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| 1 | Gut microbiome profiling and colorectal cancer in African Americans and Caucasian Americans显示文摘AIM To determine whether and to what extent the gut microbiome is involved in regulating racial disparity in colorectal cancer(CRC). METHODS All patients were recruited and experiments were performed in accordance with the relevant guidelines and regulations by the Institutional Review Boards (IRB), committees of the John D. Dingell VAMC and Wayne State University guidelines. African American (AA) and Caucasian American (CA) patients were scheduled for an outpatient screening for colonoscopy, and no active malignancy volunteer patients were doubly consented, initially by the gastroenterologist and later by the study coordinator, for participation in the study. The gut microbial communities in colonic effluents from AAs and CAs were examined using 16 sRNA profiling, and bacterial identifications were validated by performing SYBR-based Real Time PCR. For metagenomic analysis to characterize the microbial communities, multiple software/tools were used, including Metastats and R statistical software.RESULTS It is generally accepted that the incidence and mortality of CRC is higher in AAs than in CAs. However, the reason for this disparity is not well understood. We hypothesize that the gut microbiome plays a role in regulating this disparity. Indeed, we found significant differences in species richness and diversity between AAs and CAs. Bacteroidetes was more abundant in AAs than in CAs. In particular, the pro-inflammatory bacteria Fusobacterium nucleatum and Enterobacter species were significantly higher in AAs, whereas probiotic Akkermansia muciniphila and Bifidobacterium were higher in CAs. The polyphyletic Clostridia class showed a divergent pattern, with Clostridium XI elevated in AAs, and Clostridium IV, known for its beneficial function, higher in CAs. Lastly, the AA group had decreased microbial diversity overall in comparison to the CA group. In summary, there were significant differences in pro-inflammatory bacteria and microbial diversity between AA and CA, which may help explain the CRC disparity between groups.CONCLUSION Our current investigation, for the first time, demonstrates microbial dysbiosis between AAs and CAs, which could contribute to the racial disparity of CRC. | Lulu Farhana Fadi Antaki Farhan Murshed Hamidah Mahmud Stephanie L Judd Pratima Nangia-Makker Edi Levi Yingjie Yu Adhip PN Majumdar | 2018 | World Journal of Gastrointestinal Pathophysiology2018，9，2： | 3 |
| 2 | SOX1 suppresses cell growth and invasion in cervical cancer显示文摘 | Lin YW Tsao CM Yu PN | 2013 | Gyneeologie Oneology2013，131，1： | 1 |
| 3 | Comparison of a 6 month course peginterferon alpha-2b plus ribavirin and interferon alpha-2a plus ribavirin in treating Chinese patients with chronic hepatitis C in Taiwan显示文摘 | Lee SD Yu ML Cheng PN | 2005 | J Vrial Hepat2005，12，3： | 1 |
| 4 | False-negative fine-needle aspi-ration of thyroid nodules cannot be attributed to sampling error alone显示文摘 | Yu XM Patel PN Chen H | | 0，，： | 1 |
| 5 | Comparison of a 6-month course peginterferon alpha-2b plus ribavirin and interferon alpha-2a plus ribavirin in treating Chinese patients with chronic hepatitis C in Taiwan显示文摘 | Lee SD Yu ML Cheng PN | 2005 | J Viral Hepat2005，12，3： | 1 |
| 6 | Relationship of pulmonary arterycatheter use to mortality and resource utilization in patients with severesepsis显示文摘 | Yu DT Platt R Lanken PN | 2003 | Critical Care Medicine2003，31，12： | 1 |
| 7 | Effects of high-dose modi-fied-release nicotinic acid on atherosclerosis and vascular function:a randomized,placebo-controlled,magnetic resonance imaging study显示文摘 | Lee JM Robson MD Yu LM Shirodaria CC CunningtonC Kylintireas I Digby JE Bannister T Handa A Wiesmann F Durrington PN Channon KM Neubauer S Choudhury RP | 2009 | J Am Coll Cardiol2009，54，19： | 1 |
| 8 | Heparanase in primary humanosteoblasts显示文摘 | Smith PN Freeman C Yu D | 2010 | J Orthop Res2010，28，10： | 1 |
| 9 | A novel molecularly imprinted core-shell chemiluminescence sensor:preparation and pendimethalin recognition显示文摘 | Zhao PN Liu SQ Yu JH | 2011 | Journal of Inorganic and Organometallic Polymers and Materials2011，21，4： | 1 |
| 10 | Soxl suppresses cell growth and invasion in cervical cancer 显示文摘 | Lin YW Tsao CM Yu PN | 2013 | Gynecologic oncology2013，131，1： | 1 |
| 11 | Placenta growth factor expression is correlated with survival of patients with colorectal cancer显示文摘 | Wei SC Tsao PN Yu SC | 2005 | Gut2005，54，： | 1 |
| 12 | Dissecting the molecular con- trol of endothelial NO synthase by 'aveolin-I using cell-permeable peptides显示文摘 | Bernatchez PN Bauer PM Yu J | 2005 | Proc Natl Acad Sci USA2005，102，3： | 1 |
| 13 | Comparison of a 6 - month course peginterferon alpha - 2b plus ribavirin and interferon alpha - 2b plus ribavirin in treating Chinese patients with chronic hepatitis C inTaiwan显示文摘 | Lee SD Yu ML Cheng PN | 2005 | J Viral Hepat2005，12，3： | 1 |
| 14 | Dissecting the molecular control of endothelial NO synthase by caveolin - 1 using cell - permeable peptides 显示文摘 | Bernatchez PN Bauer PM Yu J | 2005 | Proc Natl Acad Sci USA2005，102，3： | 1 |
| 15 | Downregulation of miR-29contributes to cisplatin resistance of ovarian cancer cells显示文摘 | Yu PN Yan MD Lai HC | 2014 | Int J Cancer2014，134，： | 1 |
| 16 | Comparison of a 6 month course peglntefferon alpha-2b plus ribavirin and interferon alpha-2a plus ribaviria in treating Chinese patients with chronic hepatitis C in Taiwan显示文摘 | Lee SD Yu ML Cheng PN | 2010 | J Vfial Hepat2010，12，3： | 1 |
| 17 | Role of cancer stem cells in age-related rise in colorectal cancer显示文摘Colorectal cancer(CRC) that comprises about 50% of estimated gastrointestinal cancers remains a high mortality malignancy. It is estimated that CRC will result in 9% of all cancer related deaths. CRC is the third leading malignancy affecting both males and females equally; with 9% of the estimated new cancer cases and 9% cancer related deaths. Sporadic CRC, whose incidence increases markedly with advancing age, occurs in 80%-85% patients diagnosed with CRC. Little is known about the precise biochemical mechanisms responsible for the rise in CRC with aging. However, many probable reasons for this increase have been suggested; among others they include altered carcinogen metabolism and the cumulative effects of long-term exposure to cancer-causing agents. Herein, we propose a role for self-renewing, cancer stem cells(CSCs) in regulating these cellular events. In this editorial, we have briefly described the recent work on the evolution of CSCs in gastro-intestinal track especially in the colon, and how they are involved in the age-related rise in CRC. Focus of this editorial is to provide a description of(1) CSC;(2) epigenetic and genetic mechanisms giving rise to CSCs;(3) markers of CSC;(4) characteristics; and(5) age-related increase in CSC in the colonic crypt. | Pratima Nangia-Makker Yingjie Yu Adhip PN Majumdar | 2015 | World Journal of Gastrointestinal Pathophysiology2015，6，4： | 1 |
| 18 | Transgenic expression of single-chain anti-CTLA-4 Fv on beta cells protects nonobese diabetic mice from autoimmune diabetes 显示文摘 | Shieh S J Chou FC Yu PN | 2009 | J Immunol2009，183，4： | 1 |
| 19 | Dissecting the molecular control of endothelial NO synthase by caveolin - 1 using cell - per- meable peptides显示文摘 | Bernatchez PN Bauer PM Yu J | 2005 | Proc Natl Acad Sci USA2005，102，3： | 1 |
| 20 | Placenta growth factorexpression is correlated with survival of patients withcolorectal cancer显示文摘 | Wei SC Tsao PN Yu SC | 2005 | Gut2005，54，5： | 1 |
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