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| 1 | Tooth loss inhibits neurogenesis in the dentate gyrus of adult mice显示文摘Tooth loss has been shown to affect learning and memory in mice and increases the risk of Alzheimer's disease. The dentate gyrus is strongly associated with cognitive function. This study hypothesized that tooth loss affects neurons in the dentate gyrus. Adult male mice were randomly assigned to either the tooth loss group or normal control group. In the tooth loss group, the left maxillary and mandibular molars were extracted. Normal control mice did not receive any intervention. Immunofluorescence staining revealed that the density and absorbance of doublecortin- and neuronal nuclear antigen-positive cells were lower in the tooth loss group than in the normal control group. These data suggest that tooth loss may inhibit neurogenesis in the dentate gyrus of adult mice. | Shaochen Su Tao Qi Baoli Su Huibin Gu Jianlin Wang Lan Yang | 2014 | Neural Regeneration Research2014，9，17： | 4 |
| 2 | A triboelectric/electromagnetic hybrid generator for efficient wind energy collection and power supply for electronic devices显示文摘Harvesting energy from ambient environment has been considered as a promising strategy for driving portable electronic devices in a sustainable way. A wind driven triboelectric-electromagnetic hybrid nanogenerator has been fabricated to convert wind energy into electricity. It is composed of an electromagnetic generator(EMG) and a triboelectric nanogenerator(TENG) with the output power of 35 and 0.32 mW, respectively when the wind speed is 5 m/s. Generally, TENG shows a low current output with a high voltage output characteristic, on the contrary the EMG shows a high current output and a low voltage output. This hybrid nanogenerator overcomes these problems and exhibits comprehensive and efficient performance on scavenging energy.Moreover, in view of the output performance and charging ability of the hybrid nanogenerator, it shows high stability, making it suitable for charging capacitors or batteries and driving portable electronics sustainably. A new structure of integrated TENG and EMG was designed to harvest wind energy, which shows potential applications in portable and small device power supply system, especially in the areas of remote mountains, deserts, islands, etc., as emergency power supply. | XU GuanPing ZHENG YouBin FENG YanGe MA ShaoChen LUO Ning FENG Min CHEN ShouGang WANG DaoAi | 2021 | Science China(Technological Sciences)2021，64，9： | 2 |
| 3 | Bioresponsive immune-booster-based prodrug nanogel for cancer immunotherapy显示文摘The combination of chemotherapy and immunotherapy motivates a potent immune system by triggering immunogenic cell death(ICD), showing great potential in inhibiting tumor growth and improving the immunosuppressive tumor microenvironment(ITM). However, the therapeutic effectiveness has been restricted by inferior drug bioavailability. Herein, we reported a universal bioresponsive doxorubicin(DOX)-based nanogel to achieve tumor-specific co-delivery of drugs. DOX-based mannose nanogels(DM NGs) was designed and choosed as an example to elucidate the mechanism of combined chemo-immunotherapy. As expected, the DM NGs exhibited prominent micellar stability, selective drug release and prolonged survival time, benefited from the enhanced tumor permeability and prolonged blood circulation. We discovered that the DOX delivered by DM NGs could induce powerful antitumor immune response facilitated by promoting ICD. Meanwhile, the released mannose from DM NGs was proved as a powerful and synergetic treatment for breast cancer in vitro and in vivo, via damaging the glucose metabolism in glycolysis and the tricarboxylic acid cycle. Overall, the regulation of tumor microenvironment with DOX-based nanogel is expected to be an effectual candidate strategy to overcome the current limitations of ICD-based immunotherapy, offering a paradigm for the exploitation of immunomodulatory nanomedicines. | Xianbin Ma Shaochen Yang Tian Zhang Shuo Wang Qichao Yang Yao Xiao Xiaoxiao Shi Peng Xue Yuejun Kang Gang Liu Zhi-Jun Sun Zhigang Xu | 2022 | Acta Pharmaceutica Sinica B2022，12，1： | 1 |
| 4 | Engineering prodrug nanomicelles as pyroptosis inducer for codelivery of PI3K/mTOR and CDK inhibitors to enhance antitumor immunity显示文摘Aberrant activation of oncogenic signaling pathways in tumors can promote resistance to the antitumor immune response.However,single blockade of these pathways is usually ineffective because of the complex crosstalk and feedback among oncogenic signaling pathways.The enhanced toxicity of free small molecule inhibitor combinations is considered an insurmountable barrier to their clinical applications.To circumvent this issue,we rationally designed an effective tumor microenvironment-activatable prodrug nanomicelle(PNM)for cancer therapy.PNM was engineered by integrating the PI3K/m TOR inhibitor PF-04691502(PF)and the broad spectrum CDK inhibitor flavopiridol(Flav)into a single nanoplatform,which showed tumor-specific accumulation,activation and deep penetration in response to the high glutathione(GSH)tumoral microenvironment.The codelivery of PF and Flav could trigger gasdermin E(GSDME)-based immunogenic pyroptosis of tumor cells to elicit a robust antitumor immune response.Furthermore,the combination of PNM-induced immunogenic pyroptosis with antiprogrammed cell death-1(a PD-1)immunotherapy further boosted the antitumor effect and prolonged the survival time of mice.Collectively,these results indicated that the pyroptosis-induced nanoplatform codelivery of PI3K/m TOR and CDK inhibitors can reprogram the immunosuppressive tumor microenvironment and efficiently improve checkpoint blockade cancer immunotherapy. | Qichao Yang Xianbin Ma Yao Xiao Tian Zhang Leilei Yang Shaochen Yang Mengyun Liang Shuo Wang Zhizhong Wu Zhigang Xu Zhijun Sun | 2022 | Acta Pharmaceutica Sinica B2022，12，7： | 0 |
| 5 | A new approach of extracting vegetation points from urban airborne LiDAR data显示文摘Urban vegetation has been an important indicator for the evaluation of eco-cities,which is of great significance to promote eco-city construction. We study and discuss the commonly used urban vegetation extraction methods. The extraction of vegetation points in this study is completed through mathematical statistics,mean-square error,successive differences and iterative algorithm which are based on the analysis of different spatial morphological characteristics in urban point clouds. Linyi,a city of Shandong Province in China,is selected as the study area to test this method and the result shows that the proposed method has a strong practicality in urban vegetation point cloud extraction. Only 3D coordinate properties of the LiDAR point clouds are used in this method and it does not require additional information,for instance,return intensity,which makes the method more applicable and operable. | CUI Shaochen YANG Yuanxin YANG Guodong ZHANG Xuqing | 2018 | Global Geology2018，21，3： | 0 |
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