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| 1 | Tumor necrosis factor-α-G308A polymorphism is associated with liver pathological changes in hepatitis C virus patients显示文摘AIM To investigate the association of tumor necrosis factor alpha(TNFα)-G308 A polymorphism with different liver pathological changes in treatment-na?ve Egyptian patients infected with hepatitis C virus(HCV) genotype 4.METHODS This study included 180 subjects,composed of 120 treatment-na?ve chronic HCV patients with different fibrosis grades(F0-F4) and 60 healthy controls. The TNFα-G308 A region was amplified by PCR and the different genotypes were detected by restriction fragment length polymorphism analysis. The TNFα protein was detected by enzyme-linked immunosorbent assay. The influence of different TNFα-G308 A genotypes on TNFα expression and liver disease progression were statistically analyzed. The OR and 95%CI were calculated to assess the relative risk confidence.RESULTS Current data showed that the TNFα-G308 A SNP frequency was significantly different between controls and HCV infected patients(P = 0.001). Both the AA genotype and A allele were significantly higher in late fibrosis patients(F2-F4,n = 60) than in early fibrosis patients(F0-F1,n = 60)(P = 0.05,0.04 respectively). Moreover,the GA or AA genotypes increased the TNFα serum level greater than the GG genotype(P = 0.002). The results showed a clear association between severe liver pathological conditions(inflammation,steatosis and fibrosis) and(GA + AA) genotypes(P = 0.035,0.03,0.04 respectively). The stepwise logistic regression analysis showed that the TNFα genotypes(GA + AA) were significantly associated with liver inflammation(OR = 3.776,95%CI: 1.399-10.194,P = 0.009),severe steatosis(OR = 4.49,95%CI: 1.441-14.0,P = 0.010) and fibrosis progression(OR = 2.84,95%CI: 1.080-7.472,P = 0.034). Also,the A allele was an independent risk factor for liver inflammation(P = 0.003),steatosis(P = 0.003) and fibrosis(P = 0.014). CONCLUSION TNFα SNP at nucleotide-308 represents an important genetic marker that can be used for the prognosis of different liver pathological changes in HCV infected | Noha G Bader El Din Sally Farouk Reem El-Shenawy Marwa K Ibrahim Reham M Dawood Mostafa M Elhady Ahmed M Salem Naglaa Zayed Ahmed Khairy Mostafa K El Awady | 2016 | World Journal of Gastroenterology2016，22，34： | 3 |
| 2 | Attention-deficit hyperactivity disorder and the adrenergic receptors alpha 1C and alpha 2C显示文摘 | Barr CL Wigg K Zai G | 2001 | Mol Psychiatry2001，6，3： | 1 |
| 3 | Tumor necrosis factor-alpha gene is not associated with obsessive-compulsive disorder 显示文摘 | Zai G Arnold PD Burroughs E | 2006 | Psychiatr Genet2006，16，1： | 1 |
| 4 | No association between brain-derived neurotrophic factor gene and obsessivecompulsive disorder显示文摘 | ZAI G ARNOLD P STRAUSS J | 2005 | Psychiatr Genet2005，15，4： | 1 |
| 5 | 源自天然席夫碱的过渡金属配合物在分光光度法测天然水中的Fe(Ⅲ)的应用(英文)显示文摘描述了一种新颖、简便的合成含五齿配位基的大环席夫碱配体的方法,制备和表征了该席夫碱的1∶1包合物。用化学和光谱学方法测定了标题配合物的组成,认为在所有配合物中配位金属原子取八面体结构。数据表明:配体起O2N4六齿结构而每个环绕金属原子在八面体环境中。配合物的红外和1H NMR光谱符合中心金属原子的配位结果。用分光光度法测定了配合物的稳定常数。用共轭余量法(CR method)计算了在热分解的不同阶段配合物活化的动力学和热力学参数。此外,用抑菌圈直径法筛选了配体及其金属配合物抑制细菌和真菌的能力。用回收率试验研究了天然螯合配体在不同天然水体中对Fe(Ⅲ)离子配合作用的影响。 | Khalil M M H Mohamed G G Ismail E H Zayed M E Kamel B A | 2012 | 无机化学学报2012，28，7： | 1 |
| 6 | Consolidation analysis of a cross-anisotropic homogeneous elastic soil using a finite layer numerical method显示文摘 | Mei G X Yin J H Zai J M | 2004 | International Journal for Numerical and Analytical Methods in Geomechanics2004，28，2： | 1 |
| 7 | Effects of arbuscular mycorrhizal fungi on the rooting and growth of beach plum (Prunus maritima) cuttings 显示文摘 | Zai X M Qin P Wan S W Zhao F G Wang G Yan D L | 2007 | J Hort Sci Biotech2007，82，6： | 1 |
| 8 | Genetic study of the brain-derived neurotrophie factor (BDNF) gene in obsessive-compulsive disorder (OCD) 显示文摘 | ZAI G | 2009 | Biological Psychiatry2009，65，8： | 1 |
| 9 | Investigation of a heat transfer augmenter as a fouling cleaner and its optimum geometry in tube-side of a condenser 显示文摘 | Yang S R Wang J M Zai G D | 1992 | Experimental Thermal and Fluid Science1992，5，6： | 1 |
| 10 | Bio-active composts from rice straw enriched with rock phosphate and their effect on the phos-phorous nutrition and microbial community in rhizosphere of cow-pea 显示文摘 | ZAYED G ABDEL-MOTAAL H | 2005 | Bioresource Technology2005，96，8： | 1 |
| 11 | Influence of trehalose and moisture content on survival of Lactobacillus salivarius subjected to freeze-drying and storage显示文摘 | Zayed G Roos Y H | 2004 | Process Biochemistry2004，39，： | 1 |
| 12 | Environmental factors in the etiology of Parkinson's disease显示文摘 | Zayed J Ducic S Campanella G | 1990 | Can J Neurol Sci1990，17，： | 1 |
| 13 | Intravascular ultra- sound as a clinical adjunct for carotid plaque characterization 显示文摘 | Hitchner E Zayed MA Lee G | 2014 | J Vasc Surg2014，59，3： | 1 |
| 14 | Corrosion wastage model for ship crude oil tanks 显示文摘 | Soares C G Garbatov Y Zayed A | 2008 | Corrosion Science2008，50，11： | 1 |
| 15 | Experimental Investigation on A Cleaner Argenator in Tube Side of Surface Condenser显示文摘 | Yang S R Zai G D | 1988 | Second U K National Heat Transfer Conference1988，，： | 1 |
| 16 | 查看详情显示文摘 | Zayed G Winter J | | 0，，： | 1 |
| 17 | Influence of Trehalose and Moisture Content on Survival of Lactobacillus Salivatius Subjected to Freeze-drying and Storage显示文摘 | ZAYED G ROOS Y H | 2004 | Process Biochemistry2004，39，9： | 1 |
| 18 | Influence of en- vironmental factors on corrosion of ship structures in marine at- mosphere显示文摘 | SOARES C G GARBATOV Y ZAYED A | 2009 | Corrosion Science2009，51，9： | 1 |
| 19 | Removal of organic pollutants and nitrate from wastewater from the dairy industry by denitrification 显示文摘 | ZAYED G WINTER J | 1998 | Applied Microbiology and Biotechno!ogy1998，49，4： | 1 |
| 20 | Lactic acid production from salt whey using free and agar immobilized cells显示文摘 | Zayed G Zshran A S | 1991 | Lett Appl Microbiol1991，12，： | 1 |
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