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| 1 | Extragastric manifestations of Helicobacter pylori infection: Possible role of bacterium in liver and pancreas diseases显示文摘Helicobacter pylori(H. pylori) is an ancient microorganism that has co-evolved with humans for over 60000 years. This bacterium typically colonizes the human stomach and it is currently recognized as the most common infectious pathogen of the gastroduodenal tract. Although its chronic infection is associated with gastritis, peptic ulcer, dysplasia, neoplasia, MALT lymphoma and gastric adenocarcinoma, it has been suggested the possible association of H. pylori infection with several extragastric effects including hepatobiliary and pancreatic diseases. Since a microorganism resembling H. pylori was detected in samples from patients with hepatobiliary disorders, several reports have been discussed the possible role of bacteria in hepatic diseases as hepatocellular carcinoma, cirrhosis and hepatic encephalopathy, nonalcoholic fatty liver disease and fibrosis. Additionally, studies have reported the possible association between H. pylori infection and pancreatic diseases, especially because it has been suggested that this infection could change the pancreatic physiology. Some of them have related a possible association between the microorganism and pancreatic cancer. H. pylori infection has also been suggested to play a role in the acute and chronic pancreatitis pathogenesis, autoimmune pancreatitis, diabetes mellitus and metabolic syndrome. Considering that association of H. pylori to liver and pancreas diseases needs further clarification, our work offers a review about the results of some investigations related to the potential pathogenicity of H. pylori in these extragastric diseases. | Elizabeth MA Rabelo-Goncalves Bruna M Roesler Jose MR Zeitune | 2015 | World Journal of Hepatology2015，7，30： | 16 |
| 2 | Inflammatory bowel disease in an underdeveloped region of Northeastern Brazil显示文摘AIM: To evaluate the demographic characteristics and clinical phenotypes of inflammatory bowel disease(IBD) in a geographic area in Northeastern Brazil.METHODS: This retrospective study was conducted at the Hospital of the Federal University of Piauí in Northeastern Brazil. Demographic characteristics and clinical phenotypes of IBD were analyzed in relation to the time of diagnostic confirmation, which was defined as the date of disease onset. Data were collected between January 2011 and December 2012 and included all census patients 18 years of age or older during that period for whom there was diagnostic confirmation of Crohn's disease(CD), ulcerative colitis(UC), or unclassified colitis according to the Montreal criteria. We also analyzed the period of time between the onset of clinical manifestations and the diagnosis of IBD(delay in the diagnosis). Statistical analyses included means and standard deviations for numeric variables and the Pearson χ2 adherence test for nominal variables. The annual index occurrence and overall prevalence of IBD at our institution were also calculated, with P values < 0.05 indicating statistical significance. This study was approved by the Institutional Ethics and Research Committee.RESULTS: A total of 252 patients with IBD were included, including 152(60.3%) UC patients and 100(39.7%) CD patients. The clinical and demographic characteristics of all patients with IBD showed a female to male ratio of 1.3:1.0 and a mean age of35.2(SD = 14.5) years. In addition, the majority of patients were miscegenated(171, 67.9%), had received higher education(157, 62.4%), lived in urban areas(217, 86.1%), and were under the age of 40 years(97, 62.5%). For patients with CD, according to the Montreal classification, the predominant features present from the onset of disease were an age between 17 and 40 years(A2); colonic disease location(L2); and nonstricturing, nonfistulizing disease behavior(B1). However, approximately one-quarter of all CD patients demonstrated perineal involvement. We also observed considerable delay in the diagnosis of IBD throughout the entire study period(mean = 35.5 mo). In addition, the annual index occurrence rose from 0.08 to 1.53 cases/105 inhabitants/year during the study period, and the prevalence rate was 12.8 cases/105 inhabitants in 2012. Over the last two decades, there was a noted increase in the frequency of IBD in the study area.CONCLUSION: In this study, there was a predominance of patients with UC, young people under 40 years of age, individuals with racial miscegenation, and low annual incomes. | José Miguel Luz Parente Claudio Saddy Rodrigues Coy Viriato Campelo Mírian Perpétua Palha Dias Parente Leonardo Araújo Costa Renata Mendes da Silva Celso Stephan José Murilo Robilotta Zeitune | 2015 | World Journal of Gastroenterology2015，21，4： | 3 |
| 3 | One-week dual therapy with ranitidine bismuth citrate and clarithromycin for the treatment of Helicobacter pylori infection in Brazilian patients with peptic ulcer显示文摘AIM: To assess the efficacy and safety of ranitidine bismuth citrate plus clarithromycin given for 1 wk in Brazilian patients with peptic ulcer.METHODS: One hundred and twenty patients with peptic ulcer were randomized in two treatment groups: (1) 1-wk regimen consisting of ranitidine bismuth citrate 400 mg b.i.d. with clarithromycin 500 mg b.i.d. or (2) 2-wk regimen of the same treatment. Eradication of the infection was considered when both the histologic examination and the urease test were negative for the infection 3 mo after treatment.RESULTS: By intention to treat analysis, Helicobacter pylori (H pylori) was eradicated in 73% and 76% of patients, respectively treated for 1 or 2 wk (P>0.05). By per protocol analysis, the eradication rates were 80% and 83%,respectively, in patients treated for 1 or 2 wk (P>0.05). Nine patients (8.2%) reported minor side effects. CONCLUSION: One-week therapy with ranitidine bismuth citrate and clarithromycin is safe, well tolerated and effective for treatment of H pylori infection, andappears to be comparable to the 2-wk regimen in terms of efficacy. | Maria Aparecida Mesquita S(o|^)nia Letícia Silva Lorena Jazon Romilson Souza Almeida Ciro Garcia Montes Fábio Guerrazzi Luciana T Campos José Murilo Rubiota Zeitune | 2005 | World Journal of Gastroenterology2005，11，23： | 1 |
| 4 | Acute inflammatory response in the stomach of BALB/ c mice challenged with coccoidal Helicobacter pylori显示文摘 | Rabelo-Goncalves EM Nishimura NF Zeitune JM | 2002 | Mem Inst Oswaldo Cruz2002，97，： | 1 |
| 5 | Power flow solutions through tensor methods显示文摘 | Salgado R S Zeitune A F | 2009 | IET Generation Transmission & Distri- bution2009，3，5： | 1 |
| 6 | Gastric polyps: aretrospective analysis of 26,000 digestive endoscopies显示文摘 | MoraisDJ Yamanaka A Zeitune JM | 2007 | ArqGastroenterol2007，44，1： | 1 |
| 7 | Estimating the risk of a fetal autosomal trisomy at mid - trimester using maternal serum alpha -fetoprotein and age: a retrospective study of 142 pregnancies 显示文摘 | Zeitune M Aitken DA Crossley JA | 1991 | Prenat Diagn1991，11，11： | 1 |
| 8 | Does ownership affect a firm's performance and default risk in Jordan显示文摘 | Zeitun R Tian G.G | | 0，，07： | 1 |
| 9 | Endothelin and neonatal capsaicin regulate gastric resistance to injury in BDL rats显示文摘AIM: To investigate the relationship between primary afferent neurons, endothelin (ET) and the role of its receptors on ethanol-induced gastric damage in cirrhotic rats. METHODS: Cirrhosis and portal hypertension were induced in rats by bile duct ligation (BDL) while controls had a sham operation. The association between ET and afferent neurons on the gastric mucosa was evaluated by capsaicin treatment in newborn rats, the use of ET agonists or antagonists, gastric ET-1 and -3 mRNA and synthetic capacity. Ethanol-induced damage was assessed using ex vivo gastric chamber experiments.Gastric blood flow was measured by laser-Doppler flow-metry. RESULTS: ET-3 and an ETB receptor antagonist sig- nificantly reduced the extent of ethanol-induced gastric damage in BDL rats. Gastric ET-1 and -3 levels were 30% higher in BDL rats compared to control rats. Cap-saicin treatment restored the gastric resistance and blood flow responses to topical application of ethanol in BDL rats and ET-1 and -3 production to levels observed in controls. CONCLUSION: Our results suggest that the reduced resistance of the gastric mucosa of cirrhotic rats to ethanol-induced injury is a phenomenon modulated by ET through the ET B receptor and by sensory afferent neurons. | Paula RS Cmara Gerson JN Ferraz Licio A Velloso José Murilo R Zeitune Fernando AB Suassuna Jose Geraldo P Ferraz | 2012 | World Journal of Gastrointestinal Pathophysiology2012，3，4： | 1 |
| 10 | Microwave coagulation versus sclerotherapy after band ligation to prevent recurrence of high risk of bleeding esophageal varices in Child-Pugh’s A and B patients显示文摘 | Leonardo Trevizan Monici José Olympio Meirelles-Santos Elza Cotrim Soares Maria Aparecida Mesquita José Murilo Robilotta Zeitune Ciro Garcia Montes Jazon Romilson Souza Almeida Ademar Yamanaka Luis Alberto Magna | 2010 | Journal of Gastroenterology2010，，2： | 1 |
| 11 | Capital Structure and Corporate Perform- ance : Evidence from Jordan 显示文摘 | Tian Zeitun | 2007 | The Australasian Ac- counting Business & Finance Journal2007，，1： | 1 |
| 12 | Does ownership affect a firm's performance and default risk in Jordan? 显示文摘 | Zeitun R Tian G G | 2007 | Corporate Governance2007，7，1： | 1 |
| 13 | Acute inflammatory response in the stomach of BALB/c mice challenged with coccoidal Helicobacter pylori显示文摘 | Rabelo-Goncalves EM Nishimura NF Zeitune JM | 2002 | Mem Inst Oswaldo Cruz2002，97，8： | 1 |
| 14 | Gastric polyps: a retrospective analysis of 26,000 digestive endoscopies显示文摘 | Morais D J Yamanaka A Zeitune J M | 2007 | Arq Gastroenterol2007，44，1： | 1 |
| 15 | Estimat the risk of a fetal autosomal trisomy at mid-trimester using maternal serum alphafetoprotein and age: a restrostective study of 142 pregnacies显示文摘 | Zeitune M Aitken A Crossley J A | 1991 | Prenat Diag1991，11，11： | 1 |
| 16 | Albumin oxidation leads to neutrophil activation in vitro and inaccurate measurement of serum albumin in patients with diabetic nephropathy显示文摘 | Michelis R Kristal B Zeitun T | 2013 | Free Radic Biol Med2013，60，： | 1 |
| 17 | Capital structure and corporateperformance : Evidence from Jordan 显示文摘 | RAMI ZEITUN GARY GANG TIAN | 2007 | The Australasian Account-ing Business and Finance Journal2007，1，4： | 1 |
| 18 | PCR-Based Detection and Genotyping of Helicobacter pylori in Endoscopic Biopsy Samples from Brazilian Patients显示文摘 | Silvia M. Ferreira Menoni Sandra Helena Alves Bonon José Murilo Robilota Zeitune Sandra Cecília Botelho Costa Vikram Kate | 2013 | Gastroenterology Research and Practice2013，，： | 1 |
| 19 | Acute inflam-matory response in the stomach of BALB/c mice challenged withcoccoidal Helicobacter pylori显示文摘 | Rabelo-Roncalve EM Nishimura NF Zeitune JM | 2002 | Mem Inst Oswaldo Cruz2002，97，： | 1 |
| 20 | Power flow solutions through tensor methods显示文摘 | Salgado R S Zeitune A F | 2009 | IET Generation Transmission & Distribution2009，3，5： | 1 |
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