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| 1 | Accurate relocation of earthquakes in central-western China using the double-difference earthquake location algorithm显示文摘The double-difference earthquake relocation algorithm (DD algorithm) has been applied to the accurate relocation of 10057 earthquakes in the central-western China (21°-36°N, 98°-112E°) during the period of 1992-1999. In total, 79706 readings for P waves and 72169 readings for S waves were used in the relocation, and the source parameters of 6496 events were obtained. The relocation results revealed a more complete picture of the hypocentral distribution in the central-western China. In several seismic belts the relocated epicenters present a more defined lineation feature, reflecting the close correlation between the seismicity and the active tectonic structures. The relocated focal depths confirmed that most earthquakes (91 percent of the 6496 relocated events) in the central-western China were located at shallower depths not deeper than 20 km. The distribution of focal depths indicates that the seismogenic layer in the central-western China is located in the upper-mid crust with its thickness no deeper than 20 km. | YANG Zhixian (杨智娴) CHEN Yuntai (陈运泰) ZHENG Yuejun (郑月军) Yü Xiangwei (于湘伟) | 2003 | Science China Earth Sciences2003，46，z2： | 32 |
| 2 | Petrogenesis and tectonic implications of Late-Triassic high εNd(t)-εHf(t) granites in the Ailaoshan tectonic zone(SW China)显示文摘High εNd(t)-εHf(t) granites are robust evidence for crustal growth. In this paper we report results of petrologic, geochronological and geochemical investigations on the Huashiban granites from the Ailaoshan tectonic zone in western Yunnan(SW China). Zircon grains separated from the two samples(10HH-119 A and 10HH-120A) yield the weighted mean 206Pb/238 U ages of 229.9 ± 2.0 Ma and 229.3 ± 2.3 Ma, respectively, interpreted as the crystallization ages of the granites. Based on our results, in combination with the existing U-Pb geochronological data for the Ailaoshan metamorphic rocks, we propose that the Ailaoshan Group might be a rock complex composed of the Mesoproterozoic, Neoproterozoic, Hercynian, Indosinian and Himalayan components, rather than a part of the crystalline basement of the Yangtze block. The zircon grains show highly depleted Lu-Hf isotope compositions, with positive εHf(t) values ranging from 8.4 to 13.1. The Huashiban granites have high SiO2(72.66 wt%–73.70 wt%), low Mg#(0.28–0.34) with A/CNK=1.01–1.05, and can be classified as peralumious high-K calc-alkaline I-type granites. A synthesis of these data indicates that the Ailaoshan tectonic zone had evolved into a post-collisional setting by the Late-Triassic(229 Ma). Genesis of the Huashiban high εNd(t)-εHf(t) granites involved into two processes:(1) underplating of the sub-arc mantle into the lower crust, and(2) remelting of the juvenile crustal materials in response to the upwelling of the asthenospheric mantle in the post-collisional setting. | LIU HuiChuan WANG YueJun FAN WeiMing ZI JianWei CAI YongFeng YANG GuangLin | 2014 | Science China Earth Sciences2014，57，9： | 12 |
| 3 | An individualized immune signature of pretreatment biopsies predicts pathological complete response to neoadjuvant chemoradiotherapy and outcomes in patients with esophageal squamous cell carcinoma显示文摘No clinically available biomarkers can predict pathological complete response(pCR)for esophageal squamous cell carcinomas(ESCCs)with neoadjuvant chemoradiotherapy(nCRT).Considering that antitumor immunity status is an important determinant for nCRT,we performed an integrative analysis of immune-related gene profiles from pretreatment biopsies and constructed the first individualized immune signature for pCR and outcome prediction of ESCCs through a multicenter analysis.During the discovery phase,14 differentially expressed immune-related genes(DEIGs)with greater than a twofold change between pCRs and less than pCRs( | Chaoqi Zhang Guochao Zhang Nan Sun Zhen Zhang Liyan Xue Zhihui Zhang Haijun Yang Yuejun Luo Xiaoli Zheng Yonglei Zhang Yufen Yuan Ruixue Lei Zhaoyang Yang Bo Zheng Le Wang Yun Che Feng Wang Sihui Wang Shugeng Gao Qi Xue Yi Zhang Jie He | 2020 | Signal Transduction and Targeted Therapy2020，5，1： | 7 |
| 4 | Petrochemistry and Tectonic Setting of the Middle Triassic Arc-Like Volcanic Rocks in the Sayabouli Area,NW Laos显示文摘The volcanic rocks from the Sayabouli area in northwestern Laos have been poorly studied. These volcanic rocks are traditionally mapped as the Permian–Early Triassic sequences on the geological map. One basaltic-andesite from the Sayabouli area yields a zircon U-Pb age of 237.7±1.7 Ma, suggesting a Middle Triassic origin. All basalt and basaltic-andesite samples from the Sayabouli area show depletions in HFSEs(e.g., Nb, Ta, Ti) and have high LILE/HFSE ratios, and exhibit the geochemical affinity to the continental arc volcanic rocks and are geochemically similar to the continental arc volcanic rocks from the Phetchabun belt in northeastern Thailand, suggesting a Late Permian–Middle Triassic continental margin in the Sayabouli area of northwestern Laos and Phetchabun area of northeastern Thailand. Our data indicate that the Phetchabun arc volcanic belt through the western Loei sub-belt can be linked to the Sayabouli area in northwestern Laos. | Xin Qian Qinglai Feng Yuejun Wang Wenqiang Yang Chongpan Chonglakmani Denchok Monjai | 2016 | Journal of Earth Science2016，27，3： | 5 |
| 5 | Prototethyan orogenesis in southwest Yunnan and Southeast Asia显示文摘The Prototethyan Ocean has been suggested as an Early Paleozoic Ocean developed at the Gondwana northern margin. However, its spatial pattern, subduction style and closure time in SW Yunnan and SE Asia still remain unknown. The Prototethyan evolution in SW Yunnan and SE Asia and its internal connection with the South China Kwangsian(Ordo-Silurian)intracontinental orogenesis are also poorly constrained. By summarizing and analyzing the Early Paleozoic geological records in the Sibumasu and Indochina blocks, the eastern South China and SW Japan, this paper proposes the existence of a giant OrdoSilurian igneous belt along the Gondwana northern margin. A preliminary limitation has been obtained regarding the source nature and migration pattern of the igneous belt. Our data allow us to propose a model of the Early Paleozoic Andean-type active continental margin along the East Gondwana northern margin. This is the foundation to determine the southward subduction of the southern branch of the eastern Prototethyan Ocean underneath the Sibumasu and Indochina blocks along the YunxianMenghai(SW Yunnan)-Thailand Peninsula and the Tam Ky-Phouc Son suture in Central Vietnam, respectively, and the eastward linkage with the Early Paleozoic Osaka subduction zone in SW Japan across the peripheral Sanya area. These data synthetically indicate an easterly-diachronous and propagating Andean-type Cambrian(Furongian)-Silurian(Llandovery) orogenesis along the Gondwana northern margin from Nepal, NW India, South Tibet, Qiangtang to Central Vietnam across South Indochina and Sibumasu. This paper reconstructs the Early Paleozoic locations of the Sibumasu and Indochina fragments, as well as SW Japan and South China continent in the Gondwana northern margin, and proposes the far-field effect on the South China Kwangsian intra-continental orogenesis from the subduction of the Early Paleozoic Prototethyan southern branch. | Yuejun WANG Xianghong LU Xin QIAN Sainan WU Yuzhi ZHANG Yang WANG | 2022 | Science China Earth Sciences2022，65，10： | 4 |
| 6 | Volatile Compounds in the Flowers of Freesia Parental Species and Hybrids显示文摘几个世纪,小苍兰属植物是在养花工业的最重要的庄稼之一。这里,从双小苍兰属植物的全部花收集的水空间样品测定一,三四倍体小苍兰属植物栽培变种的三四倍体小苍兰属植物栽培变种,和种间染种用气体被分析用色层法分离结合了质量选择察觉者。总共, 75 不同混合物被识别。混合物主要是萜烯,烃,白酒,脂肪酸酉旨和芳香的班混合物。在这些之中,沉香醇除了无味的白四倍体 F 从所有有香味的花被检测。混合一。在 F 之间的沉香醇的稳定的继承。混合一 and 他们的 F1 子孙被观察。基于现在的分析,在小苍兰属植物和沉香醇的芳香之间的关系被讨论。 | Yang Fu Xiang Gao Yiqun Xue Yuejun Hui Fengqing Chen Quanping Su Li Wang | 2007 | Journal of Integrative Plant Biology2007，49，12： | 4 |
| 7 | Indocyanine Green-Conjugated Magnetic Prussian Blue Nanoparticles for Synchronous Photothermal/Photodynamic Tumor Therapy显示文摘Indocyanine green(ICG) is capable of inducing a photothermal effect and the production of cytotoxic reactive oxygen species for cancer therapy. However, the major challenge in applying ICG molecules for antitumor therapy is associated with their instability in aqueous conditions and rapid clearance from blood circulation,which causes insufficient bioavailability at the tumor site.Herein, we conjugated ICG molecules with Prussian blue nanoparticles enclosing a Fe_3O_4 nanocore, which was facilitated by cationic polyethyleneimine via electrostatic adsorption. The nanocarrier-loaded ICG formed stable aggregates that enhanced cellular uptake and prevented fluorescence quenching. Moreover, the strong superparamagnetism of the Fe_3O_4 core in the obtained nanocomposites further improved cellular internalization of the drugs guided by a localized magnetic field. The therapeutic efficacy of this nanoplatform was evaluated using tumor models established in nude mice, which demonstrated remarkable tumor ablation in vivo due to strong photothermal/photodynamic effects. This study provides promising evidence that this multifunctional nanoagent might function as an efficient mediator for combining photothermal and photodynamic cancer therapy. | Peng Xue Ruihao Yang Lihong Sun Qian Li Lei Zhang Zhigang Xu Yuejun Kang | 2018 | Nano-Micro Letters2018，10，4： | 3 |
| 8 | Protein identification and mRNA analysis of phyto-chrome-regulated genes in Arabidopsis under red light显示文摘Phytochromes are a family of plant photoreceptors that mediate physiological and developmental re- sponses to red and far-red light. According to the affymetrix ATH1 microarray, phytochrome A (phyA) and phytochrome B (phyB) together play a key role in transducing the Rc signals to light-responsive genes. In order to select those red light-responsive genes associated with phyA or phyB, a proteomic approach based on two-dimensional gel electrophoresis (2-DE) was used to compare the protein ex- pression patterns of the phyAphyB double mutant and the wild type of Arabidopsis thaliana (col-4) which grew under constant red light conditions for 7 d. Thirty-two protein spots which exhibited dif- ferences in protein abundance were identified by matrix-assisted laser desorption/ionization-time of flight/time of flight mass spectrometry. The expression of ten genes corresponding to ten protein spots was analyzed by a semiquantitative reverse transcription-polymerase chain reaction. Two of the ten genes were confirmed by quantitative PCR (Q-PCR). The results showed that phytochromes may exert their function by regulating mRNA or protein expressions. Proteomic analysis may provide a novel pathway for identifying phytochrome-dependent genes. | LI Xu*, YANG YueJun*, LI Yan, WANG Jie, XIAO XiaoJuan, GUO XinHong, TANG DongYing & LIU XuanMing Bioenergy and Biomaterial Research Center, College of Life Science and Biotechnology, Hunan University, Changsha 410082, China. | 2009 | Science China(Life Sciences)2009，52，4： | 2 |
| 9 | Chemistry Behind the Immunomodulatory Activity of Astragalus membranaceus显示文摘Huang Qi(黄芪Astragalus membranaceus)is a well-known and widely used herb in traditional Chinese medicine(TCM)tonic preparations.It has been used for many ailments over the last 2000 years.Flavonoids,saponins,and polysaccharides have been shown to be the main compounds responsible for the biological and pharmacological activities,especially the immunomodulatory properties,of such tonic preparations.This review summarizes the published data on Astragalus extracts and fractions and the natural compounds responsible for the immunomodulatory activity with special reference to the modulation of nuclear factor-kappa B and related pathways(e.g.,Nrf2).In addition,this review highlights the importance of Astragalus membranaceus in TCM for treating patients with diseases related to immunocompromised conditions,such as cancer and diabetes. | Mallique Qader Jian Xu Yuejun Yang Xiaohua Wu Yuancai Liu Shugeng Cao | 2021 | Chinese Medicine and Culture2021，4，4： | 2 |
| 10 | Comparative proteomics analysis of light responses in cryptochromel-304 and Columbia wild-type 4 of Arabidopsis thaliana显示文摘 | Yuejun Yang Yan Li Xu Li Xinhong Guo Xiaojuan Xiao Dongying Tang Xuanming Liu | 2008 | Acta Biochimica et Biophysica Sinica2008，40，1： | 2 |
| 11 | Kilogram-scale synthesis of Mg-Al-CO3 LDHs nanosheets using a new two-stage reactor显示文摘 | Liu Yuejun Que Yongsheng Yang Jun | 2010 | Powder Technology2010，201，： | 1 |
| 12 | The Chabu-Chasang zone in Northern Xizang(Tibet)显示文摘 | Li Yuejun HaoJie Li Hongsheng Yang Meiifang | 1994 | Scientia Geological Sinica1994，3，2： | 1 |
| 13 | A New Parity -Check Stopping Criterion for Tur- bo Decoding 显示文摘 | Yuejun Wei Yuhang Yang Lili Wei Wen Chen | 2012 | IEEE communications letters2012，16，10： | 1 |
| 14 | Bioresponsive immune-booster-based prodrug nanogel for cancer immunotherapy显示文摘The combination of chemotherapy and immunotherapy motivates a potent immune system by triggering immunogenic cell death(ICD), showing great potential in inhibiting tumor growth and improving the immunosuppressive tumor microenvironment(ITM). However, the therapeutic effectiveness has been restricted by inferior drug bioavailability. Herein, we reported a universal bioresponsive doxorubicin(DOX)-based nanogel to achieve tumor-specific co-delivery of drugs. DOX-based mannose nanogels(DM NGs) was designed and choosed as an example to elucidate the mechanism of combined chemo-immunotherapy. As expected, the DM NGs exhibited prominent micellar stability, selective drug release and prolonged survival time, benefited from the enhanced tumor permeability and prolonged blood circulation. We discovered that the DOX delivered by DM NGs could induce powerful antitumor immune response facilitated by promoting ICD. Meanwhile, the released mannose from DM NGs was proved as a powerful and synergetic treatment for breast cancer in vitro and in vivo, via damaging the glucose metabolism in glycolysis and the tricarboxylic acid cycle. Overall, the regulation of tumor microenvironment with DOX-based nanogel is expected to be an effectual candidate strategy to overcome the current limitations of ICD-based immunotherapy, offering a paradigm for the exploitation of immunomodulatory nanomedicines. | Xianbin Ma Shaochen Yang Tian Zhang Shuo Wang Qichao Yang Yao Xiao Xiaoxiao Shi Peng Xue Yuejun Kang Gang Liu Zhi-Jun Sun Zhigang Xu | 2022 | Acta Pharmaceutica Sinica B2022，12，1： | 1 |
| 15 | In situ & contro -lled preparation of platinum nanoparticles dopping into graphene sheets@cerium oxide nanocomposites sensitized screen printed electrode for nonenzymatic electrochemical sensing of hydrogen peroxide显示文摘 | Xin Yang Yuejun Ouyang Feng Wu et a/ | 2016 | Journal of Electroanalyti -cal Chemistry2016，，9： | 1 |
| 16 | Cenozoic tectonic evolution of regional fault systems in the SE Tibetan Plateau显示文摘The SE Tibetan Plateau,tectonically situated in the eastern India-Eurasia oblique convergence zone,has experienced multiple stages of deformation since the Cenozoic.Three major tectonic boundaries—the Ailaoshan-Red River,ChongshanLincang-Inthanon,and Gaoligong-Mogok shear zones—delineate the first-order tectonic framework in this region.The most striking structural features in the block interiors are a series of NW-and NE-trending fault systems,such as the Dayingjiang,Longlin-Ruili,Nantinghe,Red River,Weixi-Qiaohou,and Lancang-Genma faults,which have conjugate geometric relationships.In this study,we review these structures’geometric and kinematic characteristics and deformation histories.A synthesis of existing geological observations,geomorphological analyses,and chronological data reveals three major Cenozoic tectonothermal events,including crustal shortening,strike-slip shearing,and kinematic reversal.The boundary structures controlled the tectonic extrusion of plateau material during the early Oligocene-early Miocene.In the mid-late Miocene,NW-and NE-trending fault systems mostly experienced diachronous slip-sense inversions.The onset and spatial trend of regional kinematic reversal are constrained by existing chronologic data.Together with geophysical and geodetic observations,the activity and geodynamic drivers of the major fault systems and regional deformation styles are explored,revealing that the SE Tibetan Plateau underwent a transition from discrete(lateral block extrusion)to diffuse deformation in the mid-late Miocene.The intracontinental crustal deformation and its coupling with dynamic processes at depth during the plateau growth are discussed in the context of the IndiaEurasia convergence. | Yang WANG Yuejun WANG Peizhen ZHANG Jinjiang ZHANG Bo ZHANG Jing LIU-ZENG Renjie ZHOU Weitao WANG Huiping ZHANG Zhangjun LI | 2022 | Science China Earth Sciences2022，65，4： | 1 |
| 17 | Chronic Unpredictable Stress Before Pregnancy Reduce the Expression of Brain-Derived Neurotrophic Factor and N-Methyl-D-Aspartate Receptor in Hippocampus of Offspring Rats Associated with Impairment of Memory显示文摘 | Yuejun Huang Xuechuan Shi Hongwu Xu Hanhua Yang Tian Chen Sihong Chen Xiaodong Chen | 2010 | Neurochemical Research2010，，7： | 1 |
| 18 | Grain-size distribution characteristics of red sandy sediments in Dongjiang River valley,southern Nanling Mountains,during the MIS2 stage显示文摘Layer LJ3 of Linjiang stratigraphic section in Dongjiang River valley in the south of the Nanling Mountains is a set of red sandy sediments.Measured by thermoluminescence(TL) dating,it was found to be formed in MIS2-9,500 ± 800 yr to 19,600 ± 1,800 yr B.P.After analy-sis of the grain sizes of the 16 samples(LJ3-100 to LJ3-85) in this layer,it was discovered that(1) The contents of each grain group in dif-ferent samples are similar.(2) The values of Md,Mz,,Sk,and Kg vary from LJ3-100 to LJ3-85 in a narrow range.(3) The segments of each sample in the accumulative curves extend parallel with similar slopes.All the three aspects reveal the Aeolian characteristics of Layer LJ3.Therefore,it is thought that Layer LJ3 consists of red sandy sediments formed in MIS2 in the south of Nanling Mountain,which reflects the arid climate at that time. | ShuHuan Du 1,BaoSheng Li 1,2,DongFeng Niu 1,XiaoHao Wen 1,FengNian Wang 1,XianJiao Ou 1,Yi Yang 1,YueJun Si 1,XinNan Zhao 1 1.Department of Geography,South China Normal University,Guangzhou,Guangdong 510631,China 2.State Key Laboratory of Loess and Quaternary Geology,Institute of Earth Environment,Chinese Academy of Sciences,Xi’an,Shaanxi 710061,China | 2009 | Research in Cold and Arid Regions2009，1，5： | 1 |
| 19 | Florigen(Ⅱ):It is a Mobile Protein显示文摘The true identity of florigen-the molecule(s) that migrates from leaves to apical meristem to initiate flowering-was notoriously elusive,having made it almost the'Bigfoot'of plant biology.There was never a lack of drama in the field of florigen study,and florigen researchers have once again experienced such a swing in the last two years.We wrote a minireview last year in this journal(Yu et al.2006) to excitedly salute,among other discoveries,the notion that the flowering locus T(FT) mRNA might be the molecular form of a florigen.However,this hypothesis was challenged in a little less than two years after its initial proposition,and the original paper proposed that the FT mRNA hypothesis was retracted(Huang et al.2005;Bohlenius et al.2007).Interestingly enough,the FT gene previously proposed to encode a florigen was never challenged.Rather,the FT protein,instead of the FT mRNA,is now believed to migrate from leaves to the apical meristem to promote floral initiation.In this update,we will share with our readers some entertaining stories concerning the recent studies of florigen in five different plant species.In addition to the published reports referenced in this update,readers may also refer to our previous minireview and references therein for additional background information(Yu et al.2006). | Yuejun Yang John Klejnot Xuhong Yu Xuanming Lu Chentao Lin | 2007 | Journal of Integrative Plant Biology2007，49，12： | 1 |
| 20 | Rock magnetism and magnetic anisotropy in folded sills and basaltic flows:A case study of volcanics from the Taimyr Peninsula, Northern Russia显示文摘Magnetic measurements were performed on apparently deformed igneous rocks of 23 sites from the southeastern part of the Taimyr Peninsula. Rock magnetism and reflected light microscopy analyses reveal that fine-grained titanomagnetites up to pure magnetites mainly carry the majority of magnetic fabrics in the sills, and that the slightly coarser Ti-poor or -medium titanomagnetites carry most mag-netic fabrics in the basaltic flows. Magnetic anisotropies were determined by applying anisotropy of low-field magnetic susceptibility (AMS) on 180 unheated samples and 128 samples that had been pre-viously heated to 600°C during a paleomagnetic study to detect heating effects on the anisotropy of magnetic susceptibility (AMS) properties of volcanic rocks. Laboratory heating significantly affects anisotropy variations of these igneous rocks corresponding to the mineralogical changes during the heat treatment. | ZHANG ShuWei J. Harald WALDERHAUG YANG YueJun | 2008 | Chinese Science Bulletin2008，53，5： | 0 |
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