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| 1 | How Work Organization Affects the Prevalence of WMSDs: A Case-control Study显示文摘Objective In this study, we aimed at exploring the association between work-related musculoskeletal disorders(WMSDs) and work organization based on a case-control study. Methods A total of 1938 workers who claimed to suffer from WMSDs were selected from Beijing, Henan, Hubei, and the Guangdong province. The control group consisted of 2009 workers employed in similar industries without severe disease or musculoskeletal discomforts. We used a modified version of the questionnaire developed by the NMQ and the DMQ to investigate individual and work-related factors. Results A total of 13 variables(P<0.1) were selected by the chi-square test and finally, 7 variables entered into the equation, with 6 variables reaching statistical significance(P<0.05). The odds ratios(OR) of ‘work changing with season' and ‘sufficient rest time' did not reach 1(0.749 and 0.441, respectively). In addition, ‘sufficient rest time' seemed to be the stronger protective factor according to its higher standardized coefficient. And ‘repetitive work every minute', ‘constantly repetitive work'(every day), ‘shortage of site personnel', and ‘often switching shifts with others' seemed to be the risk factors. Conclusion Work organization may have comprehensive effects on the occurrence of WMSDs. This pattern of associations suggests that further investigation into the mechanism of how work organization affects the prevalence of WMSDs is required. | LIU Lu CHEN Song Gen TANG Shi Chuan WANG Sheng HE Li Hua GUO Ze Hua LI Jing Yun YU Shan Fa WANG Zhong Xu | 2015 | Biomedical and Environmental Sciences2015，28，9： | 11 |
| 2 | Effects of Urbanization,Soil Property and Vegetation Configuration on Soil Infiltration of Urban Forest in Changchun,Northeast China显示文摘Urban forest soil infiltration, affected by various factors, is closely related with surface runoff. This paper studied the effect of urban forest types, vegetation configuration and soil properties on soil infiltration. In our study, 191 typical plots were sampled in Changchun City, China to investigate the soil infiltration characteristics of urban forest and its influencing factors. Our results showed that the steady infiltration rates of urban forest soil were highly variable. High variations in the final infiltration rates were observed for different vegetation patterns and compaction degrees. Trees with shrubs and grasses had the highest infiltration rate and trees with bare land had the lowest infiltration rate. In addition, our results showed that the soil infiltration rate decreased with an increase in the bulk density and with a reduction in the soil organic matter content and non-capillary porosity. The soil infiltration rate also had significantly positive relationships with the total porosity and saturated soil water content. Urban soil compaction contributed to low soil infiltration rates. To increase the infiltration rate and water storage volume of urban forest soil, proper techniques to minimize and mitigate soil compaction should be used. These findings can provide useful information for urban planners about how to maximize the water volume of urban forest soil and decrease urban instantaneous flooding. | WANG Peijiang ZHENG Haifeng REN Zhibin ZHANG Dan ZHAI Chang MAO Zhixia TANG Ze HE Xingyuan | 2018 | Chinese Geographical Science2018，28，3： | 7 |
| 3 | Construction of the Ontology-Based Agricultural Knowledge Management System显示文摘Ontology is the formal representation of concepts and their mutual relations.It has wide application potential in the classification of agricultural information,the construction of information and knowledge database,the research and development of intelligent search engine,as well as the realization of cooperative information service,etc.In this research,an ontology-based agricultural knowledge management system framework is proposed,which includes modules of ontology-based knowledge acquisition,knowledge representation,knowledge organization,and knowledge mining,etc.The key technologies,building tools and applications of the framework are explored.Future researches on the theoretical refinement and intelligent simulation knowledge service are also envisioned. | ZHENG Ye-lu HE Qi-yun QIAN Ping LI Ze | 2012 | Journal of Integrative Agriculture2012，11，5： | 5 |
| 4 | Overproduction of nitric oxide inhibits vascular reactivity in portal hypertensive rats显示文摘OverproductionofnitricoxideinhibitsvascularreactivityinportalhypertensiveratsLIXiRu,WUJinSheng,HEZeSheng,MAQingJiuandGAO... | LI XiRu, WU JinSheng, HE ZeSheng, MA QingJiu and GAO DeMing | 1997 | World Journal of Gastroenterology1997，3，4： | 5 |
| 5 | Magnetostratigraphy of a Loess-Paleosol Sequence from Higher Terrace of the Daduhe River in the Eastern Margin of the Tibetan Plateau and Its Geological Significance显示文摘The eolian deposits distributed in the river valleys in the eastern margin of the Tibetan Plateau(TP)are very useful in neotectonic and paleoclimatic studies.Firstly,the climate in the eastern margin of the TP is mainly controlled by the Indian summer monsoon,and detailed studies on the loess-paleosol sequences in this region can provide valuable terrestrial evidence of past changes in the Indian summer monsoon.Secondly,the river terraces in the eastern margin of the TP are considered to be a sensitive recorder of neotectonism to reflect the timing and amplitude of the TP uplift.The formation ages of | QIAO Yansong WANG Yan YAO Haitao QI Lin HE Ze Xin CHENG Yu PENG Shasha GE Junyi | 2015 | Acta Geologica Sinica(English Edition)2015，89，1： | 5 |
| 6 | A pure blue light emitting binaphthyl derivative:Synthesis and properties显示文摘有 3 和 3 个′位置上的分核的联萘衍生物被综合并且经由铃木描绘了偶合反应。在答案最大的排放被作为参考拿 9,10-diphenyl 蒽与 68% 的量子效率在 390 nm 定位,当它与从聚集状态导致固态膜的 104 nm 的 FWHM 被转移到 450 nm 时。玻璃化转变温度(Tg ) 和分解温度被测量分别地,由 DSC 和 TGA 是 184 和 447 ° C。不同于它的光致发光光谱,电镀物品发光光谱在大约 460 nm 和表演达到顶点相应于纯蓝排出物的 69 nm 的 FWHM。刺激电压,发光性和效率最大值是有并列的 CIE 颜色的 5 V, 2953 cd/m2 和 1.37 cd/A (0.16, 0.15 ) ,在 ITO/NPB (40 nm ) 的设备结构 /PY-BN-PY (15 nm )/BPhen (40 nm )/Mg :47 号元素银的化学符号。 | Qing Guo He Zeng Ze Chu Gang Tie Lei An Jun Qin Hong Zhen Lin Feng Lian Bai Jian Gong Cheng Yong Qiu | 2008 | Chinese Chemical Letters2008，19，4： | 4 |
| 7 | Back-n white neutron source at CSNS and its applications显示文摘Back-streaming neutrons from the spallation target of the China Spallation Neutron Source(CSNS)that emit through the incoming proton channel were exploited to build a white neutron beam facility(the so-called Back-n white neutron source),which was completed in March 2018.The Back-n neutron beam is very intense,at approximately 29107 n/cm2/s at 55 m from the target,and has a nominal proton beam with a power of 100 kW in the CSNS-I phase and a kinetic energy of 1.6 GeV and a thick tungsten target in multiple slices with modest moderation from the cooling water through the slices.In addition,the excellent energy spectrum spanning from 0.5 eV to 200 MeV,and a good time resolution related tothe time-of-flight measurements make it a typical white neutron source for nuclear data measurements;its overall performance is among that of the best white neutron sources in the world.Equipped with advanced spectrometers,detectors,and application utilities,the Back-n facility can serve wide applications,with a focus on neutron-induced cross-sectional measurements.This article presents an overview of the neutron beam characteristics,the experimental setups,and the ongoing applications at Backn. | Jing-Yu Tang Qi An Jiang-Bo Bai Jie Bao Yu Bao Ping Cao Hao-Lei Chen Qi-Ping Chen Yong-Hao Chen Zhen Chen Zeng-Qi Cui Rui-Rui Fan Chang-Qing Feng Ke-Qing Gao Xiao-Long Gao Min-Hao Gu Chang-Cai Han Zi-Jie Han Guo-Zhu He Yong-Cheng He Yang Hong Yi-Wei Hu Han-Xiong Huang Xi-Ru Huang Hao-Yu Jiang Wei Jiang Zhi-Jie Jiang Han-Tao Jing Ling Kang Bo Li Chao Li Jia-Wen Li Qiang Li Xiao Li Yang Li Jie Liu Rong Liu Shu-Bin Liu Xing-Yan Liu Ze Long Guang-Yuan Luan Chang-Jun Ning Meng-Chen Niu Bin-Bin Qi Jie Ren Zhi-Zhou Ren Xi-Chao Ruan Zhao-Hui Song Kang Sun Zhi-Jia Sun Zhi-Xin Tan Xin-Yi Tang Bin-Bin Tian Li-Jiao Wang Peng-Cheng Wang Zhao-Hui Wang Zhong-Wei Wen Xiao-Guang Wu Xuan Wu Li-Kun Xie Xiao-Yun Yang Yi-Wei Yang Han Yi Li Yu Tao Yu Yong-Ji Yu Guo-Hui Zhang Lin-Hao Zhang Qi-Wei Zhang Xian-Peng Zhang Yu-Liang Zhang Zhi-Yong Zhang Lu-Ping Zhou Zhi-Hao Zhou Ke-Jun Zhu 无 | 2021 | Nuclear Science and Techniques2021，32，1： | 4 |
| 8 | A new 8-connected self-penetrating metal-organic framework based on dinuclear cadmium clusters as secondary building units显示文摘A new metal-organic framework(MOF) based on metal clusters as secondary building units(SBU),has been synthesized and structurally characterized.The reported MOF presents an interesting 8-connected self-penetrating coordination network based on dinuclear cadmium cluster with a 424·5·63 topology. Moreover,the thermal stability and luminescence property of this compound have been investigated. | Kun-Huan He Yun-Wu Li Yong-Qiang Chen Ze Chang | 2013 | Chinese Chemical Letters2013，24，8： | 4 |
| 9 | Fluid Inclusion and Geochemistry Studies of Calcite Veins in Shizhu Synclinorium,Central China:Record of Origin of Fluids and Diagenetic Conditions显示文摘Calcite veins in carbonate fracture have been investigated by petrographic, fluid inclusion, geochemical analyses and coupled with basin modeling techniques to provide useful insights into fluid activity and deformation conditions of the Cambrian to Triassic Shizhu synclinorium from the western region of Mid-Yangtze, central China. The results of the fluid inclusion microthermometry show a wide range of homogenization temperatures(78.6–215.5 °C) and salinities(0.18–23.11 wt.% NaCl equivalent), indicating the formation under diverse fluid conditions. All the calcite veins have negative Ce anomalies, which are the typical characteristic of marine carbonate sediments; it is therefore plausible that calcite veins were precipitated from the marine basin fluid. The stable carbon isotopic compositions of calcites(δ^(13)CV-PDB=-2.5‰–4.26‰) and host limestones(δ^(13)CV-PDB=-3.56‰–5.80‰) are very similar with a correlation coefficient of 0.86, however, four calcites from the Lower Permian and Lower Triassic show lower δ^(13)C values relative to the host limestones, and they are depleted in total REE concentrations(∑REE ratio varies from 0.74 to 2.06), suggesting the derivation of dissolved carbon from marine carbonates hosting the calcite veins and, less commonly, from the degradation of organic matter. Calculated δ^(18)O of the fluids-precipitating calcites(δ^(18)OV-SMOW=-0.41‰–14.42‰), ^(87)Sr/^(86)Sr ratios varying in the range of coeval seawater and the distinct REE pattern simultaneously suggest calcite-forming fluids in each stratigraphic unit could have formed from the involvement of fluids that originated from coeval seawater and evolved through different degrees of water rock interaction. However, the presence of more radiogenic ^(87)Sr/^(86)Sr ratios than coeval seawater and pronounced positive Eu anomalies in calcites of Lower to Middle Ordovician rocks indicate that terrestrial input from upper strata mudstone and siliciclastic rocks could be involved in the precipitation of the Ordovician calcite. Fluid-inclusion data combined with burial and thermal history modeling indicate there was large-scale flow of evolved basinal fluids through the carbonate formation fractures spanning a time frame from 135 to 50 Ma(Early Cretaceous–Eocene). Therefore, the geochemical characteristics of calcite veins can provide the basis for deformation events in Late Yanshanian and Early Himalayan orogeny. | Xiao Wang Jian Gao Sheng He Zhiliang He Yan Zhou Ze Tao Jiankun Zhang Yi Wang | 2017 | Journal of Earth Science2017，28，2： | 4 |
| 10 | Elastic Scattering of 7Be on Pb Target显示文摘 | Yang Yanyun Wang Jiansong Wang Qi Huang Meirong Ma Junbing Ma Peng Cao Xiguang Han Jianlong Bai Zhen Jin Shilong Hu Qiang Jin Lei Chen Jiangbo Zhang Xueying Chen Ruofu Hu Zhengguo Xu Shiwei Zhen Chuan Xu Zhiguo Xu Hushan Duan Liming Sun Zhiyu Chen Zhiqiang He Jianjun Li Songlin Lei Xiangguo Fu Fen Zhang Xueheng Yuan Xiaohua Du Chengming Yan Xinshuang Hu Jun Tang Shuwen Ye Ruiping Yang Kun Shi Fudong Zhang Wei Chen Ze Li Long Xu Xing Liu Longxiang Zhang Liyong Lin Qingyun Gou Boxing Xu Ge Zhou Xionghong Zhang Yuhu Xiao Guoqing | 2011 | IMP & HIRFL Annual Report2011，，1： | 4 |
| 11 | First experimental constraints on WIMP couplings in the effective field theory framework from CDEX显示文摘We present weakly interacting massive particles(WIMPs) search results performed using two approaches of effective field theory from the China Dark Matter Experiment(CDEX), based on the data from both CDEX-1B and CDEX-10 stages. In the nonrelativistic effective field theory approach, both time-integrated and annual modulation analyses were used to set new limits for the coupling of WIMP-nucleon effective operators at 90% confidence level(C.L.) and improve over the current bounds in the low mχregion. In the chiral effective field theory approach, data from CDEX-10 were used to set an upper limit on WIMP-pion coupling at 90% C.L. We for the first time extended the limit to the m_(χ)<6 GeV/c^(2) region. | Yi Wang Zhi Zeng Qian Yue LiTao Yang KeJun Kang YuanJing Li Mehment Agartioglu HaiPeng An JianPing Chang JingHan Chen YunHua Chen JianPing Cheng Cheng Yi Chiang WenHan Dai Zhi Deng ChangHao Fang XinPing Geng Hui Gong QiuJu Guo XuYuan Guo HongJian He Li He ShengMing He JinWei Hu TuChen Huang HanXiong Huang HaiTao Jia LiPing Jia Xi Jiang HauBin Li JianMin Li Jin Li MingXuan Li RenMingJie Li Xia Li YuLan Li Bin Liao FongKay Lin ShinTed Lin ShuKui Liu YanDong Liu Yu Liu YuanYuan Liu ZhongZhi Liu Hao Ma YuCai Mao QiYuan Nie JinHua Ning Hui Pan NingChun Qi Jie Ren XiChao Ruan ChangSong Shang Vivek Sharma Ze She Lakhwinder Singh Monoj Kumar Singh TianXi Sun ChangJian Tang WeiYou Tang Yang Tian GuangFu Wang Li Wang Qing Wang Yu Chen Wang YunXiang Wang Zhen Wang Henry Tsz-King Wong ShiYong Wu YuCheng Wu HaoYang Xing Yin Xu Tao Xue YuLu Yan Nan Yi ChunXu Yu HaiJun Yu JianFeng Yue Ming Zeng BingTao Zhang Lei Zhang FengShou Zhang ZhenYu Zhang KangKang Zhao MingGang Zhao JiFang Zhou ZuYing Zhou JingJun Zhu | 2021 | Science China(Physics,Mechanics & Astronomy)2021，64，8： | 3 |
| 12 | Kaposiform Hemangioendothelioma: Case Report and Literature Review显示文摘Kaposiform hemangioendothelioma (KHE) is a rare locally ag- gressive vascular tumor that mainly occurs in children and early adolescents. It is often associated with the | Gang Zhou Shuhua Yang Xiu Nie Jingyuan Du Jin Li Jianxiang Liu Renhao Ze Yu He | 2007 | Chinese Journal of Clinical Oncology2007，4，4： | 3 |
| 13 | Atomic-scale mechanism of the θ’’→θ’ phase transformation in Al-Cu alloys显示文摘The phase transformation of θ’’→θ’ in an Al-5.7 Cu alloy was investigated by aberration-corrected scanning transmission electron microscopy, and the tranformation mode of θ’’→θ’ during aging treatment was clarified. In the presence of the θ’ phases, θ’ was found to be formed by in-situ transformation fromθ’’ with the same plate shape, size and broad faces. The transformation starts from multiple sites within the θ’ precipitate and the whole θ’ phase finally forms as the preferential θ’ sections grow and connect with each other. Antiphase domain boundaries are also found in some θ’ precipitates when the disregistry exists between different θ’ sections. | Zhenju Shen Qingqing Ding Chunhui Liu Jiangwei Wang He Tian Jixue Li Ze Zhang | 2017 | Journal of Materials Science & Technology2017，33，10： | 3 |
| 14 | Hydrochemical and isotope characteristics of spring water discharging from Qiushe Loess Section in Lingtai, northwestern China and their implication to groundwater recharge显示文摘The loess plateau in northwestern China with an area of 640 000km^2, which has developed the loess deposits with a thickness up to 200m in typical areas, is regarded as a huge carbon stock like the karst area in southwestern China, and plays an important role in regional(even global) carbon cycle. But the spring discharging from loess is poorly known compared with karst spring so far. The objective of this study is to ascertain the characteristics and origin of spring at Qiushe Village, Lingtai County, Gansu Province by hydro-chemical and isotopic methods. The results show that the springs including LGQ, HMQ, YYQ and CZQ are the depression spring and belong to the same shallow aquifer with the well water JZJ. There are not distinct seasonal/diurnal-scale variations on the hydro-chemical characteristics of the spring water(LGQ, HMQ, YYQ, CZQ) and groundwater(JZJ). The hydro-chemical type of groundwater is Ca·Mg-HCO_3. The D and O isotope ratios indicate that the precipitation is the main recharge source of groundwater in study area. And the results of tritium(TU) and Cl concentration suggest that the recharge cycle of groundwater may be more than 60 yrs. Our study shows that the water cycle in loess plateau including rainfall, infiltration, recharge and discharge exerts a continuous impact on carbon stock in loess, which should be paid more attention to in future research on the quantitative reconstruction of paleoclimate. | SONG Chao HAN Gui-lin WANG Pan SHI Ying-chun HE Ze | 2017 | Journal of Groundwater Science and Engineering2017，5，4： | 3 |
| 15 | Application research of enhanced in-situ micro-ecological remediation of petroleum contaminated soil显示文摘Experimental study of enhanced in-situ micro-ecological remediation of petroleum contaminated loess soil was carried out in Zhongyuan oil production areas, and the enhanced in-situ micro-ecological remediation technique includes optimistic in-situ microbial communities, physical chemistry methods, alfalfa planting and regulation of soil environmental elements. Experiments showed that the oil content in the contaminated soil with oil content about 2 898.25 mg/kg can be reduced about 98.61% after in-situ micro-ecological remediation for 99 days, which demonstrated the effectiveness of in-situ micro-ecological remediation methods for petroleum contaminated soil in central plains of China, and explored the practical and feasible application of these methods. | ZHANG Sheng ZHANG Cui-yun HE Ze CHEN Li ZHANG Fa-wang YIN Mi-ying NING Zhuo SUN Zhen-hua ZHEN Shi-jun | 2016 | Journal of Groundwater Science and Engineering2016，4，3： | 2 |
| 16 | Annexin A5 regulates Leydig cell testosterone production via ERK1/2 pathway显示文摘这研究是从主要老鼠 Leydig 房间和内在的机制在睾丸激素分泌物上调查 annexin A5 的效果。孤立的老鼠 Leydig 房间与 annexin A5 被对待。睾丸激素生产被化合光试金检测。Steroidogenic 的蛋白质和 mRNA 尖锐规章(星) , P450scc, 3 β -hydroxysteroid 脱氢酶(3 β -HSD), 17 β -hydroxysteroid 脱氢酶(17 β -HSD), 和 17 α -hydroxylase 被分别地的西方的弄污和半量的 RT-PCR 检验。Annexin A5 显著地在剂量依赖者和时间依赖者礼貌从老鼠 Leydig 房间刺激了睾丸激素分泌物并且增加了 mRNA 和星的蛋白质表示, P450scc, 3 β -HSD, 和 17 β -HSD 然而并非 17 α -hydroxylase。由 siRNA 击倒的 Annexin A5 显著地减少了睾丸激素和 P450scc 的蛋白质表示的水平, 3 β -HSD, 和 17 β -HSD。ERK1/2 发信号的重要激活在 annexin A5 处理以后在 5, 10,和 30 min 被观察。在有英皇家空军之阶级最低之兵禁止者 PD98059 的 Leydig 房间的预告的处理以后(50 μ为 20 min 的摩尔 l −1) ,支持睾丸激素分泌物并且增加 P450scc 的表示上的 annexin A5 的效果, 3 β -HSD, 和 17 β -HSD 完全被废除(P <0.05 ) 。因此,发信号的 ERK1/2 在调停涉及 annexin A5 的角色睾丸激素生产和 P450scc 的表示, 3 β -HSD, 和 17 β在 Leydig 房间的 -HSD。 | Ze He Qin Sun Yuan-Jiao Liang Li Chen Yi-Feng Ge Shi-Feng Yun Bing Yao | 2016 | Asian Journal of Andrology2016，18，3： | 2 |
| 17 | The preparation of terephthalic acid by solvent-free oxidation of p-xylene with air over T(p-C1)PPMnC1 and Co(OAc)_2显示文摘被尝试了在 tetra (p-chlorophenylporphinato ) 上与空气由 p 二甲苯(PX ) 的没有溶剂的氧化准备对苯二酸酸(TPA ) 锰氯化物(T (打印机控制语言) PPMnCl ) 和钴醋酸盐。在 T (打印机控制语言) PPMnCl 和公司(OAc ) 之间的合作催化作用 2 在没有溶剂的条件下面被发现了。当时, TPA 产量能显著地被增加 T (打印机控制语言) PPMnCl 和公司(OAc ) 2 一起被使用。进在 2 显著地加速了的公司(OAc ) 上的反应混合的 T (打印机控制语言) PPMnCl 的增加到 TPA 的 PX 的氧化过程的决定率的步。反应上的温度的效果也被调查。 | Yang Xiao XiaoYan Zhang Qin Bo Wang Ze Tan Can Cheng Guo Wei Deng Zhi Gang Liu He Fei Zhang | 2011 | Chinese Chemical Letters2011，22，2： | 2 |
| 18 | Screening Winter Wheat Germplasm for Fusarium Head Blight Resistance显示文摘58 winter wheat breeding lines and 4 widely popularized varieties in Huaihe River wheat production regions of Anhui were used to screen resistant germplasms to Fusarium head blight. Incidence, disease index, percentage of infected kernels and DON content in the kernels were measured for each variety or line following artificial inoculation of Fusarium spp. pathogens. Reactions of wheat to Fusarium infection varied among genotypes and different types of resistance. The incidence of infection for each variety or line highly correlated to the severity of colonization after infection. DON content was more correlated to the percentage of kernels infected than to the overall incidence or severity. The selected control varieties were all susceptible to FHB, while seven breeding lines demonstrated good resistant performance. New FHB resistant winter wheat varieties appealing to the actual needs are expected from them. | Ze LIU Li ZHAO Xianfang HE Jianlai WANG | 2015 | Agricultural Science & Technology2015，16，9： | 2 |
| 19 | Extracellular Polysaccharide from Rhizopus nigricans Inhibits Hepatocellular Carcinoma via miR-494-3p/TRIM36 Axis and Cyclin E Ubiquitination显示文摘Background and Aims:This study was designed to uncov-er the mechanism for extracellular polysaccharide(EPS1-1)-mediated effects on hepatocellular carcinoma(HCC)devel-opment.Methods:HCC cells were treated with EPS1-1,miR-494-3p mimic,sh-TRIM36,and pcDNA3.1-TRIM36.The levels of miR-494-3p and TRIM36 were measured in nor-mal hepatocytes,THLE-2,and HepG2 and HuH7HCC cell lines,along with the protein expression of cyclin D/E and p21.The proliferation,cell cycle,and apoptosis of HCC cells were assayed.The interactions between miR-494-3p and TRIM36,and between TRIM36 and cyclin E were assessed.Finally,the expression and localization of TRIM36 and cyclin E were monitored,and tumor apoptosis was detected,in tumor xenograft model.Results:EPS1-1 suppressed HCC cell proliferation and cyclin D/E expression and promoted apoptosis and p21 expression.miR-494-3p was upregulated and TRIM36 was downregulated in HCC cells.Transfection with miR-494-3p mimic or sh-TRIM36 facilitated HCC cell proliferation and the expression of cyclin D/E protein but they inhibited apoptosis and p21 expression in the pres-ence of EPS1-1.Overexpression of TRIM36 further con-solidated EPS1-1-mediated inhibition of HCC proliferation,cyclin D/E,and the promotion of apoptosis and p21 expres-sion.Those effects were reversed by miR-494-3p overex-pression.TRIM36 was a target gene of miR-494-3p,and TRIM36 induced cyclin E ubiquitination.EPS1-1 suppressed cyclin E expression,promoted TRIM36 expression and tu-mor apoptosis,all of which were abrogated by increasing the expression of miR-494-3p in vivo.Conclusions:EPS1-1 protected against HCC by limiting its proliferation and sur-vival through the miR-494-3p/TRIM36 axis and by inducing cyclin E ubiquitination. | Haixiong Yan XiaoQian Ma Ze Mi Zhenhu He Pengfei Rong | 2022 | Journal of Clinical and Translational Hepatology2022，10，4： | 2 |
| 20 | Impact of Fungicide Treatments on the Constitution of Unsound Wheat Kernels显示文摘Nine fungicides were applied,either through seed-dressing or post-anthesis foliar-spray,to eight winter wheat varieties to understand their influences on the constitution of unsound kernels during the 2017-2018 growth season in Funan Experimental Station,Anhui,P.R.China.Three unsound kernel items,i.e.Fusarium-damaged kernels( FDKs),black-germ kernels( BGKs) and pre-harvest sprouted kernels( PHSKs),were measured from the harvested grains.A high percentage of unsound kernels was noticed as 6.00% for FDKs,8.43% for BGKs,and 38.19% for PHSKs due to excessive precipitation during the filling and maturation stages within the season.Fungicide treatments showed positive impacts on the formation of FDKs and BGKs.No significant differences were noticed on the percentage of PHSKs among treatments.The best control efficiency on FDKs,24.63%,was observed in the treatment of‘tebuconazole + prochloraz-manganese chloride complex'.The highest control efficiency on BGKs,31.54%,was achieved by the treatment of‘phenazino-1-carboxylic acid'.Significant differences were noticed among varieties with respect to the constitution of unsound kernels.Under the specific ecological conditions,70%-75% of the final grain quality of wheat was determined by the genotype itself.It was concluded that the genetic resistance or tolerance to relevant fungal pathogens and pre-harvest sprouting was the key factor determining the constitution of unsound wheat kernels,whilst chemical control might function with limited effects when crop was grown under high-pressure or stress conditions. | Ze LIU Yiliang QIAN Li ZHAO Xianfang HE Jianlai WANG | 2018 | Agricultural Biotechnology2018，7，6： | 2 |
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