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| 1 | Accuracy of triage strategies for human papillomavirus DNA-positive women in low-resource settings:A cross-sectional study in China显示文摘Objective: Care HPV is a human papillomavirus(HPV) DNA test for low-resource settings(LRS).This study assesses optimum triage strategies for care HPV-positive women in LRS.Methods: A total of 2,530 Chinese women were concurrently screened for cervical cancer with visual inspection with acetic acid(VIA),liquid-based cytology and HPV testing by physician-and self-collected care HPV,and physician-collected Hybrid Capture 2(HC2).Screen-positive women were referred to colposcopy with biopsy and endocervical curettage as necessary.HPV-positivity was defined as ≥1.0 relative light units/cutoff(RLU/CO) for both care HPV and HC2.Primary physician-HC2,physician-care HPV and self-care HPV and in sequential screening with cytology,VIA,or increased HPV test-positivity performance,stratified by age,were assessed for cervical intraepithelial neoplasia(CIN) grade 2/3 or worse(CIN2/3+) detection.Results: The sensitivities and specificities of primary HPV testing for CIN2+ were: 83.8%,88.1% for physiciancare HPV; 72.1%,88.2% for self-care HPV; and 97.1%,86.0% for HC2.Physician-care HPV test-positive women with VIA triage had a sensitivity of 30.9% for CIN2+ versus 80.9% with cytology triage.Self-care HPV testpositive women with VIA triage was 26.5% versus 66.2% with cytology triage.The sensitivity of HC2 test-positive women with VIA triage was 38.2% versus 92.6% with cytology triage.The sensitivity of physician-care HPV testing for CIN2+ decreased from 83.8% at ≥1.0 RLU/CO to 72.1% at ≥10.00 RLU/CO,while the sensitivity of selfcare HPV testing decreased from 72.1% at ≥1.0 RLU/CO to 32.4% at ≥10.00 RLU/CO; similar trends were seen with age-stratification.Conclusions: VIA and cytology triage improved specificity for CIN2/3 than no triage.Sensitivity with VIA triage was unsuitable for a mass-screening program.VIA provider training might improve this strategy.Cytology triage could be feasible where a high-quality cytology program exists.Triage of HPV test-positive women by increased test positivity cutoff adds another LRS triage option. | Margaret Wang Shangying Hu Shuang Zha o Wenhua Zhang Qinjing Pan Xun Zhang FengChen Jinxiu Han Junfei Ma Jennifer S.Smith Youlin Qiao Caihong Zhou Fanghui Zhao | 2017 | Chinese Journal of Cancer Research2017，29，6： | 6 |
| 2 | Experimental Study on the Ride Comfort of a Crawler Power Chassis Scale Model Based on the Similitude Theory显示文摘The ride comfort experimental assessment of crawler off-road vehicle is relatively overlooked, and is expensive and difficult to execute with higher and higher ride comfort performance requirements. To trade off between precise and cost, an experimental method based on the similitude theory is proposed. Under the guidance of the similitude theory, a 1:5 crawler power chassis scale model equipped with a kind of variable stiffness suspension system is used. The power spectrum density(PSD), the root mean square(RMS) of weighed acceleration, peak factor, average absorbed power(AAP) and vibration dose value(VDV) are selected as ride comfort evaluation indexes, and tests results are transformed via similarity indexes to predict the performance of full-scale power chassis. PSD shows that the low-order natural frequency of the vertical natural frequency(z axis) is 1.1 Hz, and the RMS, AAP and VDV values indicate the ride comfort performance of this kind of power chassis is between the 'A little uncomfortable' and 'Rather uncomfortable'. From the results, low-order vertical natural frequency, obtained by PSD, validates that the similarity relationship between two models is satisfied, and 1:5 scale model used in experiment meets the similarity relationship with the full-scale model; consequently, the ride comfort prophase evaluation with the 1:5 scale model is feasible. The attempt of applying the similitude theory to crawler vehicle ride comfort test study decreases the cost and improves the test feasibility with sufficient test precise. | ZHAO Jianzhu WANG Fengchen YU Bin TONG Pengcheng CHEN Kuifu | 2015 | Chinese Journal of Mechanical Engineering2015，28，3： | 2 |
| 3 | The development of ship collision avoidance auto- mation显示文摘 | ZHAO Jingsong WANG Fengchen WU Zhaolin | 1992 | Journal of Navigation1992，45，1： | 1 |
| 4 | U-Pb geochronology and geochemical characteristics of Liudaogou granodiorite in Linjiang,Jilin Province显示文摘The Liudaogou area underwent multiple large-scale tectonic movements since Archean. Little studies have been carried out on the age of Mesozoic magmatism and petrogenesis in the area. Zircon U-Pb geochronology and geochemistry of the Liudaogougranodiorite were undertaken in this study to determine the forming-age of the granodiorite and to understand its petrogenesis and tectonic background of diagenesis. Zircon in the rock samples show good idiomorphic and obvious rhythmic growth girdle zone,belonging to typical magmatic zircon.Zircon LA-ICP-MS U-Pb dating results show that the emplacement of rock mass occurred in late Early Cretaceous( 125 ± 1 Ma,MSWD = 0. 53). The geochemical data show that the rock belongs to quasi-aluminous granite of type I which has the properties of high potassium calc-alkaline adakite,with A/CNK ratio of 0. 82--0. 98( < 1. 1). The rock shows obvious enrichment of LILE and LREE but depletion of HFSE,and is characterized by high Sr( 374. 9 × 10^(-6)--777. 6 × 10^(-6)) and low Y( 8. 84 × 10^(-6)--12. 4 × 10^(-6)). The samples are rich in Si,and the K_2 O/Na_2 O ratio( 0. 99--1. 30) is very high,indicating that magma might have originated from melting upper crust. The high content of Mg~#( 49. 68--56. 92) in the samples implies that mantle-derived materials might have involved in magma. It can be concluded that in the process of delamination,the lower crust sank,and was heated by asthenosphere mantle,and partially melted. The primitive magma should be the mixture of the mantle-derived magma and the partially melting lower crust. Integrating research results on the regional contemporary igneous rock,it can be concluded that the rocks were formed in an active continental margin environment related to the subduction of the Paleo-Pacific Plate to the Eurasian Plate. | ZHENG Yuanhao ZHAO Fengchen WANG Li LIU Jinlong WU Qiong TIAN Lidan YIN Yue | 2018 | Global Geology2018，21，4： | 0 |
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