|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Source profiles of particulate organic matters emitted from cereal straw burnings显示文摘谷物稻草足够地是在中国烧的最丰富的生物资源之一,但是到好微粒的 itscontribution 不是 understood.In 这研究,三根主要类型 ofcereal 稻草从从使遭到控制烧的谷物稻草在 China.Fine 微粒事( PM2.5 )生产区域的五谷物被收集,两个在闷烧和 flamingstatus 下面,被在 thelaboratory.Element 碳( EC )使用一个特定的做的冲淡房间和采样系统取样,器官的碳( OC )是 analyzed. | ZHANG Yuan-xun SHAO Min ZHANG Yuan-hang ZENG Li-min HE Ling-yan ZHU Bin WEI Yong-jie ZHU Xian-lei | 2007 | Journal of Environmental Sciences2007，19，2： | 88 |
| 2 | Quantitative relationship between visibility and mass concentration of PM2.5 in Beijing显示文摘The pollution of particulate matter less than 2.5 mm(PM2.5) is a serio us environmental problem in Beijing. The annual average concentration of PM2.5 i n 2001 from seasonal monitor results was more than 6 times that of the U.S. nati onal ambient air quality standards proposed by U.S. EPA. The major contributors to mass of PM2.5 were organics, crustal elements and sulfate. The chemical compo sition of PM2.5 varied largely with season, but was similar at different monitor stations in the same season. The fine particles (PM2.5) cause atmospheric visib ility deterioration through light extinction. The mass concentrations of PM2.5 w ere anti-correlated to the visibility, the best fits between atmospheric visibil ity and the mass concentrations of PM2.5 were somehow different: power in spring , exponential in summer, logarithmic in autumn, power or exponential in winter. As in each season the meteorological parameters such as air temperature and rela tive humidity change from day to day, probably the reason of above correlations between PM2.5 and visibility obtained at different seasons come from the differe nces in chemical compositions of PM2.5. | WANG Jing-li ZHANG Yuan-hang SHAO Min LIU Xu-lin ZENG Li-min CHENG Cong-lan XU Xiao-feng | 2006 | Journal of Environmental Sciences2006，18，3： | 31 |
| 3 | Arsenic removal from contaminated soil using phosphoric acid and phosphate显示文摘实验室批实验被进行学习砷(作为) 从用磷酸(H3PO4 ) 和钾 dihydrogen 磷酸盐(KH2PO4 ) 的自然地污染的土壤的移动。H3PO4 和 KH2PO4 证明了作为内容以土壤减少土壤的毒性,作为在 200 mmol/L 的集中的移动达到超过 20% 。同时,土壤的使发酸和土壤部件(Ca, Mg,和 Si ) 的溶解源于使用这二提炼之物,特别 H3PO4。这二提炼之物的有效性能被归因于代替作为由磷酸盐离子(PO43 ) 。溶解的酸玷污部件的 H3PO4 的功能作为移动穿上小效果。KH2PO4 几乎搬迁了像一样,显示它是更有希望的提炼之物作为 H3PO4,而是它没导致土壤的严重损坏。当移动为土壤部件,特别 Mg 和 Ca 的 360 min,而是溶解在孵化以后到达了平衡,运动研究的结果显示出那,是很快速的。因此如果,土壤部件的溶解将是不可避免的这是进一步的搬迁。Elovich 模型最好描述了运动数据作为在四之中的移动,模型在运动学习用作。 | ZENG Min LIAO Bohan LEI Ming ZHANG Yong ZENG Qingru OUYANG Bin | 2008 | Journal of Environmental Sciences2008，20，1： | 28 |
| 4 | Schisandrol B protects against acetaminophen- induced acute hepatotoxicity in mice via activation of the NRF2/ARE signaling pathway显示文摘目的: 原子因素 erythroid 2-related 因素(NRF2 ) 2 通过抗氧化剂反应元素行动() 处理调整许多除去和为 cytoprotective 负责的抗氧化剂基因的表示。我们以前报导从五味子 sphenanthera 孤立的 Schisandrol B (SolB ) 对导致的 acetaminophen (APAP ) 生产了保护的效果肝损害。在这研究,我们调查了表明小径的 NRF2/ARE 是否涉及这 hepato 保护的 effect.Methods : 男 C57BL/6 老鼠与 SolB 被对待(200 mg· kg −1·d−1, ig ) 为在 APAP 的注射前的 3 d (400 mg/kg, ip ) 。浆液和肝织物样品被收集 6 h 以后。mRNA 和蛋白质表示分别地用 qRT-PCR 和西方的污点试金被测量。 NRF2 的激活用酶记者基因 assay.Results 在 HepG2 房间被检验:显著地减轻的 SolB 预告的处理肝的损害(肝的湾穴的大补缀的坏死和 hyperemia ),浆液著名计算机生产厂商的增加,中高音层次和肝的 MDA 满足,并且肝和 mitochondrial 谷胱甘肽的减少在 对待APAP 的老鼠铺平。而且, SolB 预告的处理显著地增加了 NRF2 的原子累积并且增加了 NRF2 下游的蛋白质的肝的表示,包括在对待 APAP 的鼠标的 GCLC, GSR, NQO1, GST, MRP2, MRP3 和 MRP4。而且,有 SolB 的处理(2.5-20 μ mol/L ) dose-dependently 在 HepG2 cells.Conclusion 增加了 NRF2 记者基因的活动: SolB 对导致 APAP 的 hepatotoxicity 展出显著保护的效果,部分,经由 NRF2/ARE 的激活, NRF2 的小径和规定指向基因,它导致 detoxification 和增加抗氧化剂能力。 | Yi-ming JIANG Ying WANG Hua-sen TAN Tao YU Xiao-mei FAN Pan CHEN Hang ZENG Min HUANG Hui-chang BI | 2016 | Acta Pharmacologica Sinica2016，37，3： | 24 |
| 5 | Role of secondary aerosols in haze formation in summer in the Megacity Beijing显示文摘A field experiment from 18 August to 8 September 2006 in Beijing, China, was carried out. A hazy day was defined as visibility < 10 km and RH(relative humidity) < 90%. Four haze episodes, which accounted for ~ 60% of the time during the whole campaign, were characterized by increases of SNA(sulfate, nitrate, and ammonium) and SOA(secondary organic aerosol) concentrations. The average values with standard deviation of SO2-+4, NO-3, NH4 and SOA were 49.8(± 31.6), 31.4(±22.3), 25.8(±16.6) and 8.9(±4.1) μg/m3, respectively, during the haze episodes, which were 4.3, 3.4, 4.1, and 1.7 times those in the non-haze days. The SO2-4,NO-3, NH+4, and SOA accounted for 15.8%, 8.8%, 7.3%, and 6.0% of the total mass concentration of PM10 during the non-haze days. The respective contributions of SNA species to PM10 rose to about27.2%, 15.9%, and 13.9% during the haze days, while the contributions of SOA maintained the same level with a slight decrease to about 4.9%. The observed mass concentrations of SNA and SOA increased with the increase of PM10 mass concentration, however, the rate of increase of SNA was much faster than that of the SOA. The SOR(sulfur oxidation ratio) and NOR(nitrogen oxidation ratio) increased from non-haze days to hazy days, and increased with the increase of RH. High concentrations of aerosols and water vapor favored the conversion of SO2 to SO2-4and NO2 to NO-3, which accelerated the accumulation of the aerosols and resulted in the formation of haze in Beijing. | Tingting Han Xingang Liu Yuanhang Zhang Yu Qu Limin Zeng Min Hu Tong Zhu | 2015 | Journal of Environmental Sciences2015，27，5： | 22 |
| 6 | Lp-PLA2 inhibition prevents Ang Ⅱ-induced cardiac inflammation and fibrosis by blocking macrophage NLRP3 inflammasome activation显示文摘Macrophage-mediated inflammation plays an important role in hypertensive cardiac remodeling,whereas effective pharmacological treatments targeting cardiac inflammation remain unclear.Lipoprotein-associated phospholipase A2(Lp-PLA2)contributes to vascular inflammation-related diseases by mediating macrophage migration and activation.Darapladib,the most advanced Lp-PLA2 inhibitor,has been evaluated in phase Ⅲ trials in atherosclerosis patients.However,the role of darapladib in inhibiting hypertensive cardiac fibrosis remains unknown.Using a murine angiotensin Ⅱ(Ang Ⅱ)infusion-induced hypertension model,we found that Pla2g7(the gene of Lp-PLA2)was the only upregulated PLA2 gene detected in hypertensive cardiac tissue,and it was primarily localized in heart-infiltrating macrophages.As expected,darapladib significantly prevented Ang Ⅱ-induced cardiac fibrosis,ventricular hypertrophy,and cardiac dysfunction,with potent abatement of macrophage infiltration and inflammatory response.RNA sequencing revealed that darapladib strongly downregulated the expression of genes and signaling pathways related to inflammation,extracellular matrix,and proliferation.Moreover,darapladib substantially reduced the Ang Ⅱ infusion-induced expression of nucleotide-binding oligomerization domain-like receptor with pyrin domain 3(NLRP3)and interleukin(IL)-1β and markedly attenuated caspase-1 activation in cardiac tissues.Furthermore,darapladib ameliorated Ang Ⅱ-stimulated macrophage migration and IL-1β secretion in macrophages by blocking NLRP3 inflammasome activation.Darapladib also effectively blocked macrophage-mediated transformation of fibroblasts into myofibroblasts by inhibiting the activation of the NLRP3 inflammasome in macrophages.Overall,our study identifies a novel anti-inflammatory and anti-cardiac fibrosis role of darapladib in Lp-PLA2 inhibition,elucidating the protective effects of suppressing NLRP3 inflammasome activation.Lp-PLA2 inhibition by darapladib represents a novel therapeutic strategy for hypertensive cardiac damage treatment. | Si-lin Lv Zi-fan Zeng Wen-qiang Gan Wei-qi Wang Tie-gang Li Yu-fang Hou Zheng Yan Ri-xin Zhang Min Yang | 2021 | Acta Pharmacologica Sinica2021，42，12： | 21 |
| 7 | Whole-Genome Sequencing and Analysis of the Chinese Herbal Plant Panax notoginseng显示文摘 | Wei Chen Ling Kui Guanghui Zhang Shusheng Zhu Jing Zhang Xiao Wang Min Yang Huichuan Huang Yixiang Liu Yong Wang Yahe Li Lipin Zeng Wen Wang Xiahong He Yang Dong Shengchao Yang | 2017 | Molecular Plant2017，10，6： | 21 |
| 8 | Introgression of qPE9-1 allele,conferring the panicle erectness,leads to the decrease of grain yield per plant in japonica rice(Oryza sativa L.)显示文摘圆锥花序建筑学是仔细与产量有关形成。qPE9-1 基因被证明了广泛地在产量很高的米饭栽培变种开发被过去常,授与在装饰用的梨树米饭的直立的圆锥花序特性。最近, qPE9-1 成功地被克隆;然而,谷物产量上的基因效果还每直立的圆锥花序等位基因 qPE9-1 的植物是争论的。在现在的学习,低垂的圆锥花序父母 Nongken 57,带 qpe9-1 等位基因,被用作周期性父母到连续地回交到从双 haploid (DH ) 的一根典型直立的圆锥花序线人口(Wuyunjing 8/Nongken 57 ) ,它以前被显示带 qPE9-1 等位基因。因此,一双 near-isogenic 线(无) 被开发。在无之间的农学的特点的比较证明当 qpe9-1 被 qPE9-1 代替时,圆锥花序建筑学从低垂树立被改变;而且,圆锥花序长度,植物高度, 1000 谷物重量和 tillers 显著地被减少,因而在 30% 每植物导致谷物产量的戏剧的减少。因此,我们断定 qPE9-1 是控制圆锥花序建筑学的一个主要因素,并且 qPE9-1 有多种的自然,与每植物的谷物产量上的否定效果。这结果强烈建议直立的圆锥花序等位基因 qPE9-1 应该在产量很高的繁殖实践和另外的有利基因被使用。另外,吃并且煮质量上的 qPE9-1 的效果也在现在的学习被讨论。 | Xiuhua Yi Zujian Zhang Shengyuan Zeng Chunyan Tian Juncheng Peng Min Li Yue Lu Qingcai Meng Minghong Gu Changjie Yan | 2011 | Journal of Genetics and Genomics2011，38，5： | 20 |
| 9 | Spatial variability of soil total nitrogen,phosphorus and potassium in Renshou County of Sichuan Basin,China显示文摘Understanding soil nutrient distributions and the factors affecting them are crucial for fertilizer management and environmental protection in vulnerable ecological regions.Based on 555 soil samples collected in 2012 in Renshou County,located in the purple soil hilly area of Sichuan Basin,China,the spatial variability of soil total nitrogen(TN),total phosphorus(TP)and total potassium(TK)was studied with geostatistical analysis and the relative roles of the affecting factors were quantified using regression analysis.The means of TN,TP and TK contents were 1.12,0.82 and 9.64 g kg^(–1),respectively.The coefficients of variation ranged from 30.56 to 38.75%and the nugget/sill ratios ranged from 0.45 to 0.61,indicating that the three soil nutrients had moderate variability and spatial dependence.Two distribution patterns were observed.TP and TK were associated with patterns of obvious spatial distribution trends while the spatial distribution of TN was characterized by higher variability.Soil group,land use type and topographic factors explained 26.5,35.6 and 8.4%of TN variability,respectively,with land use being the dominant factor.Parent material,soil group,land use type and topographic factors explained 17.5,10.7,12.0 and 5.0%of TP variability,respectively,and both parent material and land use type played important roles.Only parent material and soil type contributed to TK variability and could explain 25.1 and 13.7%of TK variability,respectively.More attention should focus on adopting reasonable land use types for the purposes of fertilizer management and consider the different roles of the affecting factors at the landscape scale in this purple soil hilly area. | GAO Xue-song XIAO Yi DENG Liang-ji LI Qi-quan WANG Chang-quan LI Bing DENG Ou-ping ZENG Min | 2019 | Journal of Integrative Agriculture2019，18，2： | 19 |
| 10 | Gambogic acid induces mitochondria-dependent apoptosis by modulation of Bcl-2 and Bax in mantle cell lymphoma JeKo-1 cells显示文摘Aim: To study the mechanisms in gambogic acid (GA) -induced JeKo-1 human Mantle Cell Lymphoma cell apoptosis in vitro. Methods: The proliferation of GA-treated JeKo-1 cells was measured by CCK-8 assay and Ki-67 immunocytochemical detection. Apoptosis, cell cycle and mitochondrial membrane potential were measured by flow cytometric analysis. Caspase-3,-8 and -9 were detected by colorimetric assay. Bcl-2 and Bax were analyzed by Western blotting. Results: GA inhibited cell growth in a time-and dose-dependent manner. GA induces apoptosis in JeKo-1 cells but not in normal bone marrow cells, which was involved in reducing the membrane potential of mitochondria, activating caspases-3, -8 and -9 and decreasing the ratio of Bcl-2 and Bax without cell cycle arresting. Conclusions: GA induced apoptosis in human MCL JeKo-1 cells by regulating Bcl-2/Bax and activating caspase-3, -8 and -9 via mitochondrial pathway without affecting cell cycle. | Jingyan Xu Min Zhou Jian Ouyang Jing Wang Qiguo Zhang Yong Xu Yueyi Xu Qian Zhang Xihui Xu Hui Zeng | 2013 | Chinese Journal of Cancer Research2013，25，2： | 18 |
| 11 | Effect of lipid on proliferation and activation of rat hepatic stellate cells(Ⅰ)显示文摘INTRODUCTIONDespitetheearlycontroversyovertheprimarycelularsourceofextracelularmatrixproteinsinliverfibrosis,compelinginvitro... | LU Lun Gen, ZENG Min De, LI Ji Qiang, HUA Jing, FAN Jian Gao, FAN Zhu Ping and QIU De Kai | 1998 | World Journal of Gastroenterology1998，4，6： | 18 |
| 12 | Genotyping for Kidd, Kell, Duffy, Scianna, and RHCE blood group antigens polymorphisms in Jiangsu Chinese Han显示文摘 | LIU Zhong ZENG Rong CHEN Qing LI Min SHI Guang-yao WEI Peng HUANG Cheng-yin TANG Rong-cai SUN Jun ZHANG Xue-guang | 2012 | Chinese Medical Journal2012，，6： | 18 |
| 13 | Expansion and differentiation of human hepatocyte-derived liver progenitor-like cells and their use for the study of hepatotropic pathogens显示文摘The study of pathophysiological mecha nisms in huma n liver disease has bee n constrained by the in ability to expa nd primary hepatocytes in vitro while maintaining proliferative capacity and metabolic function. We and others have previously shown that mouse mature hepatocytes can be con verted to liver progenitor-like cells in vitro with defined chemical factors. Here we describe a protocol achieving efficient conversion of human primary hepatocytes into liver progenitor-like cells (HepLPCs) through delivery of developmentally relevant cues, including NAD +-dependent deacetylase SIRT1 signaling. These HepLPCs could be expanded sign ifica ntly duri ng in vitro passage. The expa nded cells can readily be con verted back into metabolically functional hepatocytes in vitro and upon tran splantati on in vivo. Under three-dime nsional culture conditions, differentiated cells gen erated from HepLPCs regai ned the ability to support infect io n or reactivatio n of hepatitis B virus (HBV). Our work dem on strates the utility of the con versi on betwee n hepatocyte and liver proge nitor-like cells for studying HBV biology and an tiviral therapies. These fin dings will facilitate the study of liver diseases and regenerative medicine. | Gong-Bo Fu Wei-Jian Huang Min Zeng Xu Zhou Hong-Ping Wu Chang-Cheng Liu Han Wu Jun Weng Hong-Dan Zhang Yong-Chao Cai Charles Ashton Min Ding Dan Tang Bao-Hua Zhang Yi Gao Wei-Feng Yu Bo Zhai Zhi-Ying He Hong-Yang Wang He-Xin Yan | 2019 | Cell Research2019，29，1： | 18 |
| 14 | Differentiation of human umbilical cord blood stem cells into hepatocytes in vivo and in vitro显示文摘瞄准:学习人的脐带血干细胞(HUCBSC ) 的条件和潜力区分进 hepatocytes 在活体内或在试管内。方法:在人的脐带血的房间文化研究干细胞(HUCBSC ) 区别,人的脐带血单音的原子房间(HUCBMNC ) 被密度坡度远心沉淀分开。成纤维细胞生长因素(FGF ) 和 hepatocyte 生长因素(HGF ) 和胎儿的肝的上层清液在劝诱的组被增加。仅仅 FGF 在控制组被增加。在每个组的 HUCBMNC 的扩大和区别被观察。人的高山哈 fetoprotein (法新社) 和白朊(白长袍的) 被免疫组织化学检测。在动物实验,有在四氯化碳(CCL4 ) 以后的尖锐肝的损害的幸存 SD 老鼠注射 48 h 随机被划分成三个组。在组 A 的老鼠与人的脐带血浆液被对待。在组 B 的老鼠与 HUCBMNC 移植被对待。在组 C 的老鼠与移植为 7 d 由腹膜内出租机动三轮车磷酰胺跟随了的 HUCBMNC 被对待。在处理和肝织物是免疫组织化学检测的学习的组织病理学说的联盟者和人的法新社和白长袍的以后,老鼠在不同时间点被打死。在肝织物的人的 X 不活跃特定的抄本基因碎片被 PCR 放大发现人的 DNA。结果:房间文化的结果证明支持者房间在控制组是为法新社或白长袍的染色的 negative。然而,在劝诱的组的支持者房间染色了为法新社或白长袍的积极。动物实验的结果显示出那个不人的法新社或在组 A (控制组) 的肝织物在场的白长袍的积极细胞。然而,许多人的法新社或白长袍的积极房间在湾穴附近被散布肝我们和肝的腹片并且在在在一个月以后的组 B 和组 C 的门区域的中央静脉。人的 X 浓度基因的碎片能在组 B 和 C 的肝织物,然而并非在组 A 被检测。结论:在进肝细胞在活体内和在试管内的某些条件 HUCBSC 罐头 differentiate 下面。 | Xiao-Peng Tang Min Zhang Xu Yang Li-Min Chen Yang Zeng | 2006 | World Journal of Gastroenterology2006，12，25： | 16 |
| 15 | Seasonal variation of Microcystis in Lake Taihu and its relationships with environmental factors显示文摘In order to monitor the changes of Microcystis along with temporal and spatial variations, seasonal variation of Microcystis in Lake Taihu was investigated by 16S-23S rRNA internal transcribed spacer denaturing gradient gel electrophoresis (16S-23S rRNA-ITS DGGE) and microscopic evaluation. Samples were collected quarterly at four sites (River Mouth, Meiliang Bay, Cross Area, and Lake Center) from August 2006 to April 2007. Results showed that Microcystis dominated total phytoplankton abundance at the four sites in all seasons except winter. The average annual abundance of Microcystis was relatively high at River Mouth and Meiliang Bay, reaching 81.22 × 106 and 61.32 × 106 cells/L, respectively. For temporal variations, Shannon-Wiener diversity index (H ) according to DGGE profile revealed the richness of Microcystis in summer (H = 1.375 ± 0.034) and winter (H = 1.650 ± 0.032) was lower than that in spring (H = 2.078 ± 0.031) and autumn (H = 2.365 ± 0.032) (P < 0.05). While for spatial variations, the richness of Microcystis at River Mouth (H = 2.015 ± 0.074) was higher than at other sites during four seasons (P < 0.01). Very few dierences of Microcystis diversity in the same season were observed among the other three sites (P > 0.05). Canonical correspondence analysis (CCA) was performed to elucidate the relationships between Microcystis operational taxonomic units (OTUs) composition and the environmental factors. Results of CCA revealed that temperature was strongly positively correlated with the first axis (r = 0.963), while TSS was negative correlated with the second axis (r = -0.716). Phylogenetic tree based on the sequencing results of target bands on DGGE gel indicated that samples collected in summer and winter constituted two separated clusters. | TAN Xiao KONG Fanxiang ZENG Qingfei CAO Huansheng QIAN Shanqin ZHANG Min | 2009 | Journal of Environmental Sciences2009，21，7： | 16 |
| 16 | The cloning of Dmc1 cDNAs and a comparative study of its expression in different ploidy cyprinid fishes显示文摘Dmc1 (disrupted meiotic cDNA) is a functionally specific gene, which was firstly discovered in yeast and then found to encode a protein required for homologous chromosome synapsis during the process of meiosis. In this investigation, we cloned the partial cDNAs of Dmc1 of diploid red crucian carp, Japanese crucian carp, common carp, triploid crucian carp and allotetraploid hybrids by using a pair of degenerate primers based on the conservative sequence of amino acids of the DMC1 protein in yeast, mouse and human. The full length cDNAs were then obtained by rapid amplification of cDNA ends (RACE). Our data showed that the full length cDNAs of Dmc1 in the three diploid fishes are all 1375 bp long, while it is 1383 bp long in triploids and 1379 bp long in allotetraploids. And despite of the variation in length, all the cDNAs encode a protein of 342 amino acids. A high homology of 97.3% of the DMC1 protein can be drawn by comparing the amino acid sequences in the three diploids, which is also of 86%, 86% and 95% similarity to human, mouse and zebrafish, respectively. A comparative study of the expression pattern of Dmc1 was carried out by RT-PCR using specific primers against the same se-quences of coding regions in different ploidy cyprinid fishes, from which it was showed that Dmc1 was expressed only in gonads of these five kinds of fishes. The expression pattern of Dmc1 in both ovaries and testes from different ploidy fishes within breeding season was also studied by Real-time PCR, and the results showed that the expression of this gene was greatly different among the three different ploidy fishes, which was the highest of triploid and lowest of allotetraploids. The histological sections data showed matured gonads of both diploid red crucian carp and allotetraploids in breeding season, although the latter demonstrated a higher maturation, and no gonadal maturation could be observed in triploids. In conclusion, we suggest that Dmc1 is specifically expressed in the period of meiosis in all the ploidy cyprinid fishes and directly related with the development of gonad in a manner of ploidy-independent way. And further, the high expression of Dmc1 in female triploids might be associ-ated with abnormal meiosis and sterility. | TAO Min, LIU ShaoJun, LONG Yu, ZENG Chen, LIU JiFang, LIU LiangGuo, ZHANG Chun, DUAN Wei & LIU Yun Key Laboratory of Protein Chemistry and Developmental Biology of State Education Ministry of China, College of Life Sciences, Hunan Normal University, Changsha 410081, China | 2008 | Science China(Life Sciences)2008，51，1： | 13 |
| 17 | Schisandra sphenanthera extract(Wuzhi Tablet)protects against chronic-binge and acute alcohol-induced liver injury by regulating the NRF2-ARE pathway in mice显示文摘Alcohol abuse leads to alcoholic liver disease and no effective therapy is currently available.Wuzhi Tablet(WZ), a preparation of extract from Schisandra sphenanthera that is a traditional hepatoprotective herb, exerted a significant protective effect against acetaminophen-induced liver injury in our recent studies, but whether WZ can alleviate alcohol-induced toxicity remains unclear. This study aimed to investigate the contribution of WZ to alcohol-induced liver injury by using chronic-binge and acute models of alcohol feeding. The activities of ALT and AST in serum were assessed as well as the level of GSH and the activity of SOD in the liver. The expression of CYP2E1 and proteins in the NRF2-ARE signaling pathway including NRF2, GCLC, GCLM, HO-1 were measured, and the effect of WZ on NRF2 transcriptional activity was determined. We found that both models resulted in liver steatosis accompanied by increased transaminase activities, but that liver injury was significantly attenuated by WZ. WZ administration also inhibited CYP2E1 expression induced by alcohol, and elevated the level of GSH and the activity of SOD in the liver. Moreover, the NRF2-ARE signaling pathway was activated by WZ andthe target genes were all upregulated. Furthermore, WZ significantly activated NRF2 transcriptional activity. Collectively, our study demonstrates that WZ protected against alcohol-induced liver injury by reducing oxidative stress and improving antioxidant defense, possibly by activating the NRF2-ARE pathway. | Xuezhen Zeng Xi Li Chenshu Xu Fulin Jiang Yufei Mo Xiaomei Fan Yaoting Li Yiming Jiang Dongshun Li Min Huang Huichang Bi | 2017 | Acta Pharmaceutica Sinica B2017，7，5： | 13 |
| 18 | Distinct serumal proteomic patterns between ascending and descending types of loco-regionally advanced nasopharyngeal carcinoma assessed by surface enhanced laser desorption ionization and artificial neural network analyses显示文摘 | GUO Xiang CAO Su-mei YU Jie-kai HONG Ming-huang ZHANG Chang-qing LI Ning-wei XIANG Yan-qun QIAN Chao-nan HU Xun MIN Hua-qing ZENG Yi-xin | 2005 | Chinese Medical Journal2005，，22： | 13 |
| 19 | Stenting versus non-stenting treatment of intermediate stenosis culprit lesion in acute ST-segment elevation myocardial infarction: a multicenter random- ized clinical trial显示文摘在有单个容器中介狭窄犯人损害优点的心肌的梗塞(STEMI ) 病人进一步学习的尖锐圣片断举起的 stenting 的 BackgroundThe 利益 / 风险比率,因此现在的 study.Methods 和 resultsIt 的题目是一未来, multicenter,使随机化的控制试用。在 2012 年 4 月和 2015 年 7 月之间,有单个容器疾病和中介(40%-70%) 的 399 个尖锐 STEMI 病人在渴望 thrombectomy 或 intracoronary tirofiban 前后的犯人损害的狭窄(15 呍眠獡愠獳' 覒 X 整 ? 楷桴猠杩楮楦慣瑮椠灭潲敶敭瑮椠 ? ?癲癩污椠 ? 慰楴湥獴眠瑩 ?? | Jing DAI Shu-Zheng LYU Yun-Dai CHEN Xian-Tao SONG Min ZHANG Wei-Min LI Yang ZHENG Shang-Yu WEN Shao-Ping NIE Yu-Jie ZENG Hai GAO Yi-Tong MA Shu-Yang ZHANG Li-Jun GUO Zheng ZHANG | 2017 | Journal of Geriatric Cardiology2017，14，2： | 13 |
| 20 | Dual energy computed tomography for detection of metastatic lymph nodes in patients with hepatocellular carcinoma显示文摘BACKGROUND Regional lymph node metastasis in patients with hepatocellular carcinoma(HCC)is not uncommon, and is often under-or misdiagnosed. Regional lymph node metastasis is associated with a negative prognosis in patients with HCC, and surgical resection of lymph node metastasis is considered feasible and efficacious in improving the survival and prognosis. It is critical to characterize lymph node preoperatively. There is currently no consensus regarding the optimal method for the assessment of regional lymph nodes in patients with HCC.AIM To evaluate the diagnostic value of single source dual energy computed tomography(CT) in regional lymph node assessment for HCC patients.METHODS Forty-three patients with pathologically confirmed HCC who underwent partial hepatectomy with lymphadenectomy were retrospectively enrolled. All patients underwent dual-energy CT preoperatively. Regional lymph nodes(n = 156) were divided into either a metastatic(group P, n = 52) or a non-metastasis group(group N, n = 104), and further, according to pathology, divided into an active hepatitis(group P1, n = 34; group N1, n = 73) and a non-active hepatitis group(group P2, n = 18; group N2, n = 31). The maximal short axis diameter(MSAD),iodine concentration(IC), normalized IC(NIC), and the slope of the spectralcurve(λ_(HU)) of each group in the arterial phase(AP), portal phase(PP), and delayed phase(DP) were analyzed.RESULTS Analysis of the MSAD, IC, NIC, and λ_(HU) showed statistical differences between groups P and N(P < 0.05) during all three phases. To distinguish benign from metastatic lymph nodes, the diagnostic efficacy of IC, NIC, and λ_(HU) in the PP was the best among the three phases(AP, PP, and DP), with a sensitivity up to 81.9%,83.9%, and 81.8%, and a specificity up to 82.4%, 84.1% and 84.1%, respectively.The diagnostic value of combined analyses of MSAD with IC, NIC, or λ_(HU) in the PP was superior to the dual energy CT parameters alone, with a sensitivity up to84.5%, 86.9%, and 86.2%, and a specificity up to 83.0%, 93.6% and 89.8%,respectively. Between groups P1 and P2 and groups N1 and N2, only IC, NIC,and λ_(HU) between groups N1 and N2 in the PP had a statistically significant difference(P < 0.05).CONCLUSION Dual-energy CT contributes beneficially to regional lymph node assessment in HCC patients. Combination of MSAD with IC, NIC, or λ_(HU) values in the PP is superior to using any single parameter alone. Active hepatitis does not deteriorate the capabilities for characterization of metastatic lymph nodes. | Yu-Rong Zeng Qi-Hua Yang Qing-Yu Liu Jun Min Hai-Gang Li Zhi-Feng Liu Ji-Xin Li | 2019 | World Journal of Gastroenterology2019，25，16： | 13 |
您所在的机构暂未开通此部分的功能，请联系管理员