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| 1 | Clinically detected gastroenteropancreatic neuroendocrine tumors are on the rise: Epidemiological changes in Germany显示文摘AIM:To study the epidemiologic changes of gastroenteropancreatic neuroendocrine tumors(GEP-NET)in Germany,we analyzed two time periods 1976-1988 and1998-2006.METHODS:We evaluated epidemiological data of GEP-NET from the former East German National Cancer Registry(DDR Krebsregister,1976-1988)and its successor,the Joint Cancer Registry(GKR,1998-2006),which was founded after German reunification.Due to a particularly substantial database the epidemiological data from the federal states of Mecklenburg-Western Pomerania,Saxony,Brandenburg and Thuringia,covering a population of more than 10.8 million people,were analyzed.Survival probabilities were calculated using life table analysis.In addition,GEP-NET patients were evaluated for one or more second(non-GEP-NET)primary malignancies.RESULTS:A total of 2821 GEP neuroendocrine neoplasms were identified in the two registries.The overall incidence increased significantly between 1976 and2006 from 0.31(per 100.000 inhabitants per year)to2.27 for men and from 0.57 to 2.38 for women.In the later period studied(2004-2006),the small intestine was the most common site.Neuroendocrine(NE)neoplasms of the small intestine showed the largest absolute increase in incidence,while rectal NE neoplasms exhibited the greatest relative increase.Only the incidence of appendiceal NET in women showed little change between 1976 and 2006.Overall survival of patients varied for sex,tumor site and the two periods studied but improved significantly over time.Interestingly,about 20%of the GEP-NET patients developed one or more second malignancies.Their most common location was the gastrointestinal tract.GEP-NET patients without second malignancies fared better than those with one or more of them.CONCLUSION:The number of detected GEP-NET increased about 5-fold in Germany between 1976 and2006.At the same time,their anatomic distribution changed,and the survival of GEP-NET patients improved significantly.Second malignancies are common and influence the overall survival of GEP-NET patients.Thus,GEP-NET warrant our attention as well as intensive research on their tumorigenesis. | Hans Scherübl Brigitte Streller Roland Stabenow Hermann Herbst Michael Hopfner Christoph Schwertner Joachim Steinberg Jan Eick Wanda Ring Krishna Tiwari Soren M Zappe | 2013 | World Journal of Gastroenterology2013，19，47： | 16 |
| 2 | Synthesis- driven structure revision of' plagiochin E', a highly bioacfive bisbibenzyl显示文摘 | SPEICHER A GROH M ZAPP J | 2009 | Synlett2009，，11： | 1 |
| 3 | In vivo confocal microscopy of normal conjunctiva and conjunctivitls显示文摘 | Messmer E M Mackert M J Zapp DM | 2006 | Cornea2006，25，： | 1 |
| 4 | Variable optofluidic slit aperture显示文摘The shape of liquid interfaces can be precisely controlled using electrowetting,an actuation mechanism which has been widely used for tunable optofluidic micro-optical components such as lenses or irises.We have expanded the considerable flexibility inherent in electrowetting actuation to realize a variable optofluidic slit,a tunable and reconfigurable two-dimensional aperture with no mechanically moving parts.This optofluidic slit is formed by precisely controlled movement of the liquid interfaces of two highly opaque ink droplets.The 1.5mmlong slit aperture,with controllably variable discrete widths down to 45 mm,may be scanned across a length of 1.5mmwith switching times between adjacent slit positions of less than 120 ms.In addition,for a fixed slit aperture position,the width may be tuned to a minimum of 3 mmwith high uniformity and linearity over the entire slit length.This compact,purely fluidic device offers an electrically controlled aperture tuning range not achievable with extant mechanical alternatives of a similar size. | Stefan Schuhladen Kaustubh Banerjee Moritz Stürmer Philipp Müller Ulrike Wallrabe Hans Zappe | 2016 | Light(Science & Applications)2016，5，1： | 1 |
| 5 | Tibial tunnel enlargement following anterior cruciate ligament reconstruc- tion with patellar tendon autograft显示文摘 | FINK C ZAPP M BENEDETTO K P | 2001 | Arthroscopy2001，17，2： | 1 |
| 6 | Activation of transcription by HIV-1 Tat protein tethered to nascent RNA through another protein显示文摘 | Southgate C Zapp M L Green M R | 1990 | Nature1990，，6276： | 1 |
| 7 | A thermally tunable,silicon-based optical filter显示文摘 | Hohlfeld D Epmeier M Zappe H | 2003 | Sensors and Actuators A2003，103，： | 1 |
| 8 | Automated MEMS-based Drosophila embryo injection system for high-throughput RNAi screens显示文摘 | Zappe S Fish M Scott MP | 2006 | Lab Chip2006，6，8： | 1 |
| 9 | PEGylation of cyanovirin-N, an entry inhibitor of HIV显示文摘 | Zappe H Snell M E Bossard M J | 2008 | Adv Drug Deliv Rev2008，60，1： | 1 |
| 10 | Tibial tunnel enlargement following anterior cruciate ligament reconstruction with patellar tendon autograft显示文摘 | Fink C Zapp M Benedetto KP | | 0，，： | 1 |
| 11 | Tibial tunnel en- largement following anterior cruciate ligament recon- struction with patella~ tendon autograft 显示文摘 | Fink C Zapp M Benedetto KP | 2001 | Arthrosco- py2001，17，2： | 1 |
| 12 | In vivo confocal microscopy of pigmented conjunctival tumors显示文摘 | Messmer EM Mackert MJ Zapp D M | 2006 | Graefes Arch Clin Exp Ophthalmol2006，244，11： | 1 |
| 13 | Safety andtolerability 0f high-dose angiotensin receptor blocker therapy in patients with chronic kidney disease显示文摘 | Weinberg AJ Zappe DH Ashton M et a1 | 2004 | Am J Nephrol2004，24，3： | 1 |
| 14 | Tibial tunnel enlargementfollowing anterior cruciate ligament reconstruction with patellar ten-don autograft显示文摘 | Fink C Zapp M Benedetto K P | 2001 | Arthroscopy2001，17，2： | 1 |
| 15 | Safety and tolerability of high-dose angiotensin receptor blocker therapy in patients with chronic kidney disease: a pilot study显示文摘 | Weinberg AJ Zappe DH Ashton M | 2004 | Am J Nephrol2004，24，3： | 1 |
| 16 | Tibial ttmnel enlarge- mere following anterior cruciate ligment reconstruction with patellar tendonautograft 显示文摘 | Fink C Zapp M Benedetto K P | 2001 | Arthroscopy2001，17，2： | 1 |
| 17 | An Examination of the Relationship between Ethical Work Climate and Moral Awareness 显示文摘 | VanSandt C V Shepard J M Zappe S M | 2006 | Journal of Business Ethics2006，68，4： | 1 |
| 18 | A thermally tunable silicon-based optical filter显示文摘 | HOHLFELD D EPMEIER M ZAPPE H | 2003 | Sensors and Actuators2003，103，： | 1 |
| 19 | In vivo confocal microscopy of normal conjunctiva and conjunctivitis 显示文摘 | Messmer EM Mackert MJ Zapp D M | 2006 | Cornea2006，25，7： | 1 |
| 20 | Tibial tunnel enlargement fol- lowing anterior cruciate ligament reconstruction with patellar ten- don autograft显示文摘 | Fink C Zapp M Benedetto KP | 2001 | Arthroscopy2001，17，2： | 1 |
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