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| 1 | Preparation of human hepatocellular carcinoma-targeted liposome microbubbles and their immunological properties显示文摘AIM: To prepare the human hepatocellular carcinoma_(HCC)targeted liposome microbubbles and to investigate their immunological properties.METHODS: Human hepatocarcinoma specific monoclonal antibody HAb18 was attached to the surface of home-made liposome microbubbles by static attraction to prepare the targeted liposome microbubbles. The combination of HAb18 with liposome microbubbles was confirmed by the slide agglutination test and immunofluorescent assay. Their immunological activity was measured by ELISA. Rosette formation test, rosette formation blocking test and immunofluorescent assay were used to identify the specific binding of targeted liposome microbubbles to SMMC-7721 hepatoma cells, and cytotoxicity assay was used to detect their effect on human hepatocytes.RESULTS: The targeted liposome microbubbles were positive in the slide agglutination test and immunofluorescent assay. ELISA indicated that the immunological activity of HAb18 on the liposome microbubbles was similar to that of free HAb18. SMMC-7721 cells were surrounded by the targeting liposome microbubbles to form rosettes, while the control SGC-7901 gastric cancer cells were not. Proliferation of SMMC-7721 cells and normal human hepatocytes was not influenced by the targeted liposome microbubbles.CONCLUSION: The targeted liposome microbubbles with a high specific biological activity have been successfully prepared, which specifically bind to human hepatocarcinoma cells, and are non-cytotoxic to hepatocytes. These results indicate that the liposome microbubbles can be used as a HCC-targeted ultrasound contrast agent that may enhance ultrasound images and thus improve the diagnosis of HCC,especially at the early stage. | Ai-NaBian Yun-HuaGao Kai-BinTan PingLiu Gong-JunZeng XinZhang ZhengLiu | 2004 | World Journal of Gastroenterology2004，10，23： | 11 |
| 2 | Influence of nonionic surfactant on the solubilization and biodegradation of phenanthrene显示文摘Phenanthrene was solubilized in two different nonionic surfactants, Tween80 and Triton X-100. The bioavailability of phenanthrene to the bacteria isolated from the petroleum contaminated soils was studied based on the rotary flasks experiments. The results showed that the concentration of nonionic surfactants above the critical micelle concentration(CMC) can increase the solubility of phenanthrene in water and were innoxious to the phenanthrene-degrading bacteria; phenanthrene solubilized in the micelles of Tween80 was bioavailable and biodegradable. The research demonstrated the potential of surfactant-enhanced bioremediation of soils contaminated by hydrophobic organic compounds(HOCs). | YANGJian-gang LIUXiang LONGTao YUGang PENGShe ZHENGLiu | 2003 | Journal of Environmental Sciences2003，15，6： | 8 |
| 3 | Grey scale enhancement of rabbit liver and kidney by intravenous injection of a new lipid-coated ultrasound contrast agent显示文摘AIM: To assess the grey scale enhancement of a new lipidcoated ultrasound contrast agent in solid abdominal organs as liver and kidney.METHODS: Size distribution and concentration of the lipidcoated contrast microbubbles were analyzed by a Coulter counter. Two-dimensional (2D) second harmonic imaging of the hepatic parenchyma, the inferior vena cava and the right kidney of the rabbits were acquired before and after contrast agent injection. Images were further quantified by histogram in Adobe Photoshop 6.0. Time-intensity curves of hepatic parenchyma, inferior vena cava and renal cortex were qenerated from the oriqinal qrev scale.RESULTS: The 2D images of hepatic parenchyma and cortex of the kidney were greatly enhanced after injection and the peak time could last more than 50 min.CONCLUSION: This new lipid ultrasound contrast agent could significantly enhance the grey scale imaging of the hepatic parenchyma and the renal cortex for more than 50 min. | PingLiu Yun-HuaGao Kai-BinTan ZhengLiu SongZuo | 2004 | World Journal of Gastroenterology2004，10，16： | 3 |
| 4 | Effects of Three Target‐Controlled Concentrations of Sufentanil on MACBAR of Sevoflurane显示文摘 | ZhengLiu Jia‐FengWang YanMeng Xiao‐HuaFan Xiao‐MingDeng Jin‐BaoLi Guo‐JunCai | 2012 | CNS Neuroscience & Therapeutics2012，，： | 1 |
| 5 | Large‐Area Vapor‐Phase Growth and Characterization of MoS<sub>2</sub> Atomic Layers on a SiO<sub>2</sub> Substrate显示文摘 | YongjieZhan ZhengLiu SinaNajmaei Pulickel M.Ajayan JunLou | 2012 | Small2012，，7： | 1 |
| 6 | Nanoparticulate TiO<sub>2</sub>(B): An Anode for Lithium‐Ion Batteries显示文摘 | YuRen ZhengLiu FrédériquePourpoint A. RobertArmstrong Clare P.Grey Peter G.Bruce | 2012 | Angew Chem Int Ed2012，，9： | 1 |
| 7 | A combination strategy for multi-class classification based on multiple association rules显示文摘 | Ye Zhengliu Yuan Chunjiang Xiao Liu | 2008 | Knowledge-Based Systems2008，21，8： | 1 |
| 8 | Characteristics of acute and sub‐acute liver failure in China: nomination, classification and interval显示文摘 | QingLiu ZhengLiu TailingWang QingguoWang XiaohongShi WenbinDao | 2007 | Journal of Gastroenterology and Hepatology2007，，12： | 1 |
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