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| 1 | Single-cell transcriptomic atlas of primate cardiopulmonary aging显示文摘Aging is a major risk factor for many diseases,especially in highly prevalent cardiopulmonary comorbidities and infectious diseases including Coronavirus Disease 2019(COVID-19).Resolving cellular and molecular mechanisms associated with aging in higher mammals is therefore urgently needed.Here,we created young and old non-human primate single-nucleus/cell transcriptomic atlases of lung,heart and artery,the top tissues targeted by SARS-CoV-2.Analysis of cell type-specific aging-associated transcriptional changes revealed increased systemic inflammation and compromised virus defense as a hallmark of cardiopulmonary aging.With age,expression of the SARS-CoV-2 receptor angiotensin-converting enzyme 2(ACE2)was increased in the pulmonary alveolar epithelial barrier,cardiomyocytes,and vascular endothelial cells.We found that interleukin 7(IL7)accumulated in aged cardiopulmonary tissues and induced ACE2 expression in human vascular endothelial cells in an NF-κB-dependent manner.Furthermore,treatment with vitamin C blocked IL7-induced ACE2 expression.Altogether,our findings depict the first transcriptomic atlas of the aged primate cardiopulmonary system and provide vital insights into age-linked susceptibility to SARS-CoV-2,suggesting that geroprotective strategies may reduce COVID-19 severity in the elderly. | Shuai Ma Shuhui Sun Jiaming Li Yanling Fan Jing Qu Liang Sun Si Wang Yiyuan Zhang Shanshan Yang Zunpeng Liu Zeming Wu Sheng Zhang Qiaoran Wang Aihua Zheng Shuguang Duo Yang Yu Juan Carlos Izpisua Belmonte Piu Chan Qi Zhou Moshi Song Weiqi Zhang Guang-Hui Liu | 2021 | Cell Research2021，31，4： | 10 |
| 2 | Boron Nanosheet-Supported Rh Catalysts for Hydrogen Evolution:A New Territory for the Strong Metal-Support Interaction Effect显示文摘High-efficiency electrochemical hydrogen evolution reaction(HER)offers a promising strategy to address energy and environmental crisis.Platinum is the most effective electrocatalyst for the HER.However,challenging scarcity,valuableness,and poor electrochemical stability still hinder its wide application.Here,we designed an outstanding HER electrocatalyst,highly dispersed rhodium(Rh)nanoparticles with an average diameter of only 3 nm supported on boron(B)nanosheets.The HER catalytic activity is even comparable to that of commercial platinum catalysts,with an overpotential of only 66 mV in 0.5 M H_(2)SO_(4) and 101 mV in 1 M KOH to reach the current density of 10 mA cm−2.Meanwhile,the catalyst exhibited impressive electrochemical durability during long-term electrochemical processes in acidic and alkaline media,even the simu-lated seawater environment.Theoretical calculations unraveled that the structure-activity relationship between B(104)crystal plane and Rh(111)crystal plane is beneficial to the release of hydrogen,and surface O plays a vital role in the catalysis process.Our work may gain insights into the development of supported metal catalysts with robust catalytic performance through precise engineering of the strong metal-supported interaction effect. | Keng Chen Zeming Wang Liang Wang Xiuzhen Wu Bingjie Hu Zheng Liu Minghong Wu | 2021 | Nano-Micro Letters2021，13，10： | 1 |
| 3 | Research and Analysis of Regional Ecological Positioning in Planning Environmental Impact Assessment显示文摘The regional ecological positioning of one area is based on the region’s ecological orientation by the country or a larger region.Combined with the region’s natural geographical features,ecological background,main ecological problems,regional ecological structure,pattern,process,function and service,etc.,the position of a certain area in ecological space,structure,process,function and service,etc.is determined through the analysis and research.Regional ecological positioning is an important prerequisite and core basis for regional ecological impact assessment.However,in the current regional ecological impact assessment,most of them have not analyzed and studied the regional ecological positioning.Due to the lack of research on regional ecological positioning,it is rare to apply the research results of regional ecological positioning to the establishment of regional ecological objectives and the construction of index system.Regional ecological positioning does not guide the direction of regional ecological protection and construction well,and there is a general tendency of regional ecological positioning being one-sided and slogan-based.This paper analyzes the necessity and importance of research of regional ecological positioning,puts forward the technology framework of study on regional ecological positioning.With regional ecological positioning research in planning ecological impact assessment of the Chengdu-Chongqing Economic Zone as an example,how to carry out the study on the regional ecological positioning and how to apply the results of the study on the regional ecological positioning in regional ecological impact assessment are explained and illustrated. | Jianqiao QIN Donghang JIANG Fuxing GU Meng HU Rongjin YANG Yingli JIE Zeming ZHENG Haojia XU Xiaoxiao LIAO | 2022 | Meteorological and Environmental Research2022，13，5： | 0 |
| 4 | Toxic effects of three perfluorinated or polyfluorinated compounds(PFCs)on two strains of freshwater algae:Implications for ecological risk assessments显示文摘Perfluorinated or polyfluorinated compounds(PFCs)continue entering to the environmental as individuals or mixtures,but their toxicological information remains largely unknown.Here,we investigated the toxic effects and ecological risks of Perfluorooctane sulfonic acid(PFOS)and its substitutes on prokaryotes(Chlorella vulgaris)and eukaryotes(Microcystis aeruginosa).Based on the calculated EC50 values,the results showed that PFOS was significantly more toxic to both algae than its alternatives including Perfluorobutane sulfonic acid(PFBS)and 6:2 Fluoromodulated sulfonates(6:2 FTS),and the PFOS-PFBS mixture was more toxic to both algae than the other two PFC mixtures.The action mode of binary PFC mixtures on Chlorella vulgaris was mainly shown as antagonistic and on Microcystis aeruginosa as synergistic,by using Combination index(CI)model coupled with Monte Carlo simulation.The mean risk quotient(RQ)value of three individual PFCs and their mixtures were all below the threshold of 10^(−1),but the risk of those binary mixtures were higher than that of PFCs individually because of their synergistic effect.Our findings contribute to enhance the understanding of the toxicological information and ecological risks of emerging PFCs and provide a scientific basis for their pollution control. | Liangliang Zhang Xiaowei Zheng Xianglin Liu Jue Li Yanyao Li Zeming Wang Nan Zheng Xiangrong Wang Zhengqiu Fan | 2023 | Journal of Environmental Sciences2023，，9： | 0 |
| 5 | Quantitative research on higher order harmonics in metrology beamline显示文摘The synchrotron radiation spectra of the spherical grating monochromator(SGM)working in the soft X-ray and VUV region are often contaminated by significant amounts of higher order harmonics.They cannot be suppressed completely by suitable filters.Higher order contributions in the spectral radiation standard and metrology beamline were researched using transmission grating(made in-house)and IRD AXUV100G(USA)photodiode detector.The exit beam was dispersed with the transmission grating behind the exit slit of the monochromator,and the contributions of the different orders were analyzed.The higher order distributions were quantitatively determined for three gratings with line densities of 1800,600 and 200 l/mm.Experiment results show that in wavelengths between 5 nm and 15 nm the contributions of the higher orders to the detector signal are restricted to less than 7%even without the use of filters.In wavelength regions between 5 nm and 34 nm,the contributions of the higher orders to the detector signal are less than 14%with proper Al,Si_(3)N_(4) and Zr filters,and after being modified by quantum efficiency of the detector,the higher order contributions are restricted to less than 6.5%.The study also shows that higher orders are almost totally suppressed by MgF_(2) filter when the wavelength ranges between 115–140 nm. | Hongjun ZHOU Jinjin ZHENG Tonglin HUO Guobin ZHANG Zeming QI Pengfei ZHONG | 2008 | Frontiers of Electrical and Electronic Engineering in China2008，3，1： | 0 |
| 6 | Phase equilibrium modeling of zircon stability in mantle peridotite:Implication for crust-mantle interaction显示文摘Zircon is a common accessory mineral in various rocks,especially in the crustal ones.It is the best mineral for U-Pb dating.Meanwhile,trace elements and isotopes of the mineral can also provide much information concerning the formation and evolution of rocks.There are a growing number of reports of zircon existing in mantle peridotite.However,it is generally considered that zircon is unlikely crystallized in ultrabasic rocks due to SiO_(2)-unsaturation.In this paper,the SiO_(2) activity and zircon/baddeleyite transition curve at different conditions were calculated through thermodynamic phase equilibrium modeling,to reveal the main factors affecting the SiO_(2) activity and the stability of zircon/baddeleyite in ultrabasic and basic rocks,especially in mantle peridotite.These results provide a thermodynamic basis for interpreting the genesis and significance of zircon in mantle rocks.That is,the SiO_(2) activity is mainly controlled by stable mineral assemblages and temperature-pressure conditions.The orthopyroxene+olivine assemblage in peridotite as an effective buffer restricts the SiO_(2) activity in a relatively high range with a small variation.The upper temperature limit of zircon can reach more than 1500℃ with this mineral assemblage.During the low-temperature serpentinization of peridotite,the replacement of olivine and pyroxene by serpentine can result in a significant decrease of SiO_(2) activity,and baddeleyite can be stabilized at<530℃ and<2.7 GPa.When peridotite is strongly metasomatized by the SiO_(2)-bearing fluid,the addition of SiO_(2) can increase its activity and make zircon stable at low temperatures.The SiO_(2) activity in ultrabasic-basic rocks is not only positively correlated with the SiO_(2) content but also negatively correlated with the Ca and Na contents of rocks.This is because Ca and Na preferentially combine with Si and Al to form Si-rich minerals,such as clinopyroxene and feldspar.This process will consume excessive SiO_(2),decreasing the SiO_(2) activity.This may be the reason why zircon can be found in ultrabasic rocks,while baddeleyite can exist in some basic and alkaline rocks.The thermodynamic modeling can also reasonably explain the mutual transformation between zircon and baddeleyite in ultrabasic-basic rocks.Our results indicate that zircon can exist stably in mantle peridotite in a wide range of temperature-pressure conditions and its formation is related to melt/fluid metasomatism.That is,the presence of zircon in mantle peridotite is an important information carrier of crust-mantle interaction for deep material cycling. | Hua XIANG Jianping ZHENG Yibing LI Zeming ZHANG | 2022 | Science China Earth Sciences2022，65，2： | 0 |
| 7 | Graphene Quantum Dot‑Mediated Atom‑Layer Semiconductor Electrocatalyst for Hydrogen Evolution显示文摘The hydrogen evolution reaction performance of semiconducting 2H-phase molybdenum disulfide(2H-MoS_(2))presents a significant hurdle in realizing its full potential applications.Here,we utilize theoretical calculations to predict possible functionalized graphene quantum dots(GQDs),which can enhance HER activity of bulk MoS_(2).Subsequently,we design a functionalized GQD-induced in-situ bottom-up strategy to fabricate near atom-layer 2H-MoS_(2) nanosheets mediated with GQDs(ALQD)by modulating the concentration of electron withdrawing/donating functional groups.Experimental results reveal that the introduction of a series of functionalized GQDs during the synthesis of ALQD plays a crucial role.Notably,the higher the concentration and strength of electron-withdrawing functional groups on GQDs,the thinner and more active the resulting ALQD are.Remarkably,the synthesized near atom-layer ALQD-SO_(3)demonstrate significantly improved HER performance.Our GQD-induced strategy provides a simple and efficient approach for expanding the catalytic application of MoS_(2).Furthermore,it holds substantial potential for developing nanosheets in other transition-metal dichalcogenide materials. | Bingjie Hu Kai Huang Bijun Tang Zhendong Lei Zeming Wang Huazhang Guo Cheng Lian Zheng Liu Liang Wang | 2023 | Nano-Micro Letters2023，15，12： | 0 |
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