| 1 | Assessment of the correlation between serum prolidase and alpha-fetoprotein levels in patients with hepatocellular carcinoma显示文摘AIM: To determine the predictive value of increased prolidase activity that reflects increased collagen turnover in patients with hepatocellular carcinoma(HCC).METHODS: Sixty-eight patients with HCC(mean age of 69.1 ± 10.1), 31 cirrhosis patients(mean age of59.3 ± 6.3) and 33 healthy volunteers(mean age of51.4 ± 12.6) were enrolled in this study. Univariate and multivariate analysis were used to evaluate the association of serum α-fetoprotein(AFP) values with HCC clinicopathological features, such as tumor size,number and presence of vascular and macrovascular invasion. The patients with HCC were divided into groups according to tumor size, number and presence of vascular invasion(diameters; ≤ 3 cm, 3-5 cmand ≥ 5 cm, number; 1, 2 and ≥ 3, macrovascular invasion; yes/no). Barcelona-clinic liver cancer(BCLC)criteria were used to stage HCC patients. Serum samples for measurement of prolidase and alphafetoprotein levels were kept at-80 ℃ until use.Prolidase levels were measured spectrophotometrically and AFP concentrations were determined by a chemiluminescence immunometric commercial diagnostic assay.RESULTS: In patients with HCC, prolidase and AFP values were evaluated according to tumor size, number,presence of macrovascular invasion and BCLC staging classification. Prolidase values were significantly higher in patients with HCC compared with controls(P <0.001). Prolidase levels were significantly associated with tumor size and number(P < 0.001, P = 0.002,respectively). Prolidase levels also differed in patients in terms of BCLC staging classification(P < 0.001).Furthermore the prolidase levels in HCC patients showed a significant difference compared with patients with cirrhosis(P < 0.001). In HCC patients grouped according to tumor size, number and BCLC staging classification, AFP values differed separately(P = 0.032,P = 0.038, P = 0.015, respectively). In patients with HCC, there was a significant correlation(r = 0.616; P< 0.001) between prolidase and AFP values in terms of tumor size, number and BCLC staging classification,whereas the presence of macrovascular invasion did not show a positive association with serum prolidase and AFP levels.CONCLUSION: Considering the levels of both serum prolidase and AFP could contribute to the early diagnosing of hepatocellular carcinoma. | Sevil Uygun Ilikhan Muammer Bilici Hatice Sahin Ayse Semra Demir Akca Murat Can Ibrahim Ilker Oz Berrak Guven M Cagatay Buyukuysal Yucel Ustundag | 2015 | World Journal of Gastroenterology2015，21，22： | 8 |
| 5 | Heart rate profile during exercise in patients with early repolarization显示文摘早极化和改变的心率介绍的背景与突然的死亡被联系。在这研究,我们试图在 exercise.Methods 期间表明在早极化和心率侧面之间的一个协会 84 个题目的一个总数在学习被包括。可比较有早极化的 44 个题目和有正常心电图的 40 个题目经历了测试的锻练应力。休息心率,最大的心率,心率增长和减少两个都是 analyzed.Results 组们为包括休息的基线特征是可比较的心率。最大的心率,心率增长和在早极化组的题目的心率 decrment 显著地减少了与控制相比的最大的心率,心率增长和心率减少组织(所有 P0.05 ) 。更低的心率增长(106 beats/min ) 和心率减少(95 beats/min ) 显著地与早极化的存在被联系。在调整以后好久并且性,多重调整或早极化的存在的风险是 2.98 (95% CI 1.21-7.34 )( P=0.018 )并且(95% CI 2.84-21.03 )( P 0.001 ) 7.73 与高水平相比为更低的心率增长和心率减少,有早极化的 respectively.Conclusions 题目与控制题目相比在锻练期间改变了心率侧面。这能与突然的死亡有关。 | Serkan Cay Goksel Cagirci Ramazan Atak Yucel Balbay Ahmet Duran Demir Sinan Aydogdu | 2010 | Chinese Medical Journal2010，，17： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员