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| 1 | LA-ICPMS Zircon U-Pb Dating for Three Indosinian Granitic Plutons from Central Hunan and Western Guangdong Provinces and Its Petrogenetic Implications显示文摘典型地, Indosinian graniticplutons 产出的三的 LA-ICPMS 锆石 U-Pb 地球年代学为从在湖南的 Xiema 和 Xiangzikou plutons 的黑云母 monzomitic 花岗石的214.1+ -5.9 妈和210.3+ -4.7 妈的加权平均值~( 206 )Pb/~( 238 ) U 年龄省,并且为从 Napeng pluton 的黑云母花岗石的205.3+ -1.6Ma ,,西方的 Guandong 省分别地,显示出结晶化的类似的迟了的 Indosinian 年龄。在有在华南块(SCB ) 以内的另外的 geochronological 数据 fromIndosinian 花岗石的联合,有约 210 妈和早 Indosinian 花岗石(230-245 妈) 的年龄的那些迟了的 Indosiniangranites 在相同构造背景有类似的岩石成因论,这被建议。在 SCB 以内的 Indosinian 花岗石可能是在压缩政体的变厚的外壳的深溶酌的产品。这些数据为 Indosinian 花岗石的时间、空间的分发和 SCB 的动态进化提供进一步的理解。 | PENG Bingxia WANG Yuejun FAN Weiming PENG Touping LIANG Xinquan | 2006 | Acta Geologica Sinica(English Edition)2006，80，5： | 17 |
| 2 | Convergence of Compressible Euler-Maxwell Equations to Compressible Euler-Poisson Equations显示文摘在这篇论文,到在经由非相对论的限制的一个花托的可压缩的 Euler 泊松方程的时间依赖者 Euler 马方程的集中被学习。两个系统的光滑的答案的本地存在被为第一顺序 symmetrizable 使用精力估计证明夸张系统。为很好准备的起始的数据,答案的集中被 asymptotic 扩大的分析严厉地认为正当直到任何顺序。作者也为一般起始的数据执行起始的层分析;证明 asymptotic 扩大的集中直到第一份订单。 | Yuejun PENG Shu WANG | 2007 | Chinese Annals of Mathematics,Series B2007，28，5： | 7 |
| 3 | ROS-responsive cyclodextrin nanoplatform for combined photodynamic therapy and chemotherapy of cancer显示文摘Cyclodextrin(CD) has special spatial structure and well biological safety,so it has been widely used for constructing CD-based na noplatforms.Through functionalization,cyclodextrin can form various stimulusresponse nanoplatforms,such as pH,temperature,redox,light and magnetic fields.In this study,we designed a highly sensitive reactive oxygen species(ROS)-responsive polymer PCP which encapsulated doxorubicin(DOX) and purpurin 18(P18) to achieve the syne rgy of photodynamic and chemotherapy.The high content of reactive oxygen species(ROS) in the tumor microenvironment(TME) triggers the cleavage of the borate bond of MPEG-CD-PHB(PCP),thereby promoting the re lease of drugs.When irradiated with nea rinfrared laser,the photosensitizer P18 released by polymer micelles can produce reactive oxygen species to promote cell apoptosis.Compared with monotherapy,a series of experiments confirmed that our micelles had enhanced anti-cancer activity.This work was beneficial to the design of ROS-responsive materials and provides an effective strategy for the application of collaborative anti-tumor therapy. | Die Jia Xianbin Ma Yi Lu Xinyi Li Shengxin Hou Yuan Gao Peng Xue Yuejun Kang Zhigang Xu | 2021 | Chinese Chemical Letters2021，32，1： | 4 |
| 4 | Genetic and Molecular Characterization of H9N2 Avian Influenza Viruses Isolated from Live Poultry Markets in Hubei Province, Central China, 2013–2017显示文摘H9N2 subtype avian influenza virus(AIV)is an influenza A virus that is widely spread throughout Asia,where it jeopardizes the poultry industry and provides genetic material for emerging human pathogens.To better understand the epidemicity and genetics of H9 subtype AIVs,we conducted active surveillance in live poultry markets(LPMs)in Hubei Province from 2013 to 2017.A total of 4798 samples were collected from apparent healthy poultry and environment.Realtime RT-PCR revealed that the positivity rate of influenza A was 26.6%(1275/4798),of which the H9 subtype accounted for 50.3%(641/1275)of the positive samples.Of the 132 H9N2 viral strains isolated,48 representative strains were subjected to evolutionary analysis and genotyping.Phylogenetic analysis revealed that all H9N2 viral genes had 91.1%–100%nucleotide homology,clustered with genotype 57,and had high homology with human H9N2 viruses isolated from2013 to 2017 in China.Using a nucleotide divergence cutoff of 95%,we identified ten distinct H9N2 genotypes that continued to change over time.Molecular analysis demonstrated that six H9N2 isolates had additional potential glycosylation sites at position 218 in the hemagglutinin protein,and all isolates had I155 T and Q226 L mutations.Moreover,44 strains had A558 V mutations in the PB2 protein and four had E627 V mutations,along with H9N2 human infection strains A/Beijing/1/2016 and A/Beijing/1/2017.These results emphasize that the H9N2 influenza virus in Hubei continues to mutate and undergo mammalian adaptation changes,indicating the necessity of strengthening the surveillance of the AIV H9N2 subtype in LPMs. | Zhibin Hu Fuhu Peng Zhenghui Xiong Wanpo Zhang Tingting Li Yuejun Shi Jun Xie Xin Jin Jingjing Huang Hongde Xiao Dingren Bi Nianhua Song Zili Li | 2021 | Virologica Sinica2021，36，2： | 4 |
| 5 | Indocyanine Green-Conjugated Magnetic Prussian Blue Nanoparticles for Synchronous Photothermal/Photodynamic Tumor Therapy显示文摘Indocyanine green(ICG) is capable of inducing a photothermal effect and the production of cytotoxic reactive oxygen species for cancer therapy. However, the major challenge in applying ICG molecules for antitumor therapy is associated with their instability in aqueous conditions and rapid clearance from blood circulation,which causes insufficient bioavailability at the tumor site.Herein, we conjugated ICG molecules with Prussian blue nanoparticles enclosing a Fe_3O_4 nanocore, which was facilitated by cationic polyethyleneimine via electrostatic adsorption. The nanocarrier-loaded ICG formed stable aggregates that enhanced cellular uptake and prevented fluorescence quenching. Moreover, the strong superparamagnetism of the Fe_3O_4 core in the obtained nanocomposites further improved cellular internalization of the drugs guided by a localized magnetic field. The therapeutic efficacy of this nanoplatform was evaluated using tumor models established in nude mice, which demonstrated remarkable tumor ablation in vivo due to strong photothermal/photodynamic effects. This study provides promising evidence that this multifunctional nanoagent might function as an efficient mediator for combining photothermal and photodynamic cancer therapy. | Peng Xue Ruihao Yang Lihong Sun Qian Li Lei Zhang Zhigang Xu Yuejun Kang | 2018 | Nano-Micro Letters2018，10，4： | 3 |
| 6 | Cylindrical polymer brushes-anisotropic unimolecular micelle drug delivery system for enhancing the effectiveness of chemotherapy显示文摘Polymer systems can be designed into different structures and morphologies according to their physical and chemical performance requirements,and are considered as one of the most promising controlled delivery systems that can effectively improve the cancer therapeutic index.However,the majority of the polymer delivery systems are designed to be simple spherical nanostructures.To explore morphology/size-oriented delivery performance optimization,here,we synthesized three novel cylindrical polymer brushes(CPBs)by atom transfer radical polymerization(ATRP),which were cellulose-g-(CPT-b-OEGMA)(CCO)with different lengths(~86,~40,and~21 nm).The CPBs are composed of bio-degradable cellulose as the carrier,poly(ethylene glycol)methyl ether methacrylate(OEGMA)as hydrophily block,and glutathione(GSH)-responsive hydrophobic camptothecin(CPT)monomer as loaded anticancer drug.By controlling the chain length of the initiator,three kinds of polymeric prodrugs with different lengths(CCO-1,CCO-2,and CCO-3)could be self-organized into unimolecular micelles in water.We carried out comparative studies of three polymers,whose results verified that the shorter CPBs exhibited higher drug release efficiency,more cellular uptake,and enhanced tumor permeability,accompanied by shortened blood circulation time and lower tumor accumulation.As evidenced by in vivo experiments,the shorter CPBs exhibited higher anti-tumor efficiency,revealing that the size advantage has a higher priority than the anisotropic structure advantage.This provided vital information as to design an anisotropic polymer-based drug delivery system for cancer therapy. | Shuang Bai Die Jia Xianbin Ma Mengyun Liang Peng Xue Yuejun Kang Zhigang Xu | 2021 | Bioactive Materials2021，6，9： | 2 |
| 7 | Polydopamine(PDA)-activated cobalt sulfide nanospheres responsive to tumor microenvironment(TME)for chemotherapeutic-enhanced photothermal therapy显示文摘Most recently,cobalt sulfide(CoS)nanospheres(NSs)have been demonstrated as an ideal high-efficient photothermal agent for tumor elimination.Howeve r,the surface of CoS NSs is lack of functio nal chemical groups or active radicals to incorporate therapeutic agents,which tremendously hinders their versatile utilization in medical field.Here,surface activation of CoS NSs was realized through the growth of polydopamine(PDA)in situ via alkaline-triggered polymerization.Upon the formation of CoS@PDA NSs,thiol-polyethylene glycol(SH-PEG)and chemotherapeutic agent of doxorubicin(DOX)were loaded onto the particle surface by means ofπ-πelectrostatic interaction and Michael addition reactions.Assynthesized CoS@PDA/PEG/DOX(CoPPD)NSs exhibited an admirable photothermal property and high loading capacity of DOX(44.6%).Furthermore,drug release can be accelerated under a more acidic pH condition mimicking tumor microenvironment(TME),ascribed to the protonation of amino group in DOX molecules.Finally,a strong chemotherapeutic-enhanced photothermal therapeutic effect was demonstrated toward solid tumor under near-infrared(NIR)light irradiation without causing significant systemic toxicity.In this regard,this paradigm may offer valuable guidance for the design of multifunctional CoS-based nanoagents for medical treatment. | Mengmeng Hou Yuanxin Zhong Lei Zhang Zhigang Xu Yuejun Kang Peng Xue | 2021 | Chinese Chemical Letters2021，32，3： | 2 |
| 8 | Radiolarian fauna found from Tieshidas Group in East Kunlun显示文摘The Tieshidas Group in Qimantag, a branch of the East Kunlun Mountains, was classically considered the Caledonian basement, and classified into Middle-Upper Ordovician, Upper Ordovician or simply Lower Paleozoic. The radiolarian fauna was found, for the first time, from a chert block in the Tieshidas Group at Yaziquandaban (Pass) north to Ayakum Lake. They are Astroentactinia?mirousi Gourmelon, As. cf biaciculata Nazarov, Archocyrtium cf. diductum Deflandre, Ar. aff. diductum Deflandre, Deflandrellium? sp., Entactinia vulgaris Won, En. cf. additiva Foreman, En.? sp., Entactinosphaera palimbola Foreman, Pylentonema? sp., Triaenosphaera sp. and Tr.7 sp. The geological age of this radiolarian fauna is Early Carboniferous. Evidently, the classical interpretation about the age of Tieshidas Group needs to be checked and modified. Except the Ordovician proved with the formerly discovered fossils, it also includes, at least, Lower Carboniferous rocks. There was still an oceanic basin at Qimantag during Early | LI Yuejun JIA Chengzao HAO Jie WANG Zhaoming ZHENG Duoming PENG Gengxin | 2000 | Chinese Science Bulletin2000，45，10： | 2 |
| 9 | Zero-relaxation-time limits in the hydrodynamic equations for plasmas revisited显示文摘 | Jungel A Peng Yuejun | 2000 | Zeitschrift Far Angewandte Math- ematik und Physik2000，51，3： | 1 |
| 10 | Discussion on seismic fortification levels of offshore platforms in the Bohai Sea and its adjacent area 显示文摘 | Peng Yanju Lv Yuejun | 2006 | Acta Seismologica Sinica2006，27，6： | 1 |
| 11 | Study on design ground motion parameters and seismic fortification criteria of one oil field in the Bohai Sea 显示文摘 | Peng Yanju Lv Yuejun Tang Rongyu | 2007 | Earthquake Engineering and Engineering Vibration2007，27，4： | 1 |
| 12 | Highly specific and ultrasensitive graphene-enhanced electrochemical detection of low-abundance tumor cells using显示文摘 | WU Yafeng XU Peng KAN Yuejun | 2013 | Anal Chem2013，85，： | 1 |
| 13 | Zircon U–Pb geochronology of gneissic rocks in the Yunkai massif and its implications on the Caledonian event in the South China Block显示文摘 | Yuejun Wang Weiming Fan Guochun Zhao Shaocheng Ji Touping Peng | 2006 | Gondwana Research2006，，4： | 1 |
| 14 | Zircon U–Pb geochronology of gneissic rocks in the Yunkai massif and its implications on the Caledonian event in the South China Block显示文摘 | Yuejun Wang Weiming Fan Guochun Zhao Shaocheng Ji Touping Peng | 2006 | Gondwana Research2006，，4： | 1 |
| 15 | Convergence of compressible Euler-Maxwell equations to incompressible Euler equations 显示文摘 | Peng Yuejun Wang Shu | 2008 | Communications in Partial Differential Equations2008，33，： | 1 |
| 16 | Geochemical, 4^40Ar/^39Ar geochronological and Sr-Nd isotopic constraints on the origin of Paleoproterozoic mafic dikes from the southern Taihang Mountains and implications for the North China Craton显示文摘 | Wang Yuejun Fan Weiming Yanhua Zhang Guo Feng Zhang Hongfu Peng Touping | 2004 | Precambn Res2004，135，12： | 1 |
| 17 | Mid-Triassic felsic igneous rocks from the southern Lancangjiang Zone, SW China: Petrogenesis and implications for the evolution of Paleo-Tethys显示文摘 | Touping Peng Simon A. Wilde Yuejun Wang Weiming Fan Bingxia Peng | 2013 | LITHOS2013，，： | 1 |
| 18 | Azimuthal anisotropy of Rayleigh waves in East Asia 显示文摘 | Zhongxian Huang Yanju Peng Yan Luo Yuejun Zheng Wei Su | 2004 | Geophys Res Letters2004，31，： | 1 |
| 19 | Early Cretaceous gabbroic rocks from the Taihang Mountains:Implications for a paleosubduction-related lithospheric mantle beneath the central North China Craton显示文摘 | Wang Yuejun Fan Weiming Zhang Hongfu Peng Touping | 2006 | Lithos2006，86，34： | 1 |
| 20 | Bioresponsive immune-booster-based prodrug nanogel for cancer immunotherapy显示文摘The combination of chemotherapy and immunotherapy motivates a potent immune system by triggering immunogenic cell death(ICD), showing great potential in inhibiting tumor growth and improving the immunosuppressive tumor microenvironment(ITM). However, the therapeutic effectiveness has been restricted by inferior drug bioavailability. Herein, we reported a universal bioresponsive doxorubicin(DOX)-based nanogel to achieve tumor-specific co-delivery of drugs. DOX-based mannose nanogels(DM NGs) was designed and choosed as an example to elucidate the mechanism of combined chemo-immunotherapy. As expected, the DM NGs exhibited prominent micellar stability, selective drug release and prolonged survival time, benefited from the enhanced tumor permeability and prolonged blood circulation. We discovered that the DOX delivered by DM NGs could induce powerful antitumor immune response facilitated by promoting ICD. Meanwhile, the released mannose from DM NGs was proved as a powerful and synergetic treatment for breast cancer in vitro and in vivo, via damaging the glucose metabolism in glycolysis and the tricarboxylic acid cycle. Overall, the regulation of tumor microenvironment with DOX-based nanogel is expected to be an effectual candidate strategy to overcome the current limitations of ICD-based immunotherapy, offering a paradigm for the exploitation of immunomodulatory nanomedicines. | Xianbin Ma Shaochen Yang Tian Zhang Shuo Wang Qichao Yang Yao Xiao Xiaoxiao Shi Peng Xue Yuejun Kang Gang Liu Zhi-Jun Sun Zhigang Xu | 2022 | Acta Pharmaceutica Sinica B2022，12，1： | 1 |
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