|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | MXR7 facilitates liver cancer metastasis via epithelial-mesenchymal transition显示文摘MXR7 is a cell-surface protein and highly expressed in hepatocellular carcinoma(HCC). The aim of this study is to determine the expression profile of MXR7 in HCC and investigate the influence of MXR7 on invasion and metastasis of HCC cells. For this purpose, immunohistochemical assay was used to identify the differential expression of MXR7 in 94 HCC specimens. Expression of MXR7 in 4 pairs of HCC and portal vein tumor thrombus(PVTT) was also tested. The motility of HCC cells were characterized by transwell migration and matrigel invasion assays. In vivo metastasis potential was determined via tail vein injection assay.Moreover, compared with noninvasive HCC tumors or human HCC cell lines with low metastatic potential, invasive HCC samples and HCC cell lines with high metastatic potential exhibited higher MXR7 expression. Furthermore, forced expression of MXR7 in SMMC-7721 promoted cell proliferation, migration and invasion in vitro and accelerated tumor growth and metastasis in vivo. Conversely, knockdown of MXR7 expression in HuH7 cells inhibited proliferation and motility of cells. Mechanically,overexpression of MXR7 promoted epithelial-mesenchymal transition(EMT) progress, and MXR7 depletion repressed the EMT phenotype. In conclusion, MXR7 is a mediator of EMT and metastasis in HCC and may serve as a novel therapeutic target. | guishuai lv yexiong tan hongwei lv tian fang changzheng wang ting li yanting yu congli hu wen wen hongyang wang wen yang | 2017 | Science China(Life Sciences)2017，60，11： | 2 |
| 2 | Metabolism, signaling, and transport of jasmonates显示文摘Biosynthesis/metabolism,perception/signaling,and transport are three essential aspects of the actions of phytohormones.Jasmonates(JAs),including jasmonic acid(JA)and related oxylipins,are implicated in the regulation of a range of ecological interactions,as well as developmental programs to integrate these interactions.Jasmonoyl-isoleucine(JA-Ile)is the most bioactive JAs,and perception of JA-Ile by its coreceptor,the Skp1-Cullin1-F-box-type(SCF)protein ubiquitin ligase complex SCF^(COI1)-JAZ,in the nucleus derepresses the transcriptional repression of target genes.The biosynthesis and metabolism of JAs occur in the plastid,peroxisome,cytosol,endoplasmic reticulum,and vacuole,whereas sensing of JA-Ile levels occurs in the nucleus.It is increasingly apparent that a number of transporters,particularly members of the jasmonates transporter(JAT)family,located at endomembranes as well as the plasma membrane,constitute a network for modulating and coordinating the metabolic flux and signaling of JAs.In this review,we discuss recent advances in the metabolism,signaling,and especially the transport of JAs,focusing on intracellular compartmentation of these processes.The roles of transporter-mediated cell-cell transport in driving long-distance transport and signaling of JAs are also discussed. | Mengya Li Guanghui Yu Congli Cao Pei Liu | 2021 | Plant Communications2021，2，5： | 2 |
| 3 | Effect of see- ding methods on growth of NaA zeolite membranes 显示文摘 | Liu Yanmei Yang Zhanzhao Yu Congli | 2011 | Micro- porous and Mesoporous Materials2011，143，： | 1 |
| 4 | Classification of Chinese Soybean Paste by Fourier Transform Near-Infrared (FT-NIR) Spectroscopy and Different Supervised Pattern Recognition显示文摘 | Hui Jiang Guohai Liu Xiahong Xiao Shuang Yu Congli Mei Yuhang Ding | 2012 | Food Analytical Methods2012，，： | 1 |
| 5 | Haemotrophic mycoplasma: review of aetiology and prevalence显示文摘 | Zhibiao Yang Congli Yuan Fei Yu | 2007 | Rev Med Microbiol2007，18，1： | 1 |
| 6 | Autocatalytic reduction-assisted synthesis of segmented porous PtTe nanochains for enhancing methanol oxidation reaction显示文摘Morphology engineering has been developed as one of the most widely used strategies for improving the performance of electrocatalysts.However,the harsh reaction conditions and cumbersome reaction steps during the nanomaterials synthesis still limit their industrial applications.Herein,one-dimensional(1D)novel-segmented PtTe porous nanochains(PNCs)were successfully synthesized by the template methods assisted by Pt autocatalytic reduction.The PtTe PNCs consist of consecutive mesoporous architectures that provide a large electrochemical surface area(ECSA)and abundant active sites to enhance methanol oxidation reaction(MOR).Furthermore,1D nanostructure as a robust sustaining frame can maintain a high mass/charge transfer rate in a long-term durability test.After 2,000 cyclic voltammetry(CV)cycles,the ECSA value of PtTe PNCs remained as high as 44.47 m^(2)·gPt^(-1),which was much larger than that of commercial Pt/C(3.95 m^(2)·gPt^(-1)).The high catalytic activity and durability of PtTe PNCs are also supported by CO stripping test and density functional theory calculation.This autocatalytic reduction-assisted synthesis provides new insights for designing efficient low-dimensional nanocatalysts. | Qiqi Zhang Tianyu Xia He Huang Jialong Liu Mengyuan Zhu Hao Yu Weifeng Xu Yuping Huo Congli He Shipeng Shen Cong Lu Rongming Wang Shouguo Wang | 2023 | Nano Research Energy2023，2，1： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员