|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Is tailored therapy based on antibiotic susceptibility effective?A multicenter,open-label,randomized trial显示文摘An effective eradication therapy of Helicobacter pylori(H.pylori)should be used for the first time.In this study,we assessed whether tailored therapy based on antibiotic susceptibility testing is more effective than traditional therapy.We also evaluated the factors that cause treatment failure in high-resistance areas.For this multicenter trial,we recruited 467 H.pylori-positive patients.The patients were randomly assigned to receive tailored triple therapy(TATT),tailored bismuth-containing quadruple therapy(TABQT),or traditional bismuthcontaining quadruple therapy(TRBQT).For the TATT and TABQT groups,antibiotic selection proceeded via susceptibility testing using an agar-dilution test.The patients in the TRBQT group were given amoxicillin,clarithromycin,esomeprazole,and bismuth.Successful eradication was defined as a negative 13C-urea breath test at least eight weeks after the treatment ended.Susceptibility testing was conducted using an agar-dilution test.The eradication rate was examined via intention-to-treat(ITT)and per-protocol(PP)analyses.The clarithromycin,levofloxacin,and metronidazole resistance rates were 26.12%,28.69%,and 96.79%,respectively.Resistance against amoxicillin and furazolidone was rare.The eradication rates for TATT,TRBQT,and TABQT were 67.32%,63.69%,and 85.99%in the ITT analysis(P<0.001)and 74.64%,68.49%,and 91.22%in the PP analysis(P<0.001),respectively.The efficacy of TABQTwas affected by clarithromycin resistance,and bismuth exerted a direct influence on TATT failure.TABQT was the most efficacious regimen for use in high-resistance regions,especially among clarithromycin-susceptible patients. | Jie Pan Zhengchao Shi Dingsai Lin Ningmin Yang Fei Meng Lang Lin Zhencheng Jin Qingjie Zhou Jiansheng Wu Jianzhong Zhang Youming Li | 2020 | Frontiers of Medicine2020，14，1： | 10 |
| 2 | A highly selective dual-channel Hg^(2+) chemosensor based on an easy to prepare double naphthalene Schiff base显示文摘A non-sulfur chemosensor based on an easy to prepare double naphthalene Schiff base is reported for the colorimetric and fluorometric dual-channel sensing of Hg2+ ions by taking advantage of the twisted intramolecular charge transfer (TICT) mechanism. This work provides a novel approach for the selective recognition of mercury ions. Moreover, this sensor serves as a potential recyclable component in sensing materials and the complex L-Hg2+ (L = 1-[(2-naphthalenylimino)methyl]-2-naphthalenol) can therefore be used as a fluorescent sensor for iodine anions. Notably, the color changes are very significant and all the recognition and recycling processes can be observed by the naked eye. | ZHANG YouMing SHI BingBing ZHANG Peng HUO JianQiang CHEN Pei LIN Qi LIU Jun WEI TaiBao | 2013 | Science China Chemistry2013，56，5： | 4 |
| 3 | Selective Chemosensor of Fe3+ Based on Fluorescence Quenching by 2,2'-Bisbenzimidazole Derivative in Aqueous Media显示文摘2,2-Bisbenzimidazole 衍生物(L) 是被设计一荧光灯为 Fe3+ 的 chemosensor。简单 chemosensor 显示重要荧光与增加 Fe3+ 的集中熄灭的这在结构上。L 在水的媒介在环境地相关的金属离子之中为 Fe3+ 展出了高选择和 antidisturbance。工作的阴谋的方法显示了在 L 和 Fe3+ 之间复杂的 1:2 的形成,并且系统的可能的有约束力的模式也被建议。另外,进一步的学习证明到 Fe3+ 的传感器的荧光反应上的察觉限制对 107 摩尔敧獬感到不满吗?? | Taibao Wei Jun Liu Hong Yao Qi Lin Yongqiang Xie Bingbing Shi Peng Zhang Xingmei You Youming Zhang | 2013 | Chinese Journal of Chemistry2013，31，4： | 2 |
| 4 | High rate DC-reactive sputter deposition of Y2 O3 film on the textured metal substrate for the superconducting coated conductor 显示文摘 | Kim Ho-Sup Park Chan Ko Rock-Kil Shi Dongqi Chung Jun-Ki Ha Hong-Soo Park Yu-Mi Song Kyu-Jeong Youm Do-Jun | 2005 | Physica C2005，426，431： | 1 |
| 5 | Anti-inflammatory Effects of Rebamipide According to Helicobacter pylori Status in Patients with Chronic Erosive Gastritis: A Randomized Sucralfate-Controlled Multicenter Trial in China—STARS Study显示文摘 | Yiqi Du Zhaoshen Li Xianbao Zhan Jie Chen Jun Gao Yanfang Gong Jianlin Ren Liping He Zhijian Zhang Xiaozhong Guo Jianshen Wu Zibin Tian Ruihua Shi Bo Jiang Dianchun Fang Youming Li | 2008 | Digestive Diseases and Sciences2008，，11： | 1 |
| 6 | A Rational Designed Dual-channel Chemosensor for Mercury Ions Based on Hydrolysis of Schiff Base显示文摘A bilateral Schiff base is reported for the colorimetric and fluorometric dual-channel sensing of Hg^(2+)ions by taking advantage of the hydrolysis of carbon-nitrogen double bond,altering an ICT state mechanism and then Hg^(2+) ions coordinating with amino moieties of 1,5-DAN and leading to the aggregation of 1,5-DAN.Meanwhile,it formed a stable neutral complex of amino-Hg-amino.In addition,test strips based on L were fabricated,which also exhibited a good selectivity to Hg^(2+) as in solution.This work provides a novel approach for the selective recognition of mercury ions.Notably,the color changes are very significant and all the recognition processes can be observed by the naked eyes.We believe the test strips can act as a convenient and efficient Hg^(2+) test kit. | Guiyuan Wu Bingbing Shi Bing Hu Youming Zhang Qi Lin Hong Yao Taibao Wei | 2014 | Chinese Journal of Chemistry2014，32，7： | 0 |
| 7 | Adsorption of emerging sodium p-perfluorous nonenoxybenzene sulfonate(OBS) onto soils: Kinetics, isotherms and mechanisms显示文摘The widespread use of sodium p-perfluorous nonenoxybenzene sulfonate(OBS), a typical alternative to perfluorooctane sulfonate, has resulted in potential threats to the environment, but the adsorption behavior of OBS in soils has not yet been reported. In this study, the adsorption behaviors of OBS on five soils with different physicochemical properties were investigated. The rate of OBS adsorption was fast, and most of the OBS uptake was completed within 12 h. The good model fit of OBS adsorption to the pseudo-second-order and Elovich models indicated the occurrence of chemical adsorption. The adsorption isotherms of OBS on the soils were better described by the Freundlich model than by the Langmuir model, suggesting that the OBS adsorption sites on the soils were heterogeneous. This is possibly associated with various adsorption mechanisms including hydrophobic, π-π, hydrogen bonding, and electrostatic interactions,further confirmed by the good model fit to the D-R isotherm. Adsorption of OBS occurred on the soils, and the adsorption process was spontaneous and endothermic. In addition, the soils were more suitable for OBS adsorption at lower pH values due to the stronger electrostatic adsorption. The OBS adsorption on the soils decreased with the increase of soil depth from 0 to 30 cm. Moreover, the presence of organic matter and ammonia nitrogen in the soils was favorable for OBS adsorption, and these parameters decreased with increasing soil depth, making OBS adsorption less prominent in the deeper soil. This study indicates that OBS is easily enriched in surface soils, and that soil organic matter and ammonia nitrogen significantly affect OBS migration in soil. | Wei WANG Xue ZHANG Yuhui ZHANG Xin MI Run WANG Huilan SHI Chunli LI Ziwen DU Youming QIAO | 2021 | Pedosphere2021，31，4： | 0 |
| 8 | Synthesis of Copillar[5]arene by Co-oligomerization of Different Monomers and Its Application to Supramolecular Polymer Gel显示文摘A copillar[5]arene derivative with different repeating units was synthesized by co-oligomerization of different alkyl ethers.Copillar[5]arene-based supramolecular polymer gel was formed by a self-inclusion complexing in acetonitrile.The supramolecular polymer gel was driven by the C-H•πinteractions,and presented two phases as time went on,and finally,constructed the supramolecular organic framework.Notably,the supramolecular polymer gel showed reversible gel-sol phase transitions upon heating and cooling.Meanwhile,the transparent films formed by the supramloecular gel show the potential application in the field of anti-acid rain materials. | Hui Li Yuanrong Zhu Bingbing Shi Guiyuan Wu Youming Zhang Qi Lin Hong Yao Taibao Wei | 2015 | Chinese Journal of Chemistry2015，33，3： | 0 |
| 9 | Fabricating a novel supramolecular light-activated platform based on internal-driven forces induced by the UV-light显示文摘Recently,exploiting a novel supramolecular fabrication pathway have drawn great attention.To this endeavor,we firstly designed and reported an original light-activated platform based on the internal-driven forces of macrocyclic host by hiring the pillar[5]arene as the host molecule(H)and phenazine derivatives acting as an energetic guest molecule(G).Surprisingly,after adding the H solution into G system,the intensive fluorescence emission of the G molecule rapidly decreased under the irradiation of the UV-light(254 nm)until absolutely quenching.Delightfully,different from the traditional supramolecular host-guest interaction,the fluorescent emission of G molecule could be recovered after irradiating under the nature light.In view of this interesting observations,the interaction mechanism was carefully investigated by a series of characterizations.Those results suggested that the G molecule was easily threaded into the macrocyclic cavity(H)under the internal-driven forces induced by the UV-light irradiation,forming a 1:1 host-guest complex.Moreover,taking advantage of this especial feature,the light-activated platform of host-guest complex was further applied for ink-free light-driven printing materials,exhibiting great potential in the real application. | Xiaoni Qi Weichun Li Bingbing Shi Youming Zhang Hong Yao Qi Lin Taibao Wei | 2022 | Chinese Chemical Letters2022，33，12： | 0 |
| 10 | Genome-Wide Identification, Evolution and Expression Analyses of GA2ox Gene Family in Brassica napus L.显示文摘Gibberellin 2-oxidases(GA2ox)are important enzymes that maintain the balance of bioactive GAs in plants.GA2ox genes have been identified and characterized in many plants,but these genes were not investigated in Brassica napus.Here,we identified 31 GA2ox genes in B.napus and 15 of these BnaGA2ox genes were distributed in the A and C subgenomes.Subcellular localization predictions suggested that all BnaGA2ox proteins were localized in the cytoplasm,and gene structure analysis showed that the BnaGA2ox genes contained 2–4 exons.Phylogenetic analysis indicated that BnGA2ox family proteins in monocotyledons and dicotyledons can be divided into four groups,including two C_(19)-GA2ox and two C_(20)-GA2ox clades.Group 4 is a C_(20)-GA2ox Class discovered recently.Most BnaGA2ox genes had a syntenic relationship with AtGA2ox genes.BnaGA2ox genes in the C subgenome had experienced stronger selection pressure than genes in the A subgenome.BnaGA2ox genes were highly expressed in specific tissues such as those involved in growth and development,and most of them were mainly involved in abiotic responses,regulation of phytohormones and growth and development.Our study provided a valuable evolutionary analysis of GA2ox genes in monocotyledons and dicotyledons,as well as an insight into the biological functions of GA2ox family genes in B.napus. | Yanhua Li Hualei Huang Youming Shi Shuqin Huang Tao Liu Changming Xiao Xiaoqing Tian Ping Zhao Xiaoyan Dai Taocui Huang Yan Zhou | 2023 | Phyton-International Journal of Experimental Botany2023，92，3： | 0 |
| 11 | A Fluorescent Chemosensor for Dihydrogen Phosphate Ion Based on 2-[2-Hydroxy-4-(diethylamino)phenyl]-1Himidazo[4,5-b]phenazine-Fe^(3+)Ensemble显示文摘A long wavelength emission fluorescent(612 nm)chemosensor with high selectivity for H_(2)PO_(4)^(−)ions was designed and synthesized according to the excited state intramolecular proton transfer(ESIPT).The sensor can exist in two tautomeric forms(‘keto’and‘enol’)in the presence of Fe^(3+)ion,Fe^(3+)may bind with the‘keto’form of the sensor.Furthermore,the in situ generated GY-Fe^(3+)ensemble could recover the quenched fluorescence upon the addition of H_(2)PO_(4)^(−)anion resulting in an off-on-type sensing with a detection limit of micromolar range in the same medium,and other anions,including F^(−),Cl^(−),Br^(−),I^(−),AcO^(−),HSO^(−)_(4),ClO^(−)_(4)and CN−had nearly no influence on the probing behavior.The test strips based on 2-[2-hydroxy-4-(diethylamino)phenyl]-1H-imidazo[4,5-b]phenazine and Fe^(3+)metal complex(GY-Fe^(3+))were fabricated,which could act as convenient and efficient H_(2)PO_(4)^(−)test kits. | Taibao Wei Guiyuan Wu Bingbing Shi Qi Lin Hong Yao Youming Zhang | 2014 | Chinese Journal of Chemistry2014，32，12： | 0 |
| 12 | A recombineering system for Bacillus subtilis based on the native phage recombinase pair YqaJ/YqaK显示文摘Bacillus subtilis plays an important role in fundamental and applied research,and it has been widely used as a cell factory for the production of enzymes,antimicrobial materials,and chemicals for agriculture,medicine,and industry.However,genetic manipulation tools for B.subtilis have low efficiency.In this work,our goal was to develop a simple recombineering system for B.subtilis.We showed that genome editing can be achieved in B.subtiliis 1A751 through co-expression of YqaJ/YqaK,a native phage recombinase pair found in B.sub-tilis 168,and the competence master regulator ComK using a double-stranded DNA substrate with short ho-mology arms(100 bp)and a phosphorothioate modification at the 5′-end.Efficient gene knockouts and large DNA insertions were achieved using this new recombineering system in B.subtilis 1A751.As far as we know,this is the first recombineering system using the native phage recombinase pair YqaJ/YqaK in B.subtilis.In conclusion,this new recombineering system provides a simple and fast tool for genetic manipulation of B.sub-tilis,and it will promote studies of genome function,construction of production strains,and genome mining in B.subtilis. | Qingshu Liu Ruijuan Li Hongbo Shi Runyu Yang Qiyao Shen Qingwen Cui Xiuling Wang Aiying Li Youming Zhang Jun Fu | 2023 | Engineering Microbiology2023，3，3： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员