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| 1 | 鼠尾草酚抗乳腺癌细胞增殖活性及其雌激素受体亚型介导和调节机制的研究显示文摘既往研究已经表明,鼠尾草酚(carnoso1)具有一定的抗乳腺癌效应,但其ER亚型特异性调节和介导机制与该物质抑制细胞增殖效应的相关性尚不清楚。该研究利用雌激素受体(ER)阳性乳腺癌T47D细胞观察鼠尾草酚对细胞增殖活性的影响及其雌激素受体α,卢亚型特异性介导和调节机制。以ERα和ERβ特异性拮抗剂MPP,PHTPP为工具药,采用MTT细胞增殖实验观察鼠尾草酚对T47D细胞增殖的影响;检测T47D细胞增殖周期的变化。利用Western blot方法检测鼠尾草酚对T47D细胞ERα和ERβ表达情况的影响。研究发现,1×10^(-5)~1×10^(-7)mol·L^(-1)鼠尾草酚能够显著抑制T47D细胞增殖,该抑制作用可被ERα拮抗剂MPP增强、被ERβ拮抗剂PHTPP减弱;1×10^(-1),1×10^(-6)mol·L^(-1)鼠尾草酚可使T47D细胞增殖指数显著下降。Western blot检测结果显示1×10^(-5),1×10^(-6)mol·L^(-1)鼠尾草酚可使T47D细胞ERα和ERβ蛋白表达显著增加,并可明显提高ERα/ERβ。结果表明鼠尾草酚具有抑制ER阳性乳腺癌细胞增殖的作用,其效应是通过靶细胞雌激素受体,特别是ERβ途径实现的;同时,鼠尾草酚对靶细胞雌激素受体ERα和ERβ亚型的表达及其比例具有调节功能。 | 赵丕文 David Yue-Wei LEE Zhongze Ma 孙艳玲 陶仕英 臧金凤 牛建昭 | 2014 | 中国中药杂志2014，39，17： | 10 |
| 2 | Palaeoecological and palaeoenvironmental significance of someimportant spores and micro-algae in Quaternary deposits显示文摘Spores of ferns and allied plants, and micro-algae frequently occur in abundance in Quaternary deposits, but their palaeoenvironmental significance is seldom evaluated. This paper presents morphological descriptions of spores of Selaginella sinensis (Desv.) Spring, 1843 (Selaginellaceae) and Ceratopteris cf. thalictroides (L.) Brongniart, 1821 (Parkeriaceae) and the algae Pediastrum boryanum (Turpin) Meneghini, 1840, P. simplex Meyen, 1829, P. integrum N geli, 1849 (all Hydrodictyaceae), Spiniferites Mantell, 1850, emend. Sarjeant, 1970 (Spiniferitaceae) and Concentricystes Rossignal, 1962, emend. Jiabo, 1978 (systematic position unclear), and discusses their occurrence in mostly Quaternary sedimentary successions. All are closely associated with aquatic habitats. Extant Selaginella sinensis often colonizes fairly wet hillsides and gaps between rocks, and shady sides of ravines and slopes; it is also found within thickets of trees and shrubs (boscages) and in forests with calcareous soils. Ceratopteris thalictroides, Pediastrum and Concentricystes inhabit freshwater lakes and both natural and artificial wetlands, such as paddy fields and ditches. Spiniferites is a salt-water genus and usually associated with the marine realm. Fossil and subfossil representatives of all of these taxa can be useful proxies of biodiversity and, therefore, also important for determining environmental conditions during the Quaternary period. | TANG LingYu MAO LiMi Lü XinMiao MA QingFeng ZHOU ZhongZe YANG ChunLei KONG ZhaoChen BATTEN David J | 2013 | Chinese Science Bulletin2013，58，25： | 9 |
| 3 | Analysis of abnormal texture formation and strengthening mechanism in an extruded Mg-Gd-Y-Zn-Zr alloy显示文摘A Mg-Gd-Y-Zn-Zr magnesium alloy with different initial states was extruded under different extrusion parameters.The effect of solution treatment and extrusion parameters on the microstructure,texture and mechanical properties were analyzed in detail,and the abnormal texture formation and strengthening mechanism was revealed.When extruded at low temperature and small extrusion ratio,the bimodal microstructure consisting of fine dynamically recrystallized grains and coarse deformed grains occurred both in the as-cast alloy and solution-treated alloy.When the extrusion temperature and extrusion ratio were increased,the amount and size of dynamically recrystallized grains increased and the grain size of the solution-treated alloy showed higher growth rate.Furthermore,an abnormal texture with<0001>parallel with extrusion direction developed due to the occurrence of non-basal slip and continuous dynamic recrystallization.This could be enhanced by solution treatment,high temperature,and large extrusion ratio.Both the as-cast alloy and solution-treated alloy exhibited the highest tensile strength after extrusion at 300℃with an extrusion ratio of 9.Grain refinement was the main strengthening mechanism utilized in both the as-cast alloy and the solution-treated alloy.Work hardening played an important role in the sample extruded at low temperature and small extrusion ratio,with the highest contribution of about 33 MPa after extrusion at 300℃with an extrusion ratio of 9.Texture strengthening contributed more in the sample extruded at high temperature and large extrusion ratio,but no more than 24.1 MPa.Solution strengthening was another strengthening mechanism in the extruded as-cast alloy,especially at high temperature and large extrusion ratio(no more than 9 MPa). | Xueze Jin Wenchen Xu Zhongze Yang Can Yuan Debin Shan BugangTeng Bo Cheng Jin | 2020 | Journal of Materials Science & Technology2020，42，10： | 7 |
| 4 | Static and dynamic design based on hierarchical optimization for materials and structure of porous metals显示文摘A static and dynamic collaborative optimization method for materials and structure with uniform periodic microstructure is presented.The sensitivity formulae of hierarchical optimization,i.e.,material design,structure design and integrated design for porous metals,are given.On the base of the hierarchical optimization model,numerical experiments of an MBB beam and a cantilever one were carried out.Based on porous metals bearing multi-functionality,the differences and applicability of hierarchical optimization are discussed in the structure loading field.It is concluded that structure design is mainly oriented to structure efficiency,material design is mainly oriented to multi-functionality,and integrated design is oriented to structure efficiency and multi-functionality.This work provides some useful ideas for the selection of porous metals design method. | LIU YuanDong YIN YiHui GUO ZhongZe | 2012 | Science China(Technological Sciences)2012，55，10： | 4 |
| 5 | Structural topology optimization under stationary random base acceleration excitations显示文摘Structural topology optimization subjected to stationary random base acceleration excitations is investigated in this paper. In the random response analysis, the Large Mass Method(LMM) which attributes artificial large mass values at each driven nodal Degree Of Freedom(DOF) to transforming the base acceleration excitations into force excitations is proposed. The Complete Quadratic Combination(CQC) which is commonly used to calculate the random responses in previous optimization has been proven to be computationally expensive especially for large-scale problems. In order to conquer this difficulty, the Pseudo Excitation Method(PEM) and the combined method of PEM and Mode Acceleration Method(MAM) are adopted into the dynamic topology optimization, and random responses are calculated using these two methods to ascertain a high efficiency over the CQC. A density-based topology optimization method minimizing dynamic responses is then formulated based on the integration of LMM and PEM or the combined method of PEM and MAM. Numerical examples are presented to verify the accuracy of the proposed schemes in dynamic response analysis and the quality of the optimized design in improving dynamic performance. | Fei HE Hongqiang LIAO Jihong ZHU Zhongze GUO | 2019 | Chinese Journal of Aeronautics2019，32，6： | 3 |
| 6 | Three-Dimensional Direct Laser Writing of PEGda Hydrogel Microstructures with Low Threshold Power using a Green Laser Beam显示文摘Three-dimensional(3D)direct laser writing(DLW)based on two-photon polymerisation(TPP)is an advanced technology for fabricating precise 3D hydrogel micro-and nanostructures for applications in biomedical engineering.Particularly,the use of visible lasers for the 3D DLW of hydrogels is advantageous because it enables high fabrication resolution and promotes wound healing.Polyethylene glycol diacrylate(PEGda)has been widely used in TPP fabrication owing to its high biocompatibility.However,the high laser power required in the 3D DLW of PEGda microstructures using a visible laser in a high-water-content environment limits its applications to only those below the biological laser power safety level.In this study,a formula for a TPP hydrogel based on 2-hydroxy-2-methylpropiophenone(HMPP)and PEGda was developed for the fabrication of 3D DLW microstructures at a low threshold power(0.1 nJ per laser pulse at a writing speed of 10μm·s^(−1))in a high-water-content environment(up to 79%)using a green laser beam(535 nm).This formula enables the fabrication of microstructures with micrometre fabrication resolution and high mechanical strength(megapascal level)and is suitable for the fabrication of waterresponsive,shape-changing microstructures.These results will promote the utilisation of low-power 3D DLW for fabricating hydrogel microstructures using visible lasers in high-water-content environments. | Haoyi Yu Haibo Ding Qiming Zhang Zhongze Gu Min Gu | 2021 | Light(Advanced Manufacturing)2021，2，1： | 3 |
| 7 | Survival of patients with distal esophageal and gastric cardia tumors: A population-based analysis of gastroesophageal junction carcinomas显示文摘 | Bryan A. Whitson Shawn S. Groth Zhongze Li Robert A. Kratzke Michael A. Maddaus | 2010 | The Journal of Thoracic and Cardiovascular Surgery2010，，1： | 2 |
| 8 | Results of Clinical Trial of Superficially-placed Tumor Therapy with Carbon Ions at Heavy Ion Research Facility in Lanzhou(HIRFL显示文摘 | Zhang Hong Li Sha Wang Xiaohu Li Qiang Zhao Weiping Dai Zhongying Wei Shihua Gao Liying Xiao Guoqing Xu Hushan Hu Zhengguo Mao Ruishi Yue Yangjun Ran Juntao Tian Zhongze Song Mingtao Zhao Hongwei Zhan Wenlong | 2007 | 近代物理研究所和兰州重离子加速器实验室年报:英文版2007，，1： | 2 |
| 9 | Effect of quenching temperature on structure and properties of centrifugal casting high speed steel roll显示文摘The critical points and time-temperature-transformation(TTT)curves of the isothermal transformation diagrams for a high-speed steel casting on a horizontal centrifugal casting machine had been determined experimentally in the study.The effects of quenching temperature on the microstructures and properties of centrifugal casting high speed steel(HSS)roll has been investigated using scanning electron microscopy(SEM), light optical microscopy(LOM)and X-ray diffraction(XRD)as well as using tensile,impact,and hardness tests. The results show that the HSS roll has excellent hardenability and its matrix structure can be transformed into the martensite after being quenched in the sodium silicate solution.The retained austenite in the quenching structure increases and the hardness decreases when the quenching temperature exceeds 1,040℃.The tensile strength and impact toughness of HSS roll increase once the quenching temperature is raised from 980℃to 1,040℃. However,the tensile strength and impact toughness have no significant change when the quenching temperature exceeds 1,040℃.The HSS roll quenched at 1,040℃exhibits excellent comprehensive mechanical properties. | Fu Hanguang Cheng Xiaole Du Zhongze Lei Yingping Feng Zhenjun | 2009 | China Foundry2009，6，1： | 2 |
| 10 | Origin area and migration route: Chloroplast DNA diversity in the arctic-alpine plant Koenigia islandica显示文摘The Hengduan Mountains(henceforth H-D Mountains) on the Tibet Plateau are a distribution and diversity center for many alpine genera. We examine patterns of genetic variation in an arctic-alpine plant to evaluate the possibility that the H-D Mountains constitute the area of origin of the species as well as to uncover postglacial migration routes. 220 individuals of the arctic-alpine plant Koenigia islandica were sampled from 26 populations distributed in western China and northern Finland. DNA haplotypes were identified using restriction site analysis of two chloroplast DNA intergene spacer regions, atpB-rbcL and trnL-trnF. We examined the geographical distribution of haplotype diversity in relation to latitude, and also compared various indices of diversity in putatively glaciated and unglaciated regions. Patterns of migration were inferred using nested clade analysis. A total of 25 haplotypes were detected. High haplotype diversity was found in the H-D Mountains. H3 and its radiated haplotypes were distributed in the Himalayas. Two haplotypes were fixed concurrently in the H-D Mountains and northern Finland. High genetic diversity of K. islandica and high species diversity of K. islandica are expected in the origin area. Our observations suggest that the H-D Mountains are not only the place of origin of K. islandica, but also the refugia for K. islandica on the Tibet Plateau. What is more, the migration route for the arctic-alpine plant K. islandica must have originated in the region defined by the H-D Mountains in western China extending northward to the Arctic circumpolar, and moved westward along the Himalayas, then northward across the Altay Mountains and the Central Siberian Plateau at different time periods. | LONG Cong MIN YunJiang ZHAO XiuXia YANY ChunLei SUN Hang Lü HouYuan TANG LingYu ZHOU ZhongZe | 2014 | Science China Earth Sciences2014，57，8： | 2 |
| 11 | First Clinical Trial of Cancer Therapy with Heavy Ions at IMP显示文摘 | Zhang Hong Li Sha Li Qiang Wei Shihua Hu Zhengguo Mao Ruishi Dai Zhongying Xu Hushan Tian Zhongze Yue Yangjun ZhaoWeiping Xiao Guoqing | 2006 | 近代物理研究所和兰州重离子加速器实验室年报:英文版2006，，1： | 2 |
| 12 | Discovery and demonstration of small circular DNA molecules derived from Chinese tomato yellow leaf curl virus显示文摘Tomato yellow leaf curl viruses belong to Begomoviruses of geminiviruses. In this work, we first found and demonstrated that the small circular DNA molecules were derived from Chinese tomato yellow leaf curl viruses (TYLCV-CHI). These small circular DNA molecules are about 1.3 kb, which are half the full-length of TYLCV-CHI DNA A. It was shown by sequence determination and analysis that there was unknown-origin sequence insertion in the middle of the small molecules. These sequences of unknown-origin were neither homologous to DNA A nor to DNA B, and were formed by recombination of virus DNA and plant DNA. Although various defective molecules contained different unknown-origin sequence insertion, all the molecules contained the intergenic region and part of the AC1 (Rep) gene. But they did not contain full ORF. | YIN Qinyan ZHANG Ying ZHANG Yuman LIU Yule ZHANG Zhongze TIAN Po | 2000 | Chinese Science Bulletin2000，45，15： | 2 |
| 13 | Advances of multiplex and high throughput biomolecular detection technologies based on encoding microparticles显示文摘The rapid developments of genomics and proteomics have driven the demand for multiplex and high throughput analysis of large numbers of biomolecules in the fields of medical diagnostics, drug discovery, and environmental monitoring. Encoding the biomolecular binding events is the key technique to fulfill this demand, in which microparticles play the most important roles. This review outlines the development of multiplex and high throughput biodetections, and highlights the most recent advances in the field of encoding microparticles, together with problems that need to be resolved. | ZHAO XiangWei, ZHAO YuanJin & GU ZhongZe State Key Laboratory of Bioelectronics Southeast University, Nanjing 210096, China | 2011 | Science China Chemistry2011，54，8： | 2 |
| 14 | A Prospective Clinical Study of Proximal Humerus Fractures Treated With a Locking Proximal Humerus Plate显示文摘 | Huiguang Yang Zhongze Li Feng Zhou Daoyuan Wang Baoliang Zhong | 2011 | Journal of Orthopaedic Trauma2011，，1： | 1 |
| 15 | Rapid synthesis of monodisperse polymer spheres for self-assembled photonie crystals显示文摘 | Gu Zhongze Chen Haihua Zhang Shuai | 2007 | Colloids and Surfaces A:2007，302，： | 1 |
| 16 | Dietary glycine and renal denervation prevents eyclosporin A-induced hydroxyl radical production in rat kidney显示文摘 | ZhongZ Connor HD Yin M | 1999 | Mol Pharmacol1999，56，： | 1 |
| 17 | The investigation of electrospun polymer nanofibers as a solid-phase extraction sorbent for the determination of trazodone in human plasma显示文摘 | Xuejun Kang Cao Pan Qian Xu Yingfang Yao Yian Wang Dongjin Qi Zhongze Gu | 2007 | Analytica Chimica Acta2007，，1： | 1 |
| 18 | LRP5andLRP6indevelopmentanddisease显示文摘 | JoinerDM KeJ ZhongZ etal | 2013 | TrendsEndocrinolMetab2013，24，1： | 1 |
| 19 | Analysis of air-gap field modulation and magnetic gearing effects in switched flux permanent magnet machines显示文摘 | Wu Zhongze | 2015 | IEEE Transactions on Magnetics2015，51，5： | 1 |
| 20 | Lrp5andLrp6playcompensatoryrolesinmouseintestinaldevelopment显示文摘 | ZhongZ BakerJJ Zylstra-DiegelCR etal | 2012 | JCellBio-chem2012，113，1： | 1 |
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