|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Emerging role of Hippo pathway in gastric and othergastrointestinal cancers显示文摘More evidence has underscored the importance of Hippo signaling pathway in gastrointestinal tissue homeostasis, whereas its deregulation induces tumorigenesis. Yes-associated protein 1(YAP1) and its close paralog TAZ, transcriptional co-activator with a PDZbinding motif, function as key effectors negatively controlled by the Hippo pathway. YAP1/TAZ exerts oncogenic activities by transcriptional regulation via physical interaction with TEAD transcription factors. In various cancers, Hippo pathway cross-talks with pro- or anti-tumorigenic pathways such as GPCR, Wnt/β-catenin, Notch and TGF-β signaling and is deregulated by multiple factors including cell density/junction and micro RNAs. As YAP1 expression is significantly associated with poor prognosis of gastric and other gastrointestinal cancers, detailed delineation of Hippo regulation in tumorigenesis provides novel insight for therapeutic intervention. In current review, we summarized the recent research progresses on the deregulation of Hippo pathway in the gastrointestinal tract including stomach and discuss the molecular consequences leading to tumorigenesis. | Wei Kang Alfred SL Cheng Jun Yu Ka Fai To | 2016 | World Journal of Gastroenterology2016，22，3： | 11 |
| 2 | Adiponectin as a negative regulator in obesity-related mammary carcinogenesis显示文摘肥胖和它的联系疾病的流行在我们的社会上提出了巨大的保健影响。肥胖为许多严重医药条件是 maj 或风险因素,例如新陈代谢的症候群,类型 2 糖尿病和心血管的混乱等等。Inaddition,有癌症的肥胖的靠近的协会吸引了重要注意。包括胸,前列腺,子宫内膜,冒号和胆囊癌症,几肥胖相关的癌症有一个神经质的基础并且是生命风格相关。乳癌是最经常的癌症和在女人之中的癌症死亡的第二个领先的原因。在 pre- andpost-menopausal 年的过量脂肪过多是为乳癌的发展的一个独立风险因素,并且也与迟了阶段的疾病和差的预后被联系。 | Yu Wang | 2007 | Cell Research2007，17，4： | 3 |
| 3 | RNA interference by expression of short-interfering RNAs and hairpin RNAs in mammalian cells显示文摘 | Yu JY DeRuiter SL Turner DL | 2002 | Proc Natl Acad Sci USA2002，99，9： | 1 |
| 4 | Mediation of neuronal apoptosis by enhancement of outward potassium current显示文摘 | Yeh CH Scnsi SL | 1997 | Science1997，278，5335： | 1 |
| 5 | RNA interference by expression of short-interfering RNAs and hairpin RNAs in mammalian cells显示文摘 | DeRuiter SL Turner DL | 2002 | Proc Natl Acad Sci USA2002，99，9： | 1 |
| 6 | Medial sural artery perforator flap for intraoral reconstruction following cancer ablation 显示文摘 | Chen SL Yu CC Chang MC | 2008 | Ann Plastic Surgery2008，61，3： | 1 |
| 7 | The influence of genetic polymor- phisms and interacting drugs on initial response to warfarin in Chi- nese patients with heart valve replacement显示文摘 | Zhong SL Liu Y Yu XY | 2011 | Eur J Clin Pharma- col2011，67，6： | 1 |
| 8 | Characterization of mouse peroxiredoxin I genomic DNA and its expression显示文摘 | Lee TH Yu SL Kim SU | 1999 | Gene1999，239，2： | 1 |
| 9 | Podocyte-selective dele?tion of dicer induces proteinuria and glornerulosclero?sis显示文摘 | Shi SL Yu LD Chiu Cv | 2008 | J Am Soc Nephrol2008，19，11： | 1 |
| 10 | MicroRNA in lung cancer显示文摘 | Lin PY Yu SL Yang PC | | 0，，08： | 1 |
| 11 | RNA interference by expression of short-interfering RNAs and hairpin RNAs in mammalian cells显示文摘 | Yu JY DeRuiter SL Turner DL | 2002 | Proc Nail Acad Sci USA2002，99，9： | 1 |
| 12 | A synthetic inhibitor of p53 protects neurons against death induced by ischemic and excitotoxic insults,and amyloid β-peptide显示文摘 | Culmsee C Zhu X Yu QS Chan SL Camandola S Guo Z | 2001 | J Neurochem2001，77，1： | 1 |
| 13 | Ultrasound: a chemotherapy sensitizer显示文摘 | Yu T Li SL Zhao JZ | 2006 | Technology in Cancer Research and Treat- ment2006，5，1： | 1 |
| 14 | Root canal morphologyof permanent maxillary teeth in the Han nationality m ChineseGuanzhong area: a new modified root canal staining techni-que显示文摘 | Weng XL Yu SB Zhao SL | 2009 | J Endod2009，35，5： | 1 |
| 15 | Immunopathological roles of cytokines,chemokines, signaling molecules,and pattern-recognition receptors in systemic lupus erythe- matosus 显示文摘 | Yu SL Kuan WP Wong CK | 2012 | Chn Dev Immunol2012，，71： | 1 |
| 16 | RNA interference by expression of short-interfering RNAs and hairpin RNAs in mammalian cells显示文摘 | Yu JY DeRuiter SL Turner DL | 2002 | Proc Natl Acad Sci USA2002，99，9： | 1 |
| 17 | Medial sural artery perforator flap for intraoral reconstruction following cancer ablation显示文摘 | Chen SL Yu CC Chang MC | 2008 | Ann Plast Surg2008，61，3： | 1 |
| 18 | Pilot study of the as- sociation of the DDAH2-449G polymorphism with asymmetric dimethylarginine and hemodynamic shock in pediatric sepsis显示文摘 | WEISS SL YU M JENNINGS L | 2012 | PLoS One2012，7，33： | 1 |
| 19 | A comparative study of computer assistant sperm analysis with routine sperm analysis显示文摘 | Zhang H Cai SL Yu JJ | 2002 | Zhejiang Da Xue Xue Bao Yi Xue Ban2002，31，3： | 1 |
| 20 | Posterior C1-C2 screw and rod instrument for reduction and fixation of basilar invagination withatlantoaxial dislocation 显示文摘 | Guo SL Zhou DB Yu XG | 2014 | Eur Spine J2014，23，8： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员