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| 1 | Positive association of RhoC gene overexpression with tumour invasion and lymphatic metastasis in gastric carcinoma显示文摘Worldwide estimates establish gastric carcinoma as the second most frequent cause of cancer deaths. Tumour invasion and metastasis is the biggest impediment to gastric carcinoma cure. Active migration of tumour cells is now considered as the pivotal step in cancer invasion and metastasis. RhoC is a member of the Ras-superfamily of small guanosine triphosphatases that can regulate many cellular functions, especially cytoskeletal organization and cell locomotion. Overexpressing RhoC in vitro in the poorly metastatic cell line from human melanoma may induce a highly metastatic phenotype.1 The recent development of laser capture microdissection (LCM) affords the opportunity to further evaluate the role RhoC plays in the invasion and metastasis of gastric carcinoma cells in their native tissue environment. | WANGZhen-ning XUHui-mian JIANGLi ZHOUXin LUChong ZHANGXue | 2005 | Chinese Medical Journal2005，，6： | 48 |
| 2 | Patterns of recurrence and outcome according to breast cancer subtypes in lymph node-negative disease:results from international breast cancer study group trials VIII and IX显示文摘 | Otto MF Zhouxin S Giuseppe V | 2013 | J Clin Oncol2013，31，25： | 1 |
| 3 | Short-term exposure to fine particulate matter constituents and mortality:case-crossover evidence from 32 counties in China显示文摘A growing number of studies associated increased mortality with exposures to specific fine particulate(PM_(2.5))constituents,while great heterogeneity exists between locations.In China,evidence linking PM_(2.5)constituents and mortality was extensively sparse.This study primarily aimed to quantify short-term associations between PM_(2.5)constituents and non-accidental mortality among the Chinese population.We collected daily mortality records from 32 counties in China between January 1,2011,and December 31,2013.Daily concentrations of main PM_(2.5)constituents(organic carbon(OC),elemental carbon(EC),nitrate(NO_(3)^(-)),sulfate(SO_(4)^(2−)),and ammonium(NH_(4)^(+)))were estimated using the modified Community Multiscale Air Quality model.Time-stratified case-crossover design with conditional logistic regression models was adopted to estimate mortality risks associated with short-term exposures to PM_(2.5)mass and its constituents.Stratification analyses were done by sex,age,and season.A total of 116,959 non-accidental deaths were investigated.PM_(2.5)concentrations on the day of death were averaged at 75.7μg m^(−3)(control day:75.6μg m^(−3)),with an interquartile range(IQR)of 65.2μg m^(−3).Per IQR rise in PM_(2.5),EC,OC,NO_(3)^(-),SO_(4)^(2−),and NH_(4)^(+)at lag-04 day was associated with an increase in non-accidental mortality of 2.4%(95%confidence interval,(1.0–3.7),1.7%(0.8–2.7),2.9%(1.6–4.3),2.1%(0.4–3.9),1.0%(0.2–1.9),and 1.6%(0.3–2.9),respectively.Both PM_(2.5)mass and its constituents were strongly associated with elevated cardiovascular mortality risks,but only PM_(2.5),EC,and OC were positively associated with respiratory mortality at lag-3 day.PM_(2.5)mass and its constituents associated effects on mortality varied among sex-and age-specific subpopulations.Differences in the seasonal pattern of associations exist among PM_(2.5)constituents,with stronger effects related to EC and NO_(3)^(-)in warm months but SO_(4)^(2−)and NH_(4)^(+)in cold months.Short-term exposures to PM_(2.5)compositions were positively associated with increased risks of mortality,particularly those constituents from combustion-related sources. | Peixuan Zhou Jianlin Hu Chuanhua Yu Junzhe Bao Siqi Luo Zhihao Shi Yang Yuan Shaocai Mo Zhouxin Yin Yunquan Zhang | 2022 | Science China(Life Sciences)2022，65，12： | 1 |
| 4 | Second-order Nonlinear optical properties of a Series of Azulene Derivatives显示文摘 | ZhouXin Ren AiMin Fong Jikang | 2004 | Chinese Journal of Chemistry2004，22，： | 1 |
| 5 | 显示文摘 | MAQiang(马强) BAIHua(白桦) WANGChao(王超) ZHANGQing(张庆) ZHOUXin(周新) DONGHui(董辉) WANGBao-lin(王宝麟) | | 分析化学0，，： | 1 |
| 6 | 显示文摘 | Wu Zhouxin Niu Cheng Chen Junhua | 2010 | Ma- terials Review2010，24，3： | 1 |
| 7 | 显示文摘 | Niu Cheng Wu Zhouxin Wang Xibin | 2009 | Journal of Hainan Normal University2009，22，1： | 1 |
| 8 | Optimization of enzyme assisted extraction of polysaccharides from Astragalus membranaceus显示文摘 | CHEN Hua guo ZHOUXin ZHANG Jun-zeng | 2014 | Carbohydrate Polymers2014，111，56： | 1 |
| 9 | Research on the characteristics of acetobater xylinumHN001 strain 显示文摘 | Niu Cheng Wu Zhouxin Wang Xibin | 2009 | J Hainan Normal University2009，22，1： | 1 |
| 10 | nitiation of ER Body Formation and Indole Glucosinolate Metabolism by the Plastidia Retrograde Signaling Metabolite, MEcPP显示文摘植物发展了紧调整的发信号的网络反应并且适应包含的发信号的中心的环境不安,而是性质仍然是一个谜。我们以前建立了那 methylerythritol cyclodiphosphate (MEcPP ) , plastidial isoprenoids 的一位先锋并且一压力特定后退表明代谢物,为高顺序的适应功能启用细胞的重新调整。这里,我们明确地证明 MEcPP 支持二个 Brassicaceae 特定的特点,也就是 endoplasmic 蜂窝胃(嗯) 身体形成和吲哚 glucosinolate (IG ) 的正式就职新陈代谢有选择地,经由关键管理者 NAI1 为的 transcriptional 规定嗯身体形成 ? 并且为 IG 生合成的 MYB51/122 ) 。MEcPP 的特性被正式就职的缺乏进一步证实创伤可诱导嗯象由另外的改变的 methylerythritol 磷酸盐小径酶的 IG 一样的身体基因。基因分析揭示了这些特点的调停 MEcPP 的 COI1 依赖的正式就职。而且,发信号的 MEcPP 作为 bioactive 结束产品通过 nitrile 修饰符 protein1 和简单 nitriles 的 suppressor, ESM1,和生产的减小的正式就职集成 IG 的生合成和水解作用。调查结果位置 ? plastidial 代谢物, MEcPP 作为开始中心, transducing 发信号调整硬连线的基因电路的活动扩展 phytochemical 差异并且改变为第二等的代谢物的功能要求的联系 subcellular 结构,从而定制植物压力回答。 | Jin-Zheng Wang Baohua Li Yanmei Xiao Yu Ni Haiyan Ke Panyu Yang Amancio de Souza Marta Bjornson Xiang He Zhouxin Shen Gerd Ulrich Balcke Steve P. Briggs Alain Tissier Daniel J. Kliebenstein Katayoon Dehesh | 2017 | Molecular Plant2017，10，11： | 1 |
| 11 | 显示文摘 | MAQiang(马强) BAIHua(白桦) WANGChao(王超) MaWei(马微) ZHANGQing(张庆) XIAOQing-haK肖清海) ZHOUXin(周新) DONGYi-yang(董益阳) WANGBaoLin(王宝麟) | | 分析化学0，，： | 1 |
| 12 | 显示文摘 | CAIHong-Ju(蔡宏举) WANGMan-Yi(王满意) ZHOUXin(周鑫) etal | | HuagongXuebao0，，： | 1 |
| 13 | Epitaxial interface stabilizing iridium dioxide toward the oxygen evolution reaction under high working potentials显示文摘Proton exchange membrane water electrolyzer(PEMWE)driven by renewable electricity is a promising technique toward green hydrogen production,but the corrosive environment and high working potential pose severe challenges for developing advanced electrocatalysts for the oxygen evolution reaction(OER).Although Ir-based materials possess relatively balanced activity and stability for the OER,their dissolution behavior cannot be neglected,in particular under high working potentials.In this work,iridium dioxide(IrO_(2))nanoparticles(NPs)were anchored on the surface of exfoliated h-boron nitride(BN)nanosheets(NSs)toward the OER reaction in acid media.Highly active Ir(V)species were stabilized by the epitaxial interface between IrO_(2)and h-BN,and therefore the IrO_(2)/BN delivered stable performance at increased working potentials,while the activity of bare IrO_(2)NPs without h-BN support decreased rapidly.Also,the smaller lattice spacing of h-BN induced compressive strain for IrO_(2),resulting in improved activity.Our results demonstrate the feasibility of stabilizing highly active Ir(V)species for the OER in acid media by constructing robust interface and provide new possibilities toward designing advanced heterostructured electrocatalysts. | Guoqiang Zhao Zhouxin Luo Baohua Zhang Yaping Chen Xiangzhi Cui Jian Chen Yongfeng Liu Mingxia Gao Hongge Pan Wenping Sun | 2023 | Nano Research2023，16，4： | 1 |
| 14 | Incidence, prevalence and outcome of adult respiratory distress syndrome: A 12-month prospective multicenter survey in Shanghai显示文摘A prospective 12-month survey of incidence, risk factors and outcome of acute respiratory distress syndrome (ARDS) was conducted in 15 intensive care units(ICU) in Shanghai during 2001-2002. Of 5320 adult patients admitted to ICUs, there were 108 (2 %) with ARDS diagnosed according to the 1994 American-Eu- | LUYue-Ming SONGZhi-Fang ZHOUXin HUANGShao-Guang ZHUDu-Ming YANGXing-Yi BAIChunXue SUNBo RogerSPRAGG | 2003 | Acta Pharmacologica Sinica2003，24，12： | 0 |
| 15 | Ni-Al mixed metal oxide with rich oxygen vacancies: CO methanation performance and density functional theory study显示文摘Ni-Al mixed metal oxides have been successfully prepared by high shear mixer(HSM)and coprecipitation(CP)methods for low temperature CO methanation.In this work,Ni-Al(HSM-CP)catalyst presented small Ni crystallite size and high surface area,which all contribute to the methanation reaction at low temperature conditions.The obtained Ni-Al(HSM-CP)sample exhibited a mass of defective oxygen,thereby accelerating the dissociation of CO and ultimately increasing the activity of the catalyst.Ni-Al(HSM-CP)catalyst offered the best activity with CO conversion=100%and CH_(4) selectivity=93%at 300℃,and the CH_(4) selectivity can reach 81.8%at 200℃.In situ Fourier transform infrared spectroscopy and density functional theory show that CHO and COH intermediates with lower activation energy barriers are produced during the reaction,and hydrogen-assisted carbon–oxygen bond scission is more favorable. | Zhouxin Chang Feng Yu Zhisong Liu Zijun Wang Jiangbing Li Bin Dai Jinli Zhang | 2022 | Chinese Journal of Chemical Engineering2022，35，6： | 0 |
| 16 | Space Compartment Method for Solving Partial Derivative Equation with Neural Networks——-Application to Steady-state Heat Transfer Problem显示文摘A new method is presented to approximate the solution of Steady-state partial derivative equations (SPDE) with feed forward Artificial neural networks (ANN) in this paper. To realize this, we propose a special structure of ANN and an original way to train the ANN directly from its derivatives, and decompose the operating area into several ones. The main advantage of this approximation is to obtain a solution of SPDE in form of Non-linear functions (NLF). Because this solution can be easily included in VHDL-AMS models, the method is certainly a way to introduce SPDE in multl-domain simulators. To validate our method, we applied it to a twodimension steady-state heat transfer problem. ANN approximation is compared with the high precision solution of Finite element method (FEM). | ZHOUXin LIUBoan SHIBingxue | 2004 | Chinese Journal of Electronics2004，13，4： | 0 |
| 17 | Activation of Proteinkinase ERK Mediates Induction of Macrophage MMP-12 by OxLDL显示文摘The present study was undertaken to investigate the effect of oxidized low density lipoprotein (oxLDL) on the expression of macrophage matrix metalloproteinase-12 (MMP-12), and the possible mechanisms. Activation of extracellular signal-regulated kinase 1/2 (ERK1/2) was detected by Western blot analysis. Enzymatic activity of MMP-12 was determined by β-casein zymogra- phy. RT-PCR analysis was used to measure the mRNA expression level of MMP-12. OxLDL-stimulated macrophages produced increased casein-degrading activities and oxLDL also significantly increased the mRNA level of MMP-12 in a dose-dependent manner. OxLDL stimulated the phosphorylation of ERK1/2 in macrophages. The use of the specific inhibitor indicated that the ERK1/2 signaling pathway was required for the induction of MMP-12. These data demonstrated that oxLDL induced MMP-12 expression in macrophages through an ERK1/2-dependent pathway. | HeChun-yan ZhouXin LiXiao-ming YuHong HongJia-ling | 2004 | Wuhan University Journal of Natural Sciences2004，9，1： | 0 |
| 18 | RGDS Peptides Influence Collagen Type Ⅲ and Laminin in Sera of Liver Cirrhosis Rat and in Cultured Supernatants of Rat Hepatic Stellate Cell显示文摘 | ChengJi-lin ZhouXin LiDing-guo LuHan-ming HuangXin WeiHong-shang WangZhi-rong ZhanYu-tao ZhuJin-hong XuQing-fang | 2000 | 胃肠病学2000，5，B08： | 0 |
| 19 | Short-term effects of fine particulate matter constituents on myocardial infarction death显示文摘Existing evidence suggested that short-term exposure to fine particulate matter(PM_(2.5))may increase the risk of death from myocardial infarction(MI),while PM_(2.5) constituents responsible for this association has not been determined.We collected 12,927 MI deaths from 32 counties in southern China during 2011–2013.County-level exposures of ambient PM_(2.5) and its 5 constituents(i.e.,elemental carbon(EC),organic carbon(OC),sulfate(SO_(4)^(2-)),ammonium(NH_(4)^(+)),and nitrate(NO_(3)^(-)))were aggregated from gridded datasets predicted by Community Multiscale Air Quality Modeling System.We employed a space-time-stratified casecrossover design and conditional logistic regression models to quantify the association of MI mortality with short-term exposure to PM_(2.5) and its constituents across various lag days.Over the study period,the daily mean PM_(2.5) mass concentration was 77.8(standard deviation(SD)=72.7)μg/m^(3).We estimated an odds ratio of 1.038(95%confidence interval(CI):1.003-1.074),1.038(1.013-1.063)and 1.057(1.023-1.097)for MI mortality associated with per interquartile range(IQR)increase in the 3-day moving-average exposure to PM_(2.5)(IQR=76.3μg/m 3),EC(4.1μg/m^(3))and OC(9.1μg/m^(3)),respectively.We did not identify significant association between MI death and exposure to water-soluble ions(SO_(4)^(2-),NH_(4)^(+)and NO_(3)^(-)).Likelihood ratio tests supported no evident violations of linear assumptions for constituents-MI associations.Subgroup analyses showed stronger associations between MI death and EC/OC exposure in the elderly,males and cold months.Short-term exposure to PM_(2.5) constituents,particularly those carbonaceous aerosols,was associated with increased risks of MI mortality. | Shaocai Mo Jianlin Hu Chuanhua Yu Junzhe Bao Zhihao Shi Peixuan Zhou Zhiming Yang Siqi Luo Zhouxin Yin Yunquan Zhang | 2023 | Journal of Environmental Sciences2023，，11： | 0 |
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