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| 1 | drug-induced autoimmune liver disease:a diagnostic dilemma of an increasingly reported disease显示文摘The aetiology of autoimmune hepatitis(AIH) is uncer-tain but the disease can be triggered in susceptible patients by external factors such as viruses or drugs.AIH usually develops in individuals with a genetic back-ground mainly consisting of some risk alleles of the major histocompatibility complex(HLA).Many drugs have been linked to AIH phenotypes,which sometimes persist after drug discontinuation,suggesting that they awaken latent autoimmunity.At least three clini-cal scenarios have been proposed that refers to drug- induced autoimmune liver disease(DIAILD):AIH with drug-induced liver injury(DILI); drug induced-AIH(DI-AIH); and immune mediated DILI(IM-DILI).In addi-tion,there are instances showing mixed features of DI-AIH and IM-DILI,as well as DILI cases with positive autoantibodies.Histologically distinguishing DILI from AIH remains a challenge.Even more challenging is the differentiation of AIH from DI-AIH mainly relying in histological features; however,a detailed standard-ised histologic evaluation of large cohorts of AIH and DI-AIH patients would probably render more subtle features that could be of help in the differential diag-nosis between both entities.Growing information on the relationship of drugs and AIH is being available,being drugs like statins and biologic agents more fre-quently involved in cases of DIAILD.In addition,there is some evidence on the fact that patients diagnosed with DIAILD may have had a previous episode of hepa-totoxicity.Further collaborative studies in DIAILD will strengthen the knowledge and understanding of this intriguing and complex disorder which might represent different phenotypes across the spectrum of | Agustin Castiella Eva Zapata M Isabel Lucena Raúl J Andrade | 2014 | World Journal of Hepatology2014，6，4： | 13 |
| 2 | Management of nonalcoholic fatty liver disease:An evidence-based clinical practice review显示文摘AIM:To build a consensus among Chilean specialists on the appropriate management of patients with nonalcoholic fatty liver disease(NAFLD)in clinical practice.METHODS:NAFLD has now reached epidemic proportions worldwide.The optimal treatment for NAFLD has not been established due to a lack of evidence-based recommendations.An expert panel of members of the Chilean Gastroenterological Society and the Chilean Hepatology Association conducted a structured analysis of the current literature on NAFLD therapy.The quality of the evidence and the level of recommendations supporting each statement were assessed according to the recommendations of the United States Preventive Services Task Force.A modified three-round Delphi technique was used to reach a consensus among the experts.RESULTS:A group of thirteen experts was established.The survey included 17 open-ended questions that were distributed among the experts,who assessed the articles associated with each question.The levels of agreement achieved by the panel were 93.8%in the first round and 100%in the second and third rounds.The final recommendations support the indication of lifestyle changes,including diet and exercise,for all patients with NAFLD.Proven pharmacological therapies include only vitamin E and pioglitazone,which can be used in nondiabetic patients with biopsy-proven nonalcoholic steatohepatitis(the progressive form of NAFLD),although the long-term safety and efficacy of these therapies have not yet been established.CONCLUSION:Current NAFLD management is rapidly evolving,and new pathophysiology-based therapies are expected to be introduced in the near future.All NAFLD patients should be evaluated using a three-focused approach that considers the risks of liver disease,diabetes and cardiovascular events. | Juan P Arab Roberto Candia Rodrigo Zapata Cristián Mu?oz Juan P Arancibia Jaime Poniachik Alejandro Soza Francisco Fuster Javier Brahm Edgar Sanhueza Jorge Contreras M Carolina Cuellar Marco Arrese Arnoldo Riquelme | 2014 | World Journal of Gastroenterology2014，20，34： | 11 |
| 3 | Non-invasive methods for liver fi brosis prediction in hemochromatosis:One step beyond显示文摘Advances in recent years in the understanding of, and the genetic diagnosis of hereditary hemochromatosis (HH) have changed the approach to iron overload he-reditary diseases. The ability to use a radiologic tool (MRI) that accurately provides liver iron concentration determination, and the presence of non-invasive sero-logic markers for fibrosis prediction (ser um ferritin, platelet count, transaminases, etc), have diminished the need for liver biopsy for diagnosis and prognosis of this disease. Consequently, the role of liv er biopsy in iron metabolism disorders is changing. Furthermore, the irruption of transient elastography to assess liver stiffness, and, more recently, the ability to determine liver f ibrosis by means of MRI elastography will change this role even more, with a potential drastic decline in hepatic biopsies in years to come. This review will provide a brief summary of the different non-invasive methods available nowadays for diagnosis and prognosis in HH, and point out potential new techniques that could come about in the next years for fibrosis prediction, thus avoiding the need for liver biopsy in a greater number of patients. It is possible that liver biopsy will remain useful for the diagnosis of associated diseases, where other non-invasive means are not po-ssible, or for those rare cases displaying discrepancies between radiological and biochemical markers. | Agustin Castiella Eva Zapata José M Alústiza | 2010 | World Journal of Hepatology2010，2，7： | 3 |
| 4 | Non-lymphoid cells of the Anuran spleen:An ultrastructural study in the natterjack,Bufocalamita显示文摘 | Zapata A Carela M S Leceta J | 1983 | Amer J Anat1983，167，： | 1 |
| 5 | Reduction of pomegranate chilling injury during storage after heat treatment: Role of polyamines显示文摘 | MIRDEHGHAN S H RAHEMIC M MARTINEZ-ROMERO D GUILLEN F VALVERDE J M ZAPATA P J SERRANO M VALERO D | 2007 | Postharvest Biology and Technology2007，44，： | 1 |
| 6 | Ultrastructure of splenic white pulp of the turtle,Mauremyscaspica显示文摘 | Zapata A Leceta J Barrutia M G | 1981 | Cell Tissue Res1981，220，： | 1 |
| 7 | Dynamics of expression of apoptosis regulatory proteins Bid,Bcl-2,Bcl-x,Bax,and Bak during development of murine nervous system显示文摘 | Krajewska M Mai J K Zapata J M | 2002 | Cell Death Differ2002，9，2： | 1 |
| 8 | Polyamines and ethylene changes during germina- tion of different plant species under salinity显示文摘 | Zapata P J Serrano M A Pretel M T | 2004 | Plant Science2004，167，4： | 1 |
| 9 | Inversion control in sugarcane juice with sodium Metasilieate显示文摘 | Alexander G B Acin N D Zapata R M | 1971 | Proc Int Soc Sugarcane Technol1971，13，： | 1 |
| 10 | Genitourinary infections and their association with preterm labor显示文摘 | Gram L F Zapata M I Toy E C | | 0，，： | 1 |
| 11 | Security on VANETs:Privacy,Misbehaving Nodes,False Information and Secure Data Aggregation显示文摘 | Antolino Rivas D Barcelo-Ordinas J M Guerrero Zapata M | 2011 | Network and Computer Applications2011，34，6： | 1 |
| 12 | Expression of multiple apoptosis - regulatory genes in human breast cancer cell hnes and primary tumors显示文摘 | Zapata JM Krajewska M Krajewska S | 1998 | Breast Cancer Res Treat1998，47，2： | 1 |
| 13 | Impairment of the apaptoticaetivity of Bax by missense mutations found in gastrointestinal cancers显示文摘 | Gil J Yamamoto H Zapata J M etal | 1999 | Cancer Res1999，59，9： | 1 |
| 14 | Effect of variables on thequality of hematite precipitated from sulfate solutions 显示文摘 | RUIZ M C ZAPATA J PADILLA R | 2007 | Hydrometallurgy2007，89，2： | 1 |
| 15 | Neu tralizing monoclonal antibody to the E1 glycoprotein epitope of rubella virus mediates virus arrest in VERO cells显示文摘 | Cordoba P Grutadauria S Cuffini C Zapata M | 2000 | Viral Immunol2000，13，1： | 1 |
| 16 | Secure Ad Hoc On-Demand Distance Vector Routing显示文摘 | Zapata M G | 2002 | ACM Mobile Computing and Communications Review2002，6，3： | 1 |
| 17 | Tools to maintain postharvest fruit and vegetable quality through the inhibition of ethylene action: a review显示文摘 | MARTINEZ-ROMERO D BALIEN G SERRANO M GUILLENF VALVERDE J M ZAPATA P CASTILLO S VALERO D | 2007 | Critical Reviews in Food Science and Nutrition2007，47，： | 1 |
| 18 | Carbon isotope discrimination,leaf ash content andgrain yield in bread wheat and durum wheat grown under irrigated conditions显示文摘 | MONNEVEUX P REYNOLDS M P TRETHOWAN R PENNA J ZAPATA F | 2004 | Agronomy & Crop Science2004，190，： | 1 |
| 19 | Effect of missed combined hormonal contraceptives on contraceptive effective- ness: A systematic review显示文摘 | Zapata L B Steenland M W Brahmi D | 2013 | Contraception2013，87，5： | 1 |
| 20 | Lead-lag Rela- tionships between Trading Volume and Price Varia- bility: New Evidence显示文摘 | Carcia P R M Leuthold H Zapata | 1986 | Journal of Futures Mar- kets1986，6110，： | 1 |
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