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| 1 | Narrative overview of animal and human brucellosis in Morocco: intensification of livestock production as a driver for emergence?显示文摘Brucellosis is one of the most widespread zoonoses in the world caused by several species of the genus Brucella.The disease,eradicated in many developed countries,is a re-emerging neglected zoonosis endemic in several zones especially in the Mediterranean region,impacting on human health and livestock production.A One Health approach could address brucellosis control in Morocco but scarcity of reliable epidemiological data,as well as underreporting,hinders the implementation of sustainable control strategies.Surveillance and control policies implemented by the Moroccan government in domestic animals(cattle and small ruminants)in the last few decades are assessed for disease impact.This study considers the origins of animal brucellosis in Morocco and the potential for emergence of brucellosis during a shift from extensive to intensive livestock production. | Marie J.Ducrotoy Khaoula Ammary Hicham Ait Lbacha Zaid Zouagui Virginie Mick Laura Prevost Ward Bryssinckx Susan CWelburn Abdelali Benkirane | 2015 | Infectious Diseases of Poverty2015，4，1： | 9 |
| 2 | Efficacy and safety of anti-hepatic fibrosis drugs显示文摘Recent progress in our understanding of the pathways linked to progression from hepatic insult to cirrhosis has led to numerous novel therapies being investigated as potential cures and inhibitors of hepatic fibrogenesis. Liver cirrhosis is the final result of prolonged fibrosis, which is an intimate balance between fibrogenesis and fibrinolysis. A number of these complex mechanisms are shared across the various etiologies of liver disease. Thankfully, investigation has yielded some promising results in regard to reversal of fibrosis, particularly the indirect benefits associated with antiviral therapy for the treatment of hepatitis B and C and the farnesoid receptor agonist for the treatment of primary biliary cholangitis and metabolic associated fatty liver disease. A majority of current clinical research is focused on targeting metabolic associated fatty liver disease and its progression to metabolic steatohepatitis and ultimately cirrhosis, with some hope of potential standardized therapeutics in the near future. With our ever-evolving understanding of the underlying pathophysiology, these therapeutics focus on either controlling the primary disease(the initial trigger of fibrogenesis), interrupting receptor ligand interactions and other intracellular communications, inhibiting fibrogenesis, or even promoting resolution of fibrosis. It is imperative to thoroughly test these potential therapies with the rigorous standards of clinical therapeutic trials in order to ensure the highest standards of patient safety. In this article we will briefly review the key pathophysiological pathways that lead to liver fibrosis and present current clinical and experimental evidence that has shown reversibility of liver fibrosis and cirrhosis, while commenting on therapeutic safety. | Konstantinos Damiris Zaid H Tafesh Nikolaos Pyrsopoulos | 2020 | World Journal of Gastroenterology2020，26，41： | 8 |
| 3 | Hepatectomy by Preliminary Ligation of the Inflow and Outflow Vessels to the Diseased Side without Dissection of the Hepatic Hilus显示文摘In 1952,Lortat-Jacob and Robert first described the from the liver cross-sectional surface in transectiong the parenchyma by preliminary dissection of the bepatic hilus,ligating and dividing of the corresponding vessels and ducts,which was known as anatomical hepatectomy or | CHEN Xiaoping, WU Zaide, QIU Fazu, Hepatic Surgery Center, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China | 2002 | The Chinese-German Journal of Clinical Oncology2002，1，1： | 5 |
| 4 | Effects of pH and chloride concentration on pitting corrosion of AA6061 aluminum alloy显示文摘 | B. Zaid D. Saidi A. Benzaid S. Hadji | 2008 | Corrosion Science2008，，7： | 3 |
| 5 | Geological mapping and mining prospecting in the Aouli inlier(Eastern Meseta,Morocco)based on remote sensing and geographic information systems(GIS)显示文摘Landsat 8 Oli,ASTER,and Sentinel 2A satellite images processing was used to map geological formations,lineaments and hydrothermal alteration minerals in the Aouli inlier,as a case study to illustrate the application of digital images processing and Geographic Information System(GIS)in geological mapping and mining prospecting.Principal Component Analysis(PCA)applied to the Landsat images allowed good lithological discrimination and contributed to the updating of available geological maps.The Automatic lineament extraction from Sentinel images revealed the main tectonic structures affecting Aouli inlier.The ratio bands(b5+b7)/b6 and the false color composite(b4/b6,b2/b1,b3/b2)allowed the hydrothermal alteration minerals mapping from Aster images.Combined with available geological data and field observations,the satellite derived data were integrated and analyzed in a GIS software to establish mining prospecting guides.The results showed that the anomaly zones are intimately linked to NNE-SSW and NW-SE oriented faults and to highly fractured areas developing argillic and Fe rich alterations.Verified via field survey,this approach was successfully applied to the Aouli inlier to rapidly target potential areas to be explored in the tactical phase.This provides a model for future prospecting efforts for similar mineral deposits in other areas. | Lakhlifa Benaissi Amraoui Tarek Adnane Tobi Hassan Ibouh Khadra Zaid Khalid Elamari Mohamed Hibti | 2022 | China Geology2022，5，4： | 3 |
| 6 | The efficacy of tucatinib-based therapeutic approaches for HER2-positive breast cancer显示文摘Overexpression of human epidermal growth factor receptor 2 (HER2) occurs in approximately 15–20% of breast cancer cases. HER2 is a member of the epidermal growth factor receptor (EGFR) family with tyrosinase kinase activity, and its overexpression is linked to poor prognosis and shorter progression-free survival (PFS) and overall survival (OS). Among various treatment options, HER2-targeting monoclonal antibodies and tyrosine kinase inhibitors (TKIs) have mostly been applied in recent decades to treat HER2-positive (HER2^(+)) breast cancer patients. Although positive clinical outcomes were documented in both advanced disease and neoadjuvant settings, the development of resistance mechanisms to such approaches has been one of the major challenges with the continuous usage of these drugs. In addition, patients who experience disease progression after treatment with multiple HER2-targeted therapies often have limited treatment options. The Food and Drug Administration (FDA) has recently approved a new TKI (i.e., tucatinib) for use in combination with immunotherapy and/or chemotherapeutic agents for the treatment of advanced-stage/metastatic HER2^(+) breast cancer. This review highlights recent updates on the efficacy of tucatinib-based therapeutic approaches in experimental models as well as in the clinical settings of HER2^(+) breast cancer. | Zaid Sirhan Anita Thyagarajan Ravi P.Sahu | 2022 | Military Medical Research2022，9，5： | 2 |
| 7 | 广州市大、中学生对甲型H1N1流感认知状况调查研究显示文摘目的了解广州市大、中学生对新型甲型H1N1流感知识的知晓情况以及预防甲型H1N1流感的良好习惯形成情况。方法采用分层整群随机抽样方法,抽取广州市4所学校共1000名学生,采用自行设计的问卷对其进行H1N1流感知识调查。结果广州市大、中学生对H1N1流感总体知识回答的正确率为55.76%,19~22岁组的学生为57.83%,其次23~28岁组为54.55%,15~18岁组为52.53%(F=13.304,P<0.001),三组间进一步两两比较,仅15~18岁组与19~22岁组间的差异有统计学意义(P<0.001);女生(56.62%)高于男生(54.29%)(t=-2.140,P=0.033);大学生(57.76%)高于高中生(51.88%)(t=-5.222,P<0.001)。对甲型H1N1流感基本知识回答的正确率为58.36%,三个年龄组间差异有统计学意义(F=6.761,P=0.001),三组间进一步两两比较,仅15~18岁组与19~22岁组间的差异有统计学意义(P=0.003);大学生高于高中生(t=-3.322,P=0.001)。对甲型H1N1流感预防与治疗知识回答的正确率为52.29%,三个年龄组间有统计学差异(F=13.538,P<0.001),三组间进一步两两比较,15~18岁组与19~22岁组和23~28岁组差异有统计学意义,后两组间差异无统计学意义;大学生高于高中生(t=-5.981,P<0.001);境外学生高于境内学生(t=-3.404,P=0.001)。结论广州市大、中学生对甲型H1N1流感基本知识以及预防与治疗知识的了解还不足,预防甲型H1N1流感的良好习惯形成率不高,学校应该加强对甲型H1N1流感知识的宣传教育。 | 陈婷婷 王声湧 荆春霞 赵国香 郑然 冯大成 刘皓生 温婉惠 Zaid Alshawaf 庄小梅 温淑勋 薛仲钧 | 2010 | 中华疾病控制杂志2010，14，11： | 2 |
| 8 | COVID-19-associated diarrhea显示文摘Severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)recently emerged as a highly virulent respiratory pathogen that is known as the causative agent of coronavirus disease 2019(COVID-19).Diarrhea is a common early symptom in a significant proportion of patients with SARS-CoV-2 infection.SARS-CoV-2 can infect and replicate in esophageal cells and enterocytes,leading to direct damage to the intestinal epithelium.The infection decreases the level of angiotensinconverting enzyme 2 receptors,thereby altering the composition of the gut microbiota.SARS-CoV-2 elicits a cytokine storm,which contributes to gastrointestinal inflammation.The direct cytopathic effects of SARS-CoV-2,gut dysbiosis,and aberrant immune response result in increased intestinal permeability,which may exacerbate existing symptoms and worsen the prognosis.By exploring the elements of pathogenesis,several therapeutic options have emerged for the treatment of COVID-19 patients,such as biologics and biotherapeutic agents.However,the presence of SARS-CoV-2 in the feces may facilitate the spread of COVID-19 through fecal-oral transmission and contaminate the environment.Thus gastrointestinal SARS-CoV-2 infection has important epidemiological significance.The development of new therapeutic and preventive options is necessary to treat and restrict the spread of this severe and widespread infection more effectively.Therefore,we summarize the key elements involved in the pathogenesis and the epidemiology of COVID-19-associated diarrhea. | Klara Megyeri Áron Dernovics Zaid I I Al-Luhaibi András Rosztóczy | 2021 | World Journal of Gastroenterology2021，27，23： | 2 |
| 9 | Topical aqueous extract of Ephedra alata can improve wound healing in an animal model显示文摘PurposeEphedra alata (E。alata ) 是在巴勒斯坦和其它区域成长的长期的坚韧的灌木植物。它为各种各样的疾病的治疗在人们药经常被使用。在这个工程, E。alata 摘录为它改进创伤和灼伤 healing.MethodsAn 的能力被测试 E 的水的摘录。alata 为 phytochemical 混合物的主要的班的存在被准备并且经历几 phytochemical 分析。在那以后,聚乙烯包含 E 的摘录的基于乙二醇的软膏。alata 被准备,它的创伤和灼伤愈合活动是用为深创伤和完整的厚度皮灼伤的一个动物模型的测试 in-vivo。效果对安慰剂软膏被比较。皮肤活体检视被使失明的临床的组织病理学说评估,除了分析表明了的数字 analysis.ResultsPhytochemical phytochemical 的主要的班的存在包括 flavonoids,碱, phytosteroids,酉分的混合物,不稳定的油和丹宁在准备摘录加重。作为与安慰剂软膏相比, E。alata 软膏显著地改进了创伤溃疡愈合,而它没在灼伤 ulcers.ConclusionE 愈合的质量上显示出优点。alata 摘录富于 phytochemical 混合物并且能改善当谈论地适用时,愈合弯屈。 | Naim Kittana Hanood Abu-Rass Ruba Sabra Lama Manasra Hadeel Hanany Nidal Jaradat Fatima Hussein Abdel Naser Zaid | 2017 | Chinese Journal of Traumatology2017，20，2： | 2 |
| 10 | Mechanism of polymer adsorption on shale surfaces: Effect of polymer type and presence of monovalent and divalent salts显示文摘This paper studies the adsorption behavior of representative guar-based polymers onto the surface of source rock outcrop samples to provide a better picture of the interaction(s)of polymers with these rocks.Outcrop samples from the Barnett,Eagle Ford,and Marcellus shales were collected,analyzed for mineralogy and total organic content,and then exposed to different polymer solutions under elevated temperature and moderately elevated pressure.Viscosities of these polymer solutions were measured before and after exposure to the rock samples to establish a correlation between polymer adsorption and rock mineralogy and/or organic content.Results indicate a direct correlation between polymer adsorption and both rock mineralogy.Cationic polymers are shown to be more prone to adsorption onto the surface of the rock than non-ionic polymers.The results from this work establish that fluid-rock interactions are significant and that further research regarding shale polymer interactions and its effects on hydrocarbon production is needed with representative downhole shale samples given the trends now shown with outcrop samples. | Sudiptya Banerjee Zaid R.Abdulsattar Kaylaychi Agim Robert H.Lane Berna Hascakir | 2017 | Petroleum2017，3，3： | 2 |
| 11 | Therapeutic efficiency of bone marrow-derived mesenchymal stem cells for liver fibrosis:A systematic review of in vivo studies显示文摘Although multiple drugs are accessible for recovering liver function in patients,none are considered efficient.Liver transplantation is the mainstay therapy for end-stage liver fibrosis.However,the worldwide shortage of healthy liver donors,organ rejection,complex surgery,and high costs are prompting researchers to develop novel approaches to deal with the overwhelming liver fibrosis cases.Mesenchymal stem cell(MSC)therapy is an emerging alternative method for treating patients with liver fibrosis.However,many aspects of this therapy remain unclear,such as the efficiency compared to conventional treatment,the ideal MSC sources,and the most effective way to use it.Because bone marrow(BM)is the largest source for MSCs,this paper used a systematic review approach to study the therapeutic efficiency of MSCs against liver fibrosis and related factors.We systematically searched multiple published articles to identify studies involving liver fibrosis and BM-MSC-based therapy.Analyzing the selected studies showed that compared with conventional treatment BM-MSC therapy may be more efficient for liver fibrosis in some cases.In contrast,the cotreatment presented a more efficient way.Nevertheless,BM-MSCs are lacking as a therapy for liver fibrosis;thus,this paper also reviews factors that affect BM-MSC efficiency,such as the implementation routes and strategies employed to enhance the potential in alleviating liver fibrosis.Ultimately,our review summarizes the recent advances in the BM-MSC therapy for liver fibrosis.It is grounded in recent developments underlying the efficiency of BM-MSCs as therapy,focusing on the preclinical in vivo experiments,and comparing to other treatments or sources and the strategies used to enhance its potential while mentioning the research gaps. | Zaid Al-Dhamin Ling-Di Liu Dong-Dong Li Si-Yu Zhang Shi-Ming Dong Yue-Min Nan | 2020 | World Journal of Gastroenterology2020，26，47： | 2 |
| 12 | Effect of aging time on strength and microstructures of an Al-Cu-Li-Zn-Mg-Mn-Zr alloy显示文摘 | Li Hongying Yi Tanga Zeng Zaide | | 0，，498： | 2 |
| 13 | Optimization design of biorthogonal wavelets for embedded image coding 显示文摘 | Liu Zaide Zheng Nanning Liu Yuehu | 2007 | IEICE Transactions on Information & Systems2007，90，2： | 1 |
| 14 | Construction of parametric biorthogonal wavelet filter banks with two parameters for image coding 显示文摘 | Liu Zaide Gao Chengxiu | 2008 | Signal Image and Video Processing2008，2，3： | 1 |
| 15 | Mechanics of high speed projectile perforation 显示文摘 | ZAID M PAUL B | 1957 | Journal of Franklin Insitutet1957，264，2： | 1 |
| 16 | Interstitial PDT for vascular anomalies显示文摘 | Waseem J Tahwinder U Zaid H | 2011 | Lasers in Surgery and Medi- cine2011，43，5： | 1 |
| 17 | Uncertainty and value of information when allocating resources within and between healthcare programmes显示文摘 | Zaid C David E Claire M | 2008 | European Journal of Operational Research2008，191，2： | 1 |
| 18 | Advances in the use of terminal restriction fragment length polymorphism (T-RFLP) analysis of 16S rRNA genes to characterize microbial communities显示文摘 | Ursel M. E. Schütte Zaid Abdo Stephen J. Bent Conrad Shyu Christopher J. Williams Jacob D. Pierson Larry J. Forney | 2008 | Applied Microbiology and Biotechnology2008，，3： | 1 |
| 19 | Implications of the natriuretic peptide system in the pathogenesis of heart failure: diagnostic and therapeutic importance 显示文摘 | ZAID A TONY K SAMER E | 2004 | Pharmacol Ther2004，102，： | 1 |
| 20 | On the role of the gen- eral transcription factor spl in the activation and repression of diverse mammalian oxidative phosphorylation genes 显示文摘 | ZAID A LI R LUCIAKOVA K | 1999 | J Bioenerg Biomembr1999，31，2： | 1 |
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