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| 1 | Neuroprotective effects of the immunodepressant FTY720 on caspase-3 expression and neural apoptosis in a rat model of acute spinal cord injury显示文摘BACKGROUND:Studies on the immunodepressant FTY720 have primarily focused on organ transplantation and autoimmune disease therapy.However,the effects on caspase-3 expression and neural apoptosis following acute spinal cord injury remain uncertain.OBJECTIVE:To elucidate the underlying mechanism of the immunodepressant FTY720 to alleviate spinal cord injury by inhibiting expression of caspase-3 and neural apoptosis.DESIGN,TIME AND SETTING:A randomized,controlled,animal experiment was performed at Central Laboratory of the Second Affiliated Hospital of Dalian Medical University from April to July 2009.MATERIALS:FTY720 was provided by Wuhan Yuancheng Technology Developing,China.METHODS:A total of 120 Sprague Dawley rats were randomly assigned to sham-surgery,model,and FTY720 groups.Spinal cord injury at the T9-10 segment was induced in model groups using the free-fall method.Following establishment of spinal cord injury at the T9-10 segment in the FTY720 group,rats were treated with an intragastric injection of 0.3 mL saline-diluted FTY720 (3 mg/kg).MAIN OUTCOME MEASURES:At 6,12,24,48,and 72 hours following spinal cord injury,caspase-3 expression was detected using streptavidin-peroxidase immunohistochemistry,and neural apoptosis was detected using the TUNEL method.RESULTS:Positive caspase-3 expression and neural apoptosis was not observed in the sham-surgery group at the various time points.The number of apoptotic cells increased with time after acute spinal cord injury,peaked at 24 hours following injury,and then gradually reduced.However,neural apoptosis remained at a high level.Caspase-3 expression positively correlated with neural apoptosis (r=0.864,P < 0.05).Caspase-3 expression and neural apoptosis significantly decreased following FTY720 therapy (P < 0.05).CONCLUSION:FTY720 significantly reduced caspase-3 expression and neural apoptosis in a rat model of acute spinal cord injury. | Liang Yang Decheng Lü Lianjie Zheng Zhaohui Wang Kai Tang Wei Zhang Xiaotian Li | 2010 | Neural Regeneration Research2010，5，9： | 7 |
| 2 | Changes of CXCL12, CXCL14 and PDGF levels in the brain of patients with idiopathic demyelinating optic neuritis and neuromyelitis optica 显示文摘 | Tingjun C Zhaohui L Zhaocai J | 2015 | J Neuroimmunol2015，279，： | 1 |
| 3 | Terahertz emission from localized modes in one-dimensional disordered systems [Invited]显示文摘We demonstrate terahertz(THz) frequency laser emission around 3.2 THz from localized modes in one-dimensional disordered grating systems. The disordered structures are patterned on top of the double-metal waveguide of a THz quantum cascade laser. Multiple emission peaks are observed within a frequency range corresponding to the bandgap of a periodic counterpart with no disorder, indicating the presence of mode localization aided by Bragg scattering. Simulations and experimental measurements provide strong evidence for the spatial localization of the THz laser modes. | YONGQUAN ZENG GUOZHEN LIANG Bo QIANG Bo MENG Hou KUN LIANG SHAMPY MANSHA JIANPING LI ZHAOHUI L LIANHE LI ALEXANDER GILES DAVIES EDMUND HAROLD LINFIELD YING ZHANG YIDONG CHONG AND Qi JIE WANG | 2018 | Photonics Research2018，6，2： | 1 |
| 4 | Numerical Simulation of Dispersion Generated by a 180 Turn in a Microehannel 显示文摘 | Yao Zhaohui Yoder G L Culbertson C T | 2002 | Chinese Physies B2002，11，3： | 1 |
| 5 | Integrative mining of traditional Chinese medicine literature and MEDLINE for functional gene networks显示文摘 | Xuezhong Zh Baoyan L Zhaohui W | 2007 | Artificial Intelligence in Medicine2007，41，2： | 1 |
| 6 | Differential Sensitivity to JAK Inhibitory Drugs by Isogenic Human Erythroblasts and Hematopoietic Progenitors Generated from Patient‐Specific Induced Pluripotent Stem Cells显示文摘 | Zhaohui Ye Cyndi F. L iu Lucie Lanikova Sarah N. Dowey Chaoxia He Xiaosong Huang Robert A. Brodsky Jerry L. Spivak Josef T. Prchal Linzhao Cheng | 2014 | Stem Cells2014，，1： | 1 |
| 7 | Resuhs of repeat gamma knife treatment:stereotactie aspiration surgery can improve the effect of gamma knife treatment for cystic small brainstem glioma 显示文摘 | Chao Du Zhaohui l i Zhijia Wang | 2012 | Neurosurgery Quarterly2012，22，1： | 1 |
| 8 | A comparison of the electrode/electrolyte reaction at elevated temperatures for various Li-ion battery cathodes显示文摘 | MacNeil D D Zhonghu L Zhaohui C | 2002 | Journal of Power Sources2002，108，12： | 1 |
| 9 | Topical hemostatic proce- dures control blood loss in bilateral cemented single - stage total knee arthroplasty 显示文摘 | Zhaohui L Wanshou G Qidong Z | 2014 | J Orthop Sci2014，19，6： | 1 |
| 10 | Analysis of end-plate connections at elevated temperatures显示文摘 | Shuyuan L Zhaohui H Mizi F | 2013 | Steel and Composite Structures2013，15，81： | 1 |
| 11 | 显示文摘 | Maeneil D D Zhonghu L Zhaohui C | 2002 | Power Sources2002，108，12： | 1 |
| 12 | Topical hemostatic procedures control blood loss in bilateral cemented single - stage total knee arthroplasty 显示文摘 | Zhaohui L Wanshou G Qidong Z | 2014 | J Orthop Sei2014，19，6： | 1 |
| 13 | Effect of laparoseopic Roux-en-Y gastric bypass on body composition and insulin resistance in Chinese patients with type 2 diabetes mellitus 显示文摘 | L Weizbeng Z Liyong M Zhaohui | 2013 | Obesity Surgery2013，24，04： | 1 |
| 14 | Introductory study on female condom use among sex workers in China 显示文摘 | Yimin C Zhaohui L Xianmi W | 2002 | Contraception2002，66，： | 1 |
| 15 | Reactive oxygen species activate a Ca2+ -dependent cell death pathway in theunicellular organism Trypanosoma brucei brucei 显示文摘 | Xiong- Zhaohui Ruben L | 1999 | Bio J1999，340，1： | 1 |
| 16 | Chinese minimally invasive percutaneous nephrolitho- tomy: The guangzh0u experience 显示文摘 | XUN L I ZHAOHUI H E KAIJUN W U | 2010 | J Endourol2010，25，9： | 1 |
| 17 | A comparison of the electrode/electrolyte reaction at elevated temperatures for various Li-ion battery cathodes显示文摘 | Macneil D D Zhonghu L Zhaohui C | 2002 | J Power Sources2002，108，12： | 1 |
| 18 | A comparison of the electrode/electrolyte reaction at elevated temperatures for various Li-ion battery cathodes 显示文摘 | Macneil D D Zhonghu L Zhaohui C | 2002 | J Power Sources2002，108，12： | 1 |
| 19 | Use of the Female Condom among sex workers in China显示文摘 | Yimin C Zhaohui L Xianmi W | 2003 | International Journal of Gynecology and Obstetrics2003，81，： | 1 |
| 20 | Urinary IL-18 and NGAL as early predictive biomarkers in contrast-induced nephropathy after coronary angiography显示文摘 | L ing W Zhaohui N Ben H | 2008 | Nephron Clin Pract2008，108，3： | 1 |
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