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| 1 | Structural insights into substrate recognition by the type Ⅶ secretion system显示文摘Type VII secretion systems(T7SSs)are found in many disease related bacteria including Mycobacterium tuberculosis(Mtb).ESX-1[early secreted antigen 6 kilodaltons(ESAT-6)system 1]is one of the five subtypes(ESX-1?5)of T7SSs in Mfb,where it delivers virulence factors into host macrophages during infection.However,little is known about the molecular details as to how this occurs.Here,we provide high-resolution crystal structures of the C-terminal ATPase3 domains of EccC subunits from four different Mtb T7SS subtypes.These structures adopt a classic RecA-like a/p fold with a conserved Mg-ATP binding site.The structure of EccCbl in complex with the C-terminal peptide of EsxB identifies the location of substrate recognition site and shows how the specific signaling module XxxxMxF'for Mtb ESX-1 binds to this site resulting in a translation of the bulge loop.A comparison of all the ATPase3 structures shows there are significant differences in the shape and composition of the signal recognition pockets across the family,suggesting that distinct signaling sequences of substrates are required to be specifically recognized by different T7SSs.A hexameric model of the EccC-ATPase3 is proposed and shows the recognition pocket is located near the central substrate translocation channel.The diameter of the channel is?25-A,with a size that would allow helix-bundle shaped substrate proteins to bind and pass through.Thus,our work provides new molecular insights into substrate recognition for Mtb T7SS subtypes and also a possible transportation mechanism for substrate and/or virulence factor secretion. | Shuhui Wang Kaixuan Zhou Xiaolin Yang Bing Zhang Yao Zhao Yu Xiao Xiuna Yang Haitao Yang Luke WGuddat Jun Li Zihe Rao | 2020 | Protein & Cell2020，11，2： | 2 |
| 2 | Design of deep pile cap by strut-and-tie model显示文摘 | Adebar P ZHOU Luke | 1996 | ACI Structural Journal1996，93，4： | 1 |
| 3 | Association of a miRNA-137 Polymorphism with Schizophrenia in a Southern Chinese Han Population显示文摘 | Guoda Ma Jingwen Yin Jiawu Fu Xudong Luo Haihong Zhou Hua Tao Lili Cui You Li Zhixiong Lin Bin Zhao Zheng Li Juda Lin Keshen Li Luke Hesson | 2014 | BioMed Research International2014，，： | 1 |
| 4 | Design of deep pile caps by strut-and-tie model显示文摘 | ADEBER P ZHOU LUKE | 1996 | ACI Structural Journal1996，93，4： | 1 |
| 5 | Design of deep pile caps by strut-and-tie model 显示文摘 | Adeber P Zhou Luke | 1996 | ACI Structural Journal1996，，4： | 1 |
| 6 | Towards disentangling the classification of freshwater fish trypanosomes显示文摘Currently,new species of freshwater fish trypanosomes,which are economically important parasites,are being described based on subjectively selected features,i.e.,their cell morphology and the host species.We have performed detailed phylogenetic and haplotype diversity analyses of all 18S rRNA genes available for freshwater fish trypanosomes,including the newly obtained sequences of Trypanosoma carassii and Trypanosoma danilewskyi.Based on a sequence similarity of 99.5%,we divide these trypanosomes into 15 operational taxonomic units,and propose three nominal scenarios for distinguishing T.carassii and other aquatic trypanosomes.We find evidences for the existence of a low number of freshwater fish trypanosomes,with T.carassii having the widest geographic and host ranges.Our analyses support the existence of an umbrella complex composed of T.carassii and two sister species. | Peng Zhang Jie Liu Xiao‑Ming Yin Jun‑Yu Zhou Julius Lukeš Zhao‑Rong Lun De-Hua Lai | 2023 | Marine Life Science & Technology2023，5，4： | 1 |
| 7 | Design of deep pile caps by Strut-and-Tie models 显示文摘 | Adebar Perry Zhou Luke (Zong yu) | 1996 | ACI Structural Journal1996，93，4： | 1 |
| 8 | 结核分枝杆菌PknI激酶通过胞外传感器结构域二聚化被激活的结构研究显示文摘文章简介蛋白激酶对于宿主内结核分枝杆菌的存活起中心作用。课题组解析了丝氨酸/苏氨酸蛋白激酶(STPKs)家族里的跨膜蛋白成员Pkn I的传感器域(单体和二聚体形式)以及激酶域的高分辨率晶体结构。 | Qiaoling Yan Dunquan Jiang Lanfang Qian Qingqing Zhang Wei Zhang Weihong Zhou Kaixia Mi Luke Guddat Haitao Yang 饶子和 | 2018 | 科学新闻2018，0，4： | 0 |
| 9 | Global burden and drivers of hyperglycemia:Estimates and predictions from 1990 to 2050显示文摘Hyperglycemia is a key risk factor for death and disability worldwide.To better inform prevention strategies,we aimed to delineate and predict the temporal,spatial,and demographic patterns in mean fasting plasma glucose(FPG)levels and their related disease burden globally.Based on the Global Burden of Disease Study 2019,we estimated the distributions of mean FPG levels and high FPG-related disease burden by age,sex,year,socioeconomic status(SES),and geographical region from 1990 to 2050. | Hui-Ling Qiu Shujun Fan Kaixin Zhou Zhini He Matthew H.E.M.Browning Luke D.Knibbs Tianyu Zhao Ya-Na Luo Xiao-Xuan Liu Li-Xin Hu Jia-Xin Li Yi-Dan Zhang Yu-Ting Xie Joachim Heinrich Guang-Hui Dong Bo-Yi Yang | 2023 | The Innovation2023，4，4： | 0 |
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