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| 1 | Changes in energy metabolism in the quadriceps femoris after a single bout of acute exhaustive swimming in rats: a 31p-magnetic resonance spectroscopy study显示文摘 | Sun Yingwei Pan Shinong Chen Zhian Zhao Heng Ma Ying Zheng Liqiang Li Qi Deng Chunbo Fu Xihu Lu Zaiming Guo Qiyong | 2014 | Chinese Medical Journal2014，，5： | 5 |
| 2 | PAQR4 promotes the development of hepatocellular carcinoma by activating PI3K/AKT pathway显示文摘Progestin and adipoQ receptor 4(PAQR4)is a novel tumorigenic factor that promotes cell proliferation and metastasis in lung and breast cancer,but its role in hepatocellular carcinoma(HCC)is unknown.The aim of our study was to explore its role and underlying mechanism in the development of HCC.Analysis of GEPIA database indicated that PAQR4 was highly expressed in HCC samples,and the mRNA level of PAQR4 was negatively correlated with the overall survival of HCC patients.Knockdown of PAQR4 in Hep3B cells suppressed cell proliferation by hindering G1/S transition of cell cycle as shown by the flow cytometry analysis.PAQR4 knockdown also expedited the cell apoptosis.Knockdown of PAQR4 repressed the migratory and invasive potential of Hep3B cells.PAQR4 knockdown sensitized Hep3B cells to apatinib-based chemotherapy.PAQR4 knockdown blocked the activation of PI3K/AKT pathway,as reflected by the reduced phosphorylation of AKT and p85.Conversely,overexpression of PAQR4 exerted opposite effects in Huh-7 cells.PI3K inhibitor LY294002 could eliminate the effects of PAQR4 on cell proliferation,apoptosis,chemoresistance,and invasion.In tumor xenograft model,knockdown of PAQR4 suppressed tumor growth in vivo,while PAQR4 overexpression promoted tumor growth.Collectively,our data suggest that PAQR4 has a tumorigenic effect on HCC progression by activating PI3K/AKT pathway. | Gang Zhao Xiaobao Shi Zhanbo Sun Pengfei Zhao Zaiming Lu | 2021 | Acta Biochimica et Biophysica Sinica2021，53，12： | 2 |
| 3 | Nesprin-2 Giant (NUANCE) maintains nuclear envelope architecture and composition in skin 显示文摘 | Lu ke Y Zaim H Karakesisoglou I | 2008 | Journal of Cell Science2008，121，11： | 1 |
| 4 | Clinical Value of Interventional Embolization for Sacral Chordoma before Surgical Treatment显示文摘Objetive:To evaluate the efficacy of preoperative transcatheter arterial embolization in the treatment of sacral chordoma,and to explore the choice of embolization timing.Methods:32 patients underwent the posterior approach after TAE of the main arteries that supplied the sacral chordoma.Intraoperative bleeding amount of each patient was recorded and compared between-group differences at different operation times.Results:After embolization,12 patients were received resection within 24 hours(group A),that of 10 cases between 24~48h(group B),of another 10 cases between 48~72h(group C).All of the 32 tumors were removed intact with intraoperative bleeding about(894±199)ml,without any shock or death,nor injuries on abdominal organs such as rectum and ureter.There was no statistical significance in tumor size among group A,B and C(P>0.05).Data gave statistical significance in intraoperative blood loss between group A and B(P<0.01),there was no statistical differences between group B and C(P>0.05),in spite of group B slightly less than group C.Conclusion:Preoperative TAE for excising the sacral tumor can significantly decrease intraoperative blood loss,make the surgical field clear,and facilitate the maximal removal of the sacral chordoma.It would be best to select the embolization timing within 24 hours before surgical operation. | Zhihui CHANG Zhaoyu LIU Jiahe Zheng Zaiming LU Qiyong GUO | 2011 | 放射学实践2011，26，6： | 0 |
| 5 | Study design of deep learning based automatic detection of cerebrovascular diseases on medical imaging: a position paper from Chinese Association of Radiologists显示文摘In recent years,with the development of artificial intelligence,especially deep learning technology,researches on automatic detection of cerebrovascular diseases on medical images have made tremendous progress and these models are gradually entering into clinical practice.However,because of the complexity and flexibility of the deep learning algorithms,these researches have great variability on model building,validation process,performance description and results interpretation.The lack of a reliable,consistent,standardized design protocol has,to a certain extent,affected the progress of clinical translation and technology development of computer aided detection systems.After reviewing a large number of literatures and extensive discussion with domestic experts,this position paper put forward recommendations of standardized design on the key steps of deep learning-based automatic image detection models for cerebrovascular diseases.With further research and application expansion,this position paper would continue to be updated and gradually extended to evaluate the generalizability and clinical application efficacy of such tools. | Longjiang Zhang Zhao Shi Min Chen Yingmin Chen Jingliang Cheng Li Fan Nan Hong Wenxiao Jia Guihua Jiang Shenghong Ju Xiaogang Li Xiuli Li Changhong Liang Weihua Liao Shiyuan Liu Zaiming Lu Lin Ma Ke Ren Pengfei Rong Bin Song Gang Sun Rongpin Wang Zhibo Wen Haibo Xu Kai Xu Fuhua Yan Yizhou Yu Yunfei Zha Fandong Zhang Minwen Zheng Zhen Zhou Wenzhen Zhu Guangming Lu Zhengyu Jin on behalf of Chinese Association of Radiologists | 2022 | Intelligent Medicine2022，2，4： | 0 |
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