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| 1 | Deep Structural Framework and Genetic Analysis of Gold Concentration Areas in the Northwestern Jiaodong Peninsula, China: A New Understanding based on High-Resolution Reflective Seismic Survey显示文摘The gold concentration areas in the northwestern Jiaodong Peninsula constituted an important gold metallogenetic region in Eastern China during the Mesozoic. The deep geological bodies' texture characteristic is important for exploring the resources thoroughly and understanding the metallogenic process. The detailed textures were revealed using high-resolution seismic profiles through the three major ore-controlling structures-Sanshandao fault zone, Jiaojia fault zone and Zhaoping fault zone. This study aims to establish a deep structural framework of this area. Based on their formation mechanism, the fault structures developed in the area can be divided into regional and local fault structures. The structural styles are characterised by superimposing their compressional, strike-slip and extensional multi-stage activities. The crust is cut by vertical structures corresponding to a left-lateral strike-slip fault system on the surface. Nearby these structures are the arc-shape structures formed by multi-stage magma intrusions into the upper crust. Bounded by the Tancheng–Lujiang and Muping–Jimo fault zones, the current Jiaodong block, developed a series of NE-trending strike-slip fault systems, was probably formed by the assemblage of several obliquely aligned blocks. The intensive magmatism and hydrothermal activity between the blocks induced large-scale mineralisation. It provides a new angle of view for understanding the cratonic destruction and large ore-concentration formed during the Mesozoic. | YU Xuefeng SHAN Wei XIONG Yuxin GENG Ke SUN Yuqin CHI Naijie GUO Baokui LI Dapeng LI Hongkui SONG Yingxin YANG Deping | 2018 | Acta Geologica Sinica(English Edition)2018，92，5： | 19 |
| 2 | Piglets cloned from induced pluripotent stem cells显示文摘 | Nana Fan Jijun Chen Zhouchun Shang Hongwei Dou Guangzhen Ji Qingjian Zou Lu Wu Lixiazi He Fang Wang Kai Liu Na Liu Jianyong Han Qi Zhou Dengke Pan Dongshan Yang Bentian Zhao Zhen Ouyang Zhaoming Liu Yu Zhao Lin Lin Chongming Zhong Quanlei Wang Shouqi Wang Ying Xu Jing Luan Yu Liang Zhenzhen Yang Jing Li Chunxia Lu Gabor Vajta Ziyi Li Hongsheng Ouyang Huayan Wang Yong Wang Yang Yang Zhonghua Liu Hong Wei Zhidong Luan Miguel A Esteban Hongkui Deng Huanming Yang Duanqing Pei Ning Li Gang Pei Lin Liu Yutao Du Lei Xiao Liangxue Lai | 2013 | Cell Research2013，23，1： | 12 |
| 3 | Elimination of senescent cells byβ-galactosidase-targeted prodrug attenuates inflammation and restores physical function in aged mice显示文摘Cellular senescence,a persistent state of cell cycle arrest,accumulates in aged organisms,contributes to tissue dysfunction,and drives age-related phenotypes.The clearance of senescent cells is expected to decrease chronic,low-grade inflammation and improve tissue repair capacity,thus attenuating the decline of physical function in aged organisms.However,selective and effective clearance of senescent cells of different cell types has proven challenging.Herein,we developed a prodrug strategy to design a new compound based on the increased activity of lysosomalβ-galactosidase(β-gal),a primary characteristic of senescent cells.Our prodrug SSK1 is specifically activated byβ-gal and eliminates mouse and human senescent cells independently of senescence inducers and cell types.In aged mice,our compound effectively cleared senescent cells in different tissues,decreased the senescence-and age-associated gene signatures,attenuated low-grade local and systemic inflammation,and restored physical function.Our results demonstrate that lysosomalβ-gal can be effectively leveraged to selectively eliminate senescent cells,providing a novel strategy to develop anti-aging interventions. | Yusheng Cai Huanhuan Zhou Yinhua Zhu Qi Sun Yin Ji Anqi Xue Yuting Wang Wenhan Chen Xiaojie Yu Longteng Wang Han Chen Cheng Li Tuoping Luo Hongkui Deng | 2020 | Cell Research2020，30，7： | 12 |
| 4 | Influence of Bedding and Mineral Composition on Mechanical Properties and Its Implication for Hydraulic Fracturing of Shale Oil Reservoirs显示文摘The premise of hydraulic fracturing is to have an accurate and detailed understanding of the rock mechanical properties and fracture propagation law of shale reservoirs. In this paper,a comprehensive evaluation of the mechanical properties of the shale oil reservoir in the south of Songliao Basin is carried out. Based on the experiments and the in-situ stress analysis, the fracture propagation law of three types of shale reservoirs is obtained,and the suggestions for fracturing are put forward. The results have shown that the fracture propagation of pure shale and low mature reservoir is easy to open along the bedding plane under compression loading,which is greatly influenced by the bedding. Sand-bearing shale is slightly better,the fractures of which are not easy to open along the bedding plane. The mechanical experimental results show that all the samples have the characteristics of low compressive strength,low Young’s modulus and strong anisotropy,indicating that the shale oil reservoir is certain plastic,which is related to its high clay mineral content and controlled by the bedding development. Compared with pure shale and low mature shale,the sandbearing shale has less clay content and less developed bedding,which maybe the main reason for its slightly better brittleness. Overall,the expansion of hydraulic fracture is controlled by in-situ stress and bedding. Because of the development of bedding,it is easy to form horizontal fractures. Thus it is not suitable for horizontal well fracturing.Because of the high content of clay minerals,the applicability of conventional slick hydraulic fracturing fluid is poor. It is suggested to use vertical well or directional well to carry out volume fracturing. In this way,the effect of bedding can be effectively used to open and connect the bedding and form a larger fracture network. | WANG Xiaoqiong XU Jianguo ZHAO Chenxu LIU Tongyuan GE Hongkui SHEN Yinghao WU Shan YU Jiayao HUANG Rongyan | 2020 | Earthquake Research in China2020，34，2： | 2 |
| 5 | Ultrasound imaging of chitosan nerve conduits that bridge sciatic nerve defects in rats显示文摘The repair of peripheral nerve injuries with autologous nerve remains the gold standard(Wang et al.,2005;Yao et al.,2010;Deal et al.,2012;Kriebel et al.,2014;Liu et al.,2014;Tamaki et al.,2014;Yu et al.,2014;Zhu and Lou,2014).With advances in tissue engineering and biomaterials,tissue-engineered nerve conduits with various biomaterials and structures,such as collagen and chitosan nerve conduits,have already been used | Xiaoyang Chen Yifei Yin Tingting Zhang Yahong Zhao Yumin Yang Xiaomei Yu Hongkui Wang | 2014 | Neural Regeneration Research2014，9，14： | 1 |
| 6 | A dual channel perturbation particle filter algorithm based on GPU acceleration显示文摘The particle filter(PF) algorithm is one of the most commonly used algorithms for maneuvering target tracking. The traditional PF maps from multi-dimensional information to onedimensional information during particle weight calculation, and the incorrect transmission of information leads to the fact that the particle prediction information does not match the weight information, and its essence is the reduction of the information entropy of the useful information. To solve this problem, a dual channel independent filtering method is proposed based on the idea of equalization mapping. Firstly, the particle prediction performance is described by particle manipulations of different dimensions, and the accuracy of particle prediction is improved. The improvement of particle degradation of this algorithm is analyzed in the aspects of particle weight and effective particle number. Secondly, according to the problem of lack of particle samples, the new particles are generated based on the filtering results, and the particle diversity is increased. Finally, the introduction of the graphics processing unit(GPU) parallel computing the platform, the 'channel-level' and 'particlelevel' parallel computing the program are designed to accelerate the algorithm. The simulation results show that the algorithm has the advantages of better filtering precision, higher particle efficiency and faster calculation speed compared with the traditional algorithm of the CPU platform. | LI Fan BI Hongkui XIONG Jiajun YU Chenlong LAN Xuhui | 2018 | Journal of Systems Engineering and Electronics2018，29，4： | 1 |
| 7 | Chinese Named Entity Recognition Using Role Model 显示文摘 | Huaping Zhang Qun Liu Hongkui Yu | 2003 | Special issue 'Word Formation and Chinese Language processing' of the International Journal of Computational Linguistics and Chinese Language Processing2003，8，2： | 1 |
| 8 | Chinese named entity recognition using role model显示文摘 | Zhang Huaping Liu Qun Yu Hongkui | 2003 | The International Journal of Computational Linguistics and Chinese Language Processing2003，8，2： | 1 |
| 9 | Derivation of totipotent-like stem cells with blastocyst-like structure forming potential显示文摘It is challenging to derive totipotent stem cells in vitro that functionally and molecularly resemble cells from totipotent embryos.Here,we report that a chemical cocktail enables the derivation of totipotent-like stem cells,designated as totipotent potential stem(TPS)cells,from 2-cell mouse embryos and extended pluripotent stem cells,and that these TPS cells can be stably maintained long term in vitro.TPS cells shared features with 2-cell mouse embryos in terms of totipotency markers,transcriptome,chromatin accessibility and DNA methylation patterns.In vivo chimera formation assays show that these cells have embryonic and extraembryonic developmental potentials at the single-cell level.Moreover,TPS cells can be induced into blastocyst-like structures resembling preimplantation mouse blastocysts.Mechanistically,inhibition of HDAC1/2 and DOT1L activity and activation of RARγsignaling are important for inducing and maintaining totipotent features of TPS cells.Our study opens up a new path toward fully capturing totipotent stem cells in vitro. | Yaxing Xu Jingru Zhao Yixuan Ren Xuyang Wang Yulin Lyu Bingqing Xie Yiming Sun Xiandun Yuan Haiyin Liu Weifeng Yang Yenan Fu Yu Yu Yinan Liu Rong Mu Cheng Li Jun Xu Hongkui Deng | 2022 | Cell Research2022，32，6： | 1 |
| 10 | Unveiling E2F4,TEAD1 and AP-1 as regulatory transcription factors of the replicative senescence program by multi-omics analysis显示文摘Senescence,a stable state of growth arrest,affects many physiological and pathophysiological processes,especially aging.Previous work has indicated that transcription factors(TFs)play a role in regulating senescence.However,a systematic study of regulatory TFs during replicative senescence(RS)using multiomics analysis is still lacking.Here,we generated timeresolved RNA-seq,reduced representation bisulfite sequencing(RRBS)and ATAC-seq datasets during RS of mouse skin fibroblasts,which demonstrated that an enhanced inflammatory response and reduced proliferative capacity were the main characteristics of RS in both the transcriptome and epigenome.Through integrative analysis and genetic manipulations,we found that transcription factors E2F4,TEAD1 and AP-1 are key regulators of RS.Overexpression of E2f4 improved cellular proliferative capacity,attenuated SA-β-Gal activity and changed RS-associated differentially methylated sites(DMSs).Moreover,knockdown of Tead1 attenuated SA-β-Gal activity and partially altered the RS-associated transcriptome.In addition,knockdown of Atf3,one member of AP-1 superfamily TFs,reduced Cdkn2a(p16)expression in pre-senescent fibroblasts.Taken together,the results of this study identified transcription factors regulating the senescence program through multi-omics analysis,providing potential therapeutic targets for anti-aging. | Yuting Wang Liping Liu Yifan Song Xiaojie Yu Hongkui Deng | 2022 | Protein & Cell2022，13，10： | 1 |
| 11 | Chinese named entity recognition using role model显示文摘 | Zhang Huaping Liu Qun Yu Hongkui | 2003 | the International Journal of Computational Linguistics and Chinese Language Processing2003，8，2： | 1 |
| 12 | Chinese Named Entity Recognition Using Role Model 显示文摘 | Huaping Zhang Qun Liu Hongkui Yu Xueqi Cheng Shuo Bai | 2003 | Special Issue 'Word Formation and Chinese Language processing' of the International Journal of Computational Linguistics and Chinese Language Processing2003，8，2： | 1 |
| 13 | A Numerical Study on Hydraulic Fracturing Problems via the Proper Generalized Decomposition Method显示文摘The hydraulic fracturing is a nonlinear,fluid-solid coupling and transient problem,in most cases it is always time-consuming to simulate this process numerically.In recent years,although many numerical methods were proposed to settle this problem,most of them still require a large amount of computer resources.Thus it is a high demand to develop more efficient numerical approaches to achieve the real-time monitoring of the fracture geometry during the hydraulic fracturing treatment.In this study,a reduced order modeling technique namely Proper Generalized Decomposition(PGD),is applied to accelerate the simulations of the transient,non-linear coupled system of hydraulic fracturing problem,to match this extremely tight response time constraint.The separability of the solution in space and time dimensions is studied for a simplified model problem.The solid and fluid equations are coupled explicitly by inverting the solid discrete problem,and a simple iterative procedure to handle the non-linear characteristic of the hydraulic fracturing problem is proposed in this work.Numeral validation illustrates that the results of PGD match well with these of standard finite element method in terms o f fracture opening and fluid pressure in the hydro-fracture.Moreover,after the off-line calculations,the numerical results can be obtained in real time. | Daobing Wang Sergio Zlotnik Pedro Díez Hongkui Ge Fujian Zhou Bo Yu | 2020 | Computer Modeling in Engineering & Sciences2020，，2： | 1 |
| 14 | Difference in tolerance to potassium deficiency between two maize inbred lines显示文摘 | Cao Minjian Yu Haiqiu Yah Hongkui | 2007 | Plant Production Science2007，10，1： | 1 |
| 15 | Difference in tolerance to potassium deficiency between two maize Inbred lines显示文摘 | CAO MINJIAN YU HAIQIU YAN HONGKUI | 2007 | Plant Production Science2007，10，1： | 1 |
| 16 | The heterogeneity and dynamic equilibrium of rat embryonic stem cells显示文摘 | Yan Shen Cheng Shi Wei Wei Weidong Yu Wenlin Li Yang Yang Jun Xu Wenqin Ying Xin Sui Lingling Fang Weiwei Lin Huan Yang Sheng Ding Huan Shen Yan Shi Hongkui Deng | 2011 | Cell Research2011，21，7： | 1 |
| 17 | N-terminal of Lprotein of vesicular stomatitis virus contains a new signal sequence显示文摘The L protein (241 kD) of vesicular stomatitis virus (VSV) is the most important subunit of the replication complex. The existence of specific localization signal in the L protein was investigated by making recombinant constructs expressing truncated mutants of the L protein fused to green fluorescent protein (GFP) in transient transfection assays. The chimeric genes encoding varied N-terminal of L and GFP gene were put under the control of T7 promoter or CMV promoter. The fusion proteins were transiently expressed in BHK-21, COS-7, CHO or Hep G2 cells. When more than 120 residues were deleted or only 96 residues were kept on the N-terminal, the fusion proteins were shown to be distributed throughout the cells, cytoplasm and nucleus under the confocal microscope. However, other chimeric proteins with 120 or more amino acids were dotted and distributed in the perinuclear regions. And the fusion protein with 96120 aa has the similar distribution. A thirteen-residue peptide QGYSFLHEVDKEA (108120) was identified as localization signal, whose function would be absolutely distributed with the deficiency of D or V. Our results show that there is an independent localizing signal in N-terminal domain of L protein of VSV and this functional signal is conserved in different cell lines. | NIE Yuchun, KE Yeyan, WANG Zai, YU Xiang, DENG Hongkui & DING Mingxiao Department of Cell Biology and Genetics, College of Life Sciences, Peking University, Beijing 100871, China Correspondence should be addressed to Ding Mingxiao (e-mail: mxding@china.com.cn) | 2003 | Chinese Science Bulletin2003，48，13： | 0 |
| 18 | Precise Measurement of Subsurface Seismic Velocity Variation by Coda Wave Interferometry显示文摘A filed experiment was conducted continuously for three days,and the velocity variation was measured using coda wave interferometry.The measurement error is estimated to be around 10-4,which coincides well with the theoretical error.The velocity variation during this period is up to 10-3.The relationship between velocity variation and changes in air temperature,barometric pressure and solid earth tide was analyzed with linear least square fitting.The velocity has no dependence on air temperature,but displayed change of the order of 10-6~10-7 when the barometer or earth tide changed one Pa. | Xia Yu Wang Baoshan Ge Hongkui Chen Yong | 2008 | Earthquake Research in China2008，22，4： | 0 |
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