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| 1 | Biomarkers of aging显示文摘Aging biomarkers are a combination of biological parameters to(i)assess age-related changes,(ii)track the physiological aging process,and(iii)predict the transition into a pathological status.Although a broad spectrum of aging biomarkers has been developed,their potential uses and limitations remain poorly characterized.An immediate goal of biomarkers is to help us answer the following three fundamental questions in aging research:How old are we?Why do we get old?And how can we age slower?This review aims to address this need.Here,we summarize our current knowledge of biomarkers developed for cellular,organ,and organismal levels of aging,comprising six pillars:physiological characteristics,medical imaging,histological features,cellular alterations,molecular changes,and secretory factors.To fulfill all these requisites,we propose that aging biomarkers should qualify for being specific,systemic,and clinically relevant. | Aging Biomarker Consortium Hainan Bao Jiani Cao Mengting Chen Min Chen Wei Chen Xiao Chen Yanhao Chen Yu Chen Yutian Chen Zhiyang Chen Jagadish K Chhetri Yingjie Ding Junlin Feng Jun Guo Mengmeng Guo Chuting He Yujuan Jia Haiping Jiang Ying Jing Dingfeng Li Jiaming Li Jingyi Li Qinhao Liang Rui Liang Feng Liu Xiaoqian Liu Zuojun Liu Oscar Junhong Luo Jianwei Lv Jingyi Ma Kehang Mao Jiawei Nie Xinhua Qiao Xinpei Sun Xiaoqiang Tang Jianfang Wang Qiaoran Wang Siyuan Wang Xuan Wang Yaning Wang Yuhan Wang Rimo Wu Kai Xia Fu-Hui Xiao Lingyan Xu Yingying Xu Haoteng Yan Liang Yang Ruici Yang Yuanxin Yang Yilin Ying Le Zhang Weiwei Zhang Wenwan Zhang Xing Zhang Zhuo Zhang Min Zhou Rui Zhou Qingchen Zhu Zhengmao Zhu Feng Cao Zhongwei Cao Piu Chan Chang Chen Guobing Chen Hou-Zao Chen Jun Chen Weimin Ci Bi-Sen Ding Qiurong Ding Feng Gao Jing-Dong JHan Kai Huang Zhenyu Ju Qing-Peng Kong Ji Li Jian Li Xin Li Baohua Liu Feng Liu Lin Liu Qiang Liu Qiang Liu Xingguo Liu Yong Liu Xianghang Luo Shuai Ma Xinran Ma Zhiyong Mao Jing Nie Yaojin Peng Jing Qu Jie Ren Ruibao Ren Moshi Song Zhou Songyang Yi Eve Sun Yu Sun Mei Tian Shusen Wang Si Wang Xia Wang Xiaoning Wang Yan-Jiang Wang Yunfang Wang Catherine CL Wong Andy Peng Xiang Yichuan Xiao Zhengwei Xie Daichao Xu Jing Ye Rui Yue Cuntai Zhang Hongbo Zhang Liang Zhang Weiqi Zhang Yong Zhang Yun-Wu Zhang Zhuohua Zhang Tongbiao Zhao Yuzheng Zhao Dahai Zhu Weiguo Zou Gang Pei Guang-Hui Liu | 2023 | Science China(Life Sciences)2023，66，5： | 2 |
| 2 | Characteristics of calcaneus quantitative ultrasound normative data in Chinese mainland men and women显示文摘 | Liu W Xu CL Zhu ZQ | 2006 | Osteoporos Int2006，17，8： | 1 |
| 3 | hnmunomodulatory effect of polysac- charides from submerged cultured Cordyceps gunnii显示文摘 | Zhu ZY Chen J Si CL | 2012 | Pharm Biol2012，50，9： | 1 |
| 4 | Mechanisms of WNK1 and WNK4 interaction in the regulation of thiazide-sensitive NaCl cotransport显示文摘 | Zhu X Wang Z | 2005 | J Clin Invest2005，115，： | 1 |
| 5 | Dominant-negative regulation of WNK1 by its kidney-specific kinase-defective isoform显示文摘 | Yang CL Zhu X | 2006 | Am J Physiol Renal Physiol2006，290，： | 1 |
| 6 | Computer-aided development of a high-performance liquid chromatographic method for the determination of hydroxyanthraquinone derivatives in Chinese herb medicine rhubarb 显示文摘 | Liu CL Zhu PL Liu MC | 1999 | J Chromatogr A1999，857，： | 1 |
| 7 | A sensor of a polyoxometalate and Au-Pd alloy for simultaneously detection of dopamine and ascorbic acid显示文摘 | Zhou CL Li S Zhu W | 2013 | Eleetrochimica Acta2013，113，1： | 1 |
| 8 | Potentiation ofanalge- sic efficacy but not side effects co-administration of an alpha4beta2neuronal nicotinic aeetylcholine receptor agonist and its positive allostericmodulator in experimental models of pain in rats 显示文摘 | Zhu CZ Chin CL Rustay NR | 2011 | Biochem Pharmacol2011，82，8： | 1 |
| 9 | Association of FAS and FAS ligand polymorphisms with the susceptibility and severity of lumbar disc degen2 eration in Chinese Han population显示文摘 | Zhu GB Jiang XR Xia CL | 2011 | Biomarkers2011，16，6： | 1 |
| 10 | A comparative study of Samarium-153- ethylenediaminetetra methylene phosphonic acid with pamidronate disodium in the treatment of padents with painful metastatic bone cancer 显示文摘 | Wang RF Zhang CL Zhu SL | 2003 | Med Princ Pract2003，12，2： | 1 |
| 11 | A novel human immunoglobulin Fcγ-Fcε bifunctional fusion protein inhibits FcεRI-mediated degranulation显示文摘 | Zhu D Kepley CL Zhang M | 2002 | Nat Med2002，8，5： | 1 |
| 12 | comparative study of Sm-153-ethylenediamine-tetra-methylene phosphonic acid with pamidronate disodium in the treatment of patients with painful metastatic bone cancer显示文摘 | Zhang CL Zhu SL | 2003 | Med Princ Pract (MPP)2003，12，2： | 1 |
| 13 | A comparative study of samarium- 153-ethylenediaminetetramethy phosphonic acid with pamidronate disodium in the treatment of patients with painful metastatic bone cancer显示文摘 | Wang RF Zhang CL Zhu SL | 2003 | Med Princ Pract2003，12，2： | 1 |
| 14 | Extraction, preliminary structuralcharacterization, and antioxidant activities of polysaccharidesfrom Salvia miltiorrhiza Bunge显示文摘 | Wu W Zhu Y Zhang L et cl | 2012 | Carbohydrate Polymers2012，87，2： | 1 |
| 15 | Salvianolic acid A inhibits platelet activation and arterial thrombosis via inhibition of phosphoinositide 3-kinase显示文摘 | Huang ZS Zeng CL Zhu LJ | 2010 | J Thromb Haemost2010，8，6： | 1 |
| 16 | Intraoperative radiofrequency thermal ablation combined with portal vein infusion chemotherapy and transarterial chemoembolization for unresectable HCC显示文摘 | Shen SQ Xiang JJ Xiong CL Wu SM Zhu SS | 2005 | Hepatogastroenterology2005，52，65： | 1 |
| 17 | Neuroprotective effect of paeoniflorin on cerebral ischemic rat by activating adenosine A1 receptor in a manner different from its classical agonists显示文摘 | Liu DZ Xie KQ Ji XQ Ye Y Jiang CL Zhu XZ | 2005 | Br J Pharmacol2005，146，4： | 1 |
| 18 | Dimensional accuracy of thermosetting composites:simulation of process-induced residual stresses显示文摘 | Zhu Q Geubelle PH Li M Tucker III CL | 2001 | Journal of Composite material2001，35，24： | 1 |
| 19 | A GSK-3/TSC2/mTOR pathway regulates glucose uptake and GLUT1 glucose transporter expression 显示文摘 | Buller CL Loberg RD Fan MH Zhu Q Park JL Vesely E | 2008 | Am J Physiol Cell Physiol2008，295，3： | 1 |
| 20 | Vancomycin intermediate- resistant Staphylococcus aureus (VISA) isolated from a patient who never received vancomycin treatment显示文摘 | ZHU XH LIU CL GAO S | 2015 | Int J Infect Dis2015，33，14： | 1 |
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