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| 1 | Comparison of simple discectomy and instrumented posterior lumbar interbody fusion for treatment of lumbar disc herniation combined with Modic endplate changes显示文摘 | Cao Peng Chen Zhe Zheng Yuehuan Wang Yuren Jiang Leisheng Yang Yaoqi Zhuang Chengyu Liang Yu Zheng Tao Gong Yaocheng Zhang Xingkai Wu Wenjian Qiu Shijing | 2014 | Chinese Medical Journal2014，，15： | 15 |
| 2 | Intracellular and Extracellular Phosphatidylinositol 3-Phosphate Produced by Phytophthora Species Is Important for Infection显示文摘Phytophthora 病原体生产的 RxLR 受动器被建议了把 3 磷酸盐(PtdIns (3 ) P ) 绑在 phosphatidylinositol 调停他们的 translocation 进主人房间或到增加他们在 planta 的稳定性。因为在植物的 PtdIns (3 ) P 的层次是低的,我们检验了 Phytophthora 种类是否可以生产 PtdIns (3 ) 支持感染的 P。我们观察了 P 特定的 GFP 生物传感器能绑在 P 的那 PtdIns (3 ) 。parasitica 和 P。sojae hyphae 短暂地在 Nicotiana benthamiana 的感染期间离开 secreting 生物传感器,建议 hyphae 暴露了 PtdIns (3 ) 他们的血浆膜上的 P 或分泌 PtdIns (3 ) P。phosphatidylinositol 3-kinases (PI3K ) 的 Silencing 基因,有 LY294002 的处理,或 PtdIns (3 ) 的表示由 P 的 P 有约束力的蛋白质。sojae 在大豆上减少了病原体的毒力,显示综合病原体的 PtdIns (3 ) P 为完整的毒力被要求。PtdIns (3 ) 的分泌物 P 有约束力的蛋白质或由 N 的 PI3P-5-kinase。benthamiana 叶子显著地由 P 增加了抵抗的水平到感染。parasitica 和 P。capsici。一起,我们的结果支持假设那 Phytophthora 种生产外部 PtdIns (3 ) 帮助感染的 P,例如支持 RxLR 受动器的入口进宿主细胞。我们的结果源于 P。sojae RxLR 受动器 Avr1b 证实 N 终点和这个受动器的 C 终点能绑 PtdIns (3 ) P。 | Shan Lu | 2013 | Molecular Plant2013，6，5： | 7 |
| 3 | Performance Analysis of ACO on the Quadratic Assignment Problem显示文摘The Quadratic assignment problem(QAP)is to assign a set of facilities to a set of locations with given distances between the locations and given flows between the facilities such that the sum of the products between flows and distances is minimized, which is a notoriously difficult NP-hard combinatorial optimization problem. A lot of heuristics have been proposed for the QAP problem, and some of them have proved to be efficient approximation algorithms for this problem. Ant colony optimization(ACO) is a general-purpose heuristic and usually considered as an approximation algorithms for NP-hard optimization problems. However, we know little about the performance of ACO for QAP from a theoretical perspective. This paper contributes to a theoretical understanding of ACO on the QAP problem. The worst-case bound on a simple ACO algorithm called(1+1) Max-min ant algorithm((1+1) MMAA) for the QAP problem is presented.It is shown that a degenerate(1+1) MMAA finds an approximate solution on the QAP problem. Finally, we reveal that ACO can outperform the 2-exchange local search algorithm on an instance of the QAP problem. | XIA Xiaoyun ZHOU Yuren | 2018 | Chinese Journal of Electronics2018，27，1： | 6 |
| 4 | Breast cancer stem-like cells can promote metastasis by activating platelets and down-regulating antitumor activity of natural killer cells显示文摘OBJECTIVE:To investigate whether cancer stem cells(CSCs) more efficiently activating platelets and evading immune surveillance than non-CSCs thus promoting metastasis.METHODS:We enriched and identified sphereforming cells(SFCs) and coincubated washed platelets with several platelet activators including collagen,4T1 and SFCs.Platelet-coating tumor cells,platelet activation and TGF-β1 release were analyzed.Then natural kell cells(NK) were incubated with supernatants of different activated platelet samples what we called sample release(SR).The degranulation assay and NKG2 D expression on NK cells were conducted by flow cytometry.Finally tissue factor(TF) expression of SFCs or 4T1 were evaluated by western blot.RESULTS:Breast cancer cell line 4T1 could form spheres in serum-free medium at low adherence.Sphere-forming cells expressed high levels of the CD24-/lowCD44 + stem cell phenotype.Both sphere-forming cells or 4T1 were coated with abundant platelets while sphere-forming cells induced significantly higher expression of platelet activating receptor CD62 p than 4T1 did(P < 0.01).And sphere-forming cells induced platelets to produce more TGF-β1 than 4T1 did(P < 0.01).Furthermore,sample releases induced by sphere-forming cells caused more vigorous inhibition of NK cells antitumor reactivity(P < 0.05) and reduced NKG2 D expression(P < 0.01).The final results showed that sphere-forming cells expressed higher levels of TF than 4T1(P < 0.05).CONCLUSION:Our findings indicate that CSCs could efficiently activate platelets,induce platelets to secrete more TGF-β1,decrease NKG2 D expression and inhibit antitumor activity of NK cell,compared with 4T1.And higher levels of TF expression of CSCs may account for this correlation of CSCs and platelets. | Wang Shuo Zhang Ying Cong Weihong Liu Jie Zhang Yuren Fan Huiting XuYonggang Lin Hongsheng | 2016 | Journal of Traditional Chinese Medicine2016，36，4： | 5 |
| 5 | Interface charges boosted ultrafast lithiation in Li_4Ti_5O_12 revealed by in-situ electron holography显示文摘It is still a great challenge at present to combine the high rate capability of the electrochemical capacitor with the high electrochemical capacity feature of rechargeable battery in energy storage and transport devices.By studying the lithiation mechanism of Li_4Ti_5O_(12)(LTO)using in-situ electron holography,we find that double charge layers are formed at the interface of the insulating Li_4Ti_5O_(12)(Li4)phase and the semiconducting Li_7Ti_5O_(12)(Li7)phase,and can greatly boost the lithiation kinetics.The electron wave phase of the LTO particle is found to gradually shrink with the interface movement,leaving a positive electric field from Li7 to Li4 phase.Once the capacitive interface charges are formed,the lithiation of the core/shell particle could be established within 10 s.The ultrafast kinetics is attributed to the built-in interface potential and the mixed Ti^(3+)/Ti^(4+)sites at the interface that could be maximally lowering the thermodynamic barrier for Li ion migration. | Yuren Wen Xiao Chen Xia Lu Lin Gu | 2018 | Journal of Energy Chemistry2018，27，5： | 4 |
| 6 | PSA controls hepatic lipid metabolism by regulating the NRF2 signaling pathway显示文摘The activity of proteinase is reported to correlate with the development and progression of nonalcoholic fatty liver disease(NAFLD).Puromycin-sensitive aminopeptidase(PSA/NPEPPS)is an integral nontransmembrane enzyme that functions to catalyze the cleavage of amino acids near the N-terminus of polypeptides.A previous study suggested that this enzyme acts as a regulator of neuropeptide activity;however,the metabolic function of this enzyme in the liver has not been explored.Here,we identified the novel role of PSA in hepatic lipid metabolism.Specifically,PSA expression was lower in fatty livers from NAFLD patients and mice(HFD,ob/ob,and db/db).PSA knockdown in cultured hepatocytes exacerbated diet-induced triglyceride accumulation through enhanced lipogenesis and attenuated fatty acid β-oxidation.Moreover,PSA mediated activation of the master regulator of antioxidant response,nuclear factor erythroid 2-related factor 2(NRF2),by stabilizing NRF2 protein expression,which further induced downstream antioxidant enzymes to protect the liver from oxidative stress and lipid overload.Accordingly,liver-specific PSA overexpression attenuated hepatic lipid accumulation and steatosis in ob/ob mice.Furthermore,in human liver tissue samples,decreased PSA expression correlated with the progression of NAFLD.Overall,our findings suggest that PSA is a pivotal regulator of hepatic lipid metabolism and its antioxidant function occurs by suppressing NRF2 ubiquitination.Moreover,PSA may be a potential biomarker and therapeutic target for treating NAFLD. | Bangliang Huang Xin Xiong Linlin Zhang Xiufei Liu Yuren Wang Xiaoli Gong Qian Sang Yongling Lu Hua Qu Hongting Zheng Yi Zheng | 2021 | Journal of Molecular Cell Biology2021，13，7： | 4 |
| 7 | Ordered SnO nanoparticles in MWCNT as a functional host material for high-rate lithium-sulfur battery cathode显示文摘锂硫电池成为了下一代电池的最有希望的候选人之一,并且它仍然由于低硫传导性,大卷扩大和严重 polysulfide shuttling 被限制。此处,我们在场有第三的 nanomaterial 的一个新奇混合电极基于使硫妊娠的 multiwalled 碳 nanotubes 充满了订的听一氧化物 nanoparticles (MWCNT-SnO/S ) 。用一个干燥血浆减小方法,机械地柔韧的材料为锂硫电池作为阴极主人材料作好准备。MWCNT-SnO/S 电极在重复费用分泌物进程期间展出高电导率,捕获 polysulfides 的好能力,和小卷变化。在 situ 传播电子显微镜学和紫外可见的吸收,结果显示 MWCNT-SnO 主人高效地在 lithiation 和还原剂 polysulfide 溶解期间压制卷扩大进电解质。而且,在 MWCNT 的订的 SnO nanoparticles 由充当在 MWCNT 的墙之间的连接连接在氧化还原作用反应期间便于快离子 / 电子转移。有 70 wt.% 的一个高硫内容的 MWCNT-SnO/S 阴极展出 1,682.4 mAh 的一个起始的分泌物能力 ? 档牡敧 ? 湩猠瑩 ? 楷桴攠瑸牥慮? 硥楣慴楴湯戠 ?? 桷瑩 ? 楬桧整業瑴湩 ? 楤摯吗? | A-Young Kim Min Kyu Kim Ji Young Kim Yuren Wen Lin Gu Van-Duong Dao Ho-Suk Choi Dongjin Byun Joong Kee Lee | 2017 | Nano Research2017，10，6： | 3 |
| 8 | Periostin mediates epithelial-mesenchymal transition through the MAPK/ERK pathway in hepatoblastoma显示文摘Objective: The aim of the present study was to analyze the prognostic factors in patients with hepatoblastoma(HB) in our single center and to evaluate periostin(POSTN) expression in HB and its association with clinicopathological variables. In addition, the underlying mechanism of how POSTN promotes HB progression was discussed.Methods: POSTN expression was investigated in HB tumors by immunohistochemistry(IHC), immunofluorescence(IF) and Western blot(WB). The association among POSTN expression, clinicopathological features and overall survival(OS) was also evaluated. The migration and adhesion ability of HB cells were measured using chemotaxis and cell-matrix adhesion assays,respectively. Epithelial-mesenchymal transition(EMT)-associated markers and activation of the ERK pathway were detected by WB.Results: HB patients had poor prognosis which displayed lymph node metastasis, vascular invasion, POSTN and vimentin expression. POSTN expression was also associated with lymph node metastasis. Furthermore, overexpressed POSTN promoted migration and the adhesive ability of HB cells in vitro. In addition, we demonstrated that POSTN activated the MAPK/ERK pathway, upregulated the expression of Snail and decreased the expression of OVOL2. Finally, POSTN promoted the expression of EMT-associated markers.Conclusions: POSTN might modulate EMT via the ERK signaling pathway, thereby promoting cellular migration and invasion.Our study also suggests that POSTN may serve as a therapeutic biomarker in HB patients. | Lu Chen Xiangdong Tian Wenchen Gong Bo Sun Guangtao Li Dongming Liu Piao Guo Yuchao He Ziye Chen Yuren Xia Tianqiang Song Hua Guo | 2019 | Cancer Biology & Medicine2019，16，1： | 3 |
| 9 | Atomically Dispersed Fe-Co Bimetallic Catalysts for the Promoted Electroreduction of Carbon Dioxide显示文摘The electroreduction reaction of CO_(2)(ECO_(2)RR)requires high-performance catalysts to convert CO_(2)into useful chemicals.Transition metal-based atomically dispersed catalysts are promising for the high selectivity and activity in ECO_(2)RR.This work presents a series of atomically dispersed Co,Fe bimetallic catalysts by carbonizing the Fe-introduced Co-zeolitic-imidazolate-framework(C-Fe-Co-ZIF)for the syngas generation from ECO_(2)RR.The synergistic effect of the bimetallic catalyst promotes CO production.Compared to the pure C-Co-ZiF,C-Fe-Co-ZIF facilitates CO production with a CO Faradaic efficiency(FE)boost of 10%,with optimal FE_(CO)of 51.9%,FE_(H_(2))of 42.4%at-0.55 V,and CO current density of 8.0 mA cm^(-2)at-0.7 V versus reversible hydrogen electrode(RHE).The H_(2)/CO ratio is tunable from 0.8 to 4.2 in a wide potential window of-0.35 to-0.8 V versus RHE.The total FE_(CO+H_(2))maintains as high as 93%over 10 h.The proper adding amount of Fe could increase the number of active sites and create mild distortions for the nanoscopic environments of Co and Fe,which is essential for the enhancement of the CO production in ECO_(2)RR.The positive impacts of Cu-Co and Ni-Co bimetallic catalysts demonstrate the versatility and potential application of the bimetallic strategy for ECO_(2)RR. | Zhangsen Chen Gaixia Zhang Yuren Wen Ning Chen Weifeng Chen Tom Regier James Dynes Yi Zheng Shuhui Sun | 2022 | Nano-Micro Letters2022，14，2： | 3 |
| 10 | Reduced endoplasmic reticulum luminal calcium links saturated fatty acid-mediated endoplasmic reticulum stress and cell death in liver cells显示文摘 | Yuren Wei Dong Wang Christopher L. Gentile Michael J. Pagliassotti | 2009 | Molecular and Cellular Biochemistry (-)2009，，1： | 2 |
| 11 | Manufacturing techniques for EPDM 显示文摘 | Chin YuRen | 1999 | Europe-an Rubber Journal1999，181，1： | 1 |
| 12 | Electrospinning direct preparation of SnO2/Fe2O3 heterojunction nanotubes as an efficient visible-light photocatalyst显示文摘 | Zhu Chengquan Li Yuren Su Qing | 2013 | Journal of Alloys and Compounds2013，575，6： | 1 |
| 13 | Crack and size-dependence of shear modulus in a drying particulate film显示文摘We utilized controlled vertical drying deposition (CVDD) method,which can fabricate a uniform face-center-cubic (FCC) structure film,to investigate the crack formation and the size dependence of shear modulus in a drying particulate film.We found that both crack spacing and shear modulus depend on colloidal particle size.They drop with increase of particle radius (R) in a single range.Furthermore,compared with the shear modulus variation of a dry particulate film,it was found that both solid part and liquid part in a drying particulate film play equivalent roles in the film mechanical behavior. | CAO He LAN Ding WANG YuRen | 2012 | Science China(Physics,Mechanics & Astronomy)2012，55，6： | 1 |
| 14 | A finite element model for static and dynamical analysis of thin -walled beams with asymmetric cross-sections 显示文摘 | Yuren Hu Xianding Jin Bozhen Chen | 1996 | Computers & Structures1996，61，5： | 1 |
| 15 | An adaptive tradeoff model for constrained evolutionaryoptimization显示文摘 | Wang Yong Cai Zixing Zhou Yuren et ai | 2008 | IEEE Trans on Evolutionary Computation2008，12，1： | 1 |
| 16 | Analysis on the carbon emission reduction potential in the cement industry in terms of technology diffusion and structural adjustment:a case study of Chongqing显示文摘 | Shi Yuren Chen Lingling Liu Zhen | 2012 | Energy Procedia2012，16，： | 1 |
| 17 | A finite element model for static and dynamic analysis of thin-walled beams with asymmetric cross-sections 显示文摘 | HU Yuren JIN Xianding CHEN Bozhen | 1996 | Computers&Structures1996，61，5： | 1 |
| 18 | Numerical and Analytical Modeling ofSwitched Reluctance Machines 显示文摘 | Zhang Zhihui Li Yuren | 2012 | Journal of Computers2012，7，12： | 1 |
| 19 | Comparison of Sodium Hyaluronate of Different Molecular Weight Treated Knee Osteoarthritis显示文摘 | ZHOU QING WANG YUREN ZHOU ZIDE | 2000 | Acta universitatis medicinalis secondae shanghai2000，20，4： | 1 |
| 20 | Flotation of diaspore and aluminosilicate minerals applying novel carboxyl hydroxamic acids as collector显示文摘 | JIANG Yuren ZHAO Binnan ZHOU Xiaohong | 2010 | Hydrometallurgy2010，104，1： | 1 |
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