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| 1 | Biomarkers of aging显示文摘Aging biomarkers are a combination of biological parameters to(i)assess age-related changes,(ii)track the physiological aging process,and(iii)predict the transition into a pathological status.Although a broad spectrum of aging biomarkers has been developed,their potential uses and limitations remain poorly characterized.An immediate goal of biomarkers is to help us answer the following three fundamental questions in aging research:How old are we?Why do we get old?And how can we age slower?This review aims to address this need.Here,we summarize our current knowledge of biomarkers developed for cellular,organ,and organismal levels of aging,comprising six pillars:physiological characteristics,medical imaging,histological features,cellular alterations,molecular changes,and secretory factors.To fulfill all these requisites,we propose that aging biomarkers should qualify for being specific,systemic,and clinically relevant. | Aging Biomarker Consortium Hainan Bao Jiani Cao Mengting Chen Min Chen Wei Chen Xiao Chen Yanhao Chen Yu Chen Yutian Chen Zhiyang Chen Jagadish K Chhetri Yingjie Ding Junlin Feng Jun Guo Mengmeng Guo Chuting He Yujuan Jia Haiping Jiang Ying Jing Dingfeng Li Jiaming Li Jingyi Li Qinhao Liang Rui Liang Feng Liu Xiaoqian Liu Zuojun Liu Oscar Junhong Luo Jianwei Lv Jingyi Ma Kehang Mao Jiawei Nie Xinhua Qiao Xinpei Sun Xiaoqiang Tang Jianfang Wang Qiaoran Wang Siyuan Wang Xuan Wang Yaning Wang Yuhan Wang Rimo Wu Kai Xia Fu-Hui Xiao Lingyan Xu Yingying Xu Haoteng Yan Liang Yang Ruici Yang Yuanxin Yang Yilin Ying Le Zhang Weiwei Zhang Wenwan Zhang Xing Zhang Zhuo Zhang Min Zhou Rui Zhou Qingchen Zhu Zhengmao Zhu Feng Cao Zhongwei Cao Piu Chan Chang Chen Guobing Chen Hou-Zao Chen Jun Chen Weimin Ci Bi-Sen Ding Qiurong Ding Feng Gao Jing-Dong JHan Kai Huang Zhenyu Ju Qing-Peng Kong Ji Li Jian Li Xin Li Baohua Liu Feng Liu Lin Liu Qiang Liu Qiang Liu Xingguo Liu Yong Liu Xianghang Luo Shuai Ma Xinran Ma Zhiyong Mao Jing Nie Yaojin Peng Jing Qu Jie Ren Ruibao Ren Moshi Song Zhou Songyang Yi Eve Sun Yu Sun Mei Tian Shusen Wang Si Wang Xia Wang Xiaoning Wang Yan-Jiang Wang Yunfang Wang Catherine CL Wong Andy Peng Xiang Yichuan Xiao Zhengwei Xie Daichao Xu Jing Ye Rui Yue Cuntai Zhang Hongbo Zhang Liang Zhang Weiqi Zhang Yong Zhang Yun-Wu Zhang Zhuohua Zhang Tongbiao Zhao Yuzheng Zhao Dahai Zhu Weiguo Zou Gang Pei Guang-Hui Liu | 2023 | Science China(Life Sciences)2023，66，5： | 2 |
| 2 | HLA and NK cell inhibitory receptor genes in resolving hepatitis C virus infection显示文摘 | Khakoo SI Thio CL Martin MP | 2004 | Science2004，305，： | 1 |
| 3 | hnmunomodulatory effect of polysac- charides from submerged cultured Cordyceps gunnii显示文摘 | Zhu ZY Chen J Si CL | 2012 | Pharm Biol2012，50，9： | 1 |
| 4 | Cost bur- den of the presenteeism health outcome: diverse work- force of nurses and pharmacists 显示文摘 | Warren CL White-Means SI Wicks MN | 2011 | J Occup Environ Med2011，3，1： | 1 |
| 5 | Bcl-2 heterodimerizes in vivo with a conserved homolog,Bax,that accelerates programmed cell death显示文摘 | Oltvai ZN Milliman CL Korsmever SI | | 0，，04： | 1 |
| 6 | Antioxidant properties and neuroprotective effects of isocampneoside II on hydro- gen peroxide-induced oxidative injury in PC12 cells显示文摘 | Si CL Shen T Jiang YY | 2013 | Food and Chemical Toxicology2013，59，： | 1 |
| 7 | Lactate dehydrogenase,not vascular endothelia growth factor or basic fibroblast growth factor positively correlates to bone marrow vascularity in acute myeloid leukemia 显示文摘 | Teng CL Young JH Hsu SI | 2006 | J Chin Med Assoe2006，69，： | 1 |
| 8 | Critical roles for CCR2 and MCP-3 in monocyte mobilization from bone marrow and recruitment to inflammatory sites显示文摘 | Tsou CL Peters W Si Y | 2007 | J Clin Invest2007，117，4： | 1 |
| 9 | Critical roles for CCR2 and MCP-3 in monocyte mobilization from bone marrow and recruitment to inflammatory sites显示文摘 | Tsou CL Peters W Si Y | 2007 | J C lin Invest2007，117，4： | 1 |
| 10 | Aspartate modulates the ethanol-in- duced oxidative stress and glutathione utilizing enzymes in rat testes 显示文摘 | Oh SI Lee MS Kim CL | 2002 | Exp Mul Med2002，34，1： | 1 |
| 11 | Stress, health and well-being:the mediating role of employee and organizational commitment 显示文摘 | Jain AK Giga SI Cooper CL | 2013 | Int J Environ Res Public Health2013，10，10： | 1 |
| 12 | Ethanol effects on nitricoxide production in cerebral pial cultures 显示文摘 | Shih CL Chi SI Chiu TH | 2001 | AlcoholClin Exp Res2001，25，4： | 1 |
| 13 | Gender differences in correlations of cerebral glucose metabolic rates in young normal adults显示文摘 | Azari NP Rapoport SI Grady CL | 1992 | Brain Res1992，574，12： | 1 |
| 14 | Hcpahhs C vires Infection and bone marrow transplantation: A cohort study with 10-year follow-up 显示文摘 | Strasser SI Myemon D Spurgeon CL | 1999 | Hepatol1999，29，6： | 1 |
| 15 | Genetic variation in IL28Band spontaneous clearance of hepatitis C virus显示文摘 | Thomas DL Thio CL Martin MP Qi Y Ge D O’Huigin C Kidd J Kidd K Khakoo SI Alexander G Goedert JJ Kirk GD Donfield SM Rosen HR Tobler LH Busch MP McHutchison JG Goldstein DB Carrington M | 2009 | Nature2009，461，7265： | 1 |
| 16 | Critical roles for CCR2 and MCP-3 in monocyte mobilization from bone marrow and re- cruitment to inflammatory sites 显示文摘 | Tsou CL Peters W Si Y | 2007 | J Clin Invest2007，117，4： | 1 |
| 17 | Critical roles for CCR2 and MCP-3in monocyte mobilization from bone marrow and recruitment toinflammatory sites显示文摘 | Tsou CL Peters W Si Y ct al | 2007 | J Clin Invest2007，117，4： | 1 |
| 18 | Regulation of phosphate homeostasis by micro RNA in arabidopsis显示文摘 | Chiou T J Aung K Lin SI Wu CC Chiang SF Su CL | 2006 | The Plant Cell2006，18，： | 1 |
| 19 | Antioxidant properties and neuroprotective effects of isocampneoside lI on hydrogen peroxide-induced oxidative injury in PC12 cells显示文摘 | Si CL Shen T Jiang YY | 2013 | Food Chem Toxicol2013，59，10： | 1 |
| 20 | HLA and NK cell inhibitory receptor genes in resolving hepatitis C virus infection显示文摘 | Khakoo SI Thio CL Martin MP | 2004 | Science2004，305，5685： | 1 |
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