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| 1 | 体内腺相关病毒-常间回文重复序列丛集及其相关蛋白9介导的基因编辑可改善家族性高胆固醇血症的动脉粥样硬化显示文摘低密度脂蛋白受体(low-density lipoprotein receptor,Ldlr)基因突变是家族性高胆固醇血症的主要原因之一,可导致动脉粥样硬化,并具有很高的终生心血管病风险。常间回文重复序列丛集(clustered regularly interspaced short palindromic repeats,CRISPR)/CRISPR相关蛋白9(CRISPR-related protein 9,Cas9)系统是基因编辑纠正基因突变从而改善疾病的有效工具。该研究的目的是通过腺相关病毒(adeno-associated virus,AAV)携带的CRISPR/Cas9系统进行体内体细胞基因编辑,以确定其能否在小鼠模型中治疗由Ldlr突变体引起的家族性高胆固醇血症。 | 刘青(译) 叶鹏(审校) Zhao H Li Y He L Pu W Yu W Li Y Wu YT Xu C Wei Y Ding Q Song BL Huang H Zhou B | 2020 | 中华高血压杂志2020，28，3： | 22 |
| 2 | Exploring an Integrative Therapy for Treating COVID-19:A Randomized Controlled Trial显示文摘Objectives:To develop a new Chinese medicine(CM)-based drug and to evaluate its safety and effect for suppressing acute respiratory distress syndrome(ARDS)in COVID-19 patients.Methods:A putative ARDS-suppressing drug Keguan-1 was first developed and then evaluated by a randomized,controlled two-arm trial.The two arms of the trial consist of a control therapy(alpha interferon inhalation,50(x g twice daily;and lopinavir/ritonavir,400 and 100 mg twice daily,respectively)and a testing therapy(control therapy plus Keguan-119.4 g twice daily)by random number table at 1:1 ratio with 24 cases each group.After 2-week treatment,adverse events,time to fever resolution,ARDS development,and lung injury on newly diagnosed COVID-19 patients were assessed.Results:An analysis of the data from the first 30 participants showed that the control arm and the testing arm did not exhibit any significant differences in terms of adverse events.Based on this result,the study was expanded to include a total of 48 participants(24 cases each arm).The results show that compared with the control arm,the testing arm exhibited a significant improvement in time to fever resolution(P=0.035),and a significant reduction in the development of ARDS(P=0.048).Conclusions:Keguan-1-based integrative therapy was safe and superior to the standard therapy in suppressing the development of ARDS in COVID-19 patients.(Trial registration No.NCT 04251871 at www.clinicaltrials.gov). | WANG Jia-bo WANG Zhong-xia JING Jing ZHAO Peng DONG Jing-hui ZHOU Yong-feng YANG Guang NIU Ming ZHAO Xu JIANG Tian-jun Bl Jing-feng XU Zhe ZHANG Ping WU Dan BAI Zhao-fang GUO Yu-ming YU Si-miao SUN Yong-qiang ZHANG Zi-teng ZHAN Xiao-yan LI Peng-yan DING Jin-biao ZHAO Peng-fei SONG Xue-ai TANG Jian-yuan HE Dong-chu CHEN Zhu QIN En-qiang WANG Rui-lin XIAO Xiao-he | 2020 | Chinese Journal of Integrative Medicine2020，26，9： | 18 |
| 3 | Protective effect of bicyclol on tetracycline-induced fatty liver in mice显示文摘 | Yu HY Wang BL Zhao J | | 0，，03： | 1 |
| 4 | Water exchange in fluoroaluminate complexes in aqueous solution:a variable temperature multinuclear NMR study显示文摘 | YU P PHILLIPS BL CASEY WH | 2001 | Inorg Chem2001，40，： | 1 |
| 5 | Effect of p53 status on tumor response to antiangiogenie therapy显示文摘 | Yu JL Rak JW Coomber BL | 2002 | Science2002，295，： | 1 |
| 6 | Protective effect of bicyclol on tetracycline-induced fatty liver in mice显示文摘 | Yu HY Wang BL Zhao J | 2009 | Toxicology2009，261，1： | 1 |
| 7 | Effect of p53 status on tumor response to antiangiogenic therapy显示文摘 | Yu JL Rak JW Coomber BL | 2002 | Science2002，295，5595： | 1 |
| 8 | Ku and DNA-dependentprotein kinase dynamic conformations and assembly regulate DNA binding and the initial non-homologous end joining complex 显示文摘 | Hammel M Yu Y Mahaney BL | 2010 | J Biol Chem2010，285，2： | 1 |
| 9 | Effect of p53 status on tumor response to antiangiogenic therapy 显示文摘 | Yu JL Rak JW Coomber BL Hicklin DJ Kerbel RS | 2002 | Science2002，295，5559： | 1 |
| 10 | Apolipoprotein A5internalized by human adipocytes modulates cellular triglycerideconten显示文摘 | Zheng XY Zhao SP Yu BL | 2012 | tBiol Chem2012，393，3： | 1 |
| 11 | Joint neurodevelopmental and be- havioral effects of nonylphenol and estradiol on F ( 1 ) male rats 显示文摘 | Yu J Fan QY Hu BL | 2013 | International Journal of Environmental Health Research2013，23，4： | 1 |
| 12 | Avellis syndme as presenting manifes- tation of ulcerative colitis 显示文摘 | Ho BL Yu FJ Lai Cl | 2013 | Journal of the Neunlogical Sciences2013，325，1： | 1 |
| 13 | Protective effect of bieyelol on tetracycline- induced fatty liver in mice显示文摘 | Yu HY Wang BL Zhao J | 2009 | Toxicology2009，261，3： | 1 |
| 14 | The effect of moderate-dose versus double-dose statins on patients with acute coronary syndrome in China: Results of the CHILLAS trim 显示文摘 | Zhao SP Yu BL Peng DQ | 2014 | Atherosclerosis2014，233，2： | 1 |
| 15 | Pulmonmy cryplococcosis in non AIDS patients 显示文摘 | Yu JQ Tang KJ Xu BL | 2012 | Braz J Infect Dis2012，16，6： | 1 |
| 16 | The effect of moderate-dose versus double-dose statins on patients with acute cor-onary syndrome in China : Results of the CHILLAS trial显示文摘 | Zhao SP Yu BL Peng DQ | 2014 | Atherosclerosis2014，233，2： | 1 |
| 17 | Effect of p53 status on tumor response to antiangiogenic therapy显示文摘 | Yu JL Rak JW Coomber BL | 2002 | Science2002，295，5559： | 1 |
| 18 | Adaption of very virulent infectious bursal disease virus to chicken embryonic fibroblasts by site-directed mutagenesis of residues 279 and 284 of viral coat protein VP2显示文摘 | Lim BL Cao YC Yu T | 1999 | J Virol1999，73，4： | 1 |
| 19 | Distinct antiviral roles for hu- man 2',5 '-oligoadenylate synthetase family members against dengue virus infection显示文摘 | Lin RJ Yu HP Chang BL | 2009 | J Immunol2009，183，12： | 1 |
| 20 | A real explosion:The requirement of steam explosion pretreatment显示文摘 | Yu ZD Zhang BL Yu FQ | 2012 | Bioresource Technology2012，12，： | 1 |
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