|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Real-time dynamics and cross-correlation gating spectroscopy of free-carrier Drude slow-light solitons显示文摘Optical solitons—stable waves balancing delicately between nonlinearities and dispersive effects—have advanced the field of ultrafast optics and dynamics,with contributions spanning from supercontinuum generation to soliton fission,optical event horizons,Hawking radiation and optical rogue waves,among others.Here,we investigate picojoule soliton dynamics in silicon slow-light,photonic-bandgap waveguides under the influence of Drude-modeled,free-carrier-induced nonlinear effects.Using real-time and single-shot amplified dispersive Fourier transform spectroscopy simultaneously with high-fidelity cross-correlation frequency resolved optical gating at femtojoule sensitivity and femtosecond resolution,we examine the soliton stability limits,the soliton dynamics including free-carrier quartic slow-light scaling and acceleration,and the Drude electron–hole plasma-induced perturbations in the Cherenkov radiation and modulation instability.Our real-time single-shot and time-averaged cross-correlation measurements are matched with our detailed theoretical modeling,examining the reduced group velocity free-carrier kinetics on solitons at the picojoule scale. | Heng Zhou Shu-Wei Huang Xiujian Li James F McMillan Chi Zhang Kenneth Kin-Yip Wong Mingbin Yu Guo-Qiang Lo Dim-Lee Kwong Kun Qiu Chee Wei Wong | 2017 | Light(Science & Applications)2017，6，1： | 1 |
| 2 | Prognostic Role and Potential Mechanisms of N6-methyladenosine-related Long Noncoding RNAs in Hepatocellular Carcinoma显示文摘Background and Aims:Numerous studies have explored the important role of N6-methyladenosine(m^(6)A)in cancer.Nonetheless,the interaction between m^(6)A and long noncoding RNAs(lncRNAs)is poorly investigated.Herein,we systematically analyzed the role and prognostic value of m^(6)A-related lncRNAs in hepatocellular carcinoma(HCC).Methods:The m^(6)A-related lncRNAs were identified based on the correlation coefficients with m^(6)A-related genes in HCC from The Cancer Genome Atlas.Subsequently,a novel risk score model was determined using the least absolute shrinkage and selection operator Cox regression analyses.Univariate and multivariate Cox analyses were used to identify independent prog-nostic factors for overall survival(OS)of HCC;thereafter,a prognostic nomogram was constructed.Results:A total of 259 lncRNAs showed significant correlations with m^(6)A in HCC,while 29 lncRNAs had prognostic significance.Further,six critical m^(6)A-related lncRNAs(NRAV,SNHG3,KDM4A-AS1,AC074117.1,AC025176.1,and AL031985.3)were screened out to construct a novel risk score model which classified HCC patients into high-and low-risk groups.Survival analy-ses revealed that patients in the high-risk group exhibited worse OS,both in the training and validation groups.The risk score was also identified as an independent prognostic factor of OS,and a nomogram was established and verified with superior prediction capacity.Besides,the risk score signifi-cantly correlated with the expression of immune checkpoint genes and immune subtypes.Conclusions:These findings indicated the significant role of m^(6)A-related lncRNAs in HCC and the potential application of the novel risk score model for prognostic prediction. | Tianxing Dai Jing Li Linsen Ye Haoyuan Yu Mingbin Deng Wei Liu Hua Li Yang Yang Guoying Wang | 2022 | Journal of Clinical and Translational Hepatology2022，10，2： | 1 |
| 3 | Novel NiGe MSM photodetector featuring asymmetrical Schottky barriers using sulfur Co-implantation and segregation 显示文摘 | ANG Kah-Wee YU Mingbin ZHU Shiyang | 2008 | IEEE Electron Device Letters(S0741-3106)2008，29，7： | 1 |
| 4 | Improvements on surface carrier mobility and electrical stability of MOSFETs using HfTaO gate dielectric 显示文摘 | Yu Xiongfei Zhu Chunxiang Yu Mingbin | 2004 | IEEE Transactions on Electron Devices2004，51，12： | 1 |
| 5 | Experimental and numerical study on the dynamic shear banding mechanism of HfNbZrTi high entropy alloy显示文摘High-entropy alloys(HEAs) have attracted considerable attention in recent years because of their unique mechanical properties.In this work, the mechanism of dynamic shear banding(also called adiabatic shear bands, ASBs) in a BCC HEA HfNbZrTi was investigated combining dynamic experiments and numerical simulations. The temperature evolution during dynamic shear banding, which has been believed to play a dominant role during ASB formation in the literature, was measured using high-speed infrared thermal detectors synchronized with a split Hopkinson pressure bar system. The dynamic mechanical behavior of the BCC HEA was described using the Johnson-Cook model accompanied by damage accumulation. The process of ASB formation,considering potential contributions from thermal softening and damage softening, was numerically investigated by controlling the activation of each softening mechanism separately. Based on the results of experimental observation and numerical analysis,dynamic shear banding in this BCC HEA is proposed to be dominated by damage softening, and thermal softening only plays a secondary role, which differs from the thermal-softening-dominated ASB formation in typical FCC HEAs such as the Cantor alloy. | SONG Wei-Li MA Quan ZENG QingLei ZHU ShengXin SUI MingBin CAO TangQing QI Wei CHEN YinQiang YU XiaoQi XUE YunFei CHEN Hao-Sen | 2022 | Science China(Technological Sciences)2022，65，8： | 1 |
| 6 | Advanced HfTaON/SiO2 gate stack with high mobility and low leakage current for low-standby-power application 显示文摘 | Yu Xiongfei Yu Mingbin Zhu Chunxiang | 2006 | IEEE Electron Device Letters2006，27，6： | 1 |
| 7 | CMOS-compatible high efficiency double-etched apodizedwaveguide grating coupler 显示文摘 | Li Chao Zhang Huijuan Yu Mingbin | 2013 | Opt Express2013，21，7： | 1 |
| 8 | Real-time transition dynamics and stability of chipscale dispersion-managed frequency microcombs显示文摘Femtosecond mode-locked laser frequency combs have served as the cornerstone in precision spectroscopy,alloptical atomic clocks,and measurements of ultrafast dynamics.Recently frequency microcombs based on nonlinear microresonators have been examined,exhibiting remarkable precision approaching that of laser frequency combs,on a solid-state chip-scale platform and from a fundamentally different physical origin.Despite recent successes,to date,the real-time dynamical origins and high-power stabilities of such frequency microcombs have not been fully addressed.Here,we unravel the transitional dynamics of frequency microcombs from chaotic background routes to femtosecond mode-locking in real time,enabled by our ultrafast temporal magnifier metrology and improved stability of dispersion-managed dissipative solitons.Through our dispersion-managed oscillator,we further report a stability zone that is more than an order-of-magnitude larger than its prior static homogeneous counterparts,providing a novel platform for understanding ultrafast dissipative dynamics and offering a new path towards high-power frequency microcombs. | Yongnan Li Shu-Wei Huang Bowen Li Hao Liu Jinghui Yang Abhinav Kumar Vinod Ke Wang Mingbin Yu Dim-Lee Kwong Hui-Tian Wang Kenneth Kin-Yip Wong Chee Wei Wong | 2020 | Light(Science & Applications)2020，9，1： | 1 |
| 9 | Stimulated generation of deterministic platicon frequency microcombs显示文摘Dissipative Kerr soliton generation in chip-scale nonlinear resonators has recently observed remarkable advances,spanning from massively parallel communications, to self-referenced oscillators, and to dual-comb spectroscopy.Often working in the anomalous dispersion regime, unique driving protocols and dispersion in these nonlinear resonators have been examined to achieve the soliton and soliton-like temporal pulse shapes and coherent frequency comb generation. The normal dispersion regime provides a complementary approach to bridge the nonlinear dynamical studies, including the possibility of square pulse formation with flattop plateaus, or platicons.Here we report observations of square pulse formation in chip-scale frequency combs through stimulated pumping at one free spectral range and in silicon nitride rings with +55 fs~2∕mm normal group velocity dispersion.Tuning of the platicon frequency comb via a varied sideband modulation frequency is examined in both spectral and temporal measurements. Determined by second-harmonic autocorrelation and cross correlation, we observe bright square platicon pulse of 17 ps pulse width on a 19 GHz flat frequency comb. With auxiliary-laser-assisted thermal stabilization, we surpass the thermal bistable dragging and extend the mode-locking access to narrower 2 ps platicon pulse states, supported by nonlinear dynamical modeling and boundary limit discussions. | HAO LIU SHU-WEI HUANG WENTING WANG JINGHUI YANG MINGBIN YU DIM-LEE KWONG PIERRE COLMAN CHEE WEI WONG | 2022 | Photonics Research2022，10，8： | 0 |
| 10 | Thermally tunable GeSi electro-absorption modulator with a wide effective operating wavelength range显示文摘We demonstrate a GeSi electro-absorption modulator with on-chip thermal tuning for the first time,to the best of our knowledge.Theoretical simulation proves that the device temperature can be tuned and the effective operating wavelength range can be broadened.When the heater power is 4.63 mW,the temperature of the waveguide increases by about 27 K and the theoretical operating wavelength range is broadened by 23.7 nm.The experimental results show that the optical transmission line shifted to the longer wavelength by 4.8 nm by every 1 mW heater power.The effective static operating wavelength range of the device is increased from 34.4 nm to 60.1 nm,which means it is broadened by 25.7 nm.The band edge shift coefficient of 0.76 nm/K is obtained by temperature simulation and linear fitting of the measured data.The device has a 3 dB EO bandwidth of 89 GHz at 3 V reverse bias,and the eye diagram measurement shows a data rate of 80 Gbit/s for non-return-to-zero on–off keying modulation and 100 Gbit/s for 4 pulse amplitude modulation in the 1526.8 nm to 1613.2 nm wavelength range as the heater power increases from 0 mW to 10.1 mW. | YUFEI LIU JIALIANG SUN XINYU LI SHUXIAO WANG WENCHENG YUE YAN CAI MINGBIN YU | 2023 | Photonics Research2023，11，8： | 0 |
| 11 | CPAL, as a New Mediator of Cardiomyocyte Metabolic Alterations and Pyroptosis, Regulates Myocardial Infarction Injury in Mice显示文摘Myocardial infarction (MI), the most serious of the ischemic heart diseases, is accompanied by myocardial metabolic disorders and the loss of cardiomyocytes. Increasing evidence has shown that long noncoding RNAs (lncRNAs) are involved in various pathological conditions such as cancer and cardiovascular diseases (CVDs), and are emerging as a novel biomarker for these disorders. This study aims to investigate the regulatory role and mechanisms of lncRNAs in myocardial remodeling in the setting of MI. We find that post-infarcted hearts exhibit a reduction of adenosine triphosphate (ATP) and an alteration of the glucose and lipid metabolism genes cluster of differentiation 36 (CD36), hexokinase 1 (HK1), and clucose transporter 4 (GLUT4), accompanied by cardiomyocyte pyroptosis. We then identify a previously unknown conserved lncRNA, AK009126 (cardiomyocyte pyroptosis-associated lncRNA, CPAL), which is remarkably upregulated in the myocardial border zone of MI mice. Importantly, the adeno-associated virus 9 (AAV9)-mediated silencing of endogenous CPAL by its short hairpin RNA (shRNA) partially abrogates myocardial metabolic alterations and cardiomyocyte pyroptosis during MI in mice. Mechanistically, CPAL is shown to bind directly to nuclear factor kappa B (NFκB) and to act as an activator of NFκB to induce NFκB phosphorylation in cardiomyocytes. We also find that CPAL upregulates caspase-1 expression at the transcriptional level and consequently promotes the release of interleukin (IL)-18 and IL-1β from cardiomyocytes. Collectively, our findings reveal the conserved lncRNA CPAL as a new regulator of cardiac metabolic abnormalities and cardiomyocyte pyroptosis in the setting of MI and suggest CPAL as a new therapeutic target to protect cardiomyocytes against ischemic injury in infarcted hearts. | Jiamin Li Hongru Xue Ning Xu Liling Gong Ming Li Sijia Li Di Huang Qingwei Zhang Pengyu Li Qingsui Li Hang Yu Yining Liu Yadong Xue Haixin Chen Jiali Liu Wanyu Zhang Mingbin Liu Siyu Chang Xianzhi Lang Xingmiao Zhao Weijie Du Benzhi Cai Ning Wang Baofeng Yang | 2023 | Engineering2023，，1： | 0 |
| 12 | Upregulation of TMCO3 Promoting Tumor Progression and Contributing to the Poor Prognosis of Hepatocellular Carcinoma显示文摘Background and Aims:TMCO3,a member of the monovalent cation:proton antiporter-2 family,has been annotated as a Na^(+)/H^(+)antiporter,but its pathophysiological role is still unclear.We aimed to investigate the expression profile,prognostic significance,and oncogenic role of TMCO3 in hepatocellular carcinoma(HCC).Methods:Bioinformatic analyses were conducted using transcriptome data from public databases to determine the expression,prognosis,and functional enrichment of TMCO3 in HCC.TMCO3 expression was further validated in an independent HCC cohort from our institution.The oncogenic role of TMCO3 in HCC was evaluated using in vitro and in vivo experiments.Results:The upregulated expression of TMCO3 was identified and verified in multiple HCC cohorts,and worse overall survival and recurrence-free survival were observed in patients with high TMCO3 expression.The overexpression and knockdown of TMCO3 could affect the proliferation and metastasis of HCC cells,which might be associated with the p53-induced cell cycle regulation and epithelial-mesenchymal transition,respectively.Notably,significant correlations were found between dysregulated TMCO3 and various antitumor agents.Its role in sorafenib sensitivity was further identified by in vitro experiments and the potential mechanism might be related to the regulation of apoptosis.Positive correlations were also identified between upregulation of TMCO3 and the increased infiltration of various immune cells and the elevated expression of multiple immune checkpoint genes in HCC.Conclusions:Upregulated TMCO3 could act as an oncogenic mediator and promote sorafenib resistance in HCC,providing a potential therapeutic target for HCC treatment. | Tianxing Dai Linsen Ye Mingbin Deng Guozhen Lin Rongqiang Liu Haoyuan Yu Wei Liu Yang Yang Guoying Wang | 2022 | Journal of Clinical and Translational Hepatology2022，10，5： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员