggest that some compounds,such as fructose,stachyose and rehmaionoside,may be responsible for the differing therapeutic effects of DRR and PRR.Furthermore,improvements in quality control for PRR,which is currently lacking in the Chinese Pharmacopoeia,are recommended. | Qiande Liang Jing Ma Zengchun Ma Yuguang Wang Hongling Tan Chengrong Xiao Ming Liu Beibei Lu Boli Zhang Yue Gao | 2013 | Acta Pharmaceutica Sinica B2013，3，1： | 8 |
| 2 | Bounding surface plasticity model for stress-strain and grain-crushing behaviors of rockfill materials显示文摘Crushing of grains can greatly influence the strength,dilatancy,and stress-strain relationship of rockfill materials.The critical state line(CSL)in the void ratio versus mean effective stress plane was extended to the breakage critical state plane(BCSP).A state void-ratio-pressure index that incorporated the effect of grain crushing was proposed according to the BCSP.Rowe’s stress-dilatancy equation was modified by adding the breakage voidratio-pressure index,which was also incorporated into the formulations of the bounding stress ratio and plastic modulus.A BCSP-based bounding surface plasticity model was proposed to describe the state-dependent stressstrain behaviors and the evolution of grain crushing during shearing process of rockfill materials,and was shown to sufficiently capture the breakage phenomenon. | Yang Xiao Zengchun Sun Armin WStuedlein Chenggui Wang Zhijun Wu Zhichao Zhang | 2020 | Geoscience Frontiers2020，11，2： | 5 |
| 3 | Fertilization and litter effects on the functional group biomass, species diversity of plants, microbial biomass, and enzyme activity of two alpine meadow communities显示文摘 | Changting Wang Ruijun Long Qilan Wang Wei Liu Zengchun Jing Li Zhang | 2010 | Plant and Soil (-)2010，，1： | 1 |
| 4 | Assessing glomerular filtration rate (GFR) in elderly Chinese patients with chronic kidney disease (CKD): A comparison of various predictive equations显示文摘 | Liu Xun Wang Cheng Tang Hua Shi Chenggang Chen Zhujiang Ye Zengchun Lou Tanqi | 2009 | Archives of Gerontology and Geriatrics2009，，1： | 1 |
| 5 | Increased GSK-3β expression in DRG microglia in response to sciatic nerve crush显示文摘Neuronal 损失和 apoptosis 经常发生在外部神经损害,它与煽动性的分子的版本和 microglia/macrophages 的激活被联系[1 ] 。过多的煽动性的反应由房间能加重的 glial 调停了许多神经病学的条件和原因 allodynia,痛觉过敏,神经病的疼痛,和 opioid 忍耐[2 ] 。在受伤的背面的根中心(DRG ) 的 Iba1-immunoreactive (红外) 房间能是内在的 microglia 或导出单核白血球的巨噬细胞,哪个是肿瘤坏死因素的主要来源 -- 并且另外的煽动性的 cytokines 在神经病的疼痛症候群含有。因此,煽动性的调整可以为这些上述的疾病的治疗提供一个治疗学的答案。作为在神经系统的主要居民免疫者房间, microglia 和星形细胞在外部神经损害期间为对损坏神经原的煽动性的回答是关键的[3 ] 。在外部神经损坏以后, microglial 细胞开始增殖并且在 ipsilateral 在受伤神经原的细胞身体附近形成稠密的簇针的绳索和 DRG [4 ] 。GSK-3 是参予蛋白质合成,房间增长,区别,和煽动性的反应的规定的无所不在的 serine/threonine kinase。最近的证据表明了 GSK-3 是在在 vitro 系统和动物模型的两个的有免疫力的回答的一个有势力管理者[5 ] 。在神经系统, GSK-3 活动能在星形细胞调整煽动性的回答, microglia 的迁居,煽动性的忍耐,和促进感受性[6 ] 。然而,我们的以前的学习表明 GSK-3 没在正常条件下面在 microglia 被表示[7 ] 。尽管 GSK-3 禁止者的应用程序能稀释支持 inflammatory cytokines 和减少的版本,这被显示出在鼠标的神经病的疼痛[8 ] ,在 DRG 后面的外部神经损害的 GSK-3 的表达式尚待被探索。在现在的学习,我们在 DRG 检验了 GSK-3 | Wenjie Tang Bing Li Sheng Chen Ying Lu Ning Han Xia Li Zengchun Li Youzhen Wei | 2016 | Acta Biochimica et Biophysica Sinica2016，48，6： | 1 |
| 6 | The effects of protective enclosure on vegetation diversity, and productivity of degraded alpine Kobresia meadow (qinghai-tibetan plateau)显示文摘 | Shixiong Li Qiji Wang Zengchun Jing | 2009 | Polish Journal of Ecology2009，57，3： | 1 |
| 7 | Induction of cytochrome P450 1A1 expression byginsenoside Rg1 and Rb1 in HepG2 cells显示文摘 | Wang Yuguang Ye Xuan Ma Zengchun | 2008 | Eur JPharm2008，601，： | 1 |
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