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| 1 | Prevalence of and risk factors for postprandial hypotension in older Chinese men显示文摘ObjectiveTo 估计流行并且冒险因素因为在旧、很旧的中国 men.MethodsThe 学习之中的饭后的低血压(PPH ) 65 包括了 349 个中国人并且更旧,组织了进二个年龄范畴:组 1 (旧) 65 ~ 80 年包括了 163 个人;组 2 (很旧) 超过 80 年包括了 186 个人。在饭以后的血压变化被估计由监视的回廊血压的每 15 min。在饭摄取以后并且在相对血压变化处于基线条件站起来和变化以后的症状连续地被观察。另外的基线数据包括了身体团索引,病历,和 PPH 的药 use.ResultsThe 流行总的来说是 59.3% 并且比组织 1 在组 2 是显著地更高的(63.4% 对 54.6% , P <0.05 ) 。在组 2,在早餐(33.8%) 和午餐(32.1%) 以后的 PPH 的流行在晚饭(20.9%) 以后比那高, P <0.05。高血压和年龄是为 PPH 的重要风险因素(或 = 2.188, 95% CI:1.134 − 4.223, P = 0.02;或 = 1.86, 95% CI:1.112 − 3.11, P = 0.018,分别地) 。相反, acarbose 使用对 PPH 是保护的(或 = 0.4, 95% CI:0.189 − 0.847, P = 0.017 ) 。在血压的减少在 PPH 期间是 20 − 40 mmHg 和最大值是 90 mmHg。 PPH 通常发生在 30 − ;在饭以后的 60 min 并且持续了 30 − ; 120 min.ConclusionsThese 调查结果证明在超过 80 年的人的 PPH 的流行比在 65~80 年的人的那些显著地高,并且血压衰落为超过 80 年的人也是更高的。另外,高血压和年龄是为在老人的 PPH 的主要风险因素,它建议那阻止并且对待的 PPH 是值得的。 | Xiao ZOU Jian CAO Jian-Hua LI Yi-Xin HU Yu-Song GUO Quan-Jin SI Li FAN | 2015 | Journal of Geriatric Cardiology2015，12，6： | 20 |
| 2 | Mogroside V inhibits LPS-induced COX-2 expression/ROS production and overexpression of HO-1 by blocking phosphorylation of AKT1 in RAW264.7 cells显示文摘Momordica grosvenori is a valuable edible plant with medicinal purposes, and it is widely used in medicated diets and traditional Chinese medicine in Asia. Mogroside V (MV), the main bioactive component from M. grosvenori, is comm only used as a natural sweetener. M. grosvenori extracts have been reported to exert potent anti-inflammatory property, however the underlying molecular mechanism still remains unknown. In the present study, the biological effect of MV in inflammation was investigated in lipopolysaccharide (LPS)-stimulated RAW264.7 cells. The ELISA and western blot analysis results showed that MV significantly inhibited LPS-induced prostaglandin E2 (PGE2) production and cyclooxygenase-2 (COX-2) expression. MV markedly decreased the phosphorylation of IxB-a, increased IkB-oc, and reduced nuclear p-65 and C/EBP6. Furthermore, MV attenuated LPS-induced phosphorylation of MAPKs and AKT1, and only the phosphorylation status of AKT1 was found to be consistent with the expression trend of COX-2. Moreover, MV reduced ROS level and restored overexpressed HO-1 and AP-1 to basal level, which can be markedly reversed by AKT1 inhibitor LY294002. These results revealed that AKT1 plays a key role in LPS-induced COX-2 expression, and acts as a mediator to keep the redox balance in LPS-stimulated RAW264.7 cells. MV exerts anti-inflammatory property by blocking AKT1-mediated NF-kB and C/EBP6 activation, ROS generation and AP-1/ HO-1 expression. Therefore, the present study indicated that MV has a significant chemopreventive effect on the inflammatory lesions and suggested that AKT1 is a potential specific target of MV for relieving inflammation. | Yong Li Luyan Zou Tao Li Dengni Lai Yanyang Wu Si Qin | 2019 | Acta Biochimica et Biophysica Sinica2019，51，4： | 14 |
| 3 | Improving anode performances of lithium-ion capacitors employing carbon-Si composites显示文摘The lithium-ion capacitor is a promising energy storage system with a higher energy density than traditional supercapacitors.However,its cycling and rate performances,which depend on the electrochemical properties of the anode,are still required to be improved.In this work,soft carbon anodes reinforced using carbon-Si composites of various compositions were fabricated to investigate their beneficial influences on the performance of lithium-ion capacitors.The results showed that the specific capacities of the anodes increased significantly by 16.6 mAh g^(-1) with 1.0 wt% carbon-Si composite,while the initial discharge efficiency barely changed.The specific capacity of the anode with a 10.0 wt% carbon-Si composite reached 513.1 mAh g^(-1),and the initial discharge efficiency was 83.79%.Furthermore,the anodes with 7.5 wt% or lower amounts of carbon-Si composite demonstrated reduced charge transfer resistances,which caused an improvement in the rate performance of the lithium-ion capacitors.Moreover,the use of the optimized amount(7.5 wt%) of carbon-Si composite in the anode could significantly improve the cycling performance of the lithium-ion capacitor by compensating the consumption of active lithium.The capacity retention of the lithium-ion capacitor reached 95.14% at 20 C after 10,000 cycles,while the anode potential remained below 0.412 V,which is much lower than that of a soft carbon anode. | Ya-Bin An Si Chen Min-Min Zou Lin-Bin Geng Xian-Zhong Sun Xiong Zhang Kai Wang Yan-Wei Ma | 2019 | Rare Metals2019，38，12： | 10 |
| 4 | Facile synthesis and characterization of novel pseudo-hypercrosslinked resin显示文摘一种 pseudo-hypercrosslinked 聚合物树脂第一经由连续 Friedel 被综合苯, diphenyl 和他们的 dichloromethyl 的手艺完化聚合衍生物。并且这些树脂的微形态学和吸附性质被调查。结果证明新奇树脂有高度特定的表面积(581.26 974.88 m2/g ) ,高毛孔的体积(0.56 1.65 mL/g ) ,小平均多孔的半径(1.93 3.67 nm ) 和为小非极的器官的分子的优秀吸附性质。 | Si Guo Yuan Shao Hui Zhang Wei Hua Zou Yong Hao Zhou Xiao Hui Zhou | 2008 | Chinese Chemical Letters2008，19，5： | 9 |
| 5 | Microwave transmission properties of metamaterials with double sets of square holes显示文摘The transmission property of microwave through a kind of metamaterial is investigated experimentally.Such metamaterials are fabricated with a structure of double sets of square holes:subwavelength ones,and small ones whose sizes and spacing are smaller at least one order of magnitude than those of the subwavelength holes.The experimental results show that the peak power of the measured transmission spectra is dependent on the structure parameters of the small holes.The physical origin to create this phenomenon is that the designer surface plasmons sustained by the small holes affect on the transmission property of the microwave passing through the subwavelength holes.The results are promising for proposing some techniques for optoelectronic devices in terahertz and microwave regime. | ZOU Si LIU JinSong WANG KeJia | 2012 | Chinese Science Bulletin2012，57，28： | 8 |
| 6 | Targeting neuroinflammation in Alzheimer's disease:from mechanisms to clinical applications显示文摘Alzheimer’s disease is characterized by sustained neuroinflammation leading to memory loss and cognitive decline.The past decade has witnessed tremendous efforts in Alzheimer’s disease research;however,no effective treatment is available to prevent disease progression.An increasing body of evidence suggests that neuroinflammation plays an important role in Alzheimer’s disease pathogenesis,alongside the classical pathological hallmarks such as misfolded and aggregated proteins(e.g.,amyloid-beta and tau).Firstly,this review summarized the clinical and pathological characteristics of Alzheimer’s disease.Secondly,we outlined key aspects of glial cell-associated inflammation in Alzheimer’s disease pathogenesis and provided the latest evidence on the roles of microglia and astrocytes in Alzheimer’s disease pathology.Then,we revealed the double-edged nature of inflammatory cytokines and inflammasomes in Alzheimer’s disease.In addition,the potential therapeutic roles of innate immunity and neuroinflammation for Alzheimer’s disease were also discussed through these mechanisms.In the final section,the remaining key problems according to the current research status were discussed. | Zi-Zhen Si Chen-Jun Zou Xi Mei Xiao-Fang Li Hu Luo Yao Shen Jun Hu Xing-Xing Li Lun Wu Yu Liu | 2023 | Neural Regeneration Research2023，18，4： | 7 |
| 7 | Jet formation in shock-heavy gas bubble interaction显示文摘The influences of the acoustic impedance and shock strength on the jet formation in shock-heavy gas bubble interaction are numerically studied in this work. The process of a shock interacting with a krypton or a SF 6 bubble is studied by the numerical method VAS2D. As a validation, the experiments of a SF 6 bubble accelerated by a planar shock were performed. The results indicate that, due to the mismatch of acoustic impedance, the way of jet formation in heavy gas bubble with different species is diversified under the same initial condition. With respect to the same bubble, the manner of jet formation is also distinctly different under different shock strengths. The disparities of the acoustic impedance result in different effects of shock focusing in the bubble, and different behaviors of shock wave inside and outside the bubble. The analyses of the wave pattern and the pressure variation indicate that the jet formation is closely associated with the pressure perturbation. Moreover, the analysis of the vorticity deposition, and comparisons of circulation and baroclinic torque show that the baroclinic vorticity also contributes to the jet formation. It is concluded that the pressure perturbation and baroclinic vorticity deposition are the two dominant factors for the jet formation in shock-heavy gas bubble interaction. | Zhi-Gang Zhai Ting Si Li-Yong Zou Xi-Sheng Luo | 2013 | Acta Mechanica Sinica2013，29，1： | 6 |
| 8 | Novel high-resolution DOA estimation using subspace projection method显示文摘The performance of multiple signal classification(MUSIC) algorithm with regard to solving closely spaced direction of arrivals(DOAs) depends strongly upon the signal-to-noise ratio(SNR) and snapshots.In order to solve this problem,a method by reconstructing the spatial spectrum function with both noise subspace and signal subspace is presented in this paper.The key idea is to apply the full information contained in covariance matrix and change the projection weights of steering vector on the noise and signal subspace by their revised eigenvalues,respectively.Comparing with the MUSIC algorithm,it does not increase any computational complexity either,and remarkably,it has the advantages of simultaneously reducing noise and keeping the high-resolution ability under low SNR and small sample sized scenarios.Simulation and experiment results are included to demonstrate the superior performance of the proposed algorithm. | SI Wei-jian LAN Xiao-yu ZOU Yan | 2012 | The Journal of China Universities of Posts and Telecommunications2012，19，4： | 6 |
| 9 | The landscape of aging显示文摘Aging is characterized by a progressive deterioration of physiological integrity,leading to impaired functional ability and ultimately increased susceptibility to death.It is a major risk factor for chronic human diseases,including cardiovascular disease,diabetes,neurological degeneration,and cancer.Therefore,the growing emphasis on “healthy aging” raises a series of important questions in life and social sciences.In recent years,there has been unprecedented progress in aging research,particularly the discovery that the rate of aging is at least partly controlled by evolutionarily conserved genetic pathways and biological processes.In an attempt to bring full-fledged understanding to both the aging process and age-associated diseases,we review the descriptive,conceptual,and interventive aspects of the landscape of aging composed of a number of layers at the cellular,tissue,organ,organ system,and organismal levels. | Yusheng Cai Wei Song Jiaming Li Ying Jing Chuqian Liang Liyuan Zhang Xia Zhang Wenhui Zhang Beibei Liu Yongpan An Jingyi Li Baixue Tang Siyu Pei Xueying Wu Yuxuan Liu Cheng-Le Zhuang Yilin Ying Xuefeng Dou Yu Chen Fu-Hui Xiao Dingfeng Li Ruici Yang Ya Zhao Yang Wang Lihui Wang Yujing Li Shuai Ma Si Wang Xiaoyuan Song Jie Ren Liang Zhang Jun Wang Weiqi Zhang Zhengwei Xie Jing Qu Jianwei Wang Yichuan Xiao Ye Tian Gelin Wang Ping Hu Jing Ye Yu Sun Zhiyong Mao Qing-Peng Kong Qiang Liu Weiguo Zou Xiao-Li Tian Zhi-Xiong Xiao Yong Liu Jun-Ping Liu Moshi Song Jing-Dong J.Han Guang-Hui Liu | 2022 | Science China(Life Sciences)2022，65，12： | 4 |
| 10 | Numerical study on the evolution of the shock-accelerated SF_6 interface:Influence of the interface shape显示文摘The early phases of the shock interaction process on two-dimensional interfaces with different shapes are numerically investigated in this study,which are closely related to the shock refraction and reflection,vorticity production and transport.The numerical method employs an adaptive unstructured quadrilateral mesh,which can capture the wave pattern and interface evolution very well.Simulations are carried out under the conditions of an incident shock Mach number of 1.2 and the light/heavy (air/SF 6) interface.Five different shapes are considered in the simulations:rectangle,ellipse,diamond and two kinds of triangle.The results show that the interfacial shapes can influence the wave patterns particularly on the shape and evolution of refracted shock waves.The generation and the distribution of vorticity on the interfaces with five different shapes also have dissimilarities.The circulation deposition on five interfaces is quantitatively investigated and compared with theoretical model.A good agreement is found between the numerical results and the predictions by the theoretical model.Some characteristic scales of the interface are tracked.Under the influence of nonlinear-acoustic effect and vorticity effect,the interfaces present different evolution modes. | FAN MeiRu ZHAI ZhiGang SI Ting LUO XiSheng ZOU LiYong TAN DuoWang | 2012 | Science China(Physics,Mechanics & Astronomy)2012，55，2： | 4 |
| 11 | Is combined lipid-regulating therapy safe and feasible for the very old patients with mixed dyslipidemia?显示文摘OBJECTIVES: To detect the efficacy and safety of combined lipid-regulating therapies in the very old patients with mixed dyslipidemia and determine an appropriate therapy for them。 METHODS: Four hundred and fifty patients aged over 75 with mixed dyslipidemia were divided into five groups according to different combination therapies。 Lipid levels and drug related adverse events were tested during the study。 RESULTS: Total cholesterol (TC) and low-density lipoprotein cholesterol (LDL-C) levels were reduced in every group compared to baseline: statin + ezetimibe: -30.0% and -55.5%; statin + policosanol: -31.1% and -51.2%; statin + fibrates: -23.7% and -44.6%; statin + niacin: -25.2% and -43.0%; and niacin + fibrates: -11。3% and -23.5%。 The target achievement rates of LDL-C all exceeded 50%, except in niacin + fibrates (42.0%); statin + ezetimibe: 57.0%; statin + policosanol: 56.0%; statin + niacin: 52.0%; and statin + fibrates: 50.0%。 However, overall, the niacin + fibrates group was the most effective in decreasing triglyceride (TG) and increasing high-density lipoprotein cholesterol (HDL-C) as follows: niacin + fibrates: -39.3% and 28.6%; statin + fibrates: -29.3% and 18.4%; statin + niacin: -18.5% and 16.7%; statin + ezetimibe: -17.1% and 7.1%; and statin + policosanol: -15.6% and 9.5%。 The achievement rates of TG and HDL-C levels in niacin + fibrates (58.0% and 39.0%) were better than the other four groups: statin + niacin (34.0% and 34.0%), statin + fibrates (43.0% and 28.0%), statin + policosanol (30.0% and 24.0%) and statin + ezetimibe (28.0% and 25.0%)。 Patients in all five groups experiencing drug adverse events were only 2% and no severe adverse events occurred。 CONCLUSIONS: Statin + ezetimibe was the most effective group in lowering TC and LDL-C levels, while niacin + fibrates was the most effective in decreasing TG and increasing HDL-C levels。 The commonly used combined lipid-regulating therapies with common dosages in this study were all quite safe and feasible for the very old patients with mixed hyperlipidemia。 | Xiao Zou Quan-Jin Si | 2013 | Journal of Geriatric Cardiology2013，10，4： | 3 |
| 12 | A Dose-response Meta-analysis of Egg Intake and Breast Cancer Risk显示文摘Aim Eggs are one of the most nutritious foods in nature,but there is no unified conclusion about the association between egg intake and breast cancer risk.Methods The PubMed and Web of Science databases for the literature on egg intake and breast cancer risk were searched for papers published during the last 10 years.These were then filtered according to the inclusion and exclusion criteria.Stata16.0 software was applied to perform a meta-analysis,the generalized least squares method and constrained cubic spline model were used to assess the dose-response trends between egg intake and breast cancer risk.Results A total of 9 articles were included:6 case control studies and 3 cohort studies.The Newcastle-Ottawa scale(NOS)values of the included articles were all≥6 points.The pooled relative risks(RR)of egg intake and breast cancer risk was 0.91(95%CI:0.69-1.19).The dose-response analysis showed a linear trend for egg intake and breast cancer risk(P=0.689).With every 10 g/day increase in egg intake,the incidence of breast cancer increased by 2%(RR=1.02,95%CI:0.99-1.05).However,these results were not statistically significant.Conclusion This meta-analysis found no significant association between egg intake and breast cancer. | Peng Wei Ma Fei Fei Feng Zi Ang Shi Ke Di Xu Yuan Lin Zou Yan Li Wang Si Qi Ning Chun Hua Song | 2021 | Journal of Nutritional Oncology2021，6，2： | 3 |
| 13 | Deletion of SMARCA4 impairs alveolar epithelial type II cells proliferation and aggravates pulmonary fibrosis in mice显示文摘Alveolar epithelial cells(AECs)injury and failed reconstitution of the AECs barrier are both integral to alveolar flooding and subsequent pulmonary fibrosis(PF).Nevertheless,the exact mechanisms regulating the regeneration of AECs post-injury still remain unclear.SMARCA4 is a part of the large ATP-dependent chromatin remodelling complex SWI/SNF,which is essential for kidney and heart fibrosis.We investigates SMARCA4 function in lung fibrosis by establishing PF mice model with bleomycin firstly and found that the expression of SMARCA4 was mainly enhanced in alveolar type II(ATII)cells.Moreover,we established an alveolar epithelium-specific SMARCA4-deleted SP-C-rtTA/(tetO)7-Cre/SMARCA4f/f mice(SOSM4D/D)model,as well as a new SMARCA4-deleted alveolar type II(ATII)-like mle-12 cell line.We found that the bleomycin-induced PF was more aggressive in SOSM4D/D mice.Also,the proliferation of ATII cells was decreased with the loss of SMARCA4 in vivo and in vitro.In addition,we observed increased proliferation of ATII cells accompanied by abnormally high expression of SMARCA4 in human PF lung sections.These data uncovered the indispensable role of SMARCA4 in the proliferation of ATII cells,which might affect the progression of PF. | Danyi Peng Daozhu Si Rong Zhang Jiang Liu Hao Gou Yunqiu Xia Daiyin Tian Jihong Dai Ke Yang Enmei Liu Yujun Shi Q.Richard Lu Lin Zou Zhou Fu | 2017 | Genes & Diseases2017，4，4： | 3 |
| 14 | Glass capillary nanopore for single molecule detection显示文摘Single molecule detection based on nanopore technology is a very promising approach for medical diagnostics, drug therapy and even DNA sequencing. Compared with other biological nanopores and solid-state nanopores, the glass capillary nanopore has low cost, easy availability and stable mechanical characteristics, thus it has been widely used in the nanopore technology for single molecule detection. In this review, we will focus on the studies of the glass nanopore sensors. The popular glass nanopore fabrication methods would be introduced, and the applications of glass nanopores in the detection of nanoparticles, proteins and DNA molecules would be presented. We hope this review will help widen field of vision and promote the development of the nanopore technology based on the glass capillary nanopores. | SHA JingJie SI Wei XU Wei ZOU YiRen CHEN YunFei | 2015 | Science China(Technological Sciences)2015，58，5： | 2 |
| 15 | Analysis on internal mechanism of zedoary turmeric in treatment of liver cancer based on pharmacodynamic substances and pharmacodynamic groups显示文摘Zedoary tumeric(Curcumae Rhizoma,Ezhu in Chinese)has a long history of application and has great potential in the treatment of liver cancer.The antiliver cancer effect of zedoary tumeric depends on the combined action of multiple pharmacodynamic substances.In order to clarify the specific mechanism of zedoary tumeric against liver cancer,this paper first analyzes the mechanism of its single pharmacodynamic substance against liver cancer,and then verifies the joint anti liver cancer mechanism of its“pharmacodynamic group”.By searching the research on the antihepatoma effect of active components of zedoary tumeric in recent years,we found that pharmacodynamic substances,including curcumol,zedoarondiol,curcumenol,curzerenone,curdione,curcumin,germacrone,β-elemene,can act on multi-target and multi-channel to play an antihepatoma role.For example,curcumin can regulate miR,GLO1,CD133,VEGF,YAP,LIN28B,GPR81,HCAR-1,P53 and PI3K/Akt/mTOR,HSP70/TLR4 and NF-κB.Wnt/TGF/EMT,Nrf2/Keap1,JAK/STAT and other pathways play an antihepatoma role.Network pharmacological analysis showed that the core targets of the“pharmacodynamic group”for anti-life cancer are AKT1,EGFR,MAPK8,etc,and the core pathways are neuroactive live receiver interaction,nitrogen metabolism,HIF-1 signaling pathway,etc.At the same time,by comparing and analyzing the relationship between the specific mechanisms of pharmacodynamic substance and“pharmacodynamic group”,it is found that they have great reference significance in target,pathway,biological function,determination of core pharmacodynamic components,formation of core target protein interaction,in-depth research of single pharmacodynamic substance,increasing curative effect and so on.By analyzing the internal mechanism of zedoary tumeric pharmacodynamic substance and“pharmacodynamic group”in the treatment of liver cancer,this paper intends to provide some ideas and references for the deeper pharmacological research of zedoary tumeric and the relationship between pharmacodynamic substance and“pharmacodynamic group”. | Zeyu Li Erwei Hao Rui Cao Si Lin Linghui Zou Tianyan Huang Zhengcai Du Xiaotao Hou Jiagang Deng | 2022 | Chinese Herbal Medicines2022，14，4： | 2 |
| 16 | Synthesis and Herbicidal Activities of N'-(substituted pyrimidin-2-yl)-N-Substituted Phenoxyacetyl Thiourea Derivatives显示文摘Fifteen N’-(substituted pyrimidin-2-y1)-N-substituted phenoxyacetyl thioureas were synthesized and tested for biological activities. All of them are new compounds and their structures were confirmed by IR. IHNMR. MS and elemental analysis. Some of the target compounds showed excellent inhibitory activities against root and stalk of dicotyledon plant (such as radish). and selective on monoctyledon plant (such as rice). | Si Jia XUE Jin Shan ZOU Hai Jian YANG (Department of Chemistry, Central China Normal University, Wuhan 430079) | 2000 | Chinese Chemical Letters2000，11，1： | 2 |
| 17 | Kinetic Characterization of Tyrosinase-catalyzed Oxidation of Four Polyphenols显示文摘Phenolic compounds such as chlorogenic acid,cryptochlorogenic acid,neochlorogenic acid and caffeic acid are widely distributed in fruits,vegetables and traditional Chinese medicines with a wide range of biological activities.Tyrosinase plays a critical role in the food industry,but recent studies have proposed unexplored aspects of clinical application.Tyrosinase-catalyzed oxidation of four polyphenols as well as its underlying mechanism remains unclear.In the current work,we investigated the kinetic properties of tyrosinase-catalyzed oxidation of the four polyphenols of interest.To measure the unstable o-quinone products,an analytical method using 3-methyl-2-benzothiazolinone hydrazone(MBTH)was established.The optimal incubation time,buffer pH,temperature and enzyme concentration for the enzyme activity in the presence of each polyphenol of interest were investigated.Under the final optimized conditions,the kinetics and substrate specificity of four polyphenols were examined.K inetic data showed that tyrosinase had the greatest substrate affinity to chlorogenic acid compared with its isomers and caffeic acid.The catalytic efficiency with chlorogenic acid was 8-to 15-fold higher than that with the other 3 polyphenols.Molecular docking study demonstrated that the tight binding of chlorogenic acid at the peripheral site should be the major reason for the specificity to chlorogenic acid.In light of this,the rational design of high-affinity inhibitors against tyrosinase may focus on the binding of both the Cu site and peripheral site.This study will supply a basis for the selection of phenolic acids in food industry and health carc. | Wan-yu LIU Cong-ming ZOU Jian-hua HU Zi-jun XU Lu-qin SI Jun-jun LIU Jian-geng HUANG | 2020 | Current Medical Science2020，40，2： | 2 |
| 18 | 基于DPM模型的离心泵非定常固液两相流及磨损计算(英文)显示文摘In this paper, the discrete phase model (DPM) and semi-empirical wear model were used to simulatethe unsteady solid-liquid two-phase flows and wear in a centrifugal pump, to explore the solid particle movementand the wear of the pump. The liquid phase was solved by the fluid governing equations in the Euler coordinatesystem; the solid particle phase was treated as a discrete medium and solved by the equations of particle motion inLagrange coordinate. The solid-liquid phase coupling was performed using iterative numerical method. An IS typecentrifugal pump was selected in the simulation. Water and sand particle were chosen as the continuous phase andthe discrete phase, respectively. The particle volumetric ratio at the pump inlet was in the range of 0.5%-3%with the particle size of 0.05-0.2 mm. The flow characteristics of the solid-liquid two-phase flows, the trajectoryof the particle cluster and the distribution of wear rate in the centrifugal pump were obtained by the simulation. | Si HUANG Wen-lang ZOU Jin-ju ZHOU Dong-ping HE Tian-yang PENG | 2016 | 机床与液压2016，44，6： | 2 |
| 19 | Future Precipitation Extremes in China under Climate Change and Their Physical Quantification Based on a Regional Climate Model and CMIP5 Model Simulations显示文摘The atmospheric water holding capacity will increase with temperature according to Clausius-Clapeyron scaling and affects precipitation.The rates of change in future precipitation extremes are quantified with changes in surface air temperature.Precipitation extremes in China are determined for the 21st century in six simulations using a regional climate model,RegCM4,and 17 global climate models that participated in CMIP5.First,we assess the performance of the CMIP5 models and RCM runs in their simulation of extreme precipitation for the current period(RF:1982-2001).The CMIP5 models and RCM results can capture the spatial variations of precipitation extremes,as well as those based on observations:OBS and XPP.Precipitation extremes over four subregions in China are predicted to increase in the mid-future(MF:2039-58)and far-future(FF:2079-98)relative to those for the RF period based on both the CMIP5 ensemble mean and RCM ensemble mean.The secular trends in the extremes of the CMIP5 models are predicted to increase from 2008 to 2058,and the RCM results show higher interannual variability relative to that of the CMIP5 models.Then,we quantify the increasing rates of change in precipitation extremes in the MF and FF periods in the subregions of China with the changes in surface air temperature.Finally,based on the water vapor equation,changes in precipitation extremes in China for the MF and FF periods are found to correlate positively with changes in the atmospheric vertical wind multiplied by changes in surface specific humidity(significant at the p<0.1 level). | Peihua QIN Zhenghui XIE Jing ZOU Shuang LIU Si CHEN | 2021 | Advances in Atmospheric Sciences2021，38，3： | 2 |
| 20 | “Ferrero-like”nanoparticles knotted injectable hydrogels to initially scavenge ROS and lastingly promote vascularization in infarcted hearts显示文摘Myocardial infarction(MI)exhibits a complicated and ever-accelerated pathological change involving excessive reactive oxygen species(ROS)and the up-regulation of pro-inflammatory cytokines in the initial stage,and a permanently inadequate blood supply.Herein,an injectable hydrogel fabricated by nanoparticles(NPs)knotted thiolated hyaluronic acid(HA-SH)was reported to reverse the hostile microenvironment and rebuild the heart functions after MI.Inspired by the composite shell-core structure of Ferrero chocolate sphere,a mimetic nanocarrier was designed to consist of the hydrophobic dimethyloxalylglycine(DMOG)NPs core and a thick polydopamine(PDA)shell formed by the self-polymerization of dopamine embedded with watersoluble drug epigallocatechin-3-gallate(EGCG)throughπ-πinteractions.The resulted'Ferrero-like'NPs exhibited a'three-inone'capacity,namely loading two distinct drugs,elimination of ROS,and serving a crosslinker to knot HA-SH.'Ferrero-like'NPs and HA-SH could rapidly form a hydrogel that exhibited a stable mechanical property,high capability to capture ROS,and programmed release of EGCG and DMOG.Four weeks after deploying the'Ferrero-like'NPs knotted hydrogels into rat infarcted hearts,the ejection fraction(EF)increased by 23.7%,and the infarct size decreased by 21.1%,and the fibrotic area reduced by 24.4%.The outcomes of immunofluorescence staining and reverse transcription-polymerase chain reaction(RTPCR)demonstrated a down-regulation of inflammatory factors(tumor necrosis factor-α(TNF-α),interleukin-1β(IL-1β),interferon-γ(IFN-γ)),up-regulation of vascular related growth factors(hypoxia inducible factor-1α(HIF-1α),vascular endothelial growth factor A(VEGFA),von Willebrand factor(vWF),angiopoietin-1(Ang-1))and cardiac-related m RNAs(gap junction protein(Cx43),Cadherin 2).All in all,in this report,a very simple approach to intertemporally address the intricate and ongoing pathological changes after MI by injecting'Ferrero-like'NPs knotted hydrogels is developed to reverse hostile microenvironment,with an ability to scavenge ROS,down-regulate pro-inflammation factors in the first stage,and promote angiogenesis in a long term,thereby contributing to a significant improvement of heart functions. | HAN XiaoXu LI Lan XIE Tian CHEN Si ZOU Yang JIN Xin LI Sheng WANG Meng HAN Ning FAN GuanWei LIU WenGuang WANG Wei | 2020 | Science China(Technological Sciences)2020，63，11： | 2 |
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